Catalog No.
Product Name
Application
Product Information
Citations
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BuChE inhibitor
Iso-OMPA (Tetraisopropyl pyrophosphoramide) is a selective inhibitor of butyrylcholinesterase (BuChE), functioning through irreversible inhibition. This compound is primarily utilized in research to investigate the mechanisms of BuChE and the resulting effects on acetylcholine metabolism. Iso-OMPA has been shown to enhance soman toxicity in rat models, linked to the inhibition of plasma carboxylesterase (CarbE), making it a valuable tool in studies of nerve agent effects and cholinergic signaling. -
CYP2D6/AChE Inhibitor
Rhodiosin is a dual inhibitor of CYP2D6 and acetylcholinesterase (AChE), extracted from the root of Rhodiola rosea. It exhibits an IC50 value of 0.761 μM for CYP2D6 and a Ki of 0.769 μM. This compound demonstrates notable antioxidant and neuroprotective properties, contributing to the regulation of the HIF-1α signaling pathway, which is vital for central nervous system protection. Rhodiosin serves as a valuable tool for research in neuropharmacology and metabolic studies. -
Dual MAO/AChE Inhibitor
Ladostigil hemitartrate is a dual inhibitor of monoamine oxidase (MAO) and acetylcholinesterase (AChE), with established IC50 values of 37.1 μM for MAO-B and 31.8 μM for AChE. This compound is capable of crossing the blood-brain barrier and exhibits neuroprotective, antioxidant, and anti-inflammatory properties. Ladostigil hemitartrate is relevant for research into neurological disorders, including depression and Alzheimer's disease. Additionally, it functions as a click chemistry reagent, featuring an alkyne group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc). -
MAO/AChE Inhibitor
Ladostigil hydrochloride is a potent dual inhibitor of acetylcholinesterase (AChE) and monoamine oxidase-B (MAO-B), exhibiting IC50 values of 37.1 µM and 31.8 µM, respectively. This compound demonstrates neuroprotective, antioxidant, and anti-inflammatory properties, making it valuable for research related to depression and Alzheimer's disease. Additionally, Ladostigil hydrochloride functions as a click chemistry reagent, featuring an alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating diverse chemical applications. -
Dual MAO and AChE Inhibitor
Ladostigil is a dual inhibitor of monoamine oxidase (MAO) and acetylcholinesterase (AChE), demonstrating IC50 values of 37.1 μM for MAO-B and 31.8 μM for AChE. This compound exhibits neuroprotective, antioxidant, and anti-inflammatory properties, making it valuable for research in conditions such as depression and Alzheimer's disease. Additionally, Ladostigil features an alkyne functional group, enabling it to serve as a click chemistry reagent through copper-catalyzed azide-alkyne cycloaddition (CuAAc). -
MAO Inhibitor
ASS234 is a potent monoamine oxidase (MAO) inhibitor, targeting MAO-A and MAO-B with IC50 values of 5.2 nM and 43 nM, respectively. In addition to its primary activity, ASS234 also exhibits inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), with IC50 values of 350 nM and 460 nM, respectively. This compound can be utilized in research related to neurodegenerative diseases, mood disorders, and cholinergic signaling pathways. -
AChE-MAO B Inhibitor
Dual AChE-MAO B-IN-2 is a powerful inhibitor of both acetylcholinesterase (AChE) and monoamine oxidase B (MAO B), exhibiting IC50 values of 0.12 µM and 0.01 µM, respectively. This dual inhibition profile suggests its significant potential in the study and development of therapeutic strategies for Alzheimer's disease. Researchers can utilize Dual AChE-MAO B-IN-2 to explore mechanisms related to cholinergic dysfunction and oxidative stress in neurodegenerative conditions. -
ChEs/MAOs Inhibitor
ChEs/MAOs-IN-2 is a potent inhibitor of cholinesterases and monoamine oxidases, exhibiting IC50 values of 0.10 µM for MAO-A, 0.20 µM for MAO-B, 0.30 µM for acetylcholinesterase (AChE), and 0.40 µM for butyrylcholinesterase (BChE). This compound demonstrates significant biological activity relevant to neurodegenerative diseases, particularly Alzheimer's disease, and serves as a valuable tool for research into therapeutic strategies targeting these enzymes. -
ChE/MAO-A Inhibitor
Desoxypeganine is a potent alkaloid that serves as an inhibitor of cholinesterase (both BChE and AChE) as well as a selective inhibitor of monoamine oxidase A (MAO-A), exhibiting IC50 values of 2, 17, and 2 μM, respectively. This compound is primarily utilized in research related to alcohol abuse, offering valuable insights into the underlying mechanisms of addiction and potential therapeutic approaches. Its dual inhibitory action positions Desoxypeganine as a significant tool in the study of neurochemical pathways involved in substance use disorders. -
AChE/BChE/MAO-B Inhibitor
AChE/BChE/MAO-B-IN-5 is a multitarget inhibitor of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and monoamine oxidase B (MAO-B). With IC50 values of 0.24 µM, 6.29 µM, and 0.11 µM for AChE, BChE, and MAO-B, respectively, this compound demonstrates potent inhibition of key enzymes involved in cholinergic neurotransmission and monoamine metabolism. AChE/BChE/MAO-B-IN-5 is particularly relevant for research into neurodegenerative diseases, including Alzheimer's disease, due to its ability to penetrate the blood-brain barrier. -
AChE/BuChE/MAO-B Inhibitor
AChE/BuChE/MAO-B-IN-1 is a potent inhibitor of human acetylcholinesterase (hAChE), butyrylcholinesterase (hBuChE), and monoamine oxidase-B (hMAO-B), with IC50 values of 4.8 μM, 13.7 μM, and 1.11 μM, respectively. This compound also demonstrates a high affinity for σ1 and σ2 receptors, with Ki values of 42.8 nM and 191 nM, respectively. AChE/BuChE/MAO-B-IN-1 is potentially useful in research focused on Alzheimer's disease and related neurological disorders. -
AChE/BChE/MAO-B Inhibitor
AChE/BChE/MAO-B-IN-1 is a reversible inhibitor targeting acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and monoamine oxidase B (MAO-B), exhibiting IC50 values of 7.31 μM, 0.56 μM, and 26.1 μM, respectively. This compound effectively crosses the blood-brain barrier and demonstrates neuroprotective properties while maintaining a lack of cytotoxicity. Its multifaceted inhibition profile makes it a valuable tool for research on neurodegenerative diseases and associated pathways. -
Dual MAO-AChE Inhibitor
MAO-A/B-IN-3 is a dual inhibitor targeting both monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B), as well as acetylcholinesterase (AChE). With IC50 values of 67 nM for MAO-A, 29 nM for MAO-B, and 1370 nM for AChE, this compound demonstrates substantial multi-target efficacy. MAO-A/B-IN-3 modifies key binding sites to enhance its inhibitory activity against MAO enzymes while reducing the impact on AChE. This reagent is particularly relevant for research focused on neurodegenerative disorders. -
AChE Inhibitor
AChE-IN-20 is a potent acetylcholinesterase (AChE) inhibitor, demonstrating an IC50 value of 397.32 nM and a Ki value of 335.76 nM. In addition to its primary target, AChE-IN-20 exhibits significant inhibitory activity against human carbonic anhydrases I and II, and α-glucosidase, with IC50 values of 84.14 nM, 69.24 nM, and 52.08 nM, respectively. This compound is valuable for research into neurodegenerative diseases and enzymatic regulation, providing insights into potential therapeutic strategies. -
MAO Inhibitor
Benzylhydrazine is a potent inhibitor of monoamine oxidase (MAO), targeting both brain and liver tissues. It exhibits significant inhibitory activity with pI50 values of 6.3 and 7.0 for brain and liver MAO, respectively. In vivo studies have demonstrated its efficacy in mice, with effective doses (ED50) of 6.5 μmol/kg for brain MAO and 6.2 μmol/kg for liver MAO. This compound is useful for research involving neurochemistry and metabolic studies related to neurotransmitter regulation. -
MAOA Inhibitor
Ethyl homovanillate is a selective inhibitor of monoamine oxidase A (MAOA) with an IC50 value of 8.1 μM. This compound demonstrates significant efficacy in improving depressive-like behavior, as evidenced by enhanced scores in the forced swim test in ICR mice. Ethyl homovanillate is a valuable reagent for investigating the mechanisms underlying neurological diseases, particularly Alzheimer's disease, and offers potential insights into therapeutic strategies for mood regulation. -
Monoamine Oxidase Inhibitor
Pargyline is an irreversible monoamine oxidase (MAO) inhibitor, displaying Ki values of 13 μM and 0.5 μM for MAO-A and MAO-B, respectively. This compound exhibits notable antihypertensive and anticancer activities. Additionally, Pargyline functions as a click chemistry reagent due to its alkyne group, allowing for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. -
MAO-A Inhibitor
Clorgyline is a selective inhibitor of monoamine oxidase A (MAO-A) that is orally active and permeable to the blood-brain barrier. By inhibiting MAO-A, Clorgyline decreases the metabolism of neurotransmitters like serotonin (5-hydroxytryptamine), resulting in increased levels in the brain. This compound is particularly valuable for research applications focused on depression and neurodegenerative diseases. -
Monoamine Oxidase
Monoamine oxidase (MAO) is an enzyme that catalyzes the oxidative deamination of biogenic amines, generating hydrogen peroxide in various tissues, including the brain and peripheral systems. By modulating the levels of neurotransmitters, MAO is crucial for regulating synaptic transmission, emotional behavior, and other vital brain functions. This enzyme is an important target for research into neuropsychiatric disorders and the development of related therapeutic agents. -
MAO-B Inhibitor
Mofegiline hydrochloride is a selective, irreversible inhibitor of monoamine oxidase B (MAO-B), exhibiting a significant preference over monoamine oxidase A (MAO-A) with IC50 values of 3.6 nM and 680 nM, respectively. This compound also inhibits semicarbazide-sensitive amine oxidase (SSAO). Mofegiline hydrochloride is utilized in research focused on neurodegenerative disorders and the modulation of neurotransmitter levels. Its specific action on MAO-B makes it a valuable tool in studies addressing dopamine metabolism and potential therapeutic strategies for Parkinson's disease. -
MAO-B Inhibitor
Tisolagiline is a selective, reversible inhibitor of monoamine oxidase B (MAO-B) with an IC50 of 8 nM. This compound demonstrates neuroprotective effects and possesses anti-neuroinflammatory properties, making it valuable for research in neurological disorders. Tisolagiline may be useful in studying the role of MAO-B in neurodegenerative conditions and evaluating potential therapeutic strategies for such diseases. -
MAO-B Inhibitor
Methyl citrate is a potent inhibitor of Monoamine oxidase B (MAO-B), exhibiting an IC50 value of 0.23 mM. Isolated from the fruits of Opuntia ficus-indica var. saboten, this compound demonstrates significant biological activity relevant for neuropharmacological research. Methyl citrate may be utilized in studies investigating its potential effects on neurodegenerative diseases associated with dopaminergic dysfunction. -
hMAO-A Inhibitor
Obtusin is a selective and competitive inhibitor of human monoamine oxidase-A (hMAO-A) with an IC50 of 11.12 μM and a Ki of 6.15 μM. Isolated from the seeds of Cassia obtusifolia Linn, Obtusin demonstrates potential neuroprotective effects, making it relevant for research into neurodegenerative diseases, particularly those associated with anxiety and depression. Its ability to inhibit hMAO-A may contribute to the modulation of serotonin and norepinephrine levels, offering a valuable tool for elucidating mechanisms underlying mood disorders. -
MAO-A Inhibitor
MAO-A Inhibitor 1 is a selective inhibitor of monoamine oxidase A (MAO-A), exhibiting an IC50 of 100 μM. This compound is instrumental in research applications focused on neuropsychiatric disorders, where modulation of monoamine levels may offer therapeutic potential. It serves as a valuable tool in studies investigating the effects of MAO-A inhibition on neurotransmitter metabolism and related pathophysiological conditions. -
Monoamine Oxidase Inhibitor
Eprobemide is a non-competitive reversible inhibitor of monoamine oxidase A (MAO-A). This compound demonstrates significant activity in modulating neurotransmitter levels by inhibiting the oxidative deamination of monoamines, making it a valuable tool for research in neurochemistry and psychiatric disorders. Eprobemide is utilized in studies exploring depression, anxiety, and other conditions associated with monoamine imbalance. -
MAO-A/MAO-B Inhibitor
(-)-2-Phenylpropylamine is an inhibitor of monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B), exhibiting Ki values of 584 μM and 156 μM, respectively. This compound is utilized in research investigating neurotransmitter regulation and is of particular interest in studies related to mood disorders and neurodegenerative diseases. Its dual inhibition of MAO isoforms makes it a valuable tool for understanding the biochemical pathways involved in monoamine metabolism. -
MAO-B Inhibitor
(Rac)-Rasagiline functions as a selective inhibitor of monoamine oxidase B (MAO-B). This compound exhibits neuroprotective properties, particularly against MPTP-induced neuronal toxicity, making it a valuable tool in Parkinson's disease research. Its capacity to modulate monoaminergic systems may provide insights into therapeutic strategies for neurodegenerative disorders. -
MAO A Inhibitor
Tetrindole mesylate is a selective inhibitor of monoamine oxidase A (MAO A). It competitively inhibits rat brain mitochondrial MAO A with a Ki value of 0.4 μM, while also exhibiting weaker inhibition of MAO B with a Ki of 110 μM. This compound demonstrates antidepressant activity, making it relevant for research in psychiatric disorders and neuropharmacology. -
MAO A Inhibitor
Esuprone is a selective inhibitor of monoamine oxidase A (MAO A) with an IC50 of 7.3 nM, demonstrating significant brain penetration and oral bioavailability. This compound is valuable for neurological research, contributing to the study of mood disorders and neurodegenerative diseases by modulating neurotransmitter levels. -
MAO Inhibitor
Tetrahydroharmine is a selective monoamine oxidase (MAO) inhibitor with an IC50 value of 74 nM for MAO-A. This compound is of significant interest in the study of neurodegenerative diseases, as it may enhance monoamine neurotransmitter levels and provide neuroprotective effects. Its application in research includes exploring therapeutic strategies for conditions like depression and neurodegeneration. -
MAO-B Inhibitor
Tisolagiline monomethylsulfate is a selective, reversible inhibitor of monoamine oxidase B (MAO-B), exhibiting an IC50 of 8 nM. It demonstrates neuroprotective effects and possesses anti-neuroinflammatory properties, making it a valuable compound for researching neurodegenerative diseases and related disorders. This reagent is suitable for studies focused on neuroprotection and inflammation modulation in various cellular and animal models. -
Monoamine Oxidase Inhibitor
Chrysophanol-1-O-β-gentiobioside is an anthraquinone glycoside that selectively inhibits the hMAO-A isozyme, exhibiting an IC50 value of 96.15 μM. This compound is primarily utilized in research focused on the modulation of monoamine oxidase activity, making it relevant for studies on neurological disorders and related pharmacological applications. Its unique structure and biological properties contribute to its potential for advancing therapeutic innovations. -
MAO-A/-B Inhibitor
MAO-IN-M30 dihydrochloride is a selective and irreversible inhibitor of monoamine oxidases A and B, with IC50 values of 37 nM and 57 nM, respectively. This compound demonstrates significant neuroprotective properties, effectively mitigating brain cell apoptosis induced by Dexamethasone. Additionally, it exhibits neurorestorative effects in models of Parkinson's disease, specifically post MPTP and lactacystin. MAO-IN-M30 dihydrochloride functions as a click chemistry reagent due to its alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) for various research applications. -
Monoamine Oxidase Inhibitor
Modaline sulfate is a potent monoamine oxidase (MAO) inhibitor that plays a significant role in the modulation of neurotransmitter levels. It has been primarily investigated for its efficacy in treating depression by preventing the breakdown of serotonin, norepinephrine, and dopamine. This compound serves as a valuable tool in research focused on mood disorders and the neurochemical pathways involved in depression. -
hMAO-B Inhibitor
Ethyl 7-(diethylamino)-2-oxo-2H-chromene-3-carboxylate is a selective inhibitor of human monoamine oxidase B (hMAO-B), demonstrating an IC50 of 45.52 μM. This compound is valuable in research focused on neurodegenerative diseases, as it modulates monoamine metabolism and has implications for the treatment of conditions such as Parkinson's disease. Its potent inhibition of hMAO-B makes it a useful tool for investigating the role of this enzyme in various biological processes. -
MAO-B Inhibitor
Selegiline is a potent, selective, and irreversible inhibitor of monoamine oxidase B (MAO-B), exhibiting an IC50 of 51 nM and demonstrating 450-fold selectivity over MAO-A (IC50 = 23 μM). This compound is primarily researched for its neuroprotective effects and potential therapeutic applications in Parkinson's disease, Alzheimer's disease, and major depressive disorder. Its ability to influence dopaminergic pathways makes it a valuable reagent in studies related to neurodegeneration and mood disorders. -
MAO Inhibitor
Hydroxylamine (50% w/w in water) is a selective inhibitor of monoamine oxidase (MAO), making it valuable in research applications focused on platelet aggregation inhibition. As an important intermediate in the nitrogen cycle, it plays a role in the metabolism of aerobic ammonium-oxidizing microorganisms, including ammonium oxidizing bacteria (AOB) and complete ammonium oxidizing bacteria (comammox). Hydroxylamine also influences nitrous oxide (NO) and nitrogen gas (N2O) emissions by modulating the activity of nitrite-oxidizing bacteria (NOB). -
MAO-A Inhibitor
MAO-A Inhibitor 3 is a selective inhibitor of monoamine oxidase A (MAO-A), displaying an IC50 of greater than 100 μM. This compound is utilized in the investigation of neurological disorders, providing insights into the role of MAO-A in the metabolism of neurotransmitters and its implications in various neuropsychiatric conditions. Its application may contribute to the understanding of the biochemical pathways involved in mood regulation and depression. -
MAO-A Inhibitor
Befloxatone is a selective and reversible inhibitor of Monoamine Oxidase A (MAO-A), exhibiting an IC50 of 4 nM. By inhibiting MAO-A, Befloxatone effectively elevates the tissue levels of monoamines, including striatal dopamine and cortical norepinephrine. This compound is primarily investigated for its potential antidepressant effects, making it a valuable reagent in research related to mood disorders and neuropharmacology. -
MAO-B Inhibitor
MAO-B-IN-8 is a potent reversible inhibitor of monoamine oxidase B (MAO-B), effective in reducing the microglial production of neuroinflammatory mediators. This compound is primarily utilized in neurodegenerative disease research, making it a valuable tool for investigating therapeutic strategies aimed at modulating neuroinflammation and neuronal survival. Its ability to impact neuroinflammatory processes positions MAO-B-IN-8 as a significant reagent in the study of various neurological disorders. -
MAO-B Inhibitor
MAO-B-IN-25 is a selective inhibitor of monoamine oxidase B (MAO-B) with an IC50 of 240 nM. It demonstrates a significantly higher selectivity for MAO-B over MAO-A, with an IC50 of 0.5 nM for the latter. This compound is valuable for research focused on neurodegenerative diseases and the modulation of monoamine neurotransmitter levels, highlighting its potential role in studying Parkinson's disease and related disorders. -
Monoamine Oxidase Inhibitor
7-Hydroxy-3,4-dihydro-2(1H)-quinolinone functions as a selective monoamine oxidase A (MAO-A) inhibitor, exhibiting an IC50 value of 183 μM. This compound primarily role in inhibiting MAO-A suggests potential applications in neuropharmacology and mood disorder research. Due to its lack of effect on MAO-B, it serves as a valuable tool in studies aimed at elucidating the distinct roles of these enzymes in monoamine metabolism. -
Monoamine Oxidase Inhibitor
Glicoricone is a phenolic compound that acts as a monoamine oxidase (MAO) inhibitor, exhibiting an IC50 of 140 μM. In addition to its primary mechanism, Glicoricone interacts with estrogen receptors (ER) and demonstrates estrogen antagonist activity. This compound is valuable for research applications focused on neurodegenerative diseases and hormonal regulation. -
Monoamine Oxidase Inhibitor
MAO-IN-1 is a selective inhibitor of monoamine oxidase B (MAO B), exhibiting an IC50 value of 20 nM. This compound plays a critical role in modulating neurochemical pathways by inhibiting the breakdown of neurotransmitters such as dopamine. Researchers can utilize MAO-IN-1 in studies related to neurodegenerative diseases, psychiatric disorders, and the exploration of metabolic processes involving monoamines. -
Ser/Thr Kinase Inhibitor
Milciclib maleate is a cyclin-dependent kinase inhibitor that primarily targets Ser/Thr kinases, disrupting cell cycle progression in melanoma. It exerts substantial antiproliferative effects by down-regulating genes such as PTTG1, thereby modulating gene expression linked to cell growth regulation. This compound enhances therapeutic sensitivity in p53-mutated melanoma cells, particularly when used in conjunction with PTTG1 silencing, making it valuable for cancer research and potential therapeutic applications. -
Substrate Peptide Of Cathepsin S
Ac-KQKLR-AMC TFA is a substrate peptide for Cathepsin S, conjugated with the fluorescent indicator AMC (Excitation/Emission = 354 nm/442 nm). This reagent facilitates the measurement of Cathepsin S activity, enabling researchers to study proteolytic processes and assess enzyme function in various biological contexts. Its application is crucial for investigations into the role of Cathepsin S in physiological and pathological conditions. -
Ser/Thr Protease Inhibitor
IPR-803 is a potent Ser/Thr protease inhibitor that specifically targets the uPAR·uPA protein-protein interaction. By binding directly to uPAR with sub-micromolar affinity, IPR-803 effectively disrupts this critical interaction. This compound exhibits significant anti-tumor activity, making it a valuable reagent for cancer research and studies focused on protease-related pathways. -
Cysteine Protease
Cathepsin S, human, is a potent cysteine protease that plays a crucial role in the degradation of damaged or harmful proteins within the endolysosomal pathway. This enzyme is implicated in various pathological processes, including arthritis, cancer, and cardiovascular diseases. Its activity makes it a valuable target for research applications aimed at understanding these diseases and developing therapeutic interventions. -
Ser/Thr Protease
CatB-IN-1 is a potent inhibitor of serine/threonine proteases, specifically targeting cathepsin B. This compound exhibits significant anti-invasive activity in various cellular models, effectively reducing the invasiveness of tumor cells such as MCF-10A neoT. Research indicates that CatB-IN-1 can modulate intracellular protein metabolism, thereby influencing tumor cell behavior. Its structure-activity relationship highlights its capability to engage multiple functions of cathepsin B, making it a valuable tool for studies on tumor invasion and metastasis. -
Ser/Thr Protease
Cathepsin Inhibitor 3 is a selective inhibitor of the serine/threonine protease cathepsin S, functioning as a valuable tool in studying protease-mediated biological processes. This compound serves as a non-radioactive precursor in the synthesis of fluorine-18 radiolabeled compounds, facilitating research in molecular imaging. Additionally, Cathepsin Inhibitor 3 features an alkyne group, enabling its use in copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it a versatile reagent for click chemistry applications in chemical biology.
