UAB116 is an agonist of the Liver X Receptor (LXR) and Retinoid X Receptor (RXR). It exhibits significant biological activity by diminishing the metastatic phenotype in hepatoblastoma, primarily through inhibition of the Wnt/β-Catenin signaling pathway via upregulation of TRIM29. UAB116 effectively reduces cell proliferation, stemness, and invasiveness in metastatic hepatoblastoma cells, making it a valuable tool for research in cancer biology and therapeutic development.
UAB116 is an agonist of the Liver X Receptor (LXR) and Retinoid X Receptor (RXR). It exhibits significant biological activity by diminishing the metastatic phenotype in hepatoblastoma, primarily through inhibition of the Wnt/β-Catenin signaling pathway via upregulation of TRIM29. UAB116 effectively reduces cell proliferation, stemness, and invasiveness in metastatic hepatoblastoma cells, making it a valuable tool for research in cancer biology and therapeutic development.
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