Catalog No.
Product Name
Application
Product Information
Citations
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AhR Agonist
AFP464 is a prodrug of Aminoflavone and an agonist of the aryl hydrocarbon receptor (AhR). It exhibits significant biological activity by downregulating α6-integrin expression, inhibiting breast tumor growth, and reducing the population of tumor-initiating cells. Additionally, AFP464 disrupts mammosphere structure, induces mucin lake cluster formation, triggers DNA damage, and demonstrates antiproliferative effects. This compound is suitable for research applications focused on breast cancer. -
Aromatase/CYP19 Inhibitor
(±) Homoeriodictyol is a potent inhibitor of aromatase (CYP19), an enzyme critical in estrogen biosynthesis. This compound is primarily utilized in breast cancer research to investigate estrogen-mediated pathways and their role in tumor growth. Its inhibitory activity makes it a valuable tool for studying therapeutic strategies targeting aromatase in hormone-related cancers. -
SGK1 Inhibitor
SGK1-IN-7 is a selective inhibitor of SGK1, exhibiting a blood-brain barrier permeability with an IC50 of 0.72 μM. This compound effectively reduces the phosphorylation of TAU protein at the Ser396 and Ser214 sites and counters the toxicity induced by Okadaic acid. SGK1-IN-7 is a valuable tool for research into the mechanisms underlying Alzheimer's disease. -
SGK1/GSK3β Inhibitor
SGK1-IN-8 is a potent inhibitor of SGK1 and GSK3β, exhibiting an IC50 of 0.11 μM against human SGK1 and 3.39 μM against human GSK3β. This compound effectively inhibits the catalytic activities of both SGK1 and GSK3β, leading to a reduction in the phosphorylation of the TAU protein at the Ser214 site. SGK1-IN-8 is utilized in research focused on Alzheimer's disease and related neurodegenerative disorders. -
Cathepsin Inhibitor
Cathepsin-IN-5 is a selective inhibitor of cathepsins L and S, exhibiting IC50 values of 6.2 μM and 81 nM, respectively. This compound effectively inhibits cancer cell proliferation and induces apoptosis, while also reducing the growth of hepatocellular tumors in mouse models. Additionally, Cathepsin-IN-5 modulates the expression of genes associated with cell death and proliferation, making it a valuable reagent for research into hepatocellular carcinoma. -
Hsp90 Inhibitor
Hsp90-IN-47 is a potent Hsp90 inhibitor, demonstrating an IC50 of 0.014 μM against Hsp90α. This compound exhibits significant antifungal properties, particularly when used in combination with Fluconazole, enhancing efficacy against fluconazole-resistant strains of Candida albicans. Additionally, Hsp90-IN-47 shows promising antitumor activity, particularly in acute myeloid leukemia and non-small cell lung cancer research applications. -
Endogenous Metabolite
G-4'G-7S is an endogenous metabolite of genistein that primarily targets estrogen receptors. This compound exhibits estrogenic activity, making it valuable for research into mechanisms of hormone action and the role of phytoestrogens in biological systems. Its study may provide insights into the effects of dietary components on estrogen signaling and related health outcomes. -
Herbicide
4-Fluorophenoxyacetic acid acts as a selective herbicide, targeting monocotyledonous weeds. Its primary mechanism involves inhibiting weed growth and inducing sterility in affected plants. Additionally, this compound enhances the defense mechanisms in cereals, helping to suppress pest populations and potentially improve field crop yields. It is particularly useful in agricultural research focused on weed management and crop protection strategies. -
Sex Pheromone
Callosobruchusic acid is a key component of the sex pheromone produced by the bean pest Callosobruchus chinensis L. This compound serves as an effective attractant in insect behavior studies and pest control strategies. Its role in influencing mating behaviors makes it a valuable reagent for research in pest management and ecological interactions. -
Insect Pheromone
(E,Z)-3,13-Octadecadienyl acetate is an insect sex pheromone that targets male lesser peachtree borers, eliciting a strong attraction response. This compound is utilized in entomological research to study mating behaviors and control pest populations. Its application in pheromone trapping and behavioral studies makes it an important tool in agricultural and ecological research. -
Insect Pheromone
(Z,Z)-3,13-Octadecadien-1-ol is an insect sex pheromone primarily used for the attraction and trapping of the redwood resin borer, Synanthedon sequoiae. This compound plays a crucial role in facilitating communication between insects, making it an essential tool for studying pheromonal signaling and pest management strategies in ecological and agricultural research. Its application in trapping can significantly aid in the monitoring and control of pest populations. -
Sex Pheromone Component
(S)-2-Hydroxy-3-decanone is a volatile olfactory agonist identified as the primary sex pheromone component of Xylotrechus quadripes beetles. This compound plays a crucial role in chemical communication and mating behaviors among these insects. It holds potential for research applications in pest control and the study of insect behavior and ecology. -
Component of Sex Pheromone
3-Hydroxy-2-decanone is a minor component of the sex pheromone found in Xylotrechus quadripes beetles, functioning as a signaling molecule. This compound is of interest in entomological research, particularly for the study of insect behavior and ecology related to pest management. Its unique biological activity concerning pheromone communication may aid in the development of novel strategies for pest control and disease prevention in agricultural settings. -
Insect Pheromone
(Z)-12-Nonadecen-9-one is a sex pheromone targeting male raspberry bud moths (Heterocrossa rubophaga). This compound exhibits strong biological activity in attracting males, facilitating studies on moth behavior and ecology. It is utilized in research applications focused on pest management and the development of environmentally friendly control strategies. -
Endogenous Autacoid
Adenosine-15N5 is a 15N-labeled analogue of adenosine, an endogenous autacoid that primarily targets four G protein-coupled receptors: A1, A2A, A2B, and A3. This compound plays a critical role in various physiological processes, influencing neuronal signaling, vascular tone, platelet aggregation, and the regulation of blood cells. Its applications in research include studying cellular signaling pathways, metabolic regulation, and tissue response to physiological challenges. -
Synthetic Sex Pheromone
trans-5-Decenyl acetate is a synthetic sex pheromone targeting male Anarsia lineatella moths. This compound exhibits key biological activity by effectively attracting these moths, particularly when used in combination with trans-5-decen-1-ol. Research applications include monitoring male moth activity in peach and almond orchards, aiding in pest management and control strategies. -
Insect Pheromone
(3E,5E,7E,9E)-5.7-Diethyl-9-methyl-3,5.7,9-tridecatetraene acts as an insect pheromone, specifically identified in male C. dimidiatus. This compound plays a key role in mediating mating behaviors and communication among these insects. It serves as a valuable tool for researchers studying insect behavior, pheromone signaling, and ecological interactions. -
Ferroptosis Inducer
Tralopyril is a potent ferroptosis inducer that selectively targets the thyroid hormone system and mitochondrial oxidative phosphorylation pathways. It promotes ferroptosis by downregulating key transcription factors such as TRHR, Nkx2.1, and TRα, thereby disrupting amino acid, energy, and lipid metabolism. Despite its primary application as an antifouling insecticide, its significant toxicity to skeletal and reproductive systems, alongside its implications for developmental damage, renders it useful in toxicological studies. Tralopyril's long half-life in vivo and broad tissue distribution highlight potential risks to both aquatic organisms and human health. -
Herbicide
2,4-D Butyl ester is a synthetic phenoxy herbicide that targets broad-leaf weeds by mimicking natural auxins, leading to uncontrolled and rapid plant growth. This herbicidal activity is particularly effective against woody plants, making it a valuable tool in agricultural and horticultural weed management. Its application supports research in plant physiology and the development of effective weed control strategies. -
AhR Agonist
Dibenz[a,h]anthracene (DBA) acts as a potent agonist of the aryl hydrocarbon receptor (AhR) and is classified as a polycyclic aromatic hydrocarbon. It is known for its significant carcinogenic properties, inducing dose-dependent increases in DNA adduct formation and mutation frequency in lacZ assays. Additionally, DBA has been shown to upregulate the St3gal5 gene. This reagent is applicable in cancer research, particularly in studies examining mechanisms of carcinogenesis and the role of AhR signaling in tumor development. -
Drug Metabolite
3,4-Dimethylbenzoic acid is a drug metabolite produced during the metabolism of dimethylbenzoate by Rhodococcus rhodochrous N75. This compound serves as a significant marker in studies of biotransformation processes and can be utilized in the investigation of microbial metabolism. Its biological activity is pertinent for research applications in pharmacology and environmental microbiology, particularly in understanding the degradation pathways of aromatic compounds. -
ubiquitin activating enzyme E1 Inhibitor
N,N-dimethyldithiocarbamate potassium is an inhibitor of the ubiquitin-activating enzyme E1, leading to a decrease in the levels of activated ubiquitinated E1 (ub-E1). This compound is known to elevate intracellular copper levels, enhance oxidative stress, raise protein carbonyl levels, and promote the expression of heme oxygenase-1 (HO-1). N,N-dimethyldithiocarbamate potassium is particularly relevant for research into neurodegenerative disorders, including Parkinson's disease, by elucidating the impact of ubiquitin pathways on cellular stress responses. -
Herbicide Agent
2-Chloroacetamide is a herbicide that functions primarily by inhibiting very-long-chain fatty acid elongase, thereby interfering with lipid metabolism in plants. This compound is effective in controlling weed growth in both upland and paddy fields. Additionally, 2-Chloroacetamide serves as a biocide and is utilized in various agricultural applications, as well as in glues, paints, and coatings to enhance preservation. -
Endogenous Metabolite
Picolinic acid is an endogenous metabolite that exhibits antiviral properties by inhibiting adenovirus replication. This compound demonstrates key biological activity in cellular models and serves as a valuable tool for research related to viral infections and metabolic pathways. Its applications span virology and metabolic studies, making it a significant reagent for investigating antiviral mechanisms and therapeutic potentials. -
Endogenous Metabolite
Xanthine is an endogenous metabolite involved in purine degradation, acting as a key intermediate in the metabolic pathway. It has mild stimulant properties on the central nervous system, making it relevant in studies related to energy metabolism and neurotransmission. Xanthine is utilized in research focused on metabolic disorders, caffeine metabolism, and the physiological effects of purine compounds in biological systems. -
Monoamine Oxidase Inhibitor
Pheniprazine is a potent monoamine oxidase inhibitor that demonstrates a long-lasting effect on neurotransmitter levels. It is primarily utilized in research focused on the mechanisms underlying depression and other mood disorders. By inhibiting the breakdown of monoamines, Pheniprazine enhances mood-regulating neurotransmitter availability, making it a useful tool for studying the neurochemical basis of depression. -
Endogenous Metabolite
3-Methyl-2-oxobutanoic acid is an endogenous metabolite that serves as a precursor for pantothenic acid synthesis in Escherichia coli. This compound plays a crucial role in metabolic pathways, particularly in the biosynthesis of coenzyme A, which is essential for fatty acid metabolism. Its study is relevant for research on bacterial physiology and metabolic engineering applications. -
Triterpenoid
α-Amyrenone is a triterpenoid known for its inhibitory effect on α-glucosidase. This compound has demonstrated the ability to reduce mechanical hypersensitivity and paw edema induced by carrageenan, making it a valuable tool in pain and inflammation research. Its natural occurrence in oleoresins from Brazilian Amazon species of Protium (Burseraceae) further highlights its potential for biological investigation. -
Vitamin B6, Pyridoxal analog
Pyridoxal hydrochloride is the hydrochloride form of Pyridoxal, serving as an essential derivative of vitamin B6. This compound exhibits neuroprotective properties and is involved in key biochemical processes, including the conversion to pyridoxal phosphate, an active coenzyme in amino acid metabolism. Pyridoxal hydrochloride has potential applications in research focused on neurological conditions, notably its implications in carpal tunnel syndrome (CTS) and other vitamin B6-related disorders. -
Endogenous Metabolite
11β-Hydroxyandrosterone is an endogenous metabolite that functions as an androgen, derived from 11β-hydroxyandrostenedione. It plays a critical role in various biological processes, including steroidogenesis and the modulation of androgenic activity. This compound is utilized in research applications focused on hormonal regulation, adrenal function, and cardiovascular health. -
Endogenous Metabolite
Cholesteryl linoleate is an endogenous metabolite primarily found in low-density lipoprotein (LDL) and atherosclerotic lesions. This cholesteryl ester plays a significant role in cholesterol metabolism and is important for studying lipid-related diseases, particularly in the context of cardiovascular research and atherogenesis. Its presence in various biological systems makes it a valuable reagent for investigating lipid dynamics and related metabolic pathways. -
Endogenous Metabolite
(S)-Malic acid, also known as (S)-2-Hydroxysuccinic acid, is an endogenous metabolite that plays a crucial role in the tricarboxylic acid (TCA) cycle. This dicarboxylic acid is involved in various metabolic processes and contributes to the sour flavor profile of certain fruits. Its biological activities make it valuable for research applications in metabolic studies and food science. -
Endogenous Metabolite
5-Amino-3H-imidazole-4-carboxamide hydrochloride is a key endogenous metabolite that serves as a precursor for purine synthesis, specifically contributing to the formation of the nucleobases adenine and guanine. This compound is utilized in various research applications pertaining to cellular metabolism, nucleic acid synthesis, and studies focused on the regulation of purine levels in biological systems. Its role in metabolic pathways makes it crucial for understanding cellular processes and potential therapeutic targets. -
Endogenous Metabolite
(+)-N-[3',4'-Dihydroxy-(E)-cinnamoyl]-L-aspartic acid is an endogenous metabolite classified as an N-phenylpropenoyl amino acid. This compound exhibits notable biological activity and is primarily derived from cocoa beans, making it relevant for studies in metabolic pathways and biochemical interactions. Its research applications include investigations into flavonoid metabolism and the potential health benefits associated with cocoa-derived ingredients. -
Aggregation pheromone
Methyl (2E,4Z)-2,4-decadienoate is identified as a primary component of the male-produced aggregation pheromone in E. conspersus. This compound plays a crucial role in mediating behavioral responses related to aggregation and mating in this species. Its applications in research include investigations into pheromone signaling, insect behavior studies, and ecological interactions involving E. conspersus. -
Pheromone
Heptyl butyrate is a pheromone that functions as an effective attractant for various wasp species, particularly eliciting hovering and landing behaviors in Vespula germanica. When applied to protein baits, it significantly increases the likelihood of wasp landing, enhancing bait effectiveness. This reagent is valuable for research focused on managing invasive populations of Vespula germanica wasps. -
Sex Pheromone
(9Z,12E)-Tetradeca-9,12-dien-1-yl acetate serves as a key component of the sex pheromone in Spodoptera frugiperda. This compound operates through the attraction of moths, making it an invaluable tool in pest management strategies. Its environmentally friendly profile and lack of insecticide resistance position it as a promising candidate for studies on pest control and ecological agriculture. -
Alcohol Dehydrogenase Inhibitor
Camelliquercetiside D is a natural product that acts as an alcohol dehydrogenase inhibitor, demonstrating an IC50 of 41.5 μM against yeast ADH. This compound is isolated from the leaves of Camellia sinensis and exhibits notable scavenging activity against DPPH, making it valuable for research applications in enzymology and oxidative stress studies. -
Alcohol Dehydrogenase Inhibitor
Camelliquercetiside B is a natural product that serves as an alcohol dehydrogenase inhibitor. Isolated from the leaves of Camellia sinensis, it demonstrates significant inhibitory activity with an IC50 value of 13.7 μM against yeast alcohol dehydrogenase. In addition, Camelliquercetiside B displays scavenging activity against DPPH free radicals, making it a valuable tool for research in alcohol metabolism and oxidative stress studies. -
Endogenous Metabolite
(-)-N-[3',4'-Dihydroxy-(E)-cinnamoyl]-L-tyrosine, also known as Caffeoyl-N-tyrosine, is an N-phenylpropenoylamino acid derived from cocoa beans. This compound plays a significant role in the formation of cocoa flavor, highlighting its importance in food science and related research. Its unique chemical structure and biological properties make it a valuable reagent for studies on flavor formation and metabolite interactions in cocoa. -
Pheromone
4-Methyl-3-heptanol acts as a pheromone primarily involved in alarm signaling among ants. This fatty alcohol compound plays a crucial role in mediating social interactions and defense mechanisms within ant colonies. It is useful for studies investigating chemical communication in social insects and understanding the ecological dynamics of pheromone signaling. -
HO-1 Inhibitor
OB-24 free base is a selective inhibitor of heme oxygenase 1 (HO-1), demonstrating notable potential for targeting advanced prostate cancer. This compound effectively reduces protein carbonylation and diminishes the formation of reactive oxygen species in prostate cancer cells through its specific inhibition of HO-1 activity. In vitro studies reveal that OB-24 significantly impairs cell proliferation, while in vivo experiments show a marked reduction in tumor growth and metastasis to lymph nodes and lungs. Additionally, OB-24 displays enhanced efficacy when used in conjunction with Taxol, making it a valuable tool for cancer research. -
Sex Pheromone
(E)-5-Octadecene is a sex pheromone that plays a crucial role in insect communication and attraction. This compound has been shown to disrupt sexual attraction in female rice borers moths (Chilo suppressalis Walker), making it a valuable tool for studying pest behavior and developing pest management strategies. Its applications extend to research in chemical ecology and the development of pheromone-based traps for agricultural pest control. -
Aggregation Pheromone
(2E,4E,6Z)-Methyl deca-2,4,6-trienoate is an aggregation pheromone targeting the brown-winged green bug, Plautia stali. This compound plays a significant role in mediating insect behavior, particularly in aggregation and mating processes. It is crucial for research in entomology and pest management, particularly in developing effective trapping strategies. Caution is advised, as exposure to daylight can lead to isomerization, resulting in a complex mixture of isomers that may affect lure effectiveness. -
Heme Oxygenase/Lanosterol 14α-Demethylase Inhibitor
Azalanstat dihydrochloride is an inhibitor of heme oxygenase and lanosterol 14α-demethylase, demonstrating selective inhibitory activity against HO-1 (IC50 = 5.5 µM) and HO-2 (IC50 = 24.5 µM). This compound has been shown to reduce the maturation rate of rat oocytes and increase oocyte degeneration, as well as partially inhibit progesterone production in preovulatory follicles in rats. Its usage is pertinent in studies focused on reproductive biology and the biochemical pathways involving heme oxygenase and steroidogenesis. -
Volatile Compound
Dihydro-α-ionone is a volatile compound primarily derived from the essential oil of Persicaria hydropiper L. leaves. It exhibits notable inhibitory effects on α-glucosidase and α-amylase, making it a useful reagent in studies of carbohydrate metabolism. Its potential applications include the exploration of metabolic pathways and the development of therapeutic strategies for conditions such as diabetes. -
Insect Pheromone
(±)-p-Menthane-3,8-trans-diol is a chemosensory compound that serves as an insect pheromone. It exhibits inhibitory activity on the germination and growth of lettuce (Lactuca sativa L.), making it relevant for research in pest control and agricultural applications. This compound can be isolated from lemon eucalyptus trees (Eucalyptus citriodora), highlighting its natural origin. -
Lactate Dehydrogenase Activator
4-(Dimethylamino)phenol acts as a lactate dehydrogenase (LDH) activator, enhancing extracellular LDH levels without significantly impacting gluconeogenesis. This compound serves as a potent cyanide antidote, facilitating metabolic pathways under certain conditions. Its toxicity arises from the reaction with glutathione, resulting in the formation of covalent complexes that impair cellular function. This reagent is valuable for investigations into metabolic regulation and cellular responses to oxidative stress. -
NNMT Inhibitor
LL320 is a selective inhibitor of Nicotinamide N-methyltransferase (NNMT), with an apparent Ki of 6.8 nM. This compound has demonstrated interactions with RNA N-methyltransferase (RNMT), diphthamide biosynthesis 5 (DPH5), and S-adenosylhomocysteine hydrolase (SAHH). LL320 is valuable for research applications focused on metabolic regulation, cancer biology, and the exploration of NNMT-related pathways. -
intracellular iron chelating agent
Dexrazoxane monohydrochloride is the hydrochloride form of Dexrazoxane, primarily acting as an iron chelator and apoptosis inducer. This compound exhibits significant cardioprotective, anti-inflammatory, antioxidant, anti-tumor, and neuroprotective properties, making it a valuable tool in research. It is commonly utilized for studying cardiac protection during chemotherapy, as well as mechanisms of ferroptosis inhibition.
