Catalog No.
Product Name
Application
Product Information
Citations
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Endogenous Metabolite
(5R)-Dinoprost is an endogenous metabolite derived from the cyclooxygenase metabolism of arachidonic acid. As Prostaglandin F2β, it is known to induce a dose-dependent release of hexose-containing mucin. This compound is primarily utilized in research involving gastrointestinal physiology and reproductive biology, as well as studies exploring its roles in inflammation and smooth muscle contraction. -
Endogenous Metabolite
1a,1b-Dihomo prostaglandin F2α is a derivative of Prostaglandin F2α, acting as an endogenous metabolite. This compound plays a significant role in various biological processes, including inflammation and reproductive physiology. Its application in research is pivotal for studying prostaglandin pathways and their effects on cellular signaling and physiological functions. -
Endogenous Metabolite
1-(1Z-Octadecenyl)-2-docosahexaenoyl-sn-glycero-3-phosphocholine, also known as C18(Plasm)-22:6-PC, is an endogenous metabolite belonging to the phospholipid class. This compound exhibits significant variation in content and distribution across different fish species, making it a valuable biomarker for assessing species differentiation in ecological and nutritional studies. Its identification in fish viscera through lipidomics highlights its potential applications in marine biology and fishery science. -
Endogenous Metabolite
IRAK4-IN-29 is a selective inhibitor of the interleukin-1 receptor-associated kinase 4 (IRAK4), demonstrating low nanomolar activity. This compound effectively disrupts TLR-mediated signaling pathways and exhibits significant inhibition of cytokine production in response to LPS and R848 stimulation. In vivo studies reveal that IRAK4-IN-29 can suppress LPS-induced TNFα, mirroring the phenotype observed in IRAK4 gene-deficient mice. Furthermore, IRAK4-IN-29 possesses favorable medicinal chemistry characteristics, including microsomal stability and solubility, indicating its potential for clinical applications in inflammatory diseases. -
Endogenous Metabolite
Lu AF58801 is a selective positive allosteric modulator of the α7 nicotinic acetylcholine receptors, demonstrating potent oral bioavailability and effective brain penetration. This compound has been shown to enhance receptor activity and improve cognitive function in animal models, specifically in a novel object recognition task in mice subjected to subchronic exposure to fluchlorothiazol. Lu AF58801 serves as a valuable tool for investigating the role of α7 nicotinic receptors in cognitive processes and related disorders. -
Endogenous Metabolite
Aquacobalamin is a biologically active form of vitamin B12, primarily functioning as a cofactor in various enzymatic reactions. It enhances the oxidation of azo-dye Orange II in the presence of hydrogen persulfate, demonstrating its potential as a catalyst in oxidative reactions. Additionally, Aquacobalamin binds reversibly to hydrogen peroxide, forming a cobalt(III) hydroperoxo adduct with a dissociation constant of 0.25 mM, contributing to its diverse applications in biochemical research and oxidative stress studies. -
Endogenous Metabolite
Clinolamide is an N-cyclohexyl linoleamide that primarily targets endogenous metabolites. In studies assessing cholesterol metabolism in rats, a dietary dose of 0.3% over 21 days did not significantly alter serum, liver, or kidney cholesterol levels. However, it exhibited variable effects on cholesterol synthesis in liver slices depending on the specific substrates and concentrations used. This compound is relevant for research on lipid metabolism and cholesterol regulation. -
Endogenous Metabolite
Naftidrofuryl is an endogenous metabolite known for its capacity to enhance cellular oxidative capacity and exhibit antispasmodic activity. It is utilized primarily in the study of peripheral and cerebrovascular diseases, demonstrating efficacy in improving blood circulation. Research applications include investigating its potential therapeutic effects in conditions related to compromised vascular function. -
Fungal Metabolite
Setosusin is a fungal meroditerpenoid known for its unique spiro-fused 3(2H)-furanone structure. This compound exhibits significant biological activity, particularly as a potential antifungal agent. It serves as a valuable tool for research applications focused on fungal metabolism and the development of novel antifungal therapeutics. -
Endogenous Metabolite
H-Arg-Lys-OH is a dipeptide composed of L-arginine and L-lysine residues, serving as a significant endogenous metabolite. This compound exhibits key biological activities that may influence cellular signaling pathways and protein interactions. It is utilized in biochemical research to explore mechanisms involving peptide-mediated biological functions and to study the roles of specific amino acid sequences in various physiological processes. -
Endogenous Metabolite
T-2 Triol is an endogenous metabolite derived from the metabolism of T-2 toxin, characterized by reduced toxicity relative to its parent compound. This trichothecene mycotoxin is of interest in studies concerning its pharmacokinetics, particularly in broiler chickens, where it exhibits a half-life (t1/2λz) of 9.6 minutes, peak plasma concentration (Cmax) of 563 ng/ml, and a time to peak concentration (Tmax) of 2.5 minutes. T-2 Triol serves as a valuable reagent for investigating mycotoxin metabolite dynamics in agricultural and toxicological research. -
Endogenous Metabolite
1-Myristoyl-2-palmitoyl-3-butyryl-rac-glycerol is an endogenous metabolite classified as a triacylglycerol, consisting of myristic, palmitic, and butyric acid residues. It plays a significant role in lipid metabolism and is naturally present in human milk, contributing to the nutritional profile and health benefits associated with breastfeeding. This compound is valuable for research in metabolic disorders, lipoprotein function, and studies related to infant nutrition. -
Endogenous Metabolite
Phochinenin I is an endogenous metabolite sourced from the plant Pholidota chinensis. This natural compound exhibits notable biological activity, including potential antioxidant and anti-inflammatory properties. Researchers utilize Phochinenin I in studies related to metabolic processes and the exploration of plant-derived therapeutics. -
Endogenous Metabolite
6-Hydroxypyridin-2(1H)-one hydrochloride is an endogenous metabolite that plays a significant role in various biological processes. This compound is involved in regulating metal ion homeostasis and may influence cellular oxidative stress pathways. It is commonly used in research focused on neurochemistry, metalloprotein interactions, and the study of metabolic disorders. -
Endogenous Metabolite
MMV667492 is a potent inhibitor of the cytoskeletal protein Ezrin, effectively targeting its function in cellular processes. This compound demonstrates significant anti-invasion activity in osteosarcoma cells, hindering their metastatic potential. In addition to its in vitro efficacy, MMV667492 induces distinct morphological defects in zebrafish embryos, aligning with Ezrin inhibition mechanisms. Furthermore, it reduces lung metastasis in osteosarcoma models characterized by elevated Ezrin expression, making it a valuable tool for studying tumor biology and metastasis. -
Endogenous Metabolite
(S)-Mevalonic acid is an endogenous metabolite that serves as a crucial precursor in the mevalonate pathway, which is vital for cell growth and proliferation. It has been shown to effectively inhibit the decrease in viability induced by Simvastatin in C2C12 cells in vitro. This compound is valuable for research focused on conditions such as myopathy and heart failure, facilitating studies on metabolic disorders and potential therapeutic interventions. -
Endogenous Metabolite
PTC-510 Free Base is a selective inhibitor of hypoxia-induced VEGF expression in tumor cells. It effectively reduces endogenous VEGF production under hypoxic conditions, demonstrating significant activity in controlling tumor growth while minimizing associated toxicity. This compound offers a novel therapeutic approach to overcome the limitations of existing anti-VEGF therapies, making it a valuable tool for cancer research and therapeutic development. -
Endogenous Metabolite
Razobazam is a benzodiazepine derivative that primarily targets the central nervous system to enhance cognitive function. It has demonstrated significant effects on learning performance in socially deprived rat models, showing an 18% increase in avoidance scores post-training. Furthermore, Razobazam induces notable alterations in the optical density of specific brain regions, including a 22% reduction in the lateral habenula and a 25% increase in the ventral tegmental area, along with a 13% increase in the prefrontal cortex. This compound is valuable for research in neuropharmacology and cognitive enhancement. -
Drug Metabolite
Narcotoline is a phenylpyridine isoquinoline alkaloid that serves as a drug metabolite in the biosynthetic pathway of Noscapine. This compound is valuable for investigating the metabolic regulatory mechanisms associated with Noscapine, providing insights into its pharmacokinetics and biological activity. Researchers may utilize Narcotoline to explore the implications of Noscapine metabolism in various biological systems and applications. -
Endogenous Metabolite
Alterporriol B is an endogenous metabolite characterized by its red pigmentation, isolated from the fungus Alternaria porri, which is known to cause black spot disease in allium species. This compound is utilized in research to study fungal metabolites and their biological effects, making it a valuable reagent for investigations into plant-pathogen interactions and mycology. -
Endogenous Metabolite
R1498 is a multi-target kinase inhibitor primarily affecting Aurora kinases and VEGFR2, associated with tumorigenesis. This compound exhibits notable anti-angiogenic and anti-proliferative properties, demonstrating moderate in vitro growth inhibition across various tumor cell lines with IC50 values in the micromolar range. In vivo studies reveal that R1498 surpasses sorafenib in anti-tumor efficacy within gastric cancer and hepatocellular carcinoma xenograft models, achieving tumor growth inhibition rates exceeding 80% along with substantial tumor shrinkage in select models. Additionally, R1498 effectively inhibits Aurora A activity and reduces tumor vascularization, underscoring its potential as a therapeutic candidate in oncology research. -
Fungal Metabolite
Valinotricin is a bioactive fungal metabolite with notable antibacterial properties. It exhibits significant activity against a range of bacterial strains, making it a valuable tool for research in microbial pathogenesis and antibiotic discovery. Its unique mechanism of action may provide insights into novel therapeutic strategies against resistant bacterial infections. -
Endogenous Metabolite
H2-005 is a selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2), effectively reducing triacylglycerol synthesis in both hepatocytes and preadipocytes. This compound demonstrates significant inhibition of triacylglycerol biosynthesis in HepG2 hepatocytes and 3T3-L1 preadipocytes. Additionally, H2-005 substantially inhibits lipid droplet formation in 3T3-L1 cells when used in conjunction with a DGAT1 inhibitor. This reagent is valuable for research related to DGAT2-mediated lipid metabolism and potential therapeutic strategies for metabolic disorders. -
Endogenous Metabolite
JTV-803 mesylate is a selective inhibitor of human factor Xa, functioning as an oral anticoagulant. It demonstrates competitive inhibition with a Ki value of 0.019 μM and an IC50 value of 0.081 μM, showcasing a remarkable specificity over comparable inhibitors. JTV-803 is primarily used in research focused on thrombosis prevention and the modulation of coagulation pathways, making it a valuable tool for studies in cardiovascular and hematological contexts. -
Endogenous Metabolite
Manninotrionate potassium is a hapten utilized for the development of immunogenic protein conjugates, notably with bovine serum albumin (BSA) or ovalbumin. This reagent has shown potential in eliciting antisera that exhibits weak precipitation reactions with various endogenous metabolites, including bovine lung galactan and polysaccharides such as guaran, gum arabic, and larch arabinogalactan. Its applications in research include studies of carbohydrate recognition and immune response characterization. -
Endogenous Metabolite
5'-Deoxy-2',3'-di-O-acetyl-5-fluorocytidine is a nucleoside analogue that specifically targets HBV reverse transcriptase, effectively inhibiting its activity. This compound demonstrates significant antiviral properties, particularly in controlling hepatitis B virus (HBV) replication in vitro. Its application in research provides a promising avenue for the development of therapies aimed at suppressing chronic hepatitis B infections. -
Endogenous Metabolite
Zofenoprilat arginine is an endogenous metabolite that functions as an antihypertensive agent, primarily through the enhancement of bradykinin effects on coronary flow. This compound is of particular interest in cardiovascular research, especially in studies involving the interplay of sulfhydryl-containing converting enzyme inhibitors and bradykinin-mediated vasodilation. Its role in influencing vascular response makes it a valuable tool for understanding hypertension and related cardiovascular conditions. -
Endogenous Metabolite
NC1153 is a Mannich base that targets and inhibits IL-2-induced JAK3 activation, subsequently preventing the activation of downstream substrates such as STAT5a/b. This compound has been shown to effectively extend the survival of kidney transplants in both MHC and non-MHC mismatched rat models. Additionally, NC1153 provides comprehensive protection against toxicity for recipients when used in conjunction with cyclosporine A (CsA), demonstrating a synergistic effect to enhance graft survival while avoiding nephrotoxicity, myelotoxicity, and lipotoxicity. -
Endogenous Metabolite
N1-Acetylspermine is an endogenous metabolite that plays a significant role in cellular polyamine metabolism. This compound is primarily implicated in oncological research, particularly concerning leukemia, as it is involved in cellular proliferation and differentiation processes. Its measurement in biological samples, such as urine, can provide valuable insights into metabolic alterations associated with cancer progression and treatment response. -
Endogenous Metabolite
BuChE-IN-14 is a selective inhibitor of acetylcholinesterase (AChE), primarily targeting endogenous metabolite pathways. In vitro studies demonstrated a concentration-dependent inhibition of AChE activity in rat brain tissue, leading to increased extracellular acetylcholine (ACh) levels in the hippocampus and striatum. This compound shows potential for addressing memory impairments linked to cholinergic dysfunction, making it valuable for research into neurodegenerative diseases and cognitive enhancement. -
Fungal Metabolite
Trichodecenin I is a fungal metabolite that functions as a peptaibol, comprising a sequence of seven amino acid residues. This compound exhibits notable biological activity, particularly against various fungal strains, making it a valuable tool in antifungal research. Its unique structure and mechanism of action facilitate studies in natural product chemistry and the development of new antifungal agents. -
Endogenous Metabolite
Metanilic acid is an endogenous metabolite known for its potential anti-cancer properties. It has been investigated for use in treating various malignancies, including choriocarcinoma and pediatric acute lymphoblastic leukemia. This compound serves as a valuable tool for research in cancer biology and therapeutic development. -
Endogenous Metabolite
LY 190388 is a penicillamine-containing enkephalin peptide analog that acts as a μ-opioid receptor agonist. This compound demonstrates significant analgesic effects, as evidenced by its ability to inhibit the writhing response in mice following intracerebroventricular administration. Notably, the analgesic properties of LY 190388 are primarily attributed to its μ receptor activity, while co-administration with the δ receptor antagonist ICI 174864 produces an additive analgesic effect, supporting its potential applications in pain research. -
Endogenous metabolite
N,N-Dimethylamidino Urea is an endogenous metabolite that serves as an important intermediate in the electrochemical oxidation of Metformin. This compound can be utilized as a biomarker to investigate the metabolic pathways associated with Metformin in vivo. Its role in studying metabolic processes makes it a valuable reagent for research in diabetes and related metabolic disorders. -
Endogenous Metabolite
(E/Z)-PG-11047 is a polyamine analog that targets polyamine metabolism and exhibits potential for lung cancer inhibition. This compound has been shown to effectively inhibit the growth of both non-small cell and small cell lung cancer cells. Through significant downregulation of polyamine synthetase activity, (E/Z)-PG-11047 induces alterations in polyamine levels, making it a valuable tool for research in lung cancer biology and therapeutic development. -
Endogenous Metabolite
MR-16728 hydrochloride is an endogenous metabolite that primarily promotes the release of acetylcholine through inhibition of Ca(2+)-ATPase activity in presynaptic membranes. It effectively enhances acetylcholine release and demonstrates significant activity in the presence of low calcium concentrations. Research applications include studying neurotransmitter release mechanisms and analyzing acetylcholine dynamics under various physiological conditions. The compound shows a half-maximal effect at a concentration of 13.5 μM, making it a valuable tool for investigating synaptic transmission and neuromodulation. -
Endogenous Metabolite
15(R)-Prostaglandin F2α is an isomer of 9α,11β-Prostaglandin F2α, functioning as an endogenous metabolite found in urine. This compound plays a significant role in various biological processes, including the modulation of inflammation and smooth muscle contraction. It is particularly relevant for research in asthma and other respiratory conditions, making it a valuable tool for investigating underlying mechanistic pathways in these diseases. -
Fungal Metabolite
Verrucofortine is a fungal metabolite with notable alkaloid characteristics, derived from the amino acids tryptophan and leucine. This compound exhibits significant antifungal activity, making it a valuable reagent in the study of fungal infections and their treatment mechanisms. Research applications may include the analysis of fungal resistance and the development of antifungal therapeutics. -
Endogenous Metabolite
UM-2 is the 3-hydroxy metabolite of DX-8951, serving as an endogenous metabolite in humans. This compound plays a significant role in metabolic profiling and is relevant for studies investigating drug metabolism and pharmacokinetics. Researchers can utilize UM-2 to gain insights into metabolic pathways and the pharmacological impact of DX-8951. -
Endogenous Metabolite
ATB-429 is a novel H2S-releasing derivative of mesalamine, targeting the modulation of pain and inflammation associated with irritable bowel syndrome (IBS). It exhibits significant anti-nociceptive and anti-inflammatory activities by releasing hydrogen sulfide, effectively reducing hypersensitivity in colorectal distension models in both healthy and postcolitic rats. ATB-429 attenuates abdominal withdrawal responses, suppresses spinal c-Fos mRNA expression, and down-regulates colonic cyclooxygenase-2 and interleukin-1β mRNA levels—actions not seen with mesalamine alone. The compound's effects are mediated through ATP-sensitive K+ (KATP) channels, indicating its potential as a therapeutic agent for painful intestinal disorders linked to inflammation. -
Endogenous Metabolite
Pigment Red 53, an organic pigment, primarily serves as an endogenous metabolite. It exhibits excellent color stability and spectral properties, making it valuable in the coatings and plastics industries for providing a vibrant red hue. Additionally, Pigment Red 53 is utilized in the food and cosmetics sectors as a safe colorant, ensuring an appealing aesthetic for various products. Its versatility allows for applications in both industrial and consumer product development. -
Endogenous Metabolite
2-Aminopyrimidin-5-ol is an endogenous metabolite that plays a crucial role in various biological processes. It is involved in nucleotide metabolism and may influence cellular signaling pathways. Research applications include studies on metabolic profiling and the investigation of pyrimidine metabolism in health and disease contexts. -
Endogenous Metabolite
AMG-151 is a glucokinase agonist that enhances insulin secretion and lowers fasting plasma glucose (FPG) levels. In clinical evaluations, AMG-151 demonstrated a significant dose-response effect compared to placebo, indicating its potential in managing metabolic disorders. However, its use is associated with a higher incidence of hypoglycemia and hypertriglyceridemia. This compound holds promise for further research into the treatment of type 1 diabetes and related metabolic conditions. -
Endogenous Metabolite
DC_YM21 is an inhibitor of the menin-MLL interaction, demonstrating potent and selective activity in blocking cellular proliferation. This compound effectively induces cell cycle arrest and promotes differentiation in leukemia cells with MLL translocations. DC_YM21 holds significant potential for research applications targeting MLL-rearranged leukemia treatments. -
Endogenous Metabolite
Isocorydine hydrochloride is an endogenous metabolite derived from Dicranostigma leptopodum. This compound exhibits significant potential in enhancing the efficacy of Doxorubicin in the treatment of hepatocellular carcinoma (HCC). Its ability to synergistically work with chemotherapeutic agents makes it a valuable tool for cancer research and therapeutic studies targeting liver cancer. -
Endogenous Metabolite
Adefovir diphosphate is a potent antiviral agent that targets hepatitis B virus (HBV) by inhibiting reverse transcriptase, thereby blocking viral replication. This compound is also active against other viruses, including herpes viruses and HIV. In research applications, Adefovir diphosphate is utilized for its effectiveness in suppressing chronic hepatitis B and may help reduce the risk of developing hepatocellular carcinoma (HCC) in affected patients through its mechanism that involves inhibiting the autophosphorylation of growth factor receptors. -
Endogenous Metabolite
Galactonic acid is an endogenous metabolite and a sugar acid resulting from the metabolic breakdown of galactose. It is formed through the action of galactose dehydrogenase, which catalyzes the conversion of galactose to galactonolactone, subsequently leading to the formation of galactonic acid. This compound serves as a valuable research tool for studies involving carbohydrate metabolism and the biochemical pathways associated with galactose and its derivatives. -
Pheromone
Pheromonotropin (Pseudaletia separata) is a specific pheromone from the armyworm species Pseudaletia separata, characterized by its C-terminal pentapeptide FXPRL-amide. This compound belongs to the PK/PBAN family and plays a crucial role in stimulating sex pheromone biosynthesis in moths. Additionally, Pheromonotropin influences various biological processes, including feeding through intestinal muscle contraction, developmental stages like embryonic and pupal diapause, as well as providing defense mechanisms against natural predators. Its applications in chemical research can further elucidate pheromone signaling pathways and insect behavioral studies. -
Endogenous Metabolite
Gedocarnil is an endogenous metabolite that targets the central nervous system. It exhibits potential anxiogenic activity, making it a valuable compound for research into anxiety-related disorders. Gedocarnil can be utilized in experimental studies aimed at understanding the mechanisms underlying anxiety, although its effects may include the induction of severe anxiety attacks in clinical trial settings. -
Endogenous Metabolite
Anisperimus is an endogenous metabolite that acts as an immunosuppressant by enhancing activation-induced T cell death. It increases the sensitivity of T cells to anti-CD95 antibodies through the activation of caspase-8 and caspase-10 at the death-inducing signaling complex (DISC). Additionally, Anisperimus promotes the differentiation of Foxp3-expressing regulatory CD4 T cells, contributing to the prevention of autoimmunity within the central nervous system. This reagent is valuable for research focused on T cell regulation and autoimmune diseases.
