Catalog No.
Product Name
Application
Product Information
Citations
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ALDH1A1 Inhibitor
FSI-TN42 is a selective, irreversible inhibitor of ALDH1A1 with an IC50 of 23 nM, demonstrating significant potency with an 800-fold preference over ALDH1A2. This compound is valuable for research applications targeting metabolic pathways involving aldehyde dehydrogenases, particularly in cancer and stem cell studies. Its oral bioavailability makes it a suitable candidate for in vivo investigations of ALDH1A1's role in various biological processes. -
Acetaldehyde Dehydrogenase Inhibitor
Coprine is a mycotoxin derived from Coprinopsis atramentaria that functions as an inhibitor of acetaldehyde dehydrogenase. By inhibiting this enzyme, coprine leads to the accumulation of acetaldehyde, which can trigger the alcohol flushing reaction in susceptible individuals. This compound is useful in research focused on alcohol metabolism and the effects of acetaldehyde accumulation on physiological processes. -
Aldehyde Dehydrogenase 2 Activator
Mirivadelgat is an activator of aldehyde dehydrogenase 2 (ALDH2), which plays a crucial role in detoxifying aldehydes and maintaining cellular homeostasis. This compound exhibits potential biological activity in the investigation of interstitial lung disease, pulmonary hypertension, and various cancer models. Mirivadelgat serves as a valuable tool for researchers studying metabolic pathways and therapeutic approaches related to these conditions. -
ALDH1A1 Inhibitor
ALDH1A1-IN-4 is a potent inhibitor of aldehyde dehydrogenase (ALDH) A1, demonstrating an IC50 value of 0.32 μM. This compound is significant in cancer research, offering insights into pathways involving ALDH1A1's role in tumor biology and potential therapeutic strategies. Its inhibitory activity may contribute to the understanding of cancer metabolism and the development of novel treatments. -
ALDH1A2 Inhibitor
CM121 is a reversible inhibitor of ALDH1A2, featuring a competitive mechanism with an IC50 of 0.54 μM and a Kd of 1.1 μM. This compound demonstrates significant hydrophobic interactions at the active site, making it a valuable tool for studying ALDH1A2's role in various biological processes. It is suitable for applications in cancer research and stem cell biology, where modulation of aldehyde dehydrogenase activity is of interest. -
Acohol use disorder
Lefelsiran is a small interfering RNA (siRNA) that specifically targets aldehyde dehydrogenase 2 (ALDH2). This reagent is primarily employed in research focused on alcohol use disorder, investigating the molecular mechanisms underlying this condition. By modulating ALDH2 expression, Lefelsiran facilitates the study of its role in alcohol metabolism and the potential therapeutic interventions for alcohol dependence. -
ALDH1A1 Inhibitor
ALDH1A1-IN-3 is a selective inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), demonstrating an IC50 value of 0.379 μM. This compound effectively enhances glucose consumption in HepG2 cells, making it a valuable tool for studying glucose metabolism. ALDH1A1-IN-3 is suitable for research applications focused on metabolic regulation and potential therapeutic interventions in metabolic disorders. -
ALDH Inhibitor
Aldi-2 is a selective covalent inhibitor of aldehyde dehydrogenases (ALDHs), exhibiting IC50 values of 2.5, 6.4, and 1.9 μM for ALDH1A1, ALDH2, and ALDH3A1, respectively. This compound is particularly valuable in cancer research, providing insight into the role of ALDHs in tumor metabolism and progression. Its specificity allows for targeted studies on the modulation of ALDH activity within various biological contexts. -
Aldehyde Dehydrogenase (ALDH) Inhibitor
CM026 is a selective inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), demonstrating submicromolar potency. The compound exerts its inhibitory effect through binding to the aldehyde binding pocket, specifically involving a unique glycine residue. CM026 serves as a valuable chemical tool for investigating the role of ALDH1A1 in various pathological conditions and studying its implications in disease research. -
ALDH2 modulator
ALDH2 Modulator 1 is a potent modulator of aldehyde dehydrogenase-2 (ALDH2), showcasing effective oral bioavailability. This compound has been demonstrated to significantly reduce blood alcohol levels in murine models, highlighting its potential applications in alcohol metabolism research and related metabolic studies. -
ALDH3A1 Inhibitor
ALDH3A1-IN-4 is a selective inhibitor of ALDH3A1, exhibiting an IC50 of 0.2 μM. This compound interacts with the aldehyde-binding pocket of ALDH3A1 through hydrophobic interactions and van der Waals forces. ALDH3A1-IN-4 functions as a chemosensitizer, enhancing the antiproliferative effects of mafosfamide in ALDH3A1-expressing cancer cells while sparing non-cancer cells. It is particularly relevant for research on lung adenocarcinoma and glioblastoma. -
ALDH1A1 Inhibitor
NCT-501 hydrochloride is a highly potent and selective inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), demonstrating an IC50 of 40 nM. It exhibits superior selectivity against other ALDH isozymes, as well as various dehydrogenases, with IC50 values greater than 57 μM for hALDH1B1, hALDH3A1, and hALDH2. This compound is valuable for research applications focused on cancer biology, neurodegenerative diseases, and other conditions where ALDH1A1 activity plays a critical role. -
ALDH3A1 Inhibitor
ALDH3A1-IN-2 is a potent inhibitor of aldehyde dehydrogenase 3A1 (ALDH3A1) with an IC50 of 1.29 μM. This compound is particularly relevant for research in oncology, as ALDHs, including ALDH3A1, are often overexpressed in various tumor types, such as prostate cancer. ALDH3A1-IN-2 may provide valuable insights into the role of ALDH3A1 in cancer progression and therapeutic intervention. -
ALDH Inhibitor
GA11 is an inhibitor of aldehyde dehydrogenase (ALDH), demonstrating significant anti-glioblastoma activity in both in vitro and in vivo models. This compound is valuable for research applications focusing on cancer biology and therapeutic strategies targeting glioblastoma through ALDH modulation. -
ALDH1A1 Modulator
ALDH1A1 modulator-1 is a selective modulator of the aldehyde dehydrogenase 1A1 (ALDH1A1) enzyme. This compound exhibits the ability to influence ALDH1A1 activity, which plays a critical role in the detoxification of aldehydes and the metabolic regulation of retinoic acid. ALDH1A1 modulator-1 is valuable for research focused on cancer biology, stem cell differentiation, and metabolic disorders, providing insights into the modulation of ALDH1A1 in various biological contexts. -
ALDH Inhibitor
CM-39 is a non-covalent, reversible inhibitor of aldehyde dehydrogenase 1A (ALDH1A), exhibiting an IC50 of 0.9 μM. This compound is used in research applications focusing on the modulation of cellular aldehyde metabolism and the study of cancer biology, where ALDH1A plays a significant role in stem cell regulation and chemoresistance. It provides a valuable tool for scientists investigating the therapeutic potential of targeting ALDH pathways in various disease models. -
PKM2 Inhibitor
PKM2-IN-7 is a selective inhibitor of pyruvate kinase M2 (PKM2) that disrupts the interaction between PKM2 and ALDH1A3, demonstrating minimal toxicity to normal cells. This compound is pivotal for investigations into tumor biology, making it an essential tool for research focused on cancer metabolism and tumorigenesis. -
NNMT Inhibitor
JBSNF-000028 free base is a potent inhibitor of nicotinamide N-methyltransferase (NNMT), exhibiting IC50 values of 33 nM, 210 nM, and 190 nM for human, mouse, and monkey NNMT, respectively. This compound effectively reduces endogenous MNA levels in U2OS osteosarcoma cells, with an EC50 of 2.5 μM. JBSNF-000028 free base demonstrates notable anti-obesity and anti-diabetic effects in diet-induced obesity models, making it a valuable tool for researching metabolic disorders, including obesity, type 2 diabetes, and non-alcoholic fatty liver disease. -
NNMT Inhibitor
NCGC00685960 is a potent inhibitor of Nicotinamide N-methyltransferase (NNMT) with an IC50 value of less than 10 nM. This compound exhibits significant antitumor properties by enhancing H3K27 trimethylation levels in ovarian cancer cells and reducing α-SMA expression in NNMT-expressing ovarian fibroblasts. Additionally, NCGC00685960 lowers 1-MNA levels and reverses SAM and H3K27 hypomethylation, effectively diminishing collagen contractility in cancer-associated fibroblasts (CAFs). It is a valuable reagent for cancer research applications. -
NNMT Inhibitor
MS2734 is a potent inhibitor of nicotinamide N-methyltransferase (NNMT), exhibiting an IC50 value of 14 μM against human NNMT (hNNMT). This compound effectively disrupts the methyltransferase activity of NNMT, making it a valuable tool for investigating the role of NNMT in metabolic disorders, neurodegenerative diseases such as Parkinson's disease, and various cancers characterized by elevated NNMT levels. Its utility in research applications extends to the exploration of obesity and diabetes-related mechanisms. -
NNMT Inhibitor
NNMT-IN-6 hydrochloride is a potent inhibitor of nicotinamide N-methyltransferase (NNMT), exhibiting an IC50 value of 1.41 μM and a Kd of 5.6 μM. This compound demonstrates significant inhibitory effects on the proliferation of the HSC-2 human oral cancer cell line, making it a valuable tool for research in cancer biology and NNMT-related pathways. Its ability to modulate NNMT activity may provide insights into therapeutic strategies for diseases associated with altered methylation processes. -
NNMT Inhibitor
NNMT-IN-3 is a highly potent and selective inhibitor of nicotinamide N-methyltransferase (NNMT), exhibiting IC50 values of 1.1 nM in cell-free assays and 0.4 μM in cell-based assays. This compound plays a critical role in studying metabolic disorders and can be utilized in research involving obesity, type 2 diabetes, and cancer. Its specific inhibition of NNMT allows for detailed exploration of the enzyme's involvement in these significant diseases. -
NNMT Inhibitor
II399 is a potent and selective inhibitor of nicotinamide N-methyltransferase (NNMT), featuring an unconventional S-adenosylmethionine (SAM) mimic, with a Ki value of 5.9 nM. This compound shows competitive inhibition for nicotinamide (NAM) by binding to both substrate and cofactor binding sites. II399 is valuable for research applications in cancer, metabolic disorders, cardiovascular diseases, and neurodegenerative conditions. -
NNMT Inhibitor
4-Chloropyridine is an inhibitor of Nicotinamide N-methyltransferase (NNMT), functioning as a substrate and a precursor for suicide inhibition-based protein labeling. This compound enhances the C4 electrophilicity of pyridine nitrogen through NNMT-catalyzed methylation, allowing for aromatic nucleophilic substitution at cysteine C159, resulting in covalent modification and inactivation of NNMT. 4-Chloropyridine is valuable for research into various cancers, facilitating studies on the role of NNMT in tumor biology. -
NNMT Inhibitor
NNMT-IN-6 is a potent inhibitor of nicotinamide N-methyltransferase (NNMT), exhibiting an IC50 value of 1.41 μM and a dissociation constant (Kd) of 5.6 μM. This compound effectively inhibits cell proliferation in the HSC-2 human oral cancer cell line, making it a valuable tool for research focused on cancer biology and metabolism. Its specificity towards NNMT positions it as a promising candidate for further studies in therapeutic applications targeting NNMT-related pathways. -
NNMT Inhibitor
NNMT-IN-7 is a potent inhibitor of nicotine and nicotine metabolism transferase (NNMT) with an IC50 of 505.7 µM. This compound serves as a valuable tool for investigating the role of NNMT in metabolic and chronic diseases. Its use in research may provide insights into therapeutic strategies targeting metabolic disorders linked to altered NNMT activity. -
FXR Agonist
HPG1860 is a highly selective and potent agonist of the farnesoid X receptor (FXR), demonstrating an EC50 of 18 nM in FXR-luciferase reporter assays. This compound exhibits minimal activity on TGR5 and 13 other related nuclear receptors, with EC50 values exceeding 30.0 μM. HPG1860 is primarily utilized in research investigating non-alcoholic steatohepatitis (NASH) and related metabolic disorders. -
Hydrolase Enzyme
α-Amylase is a hydrolase enzyme that facilitates the hydrolysis of internal α-1,4-glycosidic linkages in starch, producing glucose and maltose as key products. This enzyme plays a critical role in carbohydrate metabolism and is widely used in biochemical research to study starch degradation and enzymatic activity. Its applications extend to food science, biotechnology, and various analytical methods in the life sciences. -
α-amylases Substrate
Maltopentaose is a substrate for α-amylases, serving as the shortest chain oligosaccharide. This compound is classified as maltodextrin and is instrumental in studies examining glycation and phosphorylation of α-lactalbumin. Additionally, maltopentaose facilitates the investigation of inhibition kinetics in human pancreatic α-amylase by compounds such as dehydrodieugenol B, making it valuable for enzyme kinetics and carbohydrate-related research. -
Antioxidant
Acetylregaloside C is a natural antioxidant derived from Madonna Lily (Lilium candidum L.). This compound enhances the activity of α-amylase, which is essential in carbohydrate metabolism. Acetylregaloside C is useful in research applications focused on oxidative stress and metabolic disorders, contributing to the understanding of its potential therapeutic effects. -
α-Amylase/α-Glucosidase Inhibitor
α-Amylase/α-Glucosidase-IN-23 is a potent inhibitor of α-amylase and α-glucosidase, demonstrating IC50 values of 73.68 nM and 146.18 nM, respectively. This compound is valuable for research focused on glucose metabolism and the management of hypoglycemia. Its ability to inhibit carbohydrate-hydrolyzing enzymes makes it a useful tool for studies investigating glycemic control and related metabolic disorders. -
α-Amylase Substrate
Ethylidene-4-nitrophenyl-α-D-maltoheptaoside serves as a substrate for α-amylase, facilitating the assessment of enzyme activity. Upon degradation by α-amylase, along with auxiliary enzymes like α-glucosidase, it releases a chromophore that enables quantification of amylase activity. This reagent is particularly valuable in the diagnosis of pancreatitis and other related disorders. -
Amylase
Bacterial α-Amylase targets and hydrolyzes internal α-1,4-glycosidic linkages in starch, producing low molecular weight products such as glucose, maltose, and maltotriose. This enzyme plays a crucial role in carbohydrate metabolism and is widely utilized in biochemical studies to understand starch biodegradation and enzymatic processes. Its action is fundamental in various applications, including food science and research on metabolic pathways. -
α-Glucosidase Inhibitor
Quinoline-2-carboxylic acid functions as an α-glucosidase inhibitor, demonstrating significant potential in the modulation of glucose metabolism. This compound is of interest for its antidiabetic properties and serves as a valuable intermediate for the synthesis of various biologically active compounds in chemical research. Its role in enzyme inhibition makes it a relevant agent for studies aimed at understanding carbohydrate metabolism and diabetes management. -
Amylase
α-Amylase from Aspergillus oryzae is an enzyme that catalyzes the hydrolysis of starch into simpler sugars, primarily maltose and glucose. This reagent exhibits significant activity in breaking down complex carbohydrates, making it valuable for various biochemical studies, including carbohydrate metabolism and enzymatic kinetics. It serves as an essential tool in food science, biotechnology, and clinical research applications where starch-related processes are investigated. -
α-amylase Inhibitor
Chinese gallotannin is a non-specific α-amylase inhibitor, exhibiting a Ki of 0.82 μg/mL against human salivary α-amylase. This compound demonstrates potential biological activity in modulating starch digestion and may be useful in diabetes research. Its inhibition of α-amylase activity positions it as a candidate for studying carbohydrate metabolism and metabolic disorders. -
Flavonoid
Chrysin-7-O-glucuronide is a flavonoid that targets α-glucosidase and α-amylase, exhibiting inhibitory activity with IC50 values of 612.13 and 980.73 μg/mL, respectively. This compound is known to suppress NF-κB signaling and possesses free radical scavenging abilities, functioning as a protectant for tight junctions and alleviating intestinal mucosal barrier injury. Chrysin-7-O-glucuronide is relevant for research focused on type 2 diabetes and the impacts of severe acute pancreatitis on intestinal health. -
Alkaloid
Lotusine hydroxide is an alkaloid that functions as a signaling pathway modulator and enzyme inhibitor. It exhibits notable inhibitory activity against α-amylase and α-glucosidase, with IC50 values of 30.60 μg/mL and 36.15 μg/mL, respectively. Lotusine hydroxide effectively inhibits the EGFR-Akt-ERK signaling pathway by decreasing phosphorylated levels of EGFR, Akt, and ERK, leading to apoptosis, G0/G1 cell cycle arrest, and reduced cancer cell proliferation. Additionally, it enhances antioxidant enzyme activities and is relevant for research on non-small cell lung cancer, type 2 diabetes, and autism spectrum disorder. -
α-Amylase Inhibitor
α-Amylase-IN-3 is a potent inhibitor of α-Amylase, exhibiting an IC50 of 18.04 μM, and also targets acetylcholinesterase (AChE) with IC50s of 21.04 μM and 22.2 μM, respectively. This compound demonstrates antioxidant activity, making it valuable for studies related to diabetes and diseases associated with oxidative stress. Its biochemical properties make α-Amylase-IN-3 a useful tool for researchers investigating metabolic disorders and neuroprotective mechanisms. -
α-Glucosidase Inhibitors
2,4,6-Triphenylaniline serves as an α-glucosidase inhibitor, demonstrating significant anti-diabetic properties. Its formulation in nano-emulsions enhances stability and bioavailability, enabling more efficient inhibition of both α-glucosidase and α-amylase enzymes. This compound is valuable for research focused on glycemic control and potential therapeutic strategies for diabetes management. -
Pseudodisaccharide Moiety
Acarviosin is a pseudodisaccharide moiety that serves as a potent inhibitor of α-amylase. This compound effectively interferes with carbohydrate metabolism by inhibiting starch degradation, making it valuable in research focused on diabetes and obesity. Its activity can aid in elucidating the mechanisms of carbohydrate absorption and regulation in various biological models. -
α-amylase Inhibitor, α-glucosidase Inhibitor
Lotusine is an α-amylase and α-glucosidase inhibitor, demonstrating IC50 values of 30.60 μg/mL and 36.15 μg/mL, respectively. This compound modulates the EGFR-Akt-ERK signaling pathway by lowering the levels of phosphorylated EGFR, Akt, and ERK, leading to apoptosis, G0/G1 cell cycle arrest, and reduced cancer cell proliferation. Additionally, Lotusine decreases lipid peroxidation and enhances the activities of antioxidant enzymes such as SOD, CAT, and GPx. Its potential applications include research in non-small cell lung cancer, type 2 diabetes, and autism spectrum disorder. -
α-Glycosidase Inhibitor
Inulobiose is a difructan disaccharide that serves as an α-glycosidase inhibitor, effectively inhibiting α-glycosidase and α-amylase activities with IC50 values of 1.87 mg/mL and 40.72 mg/mL, respectively. This compound is valuable for research applications focused on diabetes management and glomerular filtration rate assessment, contributing to insights in carbohydrate metabolism and potential therapeutic strategies. -
α-Amylase/α-Glucosidase Inhibitor
α-Amylase/α-Glucosidase-IN-19 is a dual inhibitor targeting α-amylase and α-glucosidase, exhibiting IC50 values of 170.7 μM and 60.37 μM, respectively. This compound demonstrates significant inhibitory activity that may be beneficial in the study of carbohydrate metabolism and the management of diabetes. Its applications include examining mechanisms of enzyme inhibition and exploring potential therapeutic strategies for controlling postprandial glucose levels. -
α-amylase/α-glucosidase Inhibitor
ABCB1-IN-4 is a potent dual inhibitor of α-amylase and α-glucosidase, exhibiting IC50 values of 1.63 μM and 0.14 μM, respectively. This compound demonstrates significant potential in the study of diabetes by modulating carbohydrate metabolism. Its orally active nature makes it a valuable tool for research applications focused on glycemic control and related metabolic pathways. -
α-amylase Inhibitor
5-O-Coumaroylquinic acid is a potent, reversible, non-competitive inhibitor of α-amylase, exhibiting an IC50 value of 69.39 μM. This compound is valuable for research into diabetes, as it interacts with the enzyme involved in carbohydrate metabolism, potentially aiding in the development of therapeutic strategies for glycemic control. Its inhibition of α-amylase may provide insights into managing postprandial glucose levels. -
α-amylase Inhibitor
8,3′,4′-Trihydroxyflavone-7-O-β-D-glucopyranoside is a natural compound derived from Bidens bipinnata, acting as an α-amylase inhibitor. It exhibits a 22% inhibitory effect on α-amylase activity at a concentration of 0.556 mg/mL. This compound may be of interest for research in diabetes management and carbohydrate metabolism studies. -
Antioxidant
Luteolin 4'-O-β-D-glucuronopyranoside is a flavonoid glycoside with notable antioxidant properties. It is derived from the aerial parts of Cyperus rotundus and has been shown to inhibit α-amylase activity. This compound is relevant for research applications focused on oxidative stress and diabetes, highlighting its potential role in managing metabolic disorders. -
α-Amylase Inhibitor
α-Amylase-IN-5 is a potent inhibitor of α-amylase, demonstrating an IC50 value of 18.8 mM. This compound is primarily utilized in research focused on carbohydrate metabolism, obesity, and diabetes management. It serves as a valuable tool for investigating the role of α-amylase in digestive processes and can aid in the development of therapeutic strategies targeting carbohydrate absorption. -
α‑amylase Inhibitor
α-Amylase-IN-8 is a selective inhibitor of α-amylase, with an IC50 value of 58.1 μM. This compound is valuable for research focused on type 2 diabetes, where the modulation of carbohydrate metabolism is of interest. Its inhibition of α-amylase can help in the understanding of glucose absorption and the subsequent effects on blood sugar levels.
