Catalog No.
Product Name
Application
Product Information
Citations
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α-Glucosidase/α-Aamylase Inhibitor
Diphlorethohydroxycarmalol is a phlorotannin that serves as an inhibitor of α-glucosidase and α-amylase, exhibiting IC50 values of 0.16 mM and 0.53 mM, respectively. This compound demonstrates significant anti-diabetic activity, making it relevant for research focused on glucose metabolism and diabetes management. Its mechanism of action highlights its potential application in developing therapeutic strategies for metabolic disorders. -
β-glucocerebrosidase Activator
N-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine is a β-glucocerebrosidase activator that enhances enzyme activity by approximately 20%. This reagent is valuable for research into lysosomal storage disorders and related protein misfolding diseases, facilitating studies aimed at understanding and potentially treating these conditions. -
α-glucosidase Inhibitor
p-Hydroxyphenethyl trans-ferulate is an α-glucosidase inhibitor known for its anti-hyperglycemic properties, exhibiting an IC50 value of 19.24 ± 1.73 µM against yeast α-glucosidase. This compound also demonstrates antioxidant and anti-inflammatory activities, making it a valuable tool in the study of metabolic disorders. Additionally, p-Hydroxyphenethyl trans-ferulate has shown potential in inhibiting cancer cell proliferation and modulating serotonergic activity, supporting its application in cancer and neurological research. -
Sugar Donor
UDP-GlcNAz serves as an analog of UDP-GlcNAc, functioning primarily as a sugar donor substrate for N-acetylgalactosaminyltransferases. These enzymes utilize UDP-GlcNAz to transfer N-acetylglucosamine to saccharide or peptide acceptors. Featuring an azide group, UDP-GlcNAz is also a valuable click chemistry reagent, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules. Its versatility makes it suitable for various applications in chemical biology and glycobiology research. -
Glycoside
2-Methylbutyl β-D-glucopyranoside is a glycoside that functions as an aroma precursor in apple fruit. Upon enzymatic hydrolysis, it releases the volatile compound 2-methylbutanol, which contributes to the characteristic aroma profile of various food products. This reagent is useful in research focused on food flavor chemistry and the biochemical processes underlying flavor development in fruits. -
GCase Modulator
GCase modulator-1 is a Quinazoline derivative targeting GCase (Glucosidase) with an AC50 of 2.23 μM. This compound serves as a potent modulator, influencing GCase activity and its associated metabolic pathways. It is primarily utilized in research focused on lysosomal storage disorders and potential therapeutic strategies for related conditions. -
α-galactosidase A Inhibitor
Migalastat is an orally active inhibitor of α-galactosidase A, functioning primarily as a molecular chaperone with an IC50 value of 0.04 μM for human α-Gal A. This compound selectively binds to the active site of specific unstable mutant forms of α-galactosidase A, promoting their proper transport to the lysosome. Upon dissociating in the acidic lysosomal environment, Migalastat enhances the biological activity of the mutant enzyme, making it a valuable tool in research related to lysosomal storage disorders. -
Endoplasmic Reticulum α-Glucosidases I and II Inhibitor
EB-0156 is a potent inhibitor of endoplasmic reticulum α-glucosidases I and II, exhibiting IC50 values of 0.0479 μM and less than 0.001 μM, respectively. Derived from valiolamine, this compound demonstrates broad-spectrum antiviral activity. EB-0156 is valuable for research focused on developing therapeutic agents against both existing and emerging viral pathogens. -
Glycosidase Inhibitor
1,3-Dipalmitoleoyl glycerol is an α-glucosidase inhibitor with significant biological activity derived from sea cucumber viscera. This compound demonstrates varying degrees of inhibitory effects on α-glucosidase from diverse sources, making it valuable for research into carbohydrate metabolism and related disorders. Its application in studying glycosidase functions can provide insights into metabolic pathways and potential therapeutic targets. -
GAA Agonist
N-4′-(p-Trifluoromethylphenyl)butyl-DAB is a potent agonist of lysosomal acid α-glucosidase (GAA). This compound enhances intracellular GAA activity in a dose-dependent manner, specifically in fibroblasts from Pompe disease patients harboring the M519V mutation. It serves as a valuable tool for research into enzyme replacement therapies and the cellular mechanisms underlying lysosomal storage disorders. -
Molecular Chaperone
N-Octyl-α-4-epivalienamine is a potent molecular chaperone that enhances the expression of deficient β-galactosidase activity. This compound has demonstrated the ability to alleviate symptoms and improve survival rates in mouse models of GM1-gangliosidosis. N-Octyl-α-4-epivalienamine is valuable for research involving neurogenetic diseases and the development of therapeutic strategies targeting lysosomal storage disorders. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-6 is a competitive inhibitor of α-glucosidase, exhibiting an IC50 of 5.69 µM. This compound demonstrates potential anti-diabetic activity by modulating carbohydrate metabolism. It is applicable in research focused on diabetes treatment and metabolic disorders. -
α-Glucosidase Inhibitor
Flaccidoside III is a triterpenoid compound that functions as an α-glucosidase inhibitor, exhibiting an IC50 value of 256.7 μM. It demonstrates significant potential for antioxidant and antidiabetic activities, making it a valuable reagent in metabolic research and studies aimed at understanding glucose regulation. Its effects on α-glucosidase modulation contribute to its implications in diabetes management research. -
α-Glucosidase Inhibitor
3-Oxo-hop-22(29)-ene is a potent inhibitor of α-glucosidase, predominantly affecting yeast enzymes. This compound exhibits moderate inhibitory effects on the viability of Trichomonas cruzi and Leishmania mexicana, suggesting its potential as a therapeutic agent against these pathogens. Additionally, 3-Oxo-hop-22(29)-ene displays marginal anti-inflammatory activity, highlighting its multifaceted biological applications in research. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-4 is a reversible, mixed-type inhibitor of α-glucosidase, exhibiting an IC50 value of 12.98 μM. This compound serves as a valuable tool for studying carbohydrate metabolism and its associated disorders, including diabetes and obesity. Its ability to modulate α-glucosidase activity makes it suitable for research into therapeutic strategies targeting glycemic control. -
Natural product
6-Prenylquercetin-3-Me ether is a natural product extracted from the leaves of Glycyrrhiza uralensis. It exhibits potent radical scavenging activity against DPPH, indicating its potential as an antioxidant. Additionally, this compound displays inhibitory activity against α-glucosidase, making it valuable for research in diabetes and metabolic disorders. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-12 is a potent inhibitor of α-glucosidase, exhibiting an IC50 value of 10.20 μM. This compound effectively modulates carbohydrate digestion and absorption, making it valuable for research on metabolic disorders such as type 2 diabetes and obesity. Its use in biochemical assays provides insights into enzymatic activity and potential therapeutic strategies. -
α-glucosidase/Acetylcholinesterase Inhibitor
7β-Hydroxybufalin is a bufadienolide that acts as a potent inhibitor of α-glucosidase and acetylcholinesterase. Isolated from the venom of Bufo bufo gargarizans, this compound demonstrates significant biological activity relevant to the modulation of carbohydrate and neurotransmitter metabolism. 7β-Hydroxybufalin is utilized in research applications focused on metabolic disorders and neurodegenerative diseases. -
α-glucosidase inhibitor
α-Homonojirimycin is a potent inhibitor of α-glucosidase, an enzyme involved in carbohydrate metabolism. By blocking α-glucosidase activity, it effectively modulates glucose absorption, making it a valuable compound for research in diabetes and metabolic disorder studies. Its inhibitory properties are also applicable in exploring the roles of glycosidases in various biological processes. -
α-Glucosidase Inhibitor
4-Ethoxy-5,8-dihydroxy-3,4-dihydronaphthalen-1(2H)-one is a naphthalene derivative that functions as a weak α-glucosidase inhibitor. This compound, which can be isolated from the leaves of Cyclocarya paliurus, is relevant in the study of diabetes management. Its inhibitory activity on α-glucosidase suggests potential applications in carbohydrate metabolism research and glycemic control studies. -
GAA Agonist
5-C-heptyl-DNJ is a potent GAA agonist, exhibiting a Ki of 0.0047 μM. This compound enhances GAA activity through chaperone effects, making it valuable for research focused on lysosomal storage disorders and related biological pathways. Its ability to modulate GAA provides insights into enzyme replacement therapies and potential treatments for diseases associated with GAA deficiency. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-16 is a potent inhibitor of α-glucosidase, exhibiting an IC50 value of 3.28 μM. This compound effectively lowers blood glucose levels in Streptozotocin-induced diabetic rats, demonstrating significant antidiabetic properties. Its use in research facilitates the exploration of therapeutic strategies for managing diabetes and related metabolic disorders. -
α-glucosidase Inhibitor
α-Glucosidase-IN-54 is a potent inhibitor of α-glucosidase, exhibiting an IC50 value of 0.011 mM. This compound, derived from Syzygium jambos, is valuable for research focused on glucose metabolism and diabetes management. Its inhibitory action makes it a useful tool for studying the mechanisms of carbohydrate digestion and potential therapeutic interventions for hyperglycemia. -
Alpha-Mannosidase Modulator
OMJ-4 is a modulator of mutant alpha-mannosidase that enhances its catalytic function. This compound promotes structural changes in the enzyme, increasing both the compactness and flexibility of the active site, which facilitates substrate binding. By inducing greater substrate reactivity, OMJ-4 decreases the activation energy needed for the enzymatic reaction. This reagent is significant for research focused on alpha-mannosidosis and related metabolic disorders. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-29 is a potent inhibitor of α-glucosidase, displaying an IC50 value of 1.21 μM and a Ki value of 1.80 μM. This compound is primarily utilized in research focused on diabetes and associated metabolic disorders, where modulation of carbohydrate absorption is critical. Its mechanistic action allows for potential exploration in understanding the therapeutic effects against glycemic control and related physiological impacts. -
Endoplasmic Reticulum α-Glucosidases I and II inhibitor
EB-0176 is a potent inhibitor of endoplasmic reticulum α-glucosidases I and II, exhibiting IC50 values of 0.6439 μM and 0.0011 μM, respectively. This N-substituted derivative of valiolamine demonstrates broad-spectrum antiviral activity, positioning it as a valuable tool for research into antiviral agents targeting both existing and emerging viruses. Its ability to inhibit key glycosylation processes makes it significant for studies in virology and therapeutic development. -
Alpha-Glucosidase Inhibitor
Vitexin-2''-O-glucoside is a selective inhibitor of alpha-glucosidase, primarily extracted from flavonoids in hawthorn leaves. It reversibly inhibits α-glucosidase activity at the brush border of the small intestine, demonstrating a potent inhibitory effect. This compound is widely utilized in research related to type 2 diabetes and may serve as a promising candidate for therapeutic development in glycemic control. -
α-Glucosidase Inhibitor
PBI-6DNJ is a potent α-glucosidase inhibitor that functions as a multivalent glycosidase inhibitor. It demonstrates significant inhibitory activity against mouse α-glucosidase, with an affinity constant (Ki) of 0.14 μM. The compound also exhibits notable hypoglycemic effects, making it a valuable tool for research related to type 2 diabetes. -
α-Glucosidase Inhibitor
16-Oxoserratenediol is a serratene-type triterpenoid that functions as an α-glucosidase inhibitor, demonstrating an inhibition rate of 43.93% at a concentration of 100 μM. This compound is derived from Lycopodium cernuum L. and is primarily utilized in research related to diabetes management and metabolic disorders. Its mechanism of action contributes to the regulation of carbohydrate metabolism, making it a valuable tool for studying glycemic control in various biological contexts. -
α-glucosidase Inhibitor
Deacylhericene is an α-glucosidase inhibitor that demonstrates a potent inhibitory effect with an IC50 of 12.5 μM. This compound functions by effectively reducing the activity of α-glucosidase, making it a valuable reagent for studying carbohydrate metabolism. Its application is particularly relevant in diabetes research and the exploration of glycemic control mechanisms. -
Glycosidase Inhibitor
(3R,4R)-4-(Hydroxymethyl)pyrrolidin-3-ol functions as a glycosidase inhibitor. This compound demonstrates significant biological activity by modulating the activity of glycosidases, which are crucial in carbohydrate metabolism. It serves as an important intermediate for the synthesis of various biologically active molecules, making it valuable in chemical research and drug development applications. -
α-Glucosidase Inhibitor
2,3-Indolobetulonic acid functions as an α-glucosidase inhibitor, exhibiting an IC50 of 1.8 µM. This triterpenoid compound is significant in research related to glucose metabolism and diabetes management. It is valuable for studies focusing on carbohydrate digestion and its modulation within metabolic pathways. -
Antioxidant Agent
Tachioside is a potent antioxidant agent that inhibits nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 cells, exhibiting an IC50 value of 12.14 μM. This compound demonstrates notable anti-obesity effects and possesses α-glucosidase inhibitory activity, making it a valuable reagent for research in oxidative stress, metabolic disorders, and inflammation. -
α-Glycosidase Inhibitor
Terrestrimine is a potent α-Glycosidase inhibitor, demonstrating an IC50 of 225.83 μM. This compound is significant in the study of metabolic disorders, as it can modulate carbohydrate metabolism and glycemic control. It serves as a valuable tool for researchers investigating the role of glycosidase enzymes in various metabolic conditions. -
Glycosidase Inhibitor
(-)-Adenophorine is a potent glycosidase inhibitor that specifically targets α-L-fucosidase, exhibiting an IC50 of 72 μM. This compound plays a crucial role in biochemical research by facilitating studies on glycoprotein metabolism and cellular signaling pathways. Its ability to modulate glycosidase activity makes it a valuable tool for investigating disease mechanisms and developing therapeutic strategies. -
Glucocerebrosidase Inhibitor
Glucocerebrosidase-IN-2 is a potent inhibitor of glucocerebrosidase, a critical enzyme in lipid metabolism linked to Gaucher disease. This quinazoline derivative enhances glucocerebrosidase translocation to lysosomes in patient-derived cells, particularly those with the N370S mutation. It effectively inhibits the hydrolysis of substrates such as 4-methylumbelliferone β-D-glucopyranoside and fluorescent glycosylceramide in N370S mutant tissues, exhibiting an AC50 of 25.29 μM. Glucocerebrosidase-IN-2 is valuable for research focused on therapeutic approaches for Gaucher disease and related lysosomal storage disorders. -
Hydrolase
Oligo-α-1,6-Glucosidase from Bacillus cereus ATCC7064 is a hydrolase enzyme that specifically targets and hydrolyzes oligosaccharides containing α-1,6-glycosidic bonds. This enzyme catalyzes the exo hydrolysis of α-1,6-glucoside linkages from nonreducing ends of substrates such as panose, palatinose, α-limit dextrins, and isomaltooligosaccharides. Oligo-α-1,6-Glucosidase plays a crucial role in the degradation of starch and glycogen, complementing the activity of α-amylase in the complete hydrolysis of amylopectin. Its applications include studies of carbohydrate metabolism and enzymatic processes involved in starch breakdown. -
α-Glucosidase Inhibitor
(-)-6β-Hydroxy-5β,8β,9β,10α-cleroda-3,13-dien-16,15-olid-18-oic acid serves as a potent α-Glucosidase inhibitor, demonstrating an IC50 value of 577.7 µM. This compound is valuable in research focused on carbohydrate metabolism and the management of postprandial hyperglycemia. Its ability to modulate α-glucosidase activity makes it a useful tool in studies related to diabetes and metabolic disorders. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-38 is a potent inhibitor of α-glucosidase, with an IC50 value of 12.44±0.38 μM. This compound is significant for its role in the management of Diabetes Mellitus (DM) by reducing carbohydrate absorption in the intestines. It is useful for research applications focused on metabolic disorders and the development of diabetes therapies. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-24 is a potent inhibitor of α-glucosidase, exhibiting an IC50 value of 451 μM. This compound is derived from the plant Swertia kouitchensis and is primarily used in research to study carbohydrate metabolism and its implications in conditions such as diabetes and obesity. Its inhibitory action on α-glucosidase makes it a valuable tool for exploring therapeutic strategies targeting metabolic disorders. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-113 is a specific inhibitor of α-glucosidase, exhibiting an IC50 of 17.52 μM. This compound demonstrates antiglycating properties and effectively inhibits the formation of advanced glycation end-products. Its applications include research into type 2 diabetes and related metabolic disorders. -
Natural Product
5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl is a natural product isolated from Dendrobium infundibulum. This compound is primarily investigated for its potential biological activities, although it has been shown to lack inhibitory effects against α-glucosidase and pancreatic lipase. It serves as a valuable tool in research focused on understanding the pharmacological properties of natural compounds and their metabolic implications. -
α-Glucosidase Inhibitor
N-Formyldehydroanonaine is a potent inhibitor of α-glucosidase, exhibiting an IC50 value of 104.6 μM against yeast α-glucosidase. This compound is useful for research into diabetes mellitus, providing insights into the management of postprandial blood sugar levels through inhibition of carbohydrate breakdown. -
α-glucosidase Inhibitor
Prunetin 5-O-β-D-glucopyranoside is an isoflavone that functions as a potent uncompetitive inhibitor of α-glucosidase, exhibiting an IC50 of 56.05 μg/mL. This compound is derived from extracts of Potentilla astracanica and plays a significant role in modulating carbohydrate metabolism. It is particularly relevant for research applications focused on type-2 diabetes and the management of postprandial hyperglycemia. -
Glycosidase Inhibitor
Glycosidase-IN-2 is a potent glycosidase inhibitor classified as an azasugar. This compound exhibits hypoglycemic activity, making it valuable in researching mechanisms related to glucose metabolism and diabetes management. Its ability to modulate glycosidase activity provides insights into carbohydrate processing and potential therapeutic applications for glycemic control. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-25 is a competitive inhibitor of α-glucosidase, exhibiting an IC50 value of 1.19 μM. This compound serves as a valuable tool in anti-diabetic research by inhibiting carbohydrate absorption and regulating postprandial blood glucose levels. Its ability to modulate α-glucosidase activity makes it a promising candidate for the development of therapeutic strategies targeting diabetes management. -
Beta-glucocerebrosidase Inhibitor
Glycosidase-IN-3 is a pyrimidine compound that acts as a selective inhibitor of beta-glucocerebrosidase. It has demonstrated significant biological activity relevant to the study of lysosomal storage disorders, particularly Gaucher's disease, as well as neurodegenerative conditions such as Parkinson's disease. This compound is suitable for use in research focused on these diseases and their underlying mechanisms. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-14 is a potent inhibitor of α-glucosidase, exhibiting an IC50 value of 5.22 μM. This compound is valuable for studying carbohydrate metabolism and related disorders, particularly in the context of diabetes management. Its ability to inhibit α-glucosidase makes it a useful tool in pharmacological research aimed at developing therapies that modulate glucose absorption and metabolism. -
Antiallergic Agent
(3R,5S)-5'-Methoxyoctahydrocurcumin is a diarylheptanoid derived from Curcuma comosa, primarily targeting antiallergic mechanisms. This compound demonstrates significant activity in inhibiting β-hexosaminidase release and mast cell degranulation, making it a valuable tool in immunological studies. Its applications include research on various allergic conditions, such as asthma, where understanding the modulation of immune responses is critical. -
α-glucosidase Inhibitor
N-(E)-Caffeoyldopamine is an α-glucosidase inhibitor derived from Clerodendranthus Spicatus, demonstrating an inhibitory activity of 53.73% against the enzyme. This compound has significant potential for applications in diabetes research, where it can be utilized to explore mechanisms of glucose metabolism and regulation. Its role in modulating α-glucosidase activity makes it a valuable tool for studying carbohydrate absorption and related metabolic disorders.
