Catalog No.
Product Name
Application
Product Information
Citations
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PPARγ Agonist
Ankaflavin is an orally active peroxisome proliferator-activated receptor gamma (PPARγ) agonist, derived from Monascus-fermented red rice. This compound demonstrates selective cytotoxicity in cancer cells, inducing apoptosis and facilitating cell death. Additionally, Ankaflavin exhibits notable anti-inflammatory, anti-cancer, anti-atherosclerotic, and hypolipidemic properties, making it useful for various research applications in cancer biology and metabolic disorders. -
Anti-inflammation/Infection Agent
β-Amyrone is a triterpene compound recognized for its anti-inflammatory properties, primarily through the inhibition of cyclooxygenase-2 (COX-2) expression. It demonstrates significant antifungal activity and exhibits antiviral effects against the Chikungunya virus. Additionally, β-Amyrone inhibits α-glucosidase and acetylcholinesterase (AChE) activities, making it a valuable compound for research in inflammation, infectious diseases, and obesity-related studies. -
Fungicide and Herbicide
Akardite II is a nitrocellulose stabilizer that functions as a scavenger for nitrogen oxides (NOx). It exhibits broad-spectrum biological activity as both a fungicide and herbicide, effectively controlling various plant pathogens and weeds. Akardite II is utilized in agricultural research applications aimed at enhancing crop protection and increasing yield by mitigating unwanted flora and fungal infections. -
Antifungal Agent
Eleutherol is a naphthalene derivative derived from E. americana, exhibiting significant antifungal properties. It effectively targets various yeast species, including Candida albicans, C. tropicalis, Saccharomyces cerevisiae, and Cryptococcus neoformans, with minimum inhibitory concentration (MIC) values ranging from 7.8 µg/mL to 250 µg/mL. Additionally, Eleutherol inhibits α-glucosidase activity, presenting an IC50 greater than 1.00 mM, indicating its potential for further research in antifungal applications and enzyme inhibition studies. -
Sulfonylurea Herbicide, Photosynthetic System Inhibitor, Acetolactate Synthase (ALS) Inhibitor, Branched-chain Amino Acids (BCAAs) Inhibitor
Nicosulfuron is a selective sulfonylurea herbicide that acts as an inhibitor of acetolactate synthase (ALS) within the photosynthetic system. It effectively disrupts the synthesis of branched-chain amino acids (BCAAs), which is beneficial for maize cultivation by enhancing adaptability through glycolysis and the tricarboxylic acid cycle. Additionally, Nicosulfuron demonstrates antifungal properties and its degradation is dependent on glucose concentration when interacting with Plectosphaerella cucumerina AR1 in a planktonic environment. This compound is widely used in agricultural research for studying herbicide efficacy and metabolic pathways. -
Sex Pheromone
Heneicosane functions as a royal-specific pheromone in insects, notably influencing the identification and social structure of subterranean termites. It mediates royal recognition and supports the maintenance of social division of labor by eliciting vibration and antennal responses in worker ants. Additionally, Heneicosane exhibits anti-inflammatory, analgesic, and antipyretic properties through the inhibition of inflammatory mediators, such as prostaglandins and cytokines. It also shows potential in inhibiting mycelial growth and aflatoxin production by fungi. This compound is valuable in the study of insect chemical ecology and offers prospects for the development of new anti-inflammatory therapeutics. -
FAAH/MAGL Inhibitor
1-Monomyristin serves as a dual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), with IC50 values of 18 μM and 32 μM, respectively. It effectively inhibits the hydrolysis of 2-oleoylglycerol via MAGL, exhibiting antibacterial and antifungal activities against pathogens such as Staphylococcus aureus, Aggregatibacter actinomycetemcomitans, and Candida albicans. Additionally, 1-Monomyristin demonstrates lethality to brine shrimp and shows marginal cytotoxicity against prostate cancer cells. This reagent is suitable for research focused on bacterial and fungal infections, as well as various cancer types, including renal cancer, prostate adenocarcinoma, and pancreatic cancer. -
Fungal CYP51 Inhibitor
VT-1598 is an orally active and selective inhibitor of fungal cytochrome P450 51 (CYP51). It exhibits potent antifungal activity against Candida auris, making it a valuable tool for research into fungal infections. Additionally, VT-1598 contains an alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) for click chemistry applications, facilitating the study of various biological interactions. -
Fungal Metabolite
Cladosporin is a fungal metabolite with potent antibiotic and antifungal properties. It demonstrates significant inhibitory activity against a range of dermatophytes, plant pathogens, and bacteria. Additionally, Cladosporin exhibits antimalarial effects by targeting cytoplasmic lysine-tRNA synthetase in Plasmodium (PfKrs1), making it a valuable compound for research in microbial resistance and antimalarial studies. -
Bacterial Inhibitor
5,6-Dihydroxyindole is a bacterial inhibitor known for its broad-spectrum antibacterial, antifungal, antiviral, and antiparasitic activities. As a precursor in melanin synthesis, it exhibits cytotoxic properties, demonstrating significant toxicity against a variety of pathogenic organisms. This compound is valuable for research applications focused on antimicrobial resistance and the development of novel therapeutic agents. -
MAO Inhibitor
Phenelzine sulfate is an irreversible, orally active monoamine oxidase (MAO-A and MAO-B) inhibitor, primarily utilized as an antidepressant agent. It enhances levels of neurotransmitters, including serotonin, norepinephrine, and dopamine, while inhibiting GABA transaminase and primary amine oxidase, and sequestering reactive aldehydes. Additionally, Phenelzine sulfate suppresses oxidative stress and lipogenesis and inhibits LSD1 (Ki: 5.6 μM). Its applications extend across research into neurological, metabolic, and oncological diseases, particularly in the context of depression, anxiety disorders, stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinson's disease, Alzheimer's disease, inflammatory pain, obesity, and prostate cancer. -
EGFR/HER2/DHFR Inhibitor
EGFR/HER2/DHFR-IN-1 is a selective inhibitor targeting the epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and dihydrofolate reductase (DHFR). This compound demonstrates potent antitumor efficacy, with IC50 values of 0.153 μM for EGFR, 0.108 μM for HER2, and 0.291 μM for DHFR. EGFR/HER2/DHFR-IN-1 effectively arrests the cell cycle at the G1/S phase and promotes apoptosis in MCF-7 breast cancer cells, making it a valuable reagent for cancer research and therapeutic development. -
DHFR Inhibitor
DHFR-IN-4 is a potent inhibitor of dihydrofolate reductase (DHFR) with an IC50 value of 123 nM. In addition to its primary activity, DHFR-IN-4 exhibits inhibitory effects on epidermal growth factor receptor (EGFR) and HER2, with IC50 values of 246 nM and 357 nM, respectively. This compound demonstrates significant cytotoxic potency across a broad spectrum of cancer cell lines, making it a valuable tool for cancer research and drug development. -
HSP90/EGFR Inhibitor
Wighteone, a prenylated isoflavone, acts as an HSP90 and EGFR inhibitor, specifically targeting the EGFR L858R/T790M mutations. This compound effectively reduces HSP90 expression, inhibits EGF-induced phosphorylation of EGFR, and disrupts downstream signaling through ERK and AKT pathways. Wighteone demonstrates significant biological activity by inducing cell cycle redistribution, inhibiting proliferation, and triggering apoptosis in various cancer cell lines. It is relevant for research on HER2-positive breast cancer, leukemia, non-small cell lung cancer with specific mutations, and also displays antifungal properties. -
PPAR Inhibitor
AZ0108 is a selective inhibitor of poly(ADP-ribose) polymerases (PARPs), including PARP1, PARP2, PARP3, PARP6, TNKS1, and TNKS2. It displays potent inhibitory activity with IC50 values of <0.03 μM for PARP1 and PARP2, and exhibits significant biological effects such as preventing centrosome clustering with an EC50 of 0.053 μM. Additionally, AZ0108 demonstrates cytotoxicity in OCI-LY-19 cells, with a GI50 value of 0.017 μM, and shows favorable pharmacokinetic properties in rat and mouse models, making it a valuable tool for cellular and molecular biology research focused on DNA repair and cancer therapeutic studies. -
Poly(ADP-ribose) Synthetase Inhibitor
2-Methylquinazolin-4-ol is a potent competitive inhibitor of poly(ADP-ribose) synthetase, exhibiting a Ki value of 1.1 μM. Additionally, it functions as an inhibitor of mammalian aspartate transcarbamylase (ATCase) with an IC50 of 0.20 mM. This compound has significant applications in research focused on cellular stress responses, DNA repair mechanisms, and metabolic regulation. -
PPAR-1 Inhibitor
AZD-9574-acid is a selective PPAR-1 inhibitor that serves as a crucial building block for the development of PROTAC molecules. Its inhibition of PPAR-1 demonstrates significant potential in the regulation of metabolic pathways and inflammatory responses. This compound is essential for researchers exploring targeted protein degradation and its applications in therapeutic development. -
Endogenous Metabolite
Purine, an endogenous metabolite, serves as a fundamental building block of nucleic acids. It plays a role in inhibiting the activation of poly(ADP-ribose) polymerase (PARP) and provides protection against oxidant-induced cellular injury. Purine is utilized in research related to cancer and neurological disorders, highlighting its significance in studying cellular processes and treatments for various diseases. -
MAO Inhibitor
Tranylcypromine-d5 hydrochloride is a deuterium-labeled derivative of the irreversible, nonselective monoamine oxidase (MAO) inhibitor, Tranylcypromine. It exhibits potent antidepressant activity by inhibiting MAO, thereby increasing levels of neurotransmitters such as serotonin and norepinephrine in the brain. Additionally, this compound has been identified as a lysine-specific demethylase 1 (LSD1) inhibitor, demonstrating efficacy in reducing lesion growth and alleviating generalized hyperalgesia in mouse models of induced endometriosis. It serves as a valuable tool in neurological and pain research applications. -
HSP90/LSD1 Inhibitor
HSP90/LSD1-IN-1 is a dual inhibitor targeting HSP90 and LSD1, effectively disrupting their interaction and function. This compound demonstrates significant antiproliferative activity in prostate cancer cell lines, exhibiting GI50 values of 0.24 μM for PC-3 and 0.30 μM for DU145. It is a valuable tool for research into therapeutic strategies against prostate cancer and the role of chaperone proteins and histone demethylases in tumor biology. -
Endogenous Metabolite
α-Hydroxyglutaric acid is an endogenous metabolite that acts as a competitive inhibitor of various α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET enzyme family responsible for converting 5-methylcytosine (5mC) to hydroxymethylcytosine (5hmC). This compound is instrumental in epigenetic research, influencing histone modification and DNA methylation processes. Its role in metabolic pathways also makes it valuable for studying glioma metabolism and hypoxia-related conditions. -
Autophagy Inducer
Loperamide hydrochloride is an opioid receptor agonist that functions primarily as an autophagy inducer. This compound selectively inhibits human intestinal carboxylesterases (hiCE), contributing to its anti-diarrheal properties. Its unique mechanism of action makes Loperamide hydrochloride a valuable reagent for studies related to gastrointestinal motility and autophagy modulation in various biological contexts. -
CYP17A1/HDAC6 Inhibitor
CYP17A1/HDAC6-IN-1 is a dual inhibitor targeting both CYP17A1 and HDAC6, exhibiting IC50 values of 0.284 μM and 0.6015 μM, respectively. This compound demonstrates significant anti-tumor activity, making it a valuable tool for research in cancer biology. Its ability to simultaneously inhibit these targets suggests potential applications in therapeutic strategies against malignancies driven by steroidogenesis and histone deacetylation. -
LSD1/HDAC6/MAO-A Inhibitor
LSD1/HDAC6-IN-2 is a potent inhibitor targeting LSD1, HDAC6, and MAO-A, with IC50 values of 5 nM, 11 nM, and 5 nM, respectively. It demonstrates significant inhibitory effects on the growth of multiple myeloma cell lines, including MM.1S, MM.1R, and RPMI-8226. This compound is suitable for research applications focused on acute myeloid leukemia and lymphoma, providing insights into potential therapeutic mechanisms. -
HDAC11 Inhibitor
TD034 is a selective, reversible, and noncovalent inhibitor of HDAC11, exhibiting an IC50 value of 5.1 nM and a Ki of 1.5 nM. This compound specifically targets HDAC11 without affecting other histone deacetylases or sirtuins, and it inhibits the defatty acylation of the substrate SHMT2. Additionally, TD034 reduces the levels of YAP1 through its action on HDAC11. This reagent is suitable for investigating the role of HDAC11 in lung cancer research. -
HDAC6/MAO-A/LSD1 Inhibitor
HDAC6-IN-3 is a potent inhibitor of histone deacetylase 6 (HDAC6), with an IC50 ranging from 0.02 to 1.54 μM for various HDAC isoforms, including HDAC1, HDAC2, HDAC3, and HDAC8. Additionally, it exhibits significant inhibitory activity against monoamine oxidase A (MAO-A) with an IC50 of 0.79 μM and lysine-specific demethylase 1 (LSD1). This compound serves as a valuable tool for research applications in cancer biology and epigenetics and is equipped with an alkyne functionality, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc). -
EZH2/HSP90 Inhibitor
EZH2/HSP90-IN-29 is a dual inhibitor targeting both EZH2 and HSP90, exhibiting IC50 values of 6.29 nM for EZH2 and 60.1 nM for HSP90. This compound enhances the expression of apoptosis and necrosis-related genes, induces M-phase cell cycle arrest, and disrupts the reactive oxygen species catabolism pathway. Additionally, EZH2/HSP90-IN-29 has the capability to cross the blood-brain barrier, making it a valuable tool for research in cancer biology and neurodegenerative diseases. -
Ferroptosis Activator
Ammonium iron(III) citrate serves as a ferroptosis activator through the induction of intracellular iron overload. By increasing cellular iron levels, it promotes oxidative stress and contributes to ferroptotic cell death. This compound is valuable for research involving cellular iron metabolism, oxidative stress studies, and investigations into ferroptosis-related pathways. Additionally, it may enhance protein production, making it relevant for applications in biochemical assays and cellular biology research. -
Ferroptosis Inhibitor
1(R)-(Trifluoromethyl)oleyl alcohol is a trifluoromethyl alcohol derivative of oleic acid that functions as a ferroptosis inhibitor. This compound effectively attenuates ferroptosis induced by Erastin and mitigates lipid peroxidation in human myoblasts with frataxin (FXN) siRNA knockdown. At a concentration of 40 μM, it enhances cell survival to 95% in models of Friedreich ataxia where cell death is largely driven by iron accumulation and glutathione depletion. This makes 1(R)-(Trifluoromethyl)oleyl alcohol a valuable reagent for studying ferroptosis and its related pathways in neurodegenerative diseases. -
Ferroptosis Inhibitor
Ferroptosis-IN-3 is a potent ferroptosis inhibitor targeting the ferroptotic cell death pathway. It effectively inhibits RSL3-induced ferroptosis in HT-1080 cells with an EC50 of 8.6 nM. Additionally, Ferroptosis-IN-3 demonstrates strong free radical scavenging properties, with EC50 values of 3.94 μM for DPPH and 6.3 μM for ABTS, and reduces lipid peroxidation. This compound is ideal for research focused on oxidative stress and cell death mechanisms. -
Glyceraldehyde Derivative
TOFA-Plasmalogen is a glyceraldehyde derivative that induces ferroptosis through the promotion of lipid peroxidation on cellular membranes. This compound exhibits cytotoxic effects with an IC50 of 32.87 μM. TOFA-Plasmalogen is valuable for research applications focused on understanding the mechanisms of cell death and oxidative stress-related disorders. -
15LOX-2 Inhibitor
FerroLOXIN-1 is a potent inhibitor of the enzyme 15-lipoxygenase-2 (15LOX-2) that effectively reduces the production of pro-ferroptotic lipid species, specifically HOO-ETE-PE. This compound has demonstrated protective effects against RSL3-induced ferroptosis, making it a valuable tool in studying ferroptotic pathways. The selective interaction of FerroLOXIN-1 with the active site residues Y154, N155, and W158 of 15LOX-2 underscores its targeted mechanism of action, positioning it as a valuable reagent for research into lipid metabolism and ferroptosis. -
Ferroptosis Inhibitor
Ferroptosis Inducer-6 is a potent inducer of ferroptosis, primarily functioning through the generation of reactive oxygen species (ROS) and the induction of oxidative stress and mitochondrial damage. This compound exhibits anti-tumor activity and serves as a valuable tool for research in type I and II photodynamic therapy. Its ability to trigger ferroptotic cell death makes it significant for studies focused on cancer treatment and exploring the mechanisms of cell death pathways. -
TrxR1 Inhibitor
CS47 is a reversible inhibitor of Thioredoxin reductase 1 (TrxR1). It activates stress-responsive pathways involving glutathione (GSH) and iron regulation, leading to GSH depletion, heightened heme oxygenase-1 (HO-1) expression, and intracellular iron overload, ultimately inducing ferroptosis in KRAS-independent lung cancer models. CS47 demonstrates significant anticancer activity while exhibiting low cytotoxicity towards normal lung fibroblasts, making it a valuable tool for studying cancer mechanisms and therapeutic strategies. -
Ferroptosis Inducer
Lepadin E is a potent ferroptosis inducer that activates cell death through the classical p53-SLC7A11-GPX4 pathway. By promoting p53 expression and downregulating SLC7A11 and GPX4, Lepadin E enhances reactive oxygen species (ROS) and lipid peroxide production while increasing ACSL4 expression. This mechanism underlies its significant antitumor efficacy, making Lepadin E a valuable tool for studying ferroptosis in cancer research. -
Ferroptosis Inhibitor
Ferroptosis-IN-11 is a potent ferroptosis inhibitor targeting the pathways involved in iron-mediated cell death. It effectively inhibits Erastin-induced ferroptosis in HT-1080 human fibroblasts, demonstrating an EC50 of 36 nM. This compound is valuable for research into cardiovascular diseases and neurodegenerative disorders, providing insights into the mechanisms of ferroptosis and potential therapeutic strategies. -
Ferroptosis/MAO-B Inhibitor
MAO-B-IN-45 is a selective inhibitor of MAO-B with an IC50 of 87.47 nM, demonstrating over 229-fold selectivity for MAO-B compared to MAO-A. This compound exhibits significant antiferroptosis activity by modulating the iron metabolic pathway and the glutathione peroxidase 4 (GPX4) axis in vitro. Research indicates that MAO-B-IN-45 enhances cognitive and behavioral functions in 3×Tg (APP/Tau/Ps1) Alzheimer's disease mouse models, while also reducing levels of ferritin heavy chain 1 (FTH1), amyloid precursor protein (APP), and phosphorylated Tau (p-Tau) in the brain. -
Ferroptosis/Apoptosis Inducer
Lepadin H is a potent ferroptosis and apoptosis inducer, demonstrating significant in vitro cytotoxicity and in vivo antitumor efficacy against cancer cells. This compound functions by decreasing the levels of GPX4 and SLC7A11, while enhancing p53 and ACSL4 expression. Lepadin H promotes the generation of lipid hydroperoxides and increases reactive oxygen species (ROS), leading to a reduction in cellular glutathione (GSH) levels and lipid peroxidation. Additionally, it causes G2/M phase cell cycle arrest and inhibits the clonogenic growth and migration of melanoma cells, making it a valuable tool for cancer research. -
Ferroptosis Inducer
AX-53802 is a potent ferroptosis inducer that targets glutathione peroxidase 4 (GPX4) with an IC50 value of 0.34 µM. This compound covalently binds to GPX4, facilitating membrane translocation and subsequent triggering of ferroptotic cell death. In combination with FAK/Src inhibitors, AX-53802 enhances the induction of cell death, making it a valuable tool for cancer research and studies involving ferroptosis mechanisms. -
Ferroptosis Inducer
Ferroptosis inducer-7 selectively induces ferroptosis via the inositol 1,4,5-trisphosphate receptor (IP3R) and calcium release-activated calcium channel protein (ORAI). This compound demonstrates significant biological activity in alleviating symptoms of anemia, suppressing activation of bone marrow cytotoxic T lymphocytes (CTLs), and enhancing hematopoietic function in cases of immune-mediated bone marrow failure. Ferroptosis inducer-7 is valuable for research applications focused on aplastic anemia and related hematological conditions. -
Ferroptosis Inhibitor
Ferrostatin-1 diyne is a potent ferroptosis inhibitor that selectively targets the ferroptotic pathway. This compound is known to accumulate in lysosomes, mitochondria, and the endoplasmic reticulum of cells. Notably, its inhibition of ferroptosis occurs independently of lysosomal and mitochondrial activity, making it a valuable tool for studying ferroptosis-related mechanisms and evaluating therapeutic strategies in various research applications. -
Ferroptosis Inducer
Anticancer agent 147 is a ferroptosis inducer that promotes intracellular accumulation of Fe2+, reactive oxygen species (ROS), and malondialdehyde (MDA). This compound enhances endoplasmic reticulum (ER) stress and upregulates the expression of activating transcription factor ATF3. Anticancer agent 147 exhibits significant anti-liver cancer effects in both in vitro and in vivo models, making it a valuable tool for research in cancer therapy and cell death mechanisms. -
Ferroptosis Inhibitor
RC574 is a novel ferroptosis inhibitor that protects mouse hippocampal cells and primary cortical neurons from glutamate-induced oxidative cell death. It enhances levels and activity of glutathione peroxidase 1 (GPx1), vital for cellular antioxidant defense. This compound is valuable for research into neuroprotection and the mechanisms underlying ferroptosis in neurodegenerative diseases. -
HMG-CoA Reductase Inhibitor
Cerivastatin is a highly potent HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. This synthetic lipid-lowering agent effectively reduces low-density lipoprotein cholesterol levels. In addition to its lipid-modulating effects, Cerivastatin has exhibited inhibitory effects on the proliferation and invasiveness of MDA-MB-231 breast cancer cells, primarily through the inhibition of RhoA signaling, indicating potential applications in cancer research. -
Apoptosis/Ferroptosis Inducer
GIC-20 is a dual inducer of apoptosis and ferroptosis, acting on key cellular pathways involved in programmed cell death. This compound demonstrates significant antitumor efficacy, particularly against fibrosarcoma. GIC-20 is valuable for research applications aimed at exploring mechanisms of cell death and potential therapeutic strategies in cancer biology. -
TrxR/EGFR Inhibitor
TrxR/EGFR-IN-1 is a potent inhibitor targeting both Thioredoxin Reductase (TrxR) and Epidermal Growth Factor Receptor (EGFR). This compound demonstrates significant anti-proliferative effects against Gefitinib-sensitive and resistant lung cancer cells, facilitating apoptosis and tumor cell death. TrxR/EGFR-IN-1 promotes GPX4 protein degradation via autophagolysosomal and proteasomal pathways, leading to ferroptosis. Additionally, it induces endoplasmic reticulum stress and triggers immunogenic cell death, making it a valuable tool for studying mechanisms underlying Gefitinib-resistant lung cancer. -
Ferroptosis Inducer
Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) acts as a ferroptosis inducer by generating lipid-based reactive oxygen species (ROS). This compound is instrumental for research exploring the mechanisms of ferroptosis, a form of regulated cell death characterized by iron-dependent lipid peroxidation. It is valuable for studies investigating cancer biology, neurodegenerative diseases, and other conditions where ferroptosis plays a critical role. -
Ferroptosis Inhibitor
Ferroptosis-IN-4 is a potent ferroptosis inhibitor, exhibiting an EC50 value of 20 μM. This compound demonstrates minimal cytotoxicity, highlighting its safety for biological applications. Ferroptosis-IN-4 provides a protective effect in models of glycerol-induced renal acute kidney injury (RM-AKI), effectively alleviating kidney dysfunction. Its ability to modulate ferroptosis makes it a valuable tool for research in cellular stress responses and kidney-related disorders. -
Ferroptosis Inducers
Ferroptocide is a potent inducer of ferroptosis, a form of regulated cell death characterized by iron-dependent lipid peroxidation. It effectively induces oxidative stress, resulting in G2/M cell cycle arrest and apoptosis in LNCaP cells, and significantly reduces cell viability in both LNCaP and TRAMP-C1 prostate cancer cell lines. Ferroptocide serves as a valuable tool for investigating mitochondrial autophagy and evaluating its potential to trigger immunogenic cell death (ICD) in prostate cancer research. -
Ferroptosis Inducer
Chaetoglobosin E is a potent ferroptosis inducer that targets and downregulates GPX4 expression in human tumor cell lines. It exhibits significant cytotoxic effects, with IC50 values of 9.14 μM against MDA-MB231 cells and 7.47 μM against A549 cells. The compound elevates intracellular Fe2+ levels and increases the lipid peroxidation marker malondialdehyde (MDA), resulting in mitochondrial alterations and the induction of ferroptosis. Chaetoglobosin E serves as a valuable tool for cancer research and the study of ferroptosis mechanisms.
