Fig. 1 · Structure
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TASP0412098
Prostaglandin Receptor
TASP0412098 is a potent and selective antagonist of the prostaglandin receptor CRTH2/DP2, exhibiting a high binding affinity with an IC50 of 2.1 nM and functional activity with an IC50 of 12 nM. This compound demonstrates potential anti-inflammatory effects and may be beneficial in suppressing asthma, as evidenced by its efficacy in mouse and guinea pig bronchial asthma models. TASP0412098 is a valuable tool for researchers investigating the role of prostaglandin receptors in respiratory conditions and inflammation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1233248-29-7 |
| Applications | Prostaglandin Receptor |
| Formula | C27H23ClN2O3 |
| Molecular Weight | 458.94 |
| SMILES | O=C(CC1=CN=C(C2=C1C=CC=C2)CC3=CC=C(C=C3)C(NCCC4=CC=C(C=C4)Cl)=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.