Catalog No.
Product Name
Application
Product Information
Citations
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MAO-B Inhibitor
MD 780236 free base is a selective inhibitor of monoamine oxidase B (MAO-B), acting as a competitive antagonist with regard to substrates such as phenylethylamine and 5-hydroxytryptamine (5-HT). By inhibiting MAO-B, this compound plays a crucial role in the modulation of neurotransmitter levels, making it valuable in research focused on neurodegenerative diseases and mood disorders. Its specificity for MAO-B provides a useful tool for investigating the biochemical pathways involving monoamine metabolism. -
MAO Inhibitor
Methyl piperate is an effective inhibitor of monoamine oxidase (MAO), showing significant inhibitory activity with an IC50 of 3.6 µM against MAO. It exhibits a preferential inhibitory effect on MAO-A (IC50 27.1 µM) compared to MAO-B (IC50 1.6 µM), demonstrating a bidirectional action. This compound is valuable in research related to mental health disorders, providing insights into therapeutic strategies targeting monoamine regulation. -
MAO Inhibitor
Caroxazone is a reversible inhibitor of monoamine oxidase (MAO), which is involved in the catabolism of neurotransmitters such as serotonin, norepinephrine, and dopamine. This compound exhibits significant antidepressant activity, making it valuable in the study of mood disorders. Caroxazone is utilized in research to explore mechanisms of depression and to evaluate potential therapeutic interventions targeting MAO. -
MAO Inhibitor
Acacetin 7-O-(6-O-malonylglucoside) is a reversible monoamine oxidase inhibitor targeting both monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) with IC50 values of 2.34 μM and 1.87 μM, respectively. This compound demonstrates significant inhibitory activity, making it a valuable tool in the research of neurodegenerative diseases and affective disorders. Its unique mechanism of action contributes to the understanding of monoamine neurotransmitter regulation in various neurological conditions. -
Monoamine Oxidase Inhibitor
Tranylcypromine is a potent monoamine oxidase (MAO) inhibitor that increases levels of neurotransmitters such as serotonin, norepinephrine, and dopamine in the brain. This compound is primarily used in the research of mood disorders and depression therapies, offering insights into the biochemical pathways involved in these conditions. Its specific mechanism of action makes it valuable for studying the modulation of neurotransmitter systems and the pharmacological effects of MAO inhibition. -
MAO Inhibitor
6,7-Dimethylisatin is a selective inhibitor of monoamine oxidase (MAO), exhibiting IC50 values of 20.3 μM for MAO-A and 6.74 μM for MAO-B. This compound holds potential for exploration in neurodegenerative diseases such as depression, Alzheimer's disease, and Parkinson's disease. Its role as a MAO inhibitor may contribute to understanding underlying mechanisms and developing therapeutic strategies in neurobiological research. -
Monoamine Oxidase Inhibitor
MAO-B-IN-1 is a selective inhibitor of monoamine oxidase B, targeting the enzyme responsible for the catabolism of neurotransmitters such as dopamine. This compound demonstrates significant potential for studying the role of monoamine oxidase B in neurological disorders, including Parkinson's disease and depression. MAO-B-IN-1 is valuable for researchers investigating the modulation of oxidative stress and neuroprotection in various neurobiological contexts. -
Anti-inflammatory Compound
Cuminaldehyde, a primary component of Cuminum cyminum, is recognized for its anti-inflammatory properties. This compound exhibits various biological activities, including inhibition of aldose reductase (IC50 = 0.00085 mg/mL), α-glucosidase (IC50 = 0.5 mg/mL), and lipoxygenase (IC50 = 1370 μM). Additionally, cuminaldehyde inhibits the fibrillation and aggregation of α-synuclein, indicating its potential application in the study of neurodegenerative diseases, cancer, diabetes, and neuropathic pain disorders. -
Keap1-Nrf2 PPI Inhibitor
Keap1-Nrf2-IN-9 is a selective inhibitor of the Keap1-Nrf2 protein-protein interaction (PPI) with a reported IC50 of 0.575 μM. This compound enhances the expression of Nrf2 target genes, including heme oxygenase 1 (Hmox1), glutathione S-transferase P (GstP), and the modulatory and catalytic subunits of glutamate-cysteine ligase (Gclc and Gclm). Keap1-Nrf2-IN-9 exhibits low cytotoxicity in ARPE19 cells, making it a valuable tool for studies focused on oxidative stress and cellular defense mechanisms. -
VHL Ligand
(S,S,S)-VH032 is a ligand for the E3 ubiquitin ligase von Hippel-Lindau (VHL), enabling targeted protein degradation through the formation of PROTACs. It plays a crucial role in the synthesis of PROTAC SGK3 degrader-2, facilitating the selective degradation of SGK3 and other target proteins. This compound is valuable for research in protein regulation and targeted therapeutic strategies. -
Biochemical Reagent
Cathepsin D (CTSD) is a lysosomal aspartic protease that plays a critical role in regulating lysosomal protease activity. Disruption of Cathepsin D function is associated with lysosomal dysfunction and the accumulation of proteins implicated in neurodegenerative diseases. Additionally, Cathepsin D is involved in the metastatic progression of breast cancer. This reagent is valuable for research applications related to cancer biology, neurodegeneration, and lysosomal disorders. -
Autoinducer Pheromone
3-Oxo-C8-HSL, or N-(3-Oxooctanoyl)-l-homoserine lactone, serves as an autoinducer pheromone involved in quorum sensing within bacterial populations. It activates the TraR-regulated promoter, resulting in a significant increase in tra gene expression. This compound is crucial for studies on bacterial communication and biofilm formation, making it valuable for research into microbial ecology and pathogenesis. -
Biochemical Reagent
6-Chloro-3-indoxyl-β-D-cellobioside is a biochemical reagent that serves as a chromogenic substrate for the detection of β-glucosidase activity. When cleaved by β-glucosidase, it produces a colored indigo product, facilitating the visual quantification of enzymatic activity. This compound is valuable in research applications involving enzyme assays, microbial activity, and cellulose degradation studies. -
Biochemical Assay Reagent
4-Methylumbelliferyl-β-D-cellobiose heptaacetate is a biochemical assay reagent that serves as a substrate for measuring the activity of β-glucosidases and related enzymes. Upon enzymatic cleavage, it releases a fluorescent product, facilitating the quantification of enzyme activity in various biological samples. This compound is utilized in enzymatic studies and is particularly valuable in carbohydrate metabolism research applications. -
S-glycosidic Bond Hydrolase
Thioglucosidase is an S-glycosidic bond hydrolase that catalyzes the hydrolysis of thioglucosides. This enzyme is significant in research related to plant defense mechanisms, particularly in the study of glucosinolates and their role in plant interactions with pests and pathogens. Thioglucosidase is a valuable tool for investigating metabolic pathways and the biochemical processes underlying plant defense strategies. -
Biochemical Assay Reagent
6-Bromo-2-naphthyl β-D-glucopyranoside is a biochemical assay reagent with a primary mechanism targeting glucosidases. This compound is commonly utilized in the detection of glucosidase activity in various biological studies, facilitating the investigation of enzyme kinetics and substrate interactions. Its application in cellular and molecular research makes it a valuable tool for understanding carbohydrate metabolism and enzyme function. -
Test Substrate
Resorufin-β-D-glucopyranoside is a fluorogenic substrate specifically designed for the detection and quantification of β-glucosidase activity. Upon enzymatic cleavage, it produces resorufin, a highly fluorescent compound that serves as an effective indicator of β-glucosidase presence in biological samples. This reagent is widely used in biochemical assays and studies involving enzyme activity, providing valuable insights into cellular and molecular processes. -
Active Compound
Stearoyl coenzyme A lithium is an active compound utilized as a substrate for the enzymatic activity of stearoyl-CoA desaturase in microsomal preparations. This reagent is important for studying lipid metabolism, particularly in the context of fatty acid desaturation processes. Applications include exploring the role of stearoyl-CoA desaturase in cellular function and investigating related metabolic pathways in biochemical research. -
Detection Substrate
3-Indoxyl butyrate serves as a chromogenic substrate for carboxylesterase (CES), leading to the generation of a blue precipitate upon enzymatic cleavage. This reaction makes it a valuable tool for detecting and quantifying CES activity in biological samples. Its sensitivity and specificity enhance research applications in enzyme kinetics and drug metabolism studies. -
Azide
4-Hydroxynonenal alkyne is a click chemical reagent that features alkynes and targets azides for bioorthogonal labeling. This compound induces heme oxygenase activity and promotes apoptosis in colon cancer (RKO) cells, making it a valuable tool for investigating oxidative stress and related cellular processes. Its applications extend to studying lipid peroxidation and the mechanism of action in cancer research. -
Biochemical Assay Reagents
8-Quinolinyl β-D-glucopyranoside is a glucoconjugate derived from 8-hydroxyquinoline, specifically designed for use as a biochemical assay reagent. This compound can be effectively cleaved by β-glucosidase in vitro, making it a valuable tool for studying enzyme activity and mechanisms. Its hydrolytic properties enable applications in various biochemical assays, including those focused on carbohydrate metabolism and enzymatic regulation. -
Biochemical Assay Reagent
4-Methylumbelliferyl 2-Amino-2-deoxy-α-D-glucopyranoside serves as a sensitive substrate for enzymes that hydrolyze glycosidic bonds, specifically targeting glucosidases. Upon enzymatic cleavage, it releases a highly fluorescent compound, enabling quantification of enzymatic activity in various biological samples. This reagent is widely utilized in biochemical assays to study carbohydrate metabolism and enzyme kinetics. -
Enzyme Substrate
Gal-G2-CNP serves as a substrate specifically for the quantitative determination of novel amylase and pancreatic amylase activities. This galactopyranosylmaltoside compound provides a valuable tool for enzyme characterization and kinetic studies, enhancing the understanding of carbohydrate metabolism. Its application is crucial in the study of digestive enzymes, facilitating advancements in biochemical and clinical research. -
Biochemical Assay Reagent
4-Methylumbelliferyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside is a biochemical assay reagent primarily utilized for the detection of β-D-glucosidase activity. This compound serves as a fluorogenic substrate, releasing 4-methylumbelliferone upon enzymatic hydrolysis, allowing for sensitive measurement of enzyme activity. It is commonly employed in various biochemical research applications, including studies on enzyme kinetics and carbohydrate metabolism. -
Test Substrate
4-Nitrophenylmaltohexaoside is a chromogenic substrate specifically designed to target α-amylase. It exhibits key biological activity by producing a measurable chromogenic product upon enzymatic cleavage, facilitating the study of α-amylase activity. This reagent is widely applicable in enzymology research and can be utilized for high-throughput screening of α-amylase inhibitors and in the assessment of starch digestion. -
Biochemical Reagent
4-Methylumbelliferyl β-D-cellopentoside is a biochemical reagent that serves as a substrate for enzyme assays, specifically targeted towards β-glucosidases. Upon enzymatic cleavage, it releases the fluorescent compound 4-methylumbelliferone, which allows for the quantification of enzyme activity. This compound is utilized in research applications involving carbohydrate metabolism and enzyme kinetics. -
Bile Pigment
Biliverdin dihydrochloride is a tetrapyrrolic pigment generated during the catabolism of heme. It functions primarily through its role in the heme degradation pathway, where it is produced by heme oxygenase and subsequently converted to bilirubin by biliverdin reductase. This compound exhibits significant biological activities, including anti-mutagenic properties, antioxidant effects, and immunosuppressive and anti-inflammatory actions. Biliverdin dihydrochloride is valuable for research applications involving oxidative stress, inflammation, and cellular protection mechanisms. -
Test Substrate
D-Glucopyranose, 98% functions as a key substrate for various glycosidase enzymes, particularly α-glucosidase. This compound is widely utilized in glycobiology research to study carbohydrate metabolism and enzyme activity, facilitating a deeper understanding of glycan interactions and biological systems. Its high purity ensures reliable results in experimental applications. -
Intermediate of SCD1/5 Inhibitor
1-Methyl-1H-pyrazole-3-carboxylic acid serves as an intermediate in the synthesis of SCD1 and SCD5 inhibitors. This compound is instrumental in investigating metabolic disorders and their mechanisms. Its role in the development of targeted therapies makes it a valuable reagent for chemical research in metabolic pathways. -
Endogenous Protein Marker
N-TCO-L-lysine is a non-canonical amino acid featuring a trans-cyclooctene (TCO) bioorthogonal reactive linker. This compound is engineered for the selective labeling of endogenous proteins through a bioorthogonal click reaction with SiR-Tz, facilitating site-specific incorporation. N-TCO-L-lysine is valuable for super-resolution and live-cell imaging applications, enabling researchers to study the dynamics and localization of proteins in their native environments. -
Pancreatic Digestive Enzymes
Pancreatin is an extract derived from porcine pancreas, enriched with key pancreatic digestive enzymes, including amylase, lipase, and protease. It facilitates the digestion of carbohydrates, fats, and proteins, making it essential for studying digestive processes and enzyme activity in various research applications. Pancreatin is commonly used in studies related to gastrointestinal disorders, enzyme replacement therapy, and metabolic research. -
PPARα Activator
Perfluoro(2-methyl-3-oxahexanoic) acid is a potent agonist of peroxisome proliferator-activated receptor α (PPARα), exhibiting an EC50 of 2.1 μM for human PPARα. This compound plays a critical role in inducing peroxisome proliferation and elevating proinflammatory mediators, which can lead to impaired intestinal barrier function and disrupted cecal flora balance. Its applications span research into developmental toxicity, hepatotoxicity, and intestinal toxicity, providing valuable insights into these biological processes. -
Biochemical Assay Reagent
3,5-Dinitrosalicylic acid is a derivative of salicylic acid primarily used as a biochemical assay reagent. It serves as a colorimetric indicator for the quantification of reducing sugars and is essential in assays for α-amylase and other carbohydrases. This compound is widely utilized in carbohydrate chemistry and enzymatic activity studies, facilitating the analysis of reducing sugars in various samples. -
Herbicide
Dicamba is a systemic herbicide that exhibits selective phytotoxicity by targeting the auxin receptor pathway in plants. It induces tissue damage and cell death in various species, including Gallium aparine L., primarily through mechanisms like lipid peroxidation. Dicamba is predominantly utilized in agricultural and horticultural applications for the effective control of broadleaf weeds. -
α-Amylase substrate
G3-CNP is a substrate for α-amylase, specifically designed to facilitate the monitoring of enzyme activity. Upon cleavage by α-amylase, G3-CNP generates 2-chloro-4-nitrophenol, which can be quantitatively measured at an absorbance of 405 nm. This compound serves as a valuable tool in enzymatic assays for the assessment of carbohydrate metabolism and related biochemical research applications. -
Biochemical Assay Reagents
6-Chloro-1H-indol-3-yl β-D-glucopyranoside is a biochemical assay reagent designed to detect β-glucosidase activity in yeast. This compound serves as a chromogenic substrate, facilitating the quantitative analysis of enzymatic reactions. It is particularly useful in studies investigating carbohydrate metabolism and enzyme function in various biological systems. -
PPO Inhibitor
PPO-IN-1 is a potent inhibitor of protoporphyrinogen IX oxidase (PPO), exhibiting a Ki value of 2.5 nM. This compound serves as a valuable click chemistry reagent, featuring an alkyne group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions. Its primary biological activity makes it useful for studying pathways involving heme biosynthesis and investigating potential therapeutic applications in diseases related to PPO dysregulation. -
Chloroquine Analog
Iodoquine is a chloroquine analog that primarily targets cancer cells. It demonstrates significant uptake in tumor cells, particularly in those with elevated ALDH1 content, such as cancer stem cells, while exhibiting minimal accumulation in normal brain tissue. This unique profile makes iodoquine a valuable tool for research applications related to tumor diagnosis and as a radiotracer in cancer studies. -
HMG-CoA
DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium hydrate is a disodium salt of HMG-CoA, functioning as a key intermediate in the biosynthesis of terpenes and ketone bodies. This compound plays a crucial role in lipid metabolism by serving as a precursor for cholesterol synthesis and modulating cholesterol levels through interaction with the low-density lipoprotein (LDL) receptor. Its applications include studying lipid metabolism, cholesterol regulation, and related metabolic pathways in various biological systems. -
CYP450 Interactor
7-Methoxyindole is a potent interactor of cytochrome P450 enzymes. This compound is utilized in research focused on drug metabolism and toxicity, as it plays a critical role in the modulation of enzymatic activity. Its pharmacological properties make it suitable for studies investigating the metabolic pathways of various xenobiotics and endogenous compounds. -
eDHFR PROTAC
PROTAC eDHFR Degrader-1 is a proteolysis-targeting chimera (PROTAC) that specifically targets eDHFR for ubiquitin-mediated degradation. This compound effectively degrades eDHFR-YFP and various protein of interest (POI), including yellow fluorescent protein (YFP) and luciferase. Its application in research can facilitate the study of protein function and dynamics through targeted protein degradation, providing insights into cellular processes and potential therapeutic pathways. -
PROTAC Linker
OTs-C6-OBn is an alkyl chain-based PROTAC linker designed for the synthesis of PROTAC conjugates targeting the SGK3 protein. This compound facilitates targeted protein degradation by linking E3 ligases to specific protein substrates, thereby enhancing the efficacy of PROTACs in biological research. It is suitable for applications in drug development and proteostasis modulation studies. -
PROTAC Linkers
PEG3-C4-OBn is a polyethylene glycol (PEG)-derived linker designed for use in PROTAC (Proteolysis Targeting Chimeras) applications. This compound facilitates the synthesis of PROTAC SGK3 degrader-1, which effectively induces targeted degradation of SGK3, a serine/threonine protein kinase. PEG3-C4-OBn is instrumental in advancing research related to targeted protein degradation and cellular regulation mechanisms. -
PROTAC Linker
Ald-CH2-PEG3-CH2-Boc is a PEG- and alkyl/ether-based PROTAC linker designed to facilitate the construction of proteolysis-targeting chimeras (PROTACs). This linker plays a crucial role in synthesizing SGK3 kinase PROTAC degraders, enabling selective degradation of target proteins. Its unique structure enhances solubility and promotes effective engagement with target proteins for research applications in targeted protein degradation and mechanistic studies of cellular pathways. -
Pheromone
5α-Cyprinol sulfate is an orally active bile salt and heterospecific pheromone that serves as a crucial signaling molecule in aquatic organisms. It enhances lipid digestion in fish by stimulating gastrointestinal processes and functions as an inhibitor of taurocholic acid uptake via apical bile salt transporters in the rat ileum. This compound is valuable for research into fish physiology and mechanisms of acute renal failure in aquatic environments. -
Drug Metabolite
13,14-Dihydro-19(R)-hydroxy prostaglandin E1 is a theoretical metabolite formed from 13,14-dihydro PGE1 through the action of ω-1 hydroxylase. This compound is utilized in research to explore the metabolic pathways of prostaglandins and their biological functions. Its study contributes to the understanding of the pharmacokinetics and dynamics of therapeutic agents derived from prostaglandins and their potential implications in drug metabolism. -
Intermediate
Methyl 4-formylbenzoate serves as a key intermediate in organic synthesis, particularly in the production of chalcone amide derivatives. Its primary biological activity involves the inhibition of α-glucosidase, making it useful for research in diabetes management and metabolic diseases. This compound can facilitate the development of novel therapeutics targeting glycemic control pathways. -
Drug Intermediate
5-Methoxyresorcinol is a drug intermediate that mimics the chemical structure of the resorcinol-type A ring found in flavonoids, particularly catechins. This compound demonstrates low reactivity with tocopherol and exhibits minimal inhibitory effects on cholesteryl ester transfer protein (CETP). Its unique properties make it a valuable tool for research applications involving flavonoid-related biochemical studies and drug development. -
Biochemical Assay Reagent
5-Bromo-4-chloro-3-indolyl-α-D-glucopyranoside is a biochemical assay reagent primarily used for the detection of glucosidase activity. This compound serves as a chromogenic substrate, resulting in a measurable color change upon enzymatic hydrolysis. It is commonly utilized in various research applications, including enzyme activity assays and studies involving carbohydrate metabolism. -
Detection Substrate
2-Chloro-4-nitrophenyl-β-D-maltotrioside is a chromogenic substrate that specifically targets α-amylase activity. It is utilized in bioluminescent and fluorescent assays, providing a valuable tool for the detection and quantification of α-amylase in various biological samples. This reagent is essential for studies involving carbohydrate metabolism and enzyme activity assays.
