Metabolism

Diquat dibromide is a potent herbicide that primarily targets plant growth by increasing the production of reactive oxygen species (ROS) and inducing mitochondrial autophagy. It generates free radicals, including superoxide anions, through redox cycling, leading to oxidative stress and subsequent plant cell death. Due to its cytotoxic, reproductive, and neurotoxic effects, diquat dibromide is commonly employed in agricultural practices, particularly for the control of harmful weeds in crops like cotton and soybean.

Odanacatib is an inhibitor of cathepsin K,an enzyme involved in bone resorption.

ML348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM), Exhibits 14-fold selectivity for LYPLA1 over LYPLA2, Also selective over a panel of ~30 other serine hydrolases.