Catalog No.
Product Name
Application
Product Information
Citations
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17β-HSD Inhibitor
HSD17B13-IN-36 is a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting an IC50 of less than 0.1 μM for estradiol as a substrate. This compound is significant in the study of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH), making it valuable for research concerning metabolic disorders and liver health. Its selective inhibition of HSD17B13 may provide insights into therapeutic interventions for liver-related diseases. -
HSD17B13 Inhbitor
HSD17B13-IN-85 is a potent inhibitor of 17β-Hydroxysteroid dehydrogenase 13 (HSD17B13), exhibiting an IC50 of less than 0.1 μM for estradiol. This compound is primarily employed in the study of nonalcoholic fatty liver disease (NAFLD) and offers significant insights into the role of HSD17B13 in metabolic regulation and liver physiology. Its specific inhibition enhances understanding of the enzyme's contribution to various biological processes and potential therapeutic targets in liver-related disorders. -
FXR/HSD17B13 Modulator
FXR/HSD17B13 modulator 1 is a potent modulator targeting the farnesoid X receptor (FXR) and hydroxysteroid dehydrogenase 17 beta 13 (HSD17B13). This compound demonstrates significant biological activity relevant to the study of metabolic dysfunction-associated steatohepatitis (MASH). Its modulation of these targets can provide insights into therapeutic strategies for liver-related metabolic disorders. -
HSD17B13 Inhbitor
HSD17B13-IN-84 is a potent inhibitor of the enzyme 17β-Hydroxysteroid dehydrogenase type 13 (HSD17B13), demonstrating an IC50 of less than 0.1 μM for estradiol. This compound is primarily utilized in research concerning nonalcoholic fatty liver disease (NAFLD), providing valuable insights into the role of HSD17B13 in lipid metabolism and liver pathophysiology. Its effective inhibition of HSD17B13 supports studies aimed at understanding disease mechanisms and potential therapeutic interventions. -
HSD17B13 Inhibitor
HSD17B13-IN-98 is a potent inhibitor of 17 β-hydroxysteroid dehydrogenase (HSD17B13), demonstrating an IC50 value for estradiol of less than 0.1 μM. This compound is particularly relevant in the investigation of nonalcoholic fatty liver disease, providing valuable insights into the biochemical pathways involved in lipid metabolism and liver function. Its specificity and efficacy make it an essential tool for research focused on metabolic disorders and related therapeutic strategies. -
HSD17B13 Inhibitor
HSD17B13-IN-59 is a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting an IC50 value of ≤ 0.1 μM for estradiol. This compound is valuable for research focused on liver diseases, metabolic disorders, and cardiovascular conditions, including non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and drug-induced liver injury (DILI). Its specific mechanism of action makes it an essential tool in elucidating the role of HSD17B13 in various pathophysiological contexts. -
17β-HSD1 Inhibitor
7-Coumaryl triflate is a selective inhibitor of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1), demonstrating an IC₅₀ of 360 nM and a Kᵢ of 173 nM. This compound selectively targets 17β-HSD2 while displaying no significant affinity for estrogen receptors ERα or ERβ. 7-Coumaryl triflate is valuable for research focused on hormone-dependent breast cancer and the modulation of estrogen metabolism. -
HSD17B13 Inhibitor
HSD17B13-IN-26 is a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13). This compound exhibits significant activity in the modulation of steroid metabolism and demonstrates potential therapeutic applications in liver diseases, including hepatitis, liver fibrosis, liver cirrhosis, and hepatocellular carcinoma. Researchers can utilize HSD17B13-IN-26 to further investigate the role of HSD17B13 in liver pathology and associated metabolic disorders. -
Anticancer Agent
Dehydrofalcarinol is a polyacetylene compound that targets 17β-hydroxysteroid dehydrogenase type 11, exhibiting notable anticancer activity. This compound has demonstrated potential in research applications focusing on triple-negative breast cancer, making it a valuable tool for investigating new therapeutic strategies in oncology. Dehydrofalcarinol's unique mechanism of action positions it as a promising candidate for further study in cancer biology. -
17β-HSD Inhibitor
4'-Hydroxyvalerophenone is a specific inhibitor of 17β-hydroxysteroid dehydrogenase (17β-HSD), exhibiting an IC50 value of 60.52 μM. This compound plays a significant role in steroid metabolism and can be utilized in various research applications related to hormonal regulation and steroid biosynthesis. Its inhibitory effects make it a valuable tool for studies investigating the role of 17β-HSD in physiological and pathological processes. -
17β-HSD5 Inhibitor
17β-HSD5 inhibitor 1 is a potent inhibitor of 17β-HSD5, demonstrating an IC50 of 2.9 nM in HEK-293 cells that overexpress human 17β-HSD5. This compound is primarily utilized in research applications related to steroid metabolism and is instrumental in studying the modulation of sex steroid biosynthesis. The selective inhibition of 17β-HSD5 can provide insights into its role in various hormonal disorders and therapeutic interventions. -
17β-HSD5 Inhibitor
17β-HSD5 inhibitor 2 is a potent inhibitor of 17β-hydroxysteroid dehydrogenase 5 (17β-HSD5), demonstrating an IC50 value of 40 nM. This compound is valuable for research into steroid metabolism and androgen biosynthesis, with potential applications in studying conditions related to hormone regulation and prostate cancer. Its inhibitory action enables the exploration of therapeutic strategies targeting 17β-HSD5 in various biological contexts. -
Herbicide
Chlorsulfuron is a selective herbicide that inhibits the enzyme acetolactate synthase, effectively blocking the biosynthesis of the amino acids valine and isoleucine in plants. This inhibition leads to the cessation of growth, making Chlorsulfuron a potent agent for controlling various weed species. It is primarily utilized in agricultural research to study plant physiology and herbicide resistance mechanisms. -
Herbicide
Pyrazosulfuron-ethyl is an herbicide that functions as an inhibitor of acetolactate synthase, a key enzyme in the biosynthetic pathway of branched-chain amino acids. This compound effectively controls a broad spectrum of weed species, making it valuable in agricultural applications, particularly in cereal, soybean, and vegetable crop production. Its selective action allows for effective weed management while minimizing harm to cultivated plants. -
Herbicide
Mesosulfuron-methyl is a sulfonylurea herbicide that targets acetolactate synthase (ALS). It exhibits effective post-emergence activity against various grass weeds, particularly ryegrass and wild oat species (Avena spp.), making it valuable in agricultural research focused on weed management in wheat cultivation. -
Herbicide
Cloransulam-methyl is a triazolopyrimidine sulfonanilide herbicide that functions primarily through the inhibition of acetolactate synthase (ALS). This compound effectively targets and controls broadleaf weeds in soybean crops. Its reliable herbicidal activity makes it a valuable tool for research focused on weed management and agricultural practices. -
Herbicide Safener
Herbicide Safener-2 is a herbicide safener that functions by competitively binding to the active site of acetolactate synthase (ALS), similar to mefenpyr-diethyl. This compound is designed to mitigate herbicide-induced injury in crops by enhancing their protection against herbicides such as mesosulfuron-methyl. Its pharmacokinetic profile allows for effective crop safeguarding during herbicide application, making it valuable for agricultural research and development. -
Herbicide
Triafamone is a sulfonamide herbicide that acts by inhibiting the enzyme acetolactate synthase (ALS). This inhibition disrupts the biosynthesis of branched-chain amino acids, leading to the effective control of various weed species. It is applicable in both pre-emergence and post-emergence scenarios in paddy fields, making it a valuable tool in agricultural weed management research. -
Sulfonylurea Herbicide
Prosulfuron is a fluorinated sulfonylurea herbicide that primarily targets acetolactate synthase (ALS), inhibiting the biosynthesis of branched-chain amino acids such as valine, leucine, and isoleucine in plants. This mechanism effectively suppresses the growth of certain weed species. Due to its low toxicity to humans and mammals, prosulfuron is utilized in research focused on broadleaf weed control in agricultural practices, particularly in maize and sweet corn. Additionally, it may influence the balance of soil microbial communities in alkaline conditions, highlighting its potential environmental impact. -
Herbicide
Pyrimisulfan is a selective inhibitor of acetolactate synthase (ALS) and functions as a broad-spectrum herbicide. It effectively targets a diverse array of paddy weeds, including annual grasses, sedges, and broadleaf species, as well as sulfonylurea-resistant biotypes, providing both pre- and post-emergence control. With its long residual activity and excellent safety profile for rice, Pyrimisulfan is valuable for research focusing on herbicidal mechanisms and paddy weed management strategies. -
Herbicide
Primisulfuron-methyl is a selective herbicide that targets the acetolactate synthase (ALS) enzyme, inhibiting its activity. This compound exhibits effective control of annual bluegrass in Kentucky bluegrass turf. Its specific mode of action makes Primisulfuron-methyl suitable for agricultural and research applications focused on turf management and weed control strategies. -
Herbicide
(E)-Pyriminobac-methyl is an acetolactate synthase inhibitor that functions as a pyrimidinylbenzoate herbicide. It effectively inhibits the biosynthesis of branched-chain amino acids, resulting in potent herbicidal activity. This compound has demonstrated efficacy against invasive species such as Echinochloa crus-galli and Leptochloa chinensis, with activity levels significantly surpassing those of certain other herbicides. Its application is essential for research focused on herbicide development and weed management strategies. -
Herbicide
Tritosulfuron is a sulfonylurea herbicide that targets acetolactate synthase, inhibiting its activity. This compound exhibits broad-spectrum efficacy as a post-emergent herbicide, specifically effective against dicotyledonous plants. It is commonly applied in the cultivation of cereals, maize, and turf to manage undesirable vegetation. -
CHI3L1 Inhibitor
CHI3L1-IN-1 is a selective inhibitor of Chitinase-3-like protein 1 (CHI3L1), also known as YKL-40, with an IC50 of 50 nM. This compound exhibits additional effects by inhibiting the hERG channel with an IC50 of 2.3 μM. CHI3L1-IN-1 is valuable for research applications focused on the roles of CHI3L1 in inflammation and cancer, offering insights into its potential as a biomarker and therapeutic target. -
Endogenous Metabolite
O-Nornuciferine is an aporphine-type alkaloid derived from lotus leaf that acts as a potent inhibitor of the hERG channel. This endogenous metabolite is significant in the study of cardiac ion channels and provides insights into drug-induced cardiac arrhythmias. Its biological activity makes it a valuable reagent in pharmacological research and safety assessments. -
CYP2D6 Inhibitor
Guanfu base A is a potent noncompetitive inhibitor of CYP2D6, with a Ki value of 1.20 μM in human liver microsomes and 0.37 μM for the recombinant form. This antiarrhythmic alkaloid, derived from Aconitum coreanum, also exhibits competitive inhibition of CYP2D in monkey and dog microsomes, with Ki values of 0.38 μM and 2.4 μM, respectively. In addition to its CYP2D6 inhibitory activity, Guanfu base A demonstrates the ability to inhibit HERG channel current, making it relevant for studies in drug metabolism and cardiac electrophysiology. -
Endogenous Metabolite
Minoxidil hydrochloride is an ATP-sensitive potassium (KATP) channel opener with significant vasodilatory properties. Its primary applications include use as a potent oral antihypertensive agent and in promoting hair growth. Additionally, Minoxidil hydrochloride exhibits inhibitory activity against soybean lipoxygenase, with an IC50 value of 20 μM, making it valuable for research in cardiovascular and dermatological studies. -
CYP2D6 Inhibitor
Guanfu base A hydrochloride is a selective inhibitor of the CYP2D6 enzyme, demonstrating significant potential in the management of arrhythmia-related disorders. This alkaloid exhibits inhibitory effects across various species, including humans, primates, and canines. Its ability to modulate CYP2D6 activity may provide valuable insights and therapeutic applications in pharmacology and toxicology research. -
Omeprazole Metabolite
4-Hydroxy omeprazole sulfide is a key metabolite of the proton pump inhibitor omeprazole, primarily involved in modifying gastric acid secretion. This compound serves as a valuable tool in pharmacokinetic and metabolic studies of omeprazole and its effects on gastric mucosa. Its biological activity is significant for understanding drug metabolism and potential drug interactions in gastrointestinal research. -
Fungal Metabolite
Acetylaszonalenin is a prenylated indole derivative that acts as a neurokinin-1 (NK1) receptor antagonist. This fungal metabolite demonstrates significant inhibition of [3H]-substance P binding to human astrocytoma cells, with a Ki value of 170 μM. Acetylaszonalenin is applicable in research exploring neurokinin signaling and its role in neuroinflammation and related neurological disorders. -
5-LOX Inhibitor
5-O-Demethylnobiletin is an effective inhibitor of 5-lipoxygenase (5-LOX), exhibiting a potent IC50 of 0.1 μM without impacting COX-2 expression. This polymethoxyflavone, derived from Citrus jambhiri Lush., demonstrates notable anti-inflammatory properties by inhibiting leukotriene B4 (LTB4) production in rat neutrophils and elastase release in human neutrophils with an IC50 value of 0.35 μM. 5-O-Demethylnobiletin is valuable for research applications related to inflammation and leukotriene signaling pathways. -
5-LO Inhibitor
Enofelast (BI-L-239) is a selective inhibitor of 5-lipoxygenase (5-LO) with an IC50 of 2.48 μM, effectively blocking calcium ionophore-induced leukotriene B4 (LTB4) production. Its ability to modulate lipid mediators makes it a valuable tool for studying inflammatory pathways and leukotriene signaling in various biological contexts. Enofelast is suitable for research applications investigating the role of 5-LO in diseases associated with inflammation and immune response. -
PA2/5-LOX/COX Inhibitor
LY256548 is a potent inhibitor of phospholipase A2, 5-lipoxygenase (5-LOX), and cyclooxygenase (COX), demonstrating significant anti-ischemic and anti-inflammatory properties. This compound effectively reduces leukotriene B4 production in response to A23187 stimulation. In preclinical models, LY256548 has shown efficacy in mitigating bone damage and paw swelling in rat models of Freund's complete adjuvant-induced arthritis (FCA), making it a valuable tool for research into inflammatory diseases and analgesic mechanisms. -
Cyclooxygenase/Lipoxygenase Inhibitor
L-652343 is a dual inhibitor of cyclooxygenase and lipoxygenase enzymes. It effectively inhibits the production of leukotriene B4 (LTB4) in isolated human polymorphonuclear leukocytes, demonstrating an IC50 value of 1.4 μM when challenged with Calcimycin. This compound is applicable in the study of inflammatory and immune diseases, providing insights into the mechanisms of these conditions and potential therapeutic interventions. -
5-LO Inhibitor
5-LOX-IN-6 is a potent and selective inhibitor of 5-lipoxygenase (5-LO), exhibiting reversible inhibition. It effectively reduces 5-LO activity in human neutrophils and recombinant human 5-LO with IC50 values of 0.23 µM and 0.086 µM, respectively. By inhibiting leukotriene biosynthesis, 5-LOX-IN-6 serves as a valuable tool in the study of inflammatory and allergic disorders. -
5-LOX Inhibitor
E 6080 is a specific inhibitor of 5-lipoxygenase (5-LOX), exhibiting an IC50 of 0.2 μM in rat basophilic leukemia cells. This compound effectively reduces leukotriene release, which is critical in the inflammatory response. E 6080 has demonstrated the ability to inhibit bronchospasm induced by antigen inhalation in sensitized guinea pigs, making it a valuable tool for asthma research and related inflammatory conditions. -
5-LOX Inhibitor
A63162 is a selective inhibitor of 5-lipoxygenase (5-LOX), a key enzyme in the biosynthesis of leukotrienes. This compound effectively inhibits both mitogen-induced proliferation of horse mononuclear cells and the synthesis of leukotriene LTB4 in response to Calcimycin at equivalent concentrations. A63162 is useful in research focused on chronic obstructive pulmonary disease, arthritis, and inflammatory bowel disease, offering insights into inflammatory pathways and potential therapeutic interventions. -
CETP Inhibitor
Obicetrapib is a potent cholesteryl ester transfer protein (CETP) inhibitor that effectively reduces atherogenic lipoproteins, including LDL-C, ApoB, and lipoprotein(a), while simultaneously increasing HDL-C levels. This compound is of significant interest in research related to dyslipidemia and atherosclerotic cardiovascular disease (ASCVD), facilitating investigations into lipid metabolism and cardiovascular health outcomes. -
Muscarinic Receptor/Phospholipase C Activator
(S)-Albuterol hydrochloride is a selective muscarinic receptor activator that enhances phospholipase C activity. This compound increases intracellular free calcium levels in airway smooth muscle, making it valuable for research on respiratory physiology and pharmacology. Its ability to modulate calcium signaling pathways makes it useful for studying smooth muscle contraction and respiratory function. -
Drug Metabolite
Piribedil N-oxide is a metabolite of the dopamine receptor agonist Piribedil, primarily functioning as a drug metabolite. This compound retains the ability to interact with dopamine receptors, contributing to studies on dopamine signaling pathways and pharmacokinetics. Its characterization is essential for understanding the metabolic fate of Piribedil and its potential implications in neurological research and therapeutic applications. -
Acetylcholinesterase Inhibitor, Butyrylcholinesterase Inhibitor, Carbonic Anhydrase I/II Inhibitor, α-Glycosidase Inhibitor
Vescalagin is a hexahydroxyphenol that acts as an inhibitor of acetylcholinesterase and butyrylcholinesterase, as well as carbonic anhydrases I and II, and α-glycosidase. It demonstrates potent inhibitory activity with Ki values of 5.87 nM for AChE, 3.89 nM for BChE, 11.75 nM for hCA I, 16.23 nM for hCA II, and 16.08 nM for α-glycosidase. Vescalagin exhibits non-competitive inhibition for hCA I, hCA II, and α-glycosidase, while also reducing hyperglycemia and hypertriglyceridemia in dietary models. Additionally, it possesses anti-inflammatory and antioxidant activities, making it a valuable compound for research in diabetes and metabolic disorders. -
Endogenous Metabolite
3-Hydroxyisobutyric acid sodium is an endogenous metabolite involved in the metabolic pathways of L-valine and thymine. It serves as a mediator in endothelial cell fatty acid transport and has implications in insulin resistance. Additionally, this compound can inhibit key enzymes involved in energy metabolism in the cerebral cortex of young rats. Elevated levels of 3-Hydroxyisobutyric acid sodium are associated with conditions such as 3-hydroxyisobutyric aciduria, diabetes, and ketoacidosis, making it a significant target for research on metabolic disorders. -
Stable Isotope
Verapamil-d3 hydrochloride is a deuterium-labeled derivative of the calcium channel blocker, verapamil hydrochloride. It serves as a potent inhibitor of P-glycoprotein (P-gp) and CYP3A4, facilitating detailed pharmacological studies. This stable isotope is primarily utilized in research related to hypertension, cardiac arrhythmias, and angina, providing insight into drug metabolism and transport mechanisms in various biological systems. -
IDO1 Inhibitor
IDO1-IN-19 is a selective inhibitor of Indoleamine 2,3-dioxygenase 1 (IDO1), exhibiting an IC50 value of 8.64 μM for CYP2C9. In addition, it modulates cardiac ion channels with IC50 values of 12 μM for IKr, 40 μM for INa, and 8.3 μM for ICa. This compound is valuable for investigating the mechanisms of cancer biology and has potential applications in cancer therapeutics. -
IDHP Isomer
(R)-IDHP is an isomer of isovaleryl-DL-3-hydroxybutyric acid, functioning primarily by inhibiting Ca2+ release and modulating Ca2+ inward flow in both voltage-dependent and receptor-operated calcium channels in vascular smooth muscle cells. This compound exhibits vasorelaxant properties and is valuable in research focused on cardiovascular disease mechanisms and treatments. Its biological activity makes it a useful tool for investigating vascular dynamics and related pathophysiological conditions. -
Drug Metabolite
α-Hydroxy etizolam is the primary metabolite of Etizolam, exhibiting a similar pharmacological profile and high affinity for benzodiazepine receptors. This compound plays a significant role in understanding the metabolic pathways and effects of Etizolam in biological systems. It is utilized in biochemical research to investigate the pharmacodynamics and pharmacokinetics associated with anxiolytic and sedative activities. -
Endogenous Metabolite
Stearoyl-L-carnitine chloride is an endogenous long-chain acylcarnitine that serves as a modulator of glycine transport. It exhibits inhibitory activity on the GlyT2 receptor, reducing glycine responses by 16.8% at concentrations up to 3 μM. This compound is of interest in research focusing on neurotransmitter regulation and metabolic processes related to acylcarnitines. -
Endogenous Metabolite
24(S)-Hydroxycholesterol (24S-OHC) is an endogenous metabolite primarily involved in cholesterol homeostasis within the brain. As a potent and selective positive allosteric modulator of N-methyl-D-aspartate receptors (NMDARs), 24S-OHC functions through a unique mechanism distinct from other allosteric modulators. Its high levels in both the brain and circulation make it a valuable tool for research into neurological functions and disorders related to cholesterol metabolism and synaptic transmission. -
Endogenous Metabolite
NSC 16590 is an inhibitor of endogenous ethylene synthesis. This compound has been shown to effectively suppress the production of ethylene in cotyledonary segments of cocklebur, making it a valuable tool for studies on plant physiology and development. Its application in research can elucidate the roles of ethylene in growth processes and stress responses in plants. -
FXR Modulator
3-Epideoxycholic acid is a modulator of the Farnesoid X receptor (FXR), primarily influencing dendritic cell function. This compound reduces the immunostimulatory capacity of dendritic cells, facilitating the generation of regulatory T cells (Tregs) and exhibiting notable anti-inflammatory effects. Additionally, 3-Epideoxycholic acid promotes the growth of beneficial gut bacteria, specifically Bacteroides, making it relevant for research in immunology and microbiome studies.
