TASP0412098

Catalog No.: A63405
Prostaglandin Receptor
TASP0412098 is a potent and selective antagonist of the prostaglandin receptor CRTH2/DP2, exhibiting a high binding affinity with an IC50 of 2.1 nM and functional activity with an IC50 of 12 nM. This compound demonstrates potential anti-inflammatory effects and may be beneficial in suppressing asthma, as evidenced by its efficacy in mouse and guinea pig bronchial asthma models. TASP0412098 is a valuable tool for researchers investigating the role of prostaglandin receptors in respiratory conditions and inflammation.
Grouped product items
Size Price Stock Qty
25mg
$1,780.00
In stock
50mg
$2,280.00
In stock
100mg
$2,960.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTASP0412098 is a potent and selective antagonist of the prostaglandin receptor CRTH2/DP2, exhibiting a high binding affinity with an IC50 of 2.1 nM and functional activity with an IC50 of 12 nM. This compound demonstrates potential anti-inflammatory effects and may be beneficial in suppressing asthma, as evidenced by its efficacy in mouse and guinea pig bronchial asthma models. TASP0412098 is a valuable tool for researchers investigating the role of prostaglandin receptors in respiratory conditions and inflammation.
Product Information
Catalog NumA63405
FormulaC27H23ClN2O3
Molecular Weight458.94
CAS Number1233248-29-7
SMILESO=C(CC1=CN=C(C2=C1C=CC=C2)CC3=CC=C(C=C3)C(NCCC4=CC=C(C=C4)Cl)=O)O
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