Fig. 1 · Structure
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CRTH2-IN-1
Prostaglandin Receptor Antagonist
CRTH2-IN-1 is a selective antagonist of the prostaglandin D2 receptor, also known as CRTH2, with an IC50 value of 6 nM in human DP2 binding assays. This compound is utilized in research focused on elucidating the role of DP2 in various biological pathways, including inflammation and immune response. Its properties make it a valuable tool for investigating therapeutic strategies in conditions associated with prostaglandin signaling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 926661-54-3 |
| Applications | Prostaglandin Receptor Antagonist |
| Formula | C21H21FN2O4S |
| Molecular Weight | 416.47 |
| Synonyms | Ramatroban analog |
| SMILES | O=C(O)CC1=C(CCC(N(S(=O)(C2=CC=C(F)C=C2)=O)C)C3)N3C4=C1C=CC=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.