Catalog No.
Product Name
Application
Product Information
Citations
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Torvoside H Derivative
26-Degluco-torvoside H is a furostanol glycoside derivative that serves as a modified form of Torvoside H. This compound is produced through the hydrolysis of Torvoside H by β-glucosidase derived from Solanum torvum leaves. It exhibits potential biological activities related to glycoside metabolism and can be utilized in various research applications, including the study of plant metabolites and their effects on biological systems. -
α-Glucosidase Inhibitor
Mortatarin G is a prenylated flavonoid that functions as an α-glucosidase inhibitor. It demonstrates significant inhibitory activity against α-glucosidase, with an IC50 value of 20.4±1.4 μM. This compound is useful for research applications focused on carbohydrate metabolism and potential therapeutic strategies for managing diabetes and related metabolic disorders. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-3 is an oleanolic acid oxime ester derivative that acts as an inhibitor of α-glucosidase, exhibiting an IC50 value of 0.35 µM. This compound also demonstrates inhibitory activity against α-amylase, making it a valuable tool for studies focused on carbohydrate metabolism. Its potential applications include investigating the mechanisms of diabetes management and exploring the therapeutic effects of glycosidase inhibition in metabolic disorders. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-28 is a potent α-glucosidase inhibitor, exhibiting an IC50 of 0.62 μM and a Ki of 3.93 μM. This compound selectively binds to the original binding site of α-glucosidase, engaging in multiple hydrophobic interactions with adjacent amino acids. α-Glucosidase-IN-28 is primarily utilized in research related to diabetes and its associated metabolic disorders, providing valuable insights into glucose regulation and enzyme modulation. -
Alpha-glucosidase Inhibitor
α-Glucosidase-IN-15 is a potent inhibitor of α-glucosidase, demonstrating an IC50 value of 3.34 μM. This compound exhibits significant antidiabetic activity by preventing the hydrolysis of carbohydrates, thereby reducing postprandial blood glucose levels. It is suitable for research applications focused on diabetes management and metabolic disorders. -
α-Glucosidase Product
Alglucosidase alfa is a recombinant human α-glucosidase that acts as a hydrolytic enzyme, targeting lysosomal glycogen metabolism. This reagent is primarily utilized in research related to Pompe disease, a glycogen storage disorder. It aids in elucidating the pathogenic mechanisms of the disease and evaluates potential therapeutic strategies aimed at restoring α-glucosidase activity and improving glycogen clearance. -
Antioxidant
Ferruginoside C is a phenylethanoid that exhibits potent antioxidant activity. Isolated from V. leiocarpum, it demonstrates significant alpha-glucosidase inhibitory properties with an IC50 of 19.93 μM. This compound is of interest in cancer research, particularly in studies related to cervical, ovarian, and colon cancers. Ferruginoside C serves as a valuable tool for exploring therapeutic strategies and understanding the mechanisms of oxidative stress in these cancer types. -
α-Glucosidase Inhibitor
Kouitchenside G is a natural inhibitor of α-Glucosidase, isolated from the plant Swertia kouitchensis. It demonstrates inhibitory activity with an IC50 value of 956 μM, making it a valuable tool for studying carbohydrate metabolism and enzyme modulation. This compound is pertinent for research applications focused on diabetes and metabolic disorders. -
α-Glucosidase Inhibitor
Resinacein L is a potent inhibitor of α-glucosidase, exhibiting an IC50 value of 0.635 mM. By impeding the digestion and absorption of carbohydrates in the gastrointestinal tract, Resinacein L effectively reduces postprandial blood glucose levels. This compound is valuable in research applications focused on diabetes management and the study of carbohydrate metabolism. -
Fusion Protein
Clervonafusp alfa is a fusion protein designed to target both cytosolic and lysosomal glycogen. It consists of the Fab portion of a cell-penetrating antibody that utilizes the nucleoside transporter ENT-2 for cytosolic access, along with recombinant human acid alpha-glucosidase (rhGAA) that enters lysosomes via mannose-6-phosphate receptors. This reagent is primarily used in research related to late-onset Pompe disease, facilitating studies on glycogen storage disorders and potential therapeutic approaches. -
β-Glucosidase Substrate
2-Nitrophenyl a-D-glucopyranoside serves as a substrate for the enzyme β-glucosidase. Its hydrolysis by β-glucosidase produces a yellow chromogenic product, allowing for the quantification of enzyme activity. This reagent is widely used in biochemical assays to study glycoside hydrolase activity and in research focused on carbohydrate metabolism. -
Glycosidase Inhibitor
Glycosidase-IN-1 is a glycosidase inhibitor derived from D-mannose. This compound exhibits hypoglycemic activity and holds potential for the synthesis of immunosuppressive agents and β-glucosidase inhibitors. Its ability to modulate glycosidase activity makes it a valuable tool in biochemical research focused on carbohydrate metabolism and related diseases. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-10 is a potent inhibitor of α-glucosidase, exhibiting an IC50 value of 92.7 μM. This compound serves as a valuable tool for investigating the modulation of carbohydrate metabolism and is particularly relevant for research in type II diabetes. Its ability to effectively inhibit α-glucosidase makes it suitable for studies focused on glucose absorption regulation and diabetes management strategies. -
α-glucosidase Inhibitor
Bisabolone oxide A is an α-glucosidase inhibitor that modulates carbohydrate metabolism by delaying the absorption of glucose in the intestine. This compound demonstrates significant potential in research applications related to diabetes management and glycemic control. Its ability to influence α-glucosidase activity makes it a valuable tool for studies focused on metabolic disorders and enzymatic regulation. -
Alpha-glucosidase Inhibitor
α-Glucosidase-IN-17 is a potent inhibitor of α-glucosidase, displaying an IC50 value of 3.79 μM. This compound demonstrates significant antidiabetic activity, making it a valuable research tool for studying the regulation of carbohydrate metabolism and the management of diabetes. It can be utilized in pharmacological studies aimed at exploring the modulation of blood glucose levels. -
α-glucosidase Inhibitor
α-Glucosidase-IN-21 is a potent inhibitor of α-glucosidase, demonstrating an IC50 of 2.62 μM. This compound exhibits significant anti-diabetic activity, making it valuable for research into glycemic control and obesity-related metabolic disorders. Its efficacy as an α-glucosidase inhibitor supports its use in studies targeting carbohydrate metabolism and related therapeutic applications. -
α-glucosidase Inhibitor
α-Glucosidase-IN-20 is a potent orally active inhibitor of α-glucosidase, with an IC50 value of 3.01 μM. This compound demonstrates significant anti-diabetic activity by modulating carbohydrate metabolism and reducing postprandial glucose levels. It is suitable for research applications aimed at exploring therapeutic strategies for managing type 2 diabetes and related metabolic disorders. -
α-glucosidase Inhibitor
(+)-Cembrene A is an α-glucosidase inhibitor, exhibiting an IC50 of 30.31 μM. This compound demonstrates nontoxicity towards human normal hepatocyte (LO2) cells, making it a suitable candidate for research in metabolic disorders and carbohydrate metabolism regulation. Its ability to modulate α-glucosidase activity suggests potential applications in studies focused on diabetes and related pathophysiological conditions. -
Glucosidase Inhibitor
Afegostat tartrate is a potent glucosidase inhibitor that selectively binds to acid-β-glucosidase (GCase) within the endoplasmic reticulum, functioning as a pharmacological chaperone. This compound enhances enzyme stability and promotes proper folding, making it valuable for research related to Gaucher disease and other lysosomal storage disorders. Its ability to influence GCase activity makes it an important tool for studies aimed at understanding enzyme deficiencies and developing therapeutic strategies. -
Natural Products
α-Glucosidase-IN-35 is a chromene that functions as a potent inhibitor of α-glucosidase, exhibiting an IC50 value of 0.169 mg/mL. Isolated from the aqueous extract of the aerial parts of Brickellia cavanillesii, this compound is valuable in studies targeting carbohydrate metabolism and diabetes research. Its application may facilitate the exploration of α-glucosidase inhibition as a therapeutic strategy in metabolic disorders. -
α-Glucosidase Inhibitor
Saponin QS-L1 is a triterpenoid saponin that acts as an α-glucosidase inhibitor, exhibiting an IC50 value of 23.1 μM. This compound is valuable for research into diabetes management and glucose regulation. Its inhibition of α-glucosidase may provide insights into therapeutic strategies for glycemic control in diabetic patients. -
alpha-Glucosidase Inhibitor
9-(4′-Hydroxyphenyl)-2-methoxyphenalen-1-one is a mixed competitive inhibitor of alpha-glucosidase, primarily targeting the enzyme from Bacillus stearothermophilus, with an IC50 value of 3.86 mg/L. This compound exhibits potential as a phytoalexin, demonstrating biological activity relevant for research in glycemic control and carbohydrate metabolism. Its inhibitory properties make it suitable for studies investigating the modulation of glucose absorption and related metabolic disorders. -
Glycosidase Inhibitor
Panosialin wA is a potent glycosidase inhibitor that selectively targets α,β-glucosidase and mannose glycosidase. Its ability to modulate these enzymes may have applications in research related to carbohydrate metabolism and pathogen interaction. While Panosialin wA does not inhibit the influenza virus, it exhibits a weak anti-microbial effect, making it a useful tool in studies of microbial activity. -
α-Glucosidase Inhibitor
N-Methyltetrachlorophthalimide is a potent inhibitor of α-glucosidase, exhibiting an IC50 of 22.1 μM. This compound is valuable for research focused on anti-diabetic mechanisms as well as antiviral applications, enabling the exploration of therapeutic strategies against conditions related to glycemic control and viral infections. -
Active Compound
Afegostat TFA is a pharmacological chaperone that selectively and reversibly binds to acid-β-glucosidase (GCase) within the endoplasmic reticulum. This interaction enhances the stability and activity of GCase, addressing enzyme deficiencies associated with Gaucher disease. Afegostat TFA is utilized in research exploring enzyme therapy and cellular mechanisms of lysosomal storage disorders. -
Natural product
Sumaresinolic acid is a natural product extracted from the root of Heterophyllum species. Its primary mechanism involves the inhibition of alpha-glucosidase, an enzyme implicated in carbohydrate metabolism. This compound exhibits significant biological activity in regulating blood glucose levels, making it valuable for research in diabetes and metabolic disorders. Its potential applications extend to studies on glycemic control and the development of therapeutic agents targeting carbohydrate metabolism. -
α-Glucosidase inhibitor
α-Glucosidase-IN-45 is an inhibitor targeting α-glucosidase, a key enzyme involved in carbohydrate metabolism. This novel indol-fused pyrano[2,3-D]pyrimidine compound exhibits significant biological activity by obstructing the enzyme's function, thereby influencing glucose absorption and metabolism. It is suitable for research applications related to diabetes, metabolic disorders, and carbohydrate enzyme modulation. -
α-glucosidase Inhibitor
1'-O-Methyl neochebulinate is a hydrolyzable tannin that functions as an α-glucosidase inhibitor, exhibiting an IC50 value of 59.5 μM. Isolated from the fruits of Terminalia chebula Retz, this compound significantly impedes the activity of α-glucosidase, making it relevant for studies in diabetes management and carbohydrate metabolism. Its inhibitory properties provide a useful tool for investigating potential therapeutic strategies for controlling postprandial glucose levels. -
Stable Isotope
Acarbose-d4 is a deuterium-labeled derivative of Acarbose, targeting alpha-glucosidases. This stable isotope maintains the biological activity of its parent compound, functioning as an antihyperglycemic agent with an IC50 of 11 nM. Acarbose-d4 is utilized in research to study glucose metabolism and the enhancement of hypoglycemic effects in combination therapies involving sulfonylureas or insulin. -
Glucosidase Inhibitor
N-5-Carboxypentyl-1-deoxynojirimycin is an alpha-glucosidase inhibitor with significant potential in glycosidase research. This compound is utilized for its ability to selectively inhibit glucosidase enzymes, making it valuable in studies exploring carbohydrate metabolism and related pathways. Additionally, it serves as a precursor for the preparation of affinity matrices, facilitating the binding of target proteins to resins for purification and analysis. -
α-Glucosidase Inhibitor
Sativanone is a potent α-glucosidase inhibitor, exhibiting an EC50 value of 0.357 mg/mL for rat α-glucosidase. Isolated from Dalbergia tonkinensis, this compound demonstrates antibacterial activity against Ralstonia solanacearum. Additionally, Sativanone exhibits anti-senescent and antioxidant properties, making it a valuable reagent for research in metabolic disorders, bacterial infections, and oxidative stress-related studies. -
Glycosidase Inhibitor
Panosialin D is a glycosidase inhibitor that selectively targets α,β-glucosidase and mannose glycosidase. This compound does not exhibit activity against the influenza virus; however, it demonstrates weak antimicrobial properties. It serves as a valuable reagent for research focused on glycosidase-related pathways and antimicrobial studies. -
α-glucosidase Inhibitor
Enhydrin is a naturally occurring α-glucosidase inhibitor derived from the leaves of Smallanthus sonchifolius. It demonstrates potent inhibitory activity with an IC50 value of 34.17 μg/mL, making it relevant for the management of postprandial hyperglycemia. Research indicates that Enhydrin can effectively reduce blood glucose levels in diabetic rat models, supporting its potential application in diabetes research and therapy development. -
α-Glucosidase Inhibitor
Cembrene A is an α-glucosidase inhibitor derived from the soft coral S. crassa, demonstrating an IC50 value of 30.31 μM. This compound exhibits minimal cytotoxicity in human normal hepatocyte (LO2) cells, with an IC50 greater than 100 μM. Cembrene A is a valuable reagent for research focused on diabetes and the modulation of carbohydrate metabolism. -
Alpha-Glucosidase Inhibitor
Acarbose sulfate is a potent alpha-glucosidase inhibitor, exhibiting an IC50 of 11 nM. This antihyperglycemic agent is utilized in research to investigate its potential to enhance the hypoglycemic effects of sulfonylureas or insulin. Its mechanism of action involves the modulation of carbohydrate absorption, making it valuable in studies related to diabetes and blood glucose regulation. -
α-Glucosidase Inhibitor
Arisanschinin D is an inhibitor of α-Glucosidase, a critical enzyme involved in carbohydrate metabolism. This compound can be isolated from Schisandra arisanensis and is of particular interest for research in diabetes management and metabolic disorders. Its ability to modulate enzyme activity makes it a valuable tool for studying the effects of carbohydrate absorption and glucose homeostasis. -
Glycosidase Inhibitor
Cefetrizole is an α-Glucosidase inhibitor that exhibits potent enzymatic activity, with an IC50 of 2.1 μM and a Ki value of 0.578 μM. This compound is primarily utilized in research applications focused on carbohydrate metabolism and associated disorders. Its ability to inhibit glycosidase activity makes it a valuable tool for investigating enzymatic pathways and developing therapeutic strategies. -
Iron-containing Protein
Hemoglobin is an iron-containing protein found in red blood cells that primarily functions in oxygen transport and binding. It plays a crucial role in gas exchange by transporting carbon dioxide, nitric oxide, hydrogen sulfide, and sulfide. Additionally, hemoglobin acts as an inducer of heme oxygenase-1 (HO-1), contributing to antioxidant defense in tissues by absorbing excess oxygen. Its biological activity makes it a valuable reagent for studies in oxygen metabolism, respiratory physiology, and redox signaling. -
Heme Oxygenase Inhibitor
Zn(II) Mesoporphyrin IX is a potent inhibitor of heme oxygenase, particularly affecting the enzymatic activity in bone marrow. This compound demonstrates significant biological activity by inhibiting the growth of erythroid and myeloid progenitor cells, as well as blocking rhG-CSF-induced mobilization of these cells into peripheral blood. Zn(II) Mesoporphyrin IX is suitable for research applications involving hematopoietic regulation. However, its photochemical properties and potential toxicity to hematopoietic growth warrant careful consideration in experimental designs. -
Negative Control for Zn (II) Protoporphyrin
Cu(II) Protoporphyrin IX serves as a negative control for Zn(II) Protoporphyrin, which acts as an inhibitor of heme oxygenase. Heme oxygenase plays a significant role in various biological processes, including tumor cell resistance to chemotherapy, modulation of free radical formation, and management of inflammation. This reagent is valuable for studies investigating the pathways linked to vascular repair and the mechanistic understanding of heme oxygenase-related processes. -
Heme Oxygenase (HO) Inducer
Mn(III) Protoporphyrin IX Chloride is a potent inducer of heme oxygenase (HO) that enhances the expression of δ-aminolevulinate synthase and HO genes in chick embryo liver cells at a concentration of 10 μM. This metalloporphyrin is relevant for studying heme biosynthesis and degradation pathways. Additionally, Mn(III) protoporphyrin IX chloride has been utilized in the development of nanobialys for magnetic resonance imaging (MRI) of fibrin clots in vitro, as well as in the synthesis of metalloporphyrin conjugates with microperoxidase activity, further expanding its applications in chemical research. -
HO-1 Inducer
Probucol dithiobisphenol (DTBP) is a potent inducer of heme oxygenase 1 (HO-1) with notable antioxidant properties. It effectively inhibits atherosclerotic lesions in the aorta of Apoe−/− mice and promotes re-endothelialization, thereby reducing restenosis in rabbit arterial injury models. This compound is orally active, making it a valuable reagent for investigating vascular health and potential therapeutic applications in cardiovascular diseases. -
HO-1 Inhibitor
Heme Oxygenase-1-IN-3 is a selective inhibitor of heme oxygenase-1 (HO-1), characterized by a dissociation constant (Kd) of 141 nM. This compound is valuable for investigating the role of HO-1 in cancer progression and neurodegenerative diseases. Its specificity makes it an essential tool for researchers studying the mechanism of HO-1 and its implications in various pathological conditions. -
Herbicide
Glufosinate ammonium is a phosphinic acid analogue of glutamic acid, primarily functioning as a herbicide. Upon uptake by plant cells, it is converted into L-phosphinothricin (PT), which disrupts amino acid synthesis, leading to the inhibition of protein synthesis. This compound demonstrates neurotoxic effects, making it significant in studies related to herbicidal activity and plant defense mechanisms. Its applications extend to agricultural research and the investigation of herbicide resistance in crops. -
Herbicide
4-Chloropinselin is a chlorine-substituted xanthone that serves as an effective herbicide. This compound exhibits significant phytotoxicity, effectively inhibiting the growth of various weeds, including field sowthistle. Additionally, 4-Chloropinselin demonstrates antimicrobial properties, making it valuable for research in agricultural and microbiological applications. Its role as a biosynthetic precursor or degradation product of chloromonilicin further highlights its relevance in studying herbicidal mechanisms and microbial interactions. -
Auxin Herbicide
Fluroxypyr is an auxin herbicide that targets the plant auxin signaling pathway to effectively control both annual and perennial weeds. It works by inducing auxin overdose, leading to elevated endogenous auxin concentrations that disrupt auxin homeostasis and interact with other hormonal pathways in plant tissues. Fluroxypyr is widely used in agricultural research to study plant growth regulation and herbicide resistance mechanisms. -
Herbicide
Picloram is a synthetic auxin herbicide that targets growth regulation pathways in plants. It effectively controls a variety of dicotyledonous weeds by disrupting their normal growth processes. Picloram is commonly utilized in agricultural and environmental management applications to maintain crop health and improve land usability. Its selective herbicidal properties make it valuable for research on plant physiology and herbicide resistance. -
Bleaching Herbicide
Norflurazon is a bleaching herbicide that primarily targets phytoene desaturase, inhibiting carotenoid biosynthesis. This mechanism leads to the disruption of chlorophyll production in plants, resulting in bleaching and subsequent plant growth inhibition. Norflurazon is widely used in agricultural research to study herbicide resistance, plant physiology, and the effects of carotenoid depletion on plant metabolism. -
PROTOX Inhibitor
Acifluorfen is a protoporphyrinogen oxidase (PROTOX) inhibitor primarily utilized as a herbicide. It effectively promotes the accumulation of protoporphyrin IX (PPIX), leading to significant photooxidative damage in sensitive plant species. Additionally, Acifluorfen has been shown to induce tumors in rodent liver models, making it relevant for research applications focused on oxidative stress and tumorigenesis. -
Herbicide
Chlorimuron-ethyl is a selective herbicide that targets the acetolactate synthase (ALS) enzyme, disrupting branched-chain amino acid biosynthesis in plants. This compound induces oxidative stress, leading to the inhibition of weed growth and development. Chlorimuron-ethyl is primarily utilized in agricultural research, particularly in studies of herbicide resistance and weed management strategies in soybean production.
