Catalog No.
Product Name
Application
Product Information
Citations
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α-Glucosidase Inhibitor
α-Glucosidase-IN-70 is a potent α-glucosidase inhibitor with an IC50 of 31.1 μM, derived from the traditional Chinese herbal medicine Swertia mussotii. This compound is valuable for investigating the modulation of carbohydrate metabolism, particularly in the context of diabetes research. Its inhibitory action on α-glucosidase makes it a suitable candidate for further studies exploring therapeutic strategies to manage postprandial hyperglycemia. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-111 is a selective inhibitor of α-glucosidase, demonstrating an IC50 of 34.99 μg/mL. In addition to its inhibitory effects on α-glucosidase, it exhibits strong antioxidant properties, effectively scavenging DPPH and ABTS free radicals with IC50 values of 5.33 and 5.84 μg/mL, respectively. This compound is valuable for research focused on type 2 diabetes and related metabolic disorders, making it a useful tool for studying glycemic control and oxidative stress mechanisms. -
Alpha-glucosidase Inhibitor
Valibose is an alpha-glucosidase inhibitor that plays a crucial role in regulating carbohydrate metabolism. It has been shown to improve metabolic disorders related to glucose and lipid levels, as well as alleviate nephropathy in Streptozotocin-induced diabetic rat models. This compound is valuable for research focused on diabetes and associated metabolic conditions. -
α±-Glucosidase Inhibitor
Chrysin 6-C-arabinoside 8-C-glucoside is an α±-glucosidase inhibitor that demonstrates significant potential in the management of type 2 diabetes. By inhibiting α-glucosidase activity, this compound can effectively reduce carbohydrate digestion and absorption, potentially leading to improved glycemic control. Its biological activity makes it a valuable tool for research into metabolic disorders and the development of antidiabetic therapies. -
α-glucosidase Inhibitor
α-Glucosidase-IN-22 is a benzimidazole derivative that serves as a potent inhibitor of α-glucosidase, exhibiting an IC50 value of 0.64 μM. This compound demonstrates significant anti-diabetic properties, making it a promising candidate for research in type 2 diabetes mellitus (T2DM). Its ability to modulate carbohydrate digestion positions α-Glucosidase-IN-22 as a valuable tool in glucose metabolism studies and diabetes management investigations. -
GCase Modulator
JZ-4109 is a potent β-Glucocerebrosidase (GCase) modulator, exhibiting an IC50 of 8 nM against wild-type recombinant GCase. This compound binds to an allosteric site at the GCase dimer interface, promoting dimerization and stabilizing both wild-type and GCase N370S mutant variants. JZ-4109 enhances GCase protein abundance, making it a valuable tool for research into Parkinson's disease and related conditions. -
Glycosidase Inhibitor
L-Afegostat (5-epi-Isofagomine) is a glycosidase inhibitor that targets β-Glucosidase, exhibiting enzyme inhibition with a Ki of 30 μM. This iminosugar plays a significant role in carbohydrate synthesis and is valuable for studying glycosidase-related metabolic processes. It is particularly useful in research focused on enzyme regulation and glycosylation mechanisms. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-43 is a potent α-glucosidase inhibitor with an IC50 value of 4.32 μM, demonstrating significant hypoglycemic activity. This compound exhibits low toxicity in normal mouse fibroblasts and shows efficacy in vivo, effectively rescuing streptozotocin-induced diabetic rats. α-Glucosidase-IN-43 is valuable for investigating postprandial hyperglycemia and related metabolic disorders in diabetes research. -
α-glucosidase Inhibitor
Quercetin 3'-methoxy-3-O-α-L-arabinofuranoside is an α-glucosidase inhibitor, derived from the leaves and twigs of Fagus hayatae. This compound demonstrates weak inhibitory activity against α-glucosidase, an enzyme involved in carbohydrate metabolism. It serves as a valuable tool for research in glycemic control and metabolic studies. -
Glycosidase Inhibitor
Nojirimycin is a nitrogen-containing sugar analog that functions as a glycosidase inhibitor. Its unique structure includes a ring nitrogen atom, which acts as an isostere of the oxygen atom in sugar rings, effectively inhibiting the activity of glycosidases. This compound is valuable in biochemical research for studying enzymatic functions and exploring metabolic pathways involving glycosidases. -
Anti-hyperglycemic Agent
Anti-hyperglycemic agent-1 is a potent α-Glucosidase inhibitor, exhibiting an IC50 of 0.53 μM. This compound is primarily utilized in diabetes research to investigate mechanisms of glucose metabolism and control postprandial hyperglycemia. Its selective inhibition of α-Glucosidase makes it a valuable tool for studying the biochemical pathways involved in carbohydrate absorption and insulin sensitivity. -
Glycosidase
Agarase is a glycosidase enzyme that catalyzes the hydrolysis of agar into oligosaccharides. This biochemical process is pivotal in the study of polysaccharide degradation and has applications in food science, molecular biology, and biotechnology. Agarase's ability to produce oligosaccharides from agar enhances research into carbohydrate metabolism and the development of agarose-based products. -
α-Glucosidase Inhibitor
Falandioside B is an α-glucosidase inhibitor with an IC50 of 107.52 μM, effectively modulating carbohydrate metabolism. It exhibits antioxidant activity by scavenging ABTS radical cations, making it relevant for studies on oxidative stress. This compound is primarily utilized in research focused on managing postprandial hyperglycemia and its associated metabolic implications. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-9 is a potent inhibitor of α-glucosidase, exhibiting an IC50 of 55.6 μM. This compound is relevant for research applications focused on type II diabetes, enabling the investigation of carbohydrate digestion and glucose absorption. Through its inhibitory action, α-Glucosidase-IN-9 provides a valuable tool for studying the metabolic implications associated with dysregulated glucose homeostasis. -
Human Glucocerebrosidase
Imiglucerase is a recombinant human glucocerebrosidase that catalyzes the hydrolysis of glucosylceramide into glucose and ceramide. This enzyme is primarily utilized in the research of type 1 (non-neuronopathic) and type 3 (chronic neuronopathic) Gaucher's disease. Imiglucerase facilitates studies on enzyme replacement therapy and its effects on cellular metabolism in Gaucher's disease pathophysiology. -
Antiallergic Agent
Mudanpioside E is a paeoniflorin-type monoterpene glycoside that acts as an antiallergic agent by inhibiting IgE-mediated β-hexosaminidase release with an IC50 of 40.34 μM. It effectively reverses the inhibitory effect of modified extracts of the Xiaoqinglong Decoction on passive cutaneous anaphylaxis in murine models. While Mudanpioside E does not exhibit direct activity against passive cutaneous anaphylaxis, it serves as a valuable tool for research investigating allergic diseases and potential therapeutic strategies. -
Endoplasmic Reticulum α-Glucosidases I/II inhibitor
EB-0150 is a selective inhibitor of endoplasmic reticulum α-glucosidases I and II, exhibiting IC50 values of 0.73 µM and 0.0337 µM, respectively. This N-substituted derivative of valiolamine demonstrates broad-spectrum antiviral activity and can be utilized in research aimed at developing agents against both existing and emerging viral pathogens. Additionally, EB-0150 serves as a versatile click chemistry reagent, possessing an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing and DBCO or BCN-labeled molecules. -
Alpha-glucosidase Inhibitor
6,8-Dihydroxy-1,2,7-trimethoxy-3-methylanthraquinone is an anthraquinone that serves as an α-glucosidase inhibitor, exhibiting an IC50 value of 185 μM. This compound, which can be isolated from Cassia seeds, is valuable for investigating carbohydrate metabolism and potential therapeutic applications in managing diabetes. Its inhibitory activity makes it a suitable candidate for research focused on the modulation of glucose absorption. -
α-Glucosidase Inhibitor
Ganoderlactone D is a potent inhibitor of α-Glucosidase, demonstrating an IC50 value of 41.7 μM in yeast models. This compound is utilized in research to explore its potential effects on carbohydrate metabolism and its role in the management of postprandial hyperglycemia. Its inhibitory action provides a valuable tool for studying the modulation of glucose absorption and its implications in diabetes research. -
α-Glucosidase Inhibitor
(2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid is a natural saponin extracted from Rubus ellipticus var. obcordatus that acts as an α-Glucosidase inhibitor. This compound exhibits an inhibitory activity with an IC50 of 1.68 mM, making it a valuable tool for research focused on carbohydrate metabolism and diabetes management. Its biological properties facilitate studies exploring the regulation of glucose absorption and potential therapeutic approaches in glycemic control. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-18 is a potent inhibitor of α-glucosidase, exhibiting an IC50 value of 3.96 μM. This compound demonstrates significant antidiabetic activity, making it a valuable tool for research in glucose metabolism and diabetes treatment. Its oral bioavailability supports its potential applications in pharmacological studies targeting carbohydrate digestion and postprandial blood glucose regulation. -
β-Glucosidase Substrate
2-Nitrophenyl β-D-glucopyranoside serves as a substrate for β-glucosidase, facilitating the analysis of enzymatic activity. Upon hydrolysis by β-glucosidase, it produces a colored product, enabling quantification of enzyme function. This compound is predominantly utilized in research applications involving carbohydrate metabolism and enzymatic assays. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-23 is a potent inhibitor of α-glucosidase, demonstrating an IC50 value of 4.48 μM. This compound effectively lowers blood glucose levels by inhibiting the enzyme α-glucosidase, making it a valuable tool in diabetes research. α-Glucosidase-IN-23 is suitable for studies focused on glucose metabolism and the development of therapeutic strategies for diabetes management. -
Hexosaminidases Inhibitor
α-HNJNAc is a potent, competitive inhibitor of hexosaminidases, selectively targeting these enzymes while demonstrating no interference with other glycosidases. This specificity makes α-HNJNAc an invaluable tool for research applications focused on the modulation of glycan metabolism and the study of lysosomal storage disorders. Its ability to inhibit hexosaminidases can aid in unraveling the biochemical pathways involved in glucosamine metabolism and related enzymatic activities. -
α‐Glucosidase Inhibitor
α-Glucosidase-IN-56 is a potent inhibitor of α-glucosidase, with an IC50 value of 45.86 μM. This compound exhibits significant anti-glycation activity, making it a valuable tool for research in the fields of diabetes and metabolic disorders. Its ability to inhibit carbohydrate digestion positions it as a candidate for further studies aimed at understanding and managing glycemic responses. -
Alpha-glucosidase Inhibitor
α-Glucosidase-IN-13 is an α-glucosidase inhibitor, demonstrating an IC50 value of 5.69 μM. This compound effectively interferes with the enzyme's activity, making it a valuable tool for studying carbohydrate metabolism and the regulation of blood glucose levels. Its applications extend to diabetes research and the development of therapeutic strategies targeting glycemic control. -
α-glucosidase Inhibitor
α-Glucosidase-IN-30 is a competitive inhibitor of α-glucosidase, exhibiting a Ki value of 40.0 µM and an IC50 of 49.0 µM. This reagent demonstrates non-cytotoxicity in both cancer (MCF-7) and normal (HDF) cell lines, making it suitable for research applications in Type 2 diabetes studies. Its oral bioactivity and selectivity position it as an important tool for exploring therapeutic interventions targeting carbohydrate metabolism. -
CHI3L1 Binder
CHI3L1 binder 1 is a selective CHI3L1 inhibitor with a dissociation constant (Kd) of 182 µM. This compound is valuable for studying various biological processes, including immune response, tissue remodeling, and cancer progression. Its specificity for CHI3L1 makes it a useful tool for researchers investigating the role of this protein in disease mechanisms and therapeutic interventions. -
α-glucosidase Inhibitor
α-Glucosidase-IN-100 is a potent inhibitor of α-glucosidase, a key enzyme involved in carbohydrate metabolism. This compound is instrumental in exploring metabolic disorders, particularly diabetes, by modulating glucose absorption and metabolism. Its use in research may provide insights into therapeutic strategies for managing hyperglycemia and associated metabolic conditions. -
Alpha-Glucosidase Inhibitor
Valienamine is an alpha-glucosidase inhibitor that plays a crucial role in the regulation of carbohydrate metabolism. This compound is a fundamental structural component of various natural glycosidase inhibitors, including the agricultural fungicide validamycin A and the antidiabetic drug acarbose. Valienamine is primarily utilized in research applications focused on diabetes management and crop protection strategies. -
α-Glucosidase Inhibitor
1,6,8-Trihydroxy-2,7-dimethoxy-3-methylanthraquinone is a potent α-glucosidase inhibitor isolated from Cassia obtusefolia. It demonstrates a significant inhibitory effect with an IC50 value of 120.65 μg/mL. This compound is valuable for research into diabetic mechanisms and potential therapeutic interventions. Its efficacy in modulating carbohydrate metabolism makes it a useful tool in the study of metabolic disorders. -
Herbicide
Fluopipamine is an antagonist of Cellulose Synthase 1 (CESA1), exhibiting an IC50 of 0.78 μM. This compound disrupts glucose uptake into cellulose and promotes the hyperaccumulation of CESA proteins at the plasma membrane in etiolated Arabidopsis seedlings. Fluopipamine serves as a valuable tool for research into cellulose biosynthesis and plant physiology, particularly in studies investigating herbicide mechanisms. -
α-Glucosidase Inhibitor
α-Amylase-IN-2 is an oleanolic acid oxime ester derivative that acts as a potent α-glucosidase inhibitor, exhibiting an IC50 value of 1.28 µM. Additionally, it demonstrates inhibitory activity against α-amylase with an IC50 of 3.8 µM. This compound is valuable for research applications focused on metabolic disorders such as diabetes, where modulation of carbohydrate digestion is critical. -
GAA Activator
5-C-phenethyl-DNJ hydrochloride is a potent activator of acid α-glucosidase (GAA). It enhances GAA activity across multiple tissues, notably in the diaphragm, making it a valuable tool for research into metabolic disorders, including Pompe disease. This compound provides insights into therapeutic strategies aimed at modulating GAA activity for the treatment of glycemic imbalances. -
alpha-glucosidase Inhibitor
6β-Hydroxyipolamiide is an α-glucosidase inhibitor identified in the methanolic extract of S. jamaicensis leaves. It demonstrates significant inhibitory activity with an IC50 of 539.17 μg/mL. This compound is relevant for research focused on carbohydrate metabolism and the management of conditions related to glycemic control. -
Acid α-glucosidase Molecule Chaperone
ML247 is a selective small molecule chaperone that targets acid α-glucosidase, facilitating proper protein folding and function. This compound enhances enzyme activity and stability, making it a valuable tool for investigating metabolic disorders, particularly Pompe disease. Its role in improving enzyme efficacy underscores its potential in research applications focused on lysosomal storage diseases and enzyme replacement therapies. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-68 is a selective inhibitor of α-glucosidase, demonstrating an IC50 of 0.251 μM, along with inhibition of AChE and BChE at 0.774 μM and 0.793 μM, respectively. This compound exhibits strong antioxidant properties, with IC50 values of 0.69 μM in the DPPH assay and 0.02 μM in the ABTS assay. Additionally, α-Glucosidase-IN-68 has been shown to have an antidiabetic effect in streptozotocin-induced diabetic rat models, making it a valuable tool for research in diabetes and related metabolic disorders. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-2 is a potent inhibitor of α-Glucosidase, exhibiting an IC50 of 9.48 µM. This compound demonstrates significant antidiabetic activity by impeding carbohydrate digestion and absorption, thereby lowering postprandial blood glucose levels. It serves as a valuable tool for research in diabetes management and metabolic studies. -
Natural Product
Timosaponin N is a natural steroidal saponin that acts as an inhibitor of α-Glucosidase. Its primary mechanism involves reducing glucose absorption in the intestine, making it an important research tool in studies related to diabetes and glycemic control. Timosaponin N may provide insights into therapeutic pathways for managing blood sugar levels in diabetic patients. -
α-Amylase/α-Glucosidase Inhibitor
α-Amylase/α-Glucosidase-IN-2 is a potent dual inhibitor of α-amylase and α-glucosidase, demonstrating IC50 values of 13.02 µM and 13.09 µM, respectively. This compound is primarily utilized in research investigating diabetic complications, offering significant insights into glucose metabolism and potential therapeutic strategies for managing diabetes. Its dual mechanism of action makes it a valuable tool for studying carbohydrate digestion and its implications in hyperglycemia. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-41 is a potent inhibitor of α-glucosidase, functioning by altering the secondary structure of the enzyme to impede its catalytic activity. This compound is valuable in research focused on diabetes mellitus, providing insights into carbohydrate metabolism and potential therapeutic strategies. Its efficacy in modulating enzyme activity makes it a pertinent tool for studying glycemic control and related metabolic disorders. -
α-Glucosidase Inhibitor
(E)-p-Coumaramide acts as an α-Glucosidase inhibitor, playing a significant role in carbohydrate metabolism regulation. This compound, which can be isolated from Welsh onion, demonstrates potential biological activity in managing glucose levels and may contribute to diabetes research. Its application extends to studies aimed at understanding the mechanisms of glycosidase enzymes in metabolic disorders. -
α-Glucosidase Inhibitor
5-C-phenethyl-DNJ is a selective α-glucosidase inhibitor, targeting glycosylation pathways with a Ki value of 0.81 μM for recombinant human acid α-glucosidase (rhGAA). This compound demonstrates notable selectivity for glycosyltransferases GANAB, GBA1, and GBA2. 5-C-phenethyl-DNJ is particularly valuable in the research of Pompe disease, enabling insights into enzymatic deficiencies and potential therapeutic strategies. -
α-glucosidase Inhibitor
2'-Rhamnoechinacoside (Michelioside A) is an α-glucosidase inhibitor derived from Phlomis stewartii, demonstrating notable anti-tumor activity. This phenylethanoid glycoside can be utilized in research focused on UV absorption and cancer biology, offering insights into therapeutic strategies against glucose-related disorders. Its mechanism of action and biological activity make it a valuable tool for studying metabolic processes and developing potential cancer treatments. -
α-Glucosidase Inhibitor
Lucidal is a natural lanosto-type triterpene aldehyde that functions as an inhibitor of α-glucosidase, exhibiting an IC50 of 0.635 mM. This compound demonstrates significant biological activities, including anticancer and antidiabetic effects. It is useful for research applications targeting metabolic disorders and cancer biology. -
α-glucosidase Inhibitor
Giffonin P is a selective inhibitor of α-glucosidase, exhibiting an IC50 value of 55.3 μM. This compound effectively delays carbohydrate hydrolysis and glucose absorption, contributing to its anti-hyperglycemic properties. Giffonin P is primarily utilized in research related to type 2 diabetes, particularly in studies focused on managing postprandial blood glucose levels. -
α-glucosidase Inhibitor
α-Glucosidase-IN-8 is a potent competitive inhibitor of α-glucosidase, exhibiting an IC50 value of 0.18 µg/mL. This compound effectively blocks the enzymatic activity of α-glucosidase, which plays a crucial role in carbohydrate metabolism. Its primary applications include studying glucose absorption and management of conditions like diabetes, making it valuable for research in metabolic disease and pharmacology. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-36 is a selective inhibitor of α-glucosidase, exhibiting an IC50 value of 6.69 ± 0.18 μM and Ki and Kis values of 1.65 μM and 4.54 μM, respectively. This compound functions by binding to the active site of α-glucosidase, leading to alterations in its secondary structure, which subsequently inhibits enzyme activity. α-Glucosidase-IN-36 is valuable for research applications related to type 2 diabetes mellitus (T2DM), enabling investigations into carbohydrate metabolism and glycemic control. -
α-glucosidase Inhibitor
MDL-25637 is an α-glucosidase inhibitor that effectively inhibits the activity of enzymes such as sucrose, maltase, isomaltase, glucose amylase, and trehalose in the intestinal tract. This compound is primarily utilized in diabetes research to investigate the regulation of carbohydrate absorption and its implications for glucose homeostasis. Its ability to modulate enzymatic activity makes it a valuable tool for studying metabolic disorders associated with diabetes. -
α-Amylase/α-Glucosidase Inhibitor
α-Amylase/α-Glucosidase-IN-1 is a potent inhibitor of both α-amylase and α-glucosidase, exhibiting IC50 values of 2.01 µM and 2.09 µM, respectively. This compound is utilized in biochemical research to investigate mechanisms of glycemic control and has potential applications in the management of hyperglycemia. The inhibitory activity of α-Amylase/α-Glucosidase-IN-1 makes it a valuable tool for studying carbohydrate metabolism and related metabolic disorders.
