Catalog No.
Product Name
Application
Product Information
Citations
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Endogenous Metabolite
Butaperazine dimaleate is an antipsychotic compound that serves as a reactive agent for the detection of vanadium (V). This reagent undergoes a reaction in phosphoric acid medium, resulting in the formation of a red radical cation that exhibits a maximum absorption at 513 nm. It follows Beer's law, applicable for concentrations ranging from 0.25 to 5.0 μg/ml, with a sensitivity of 6.1 ng/cm2. Butaperazine dimaleate is ideal for the analysis of vanadium in steel, minerals, biological samples, and soil. -
Endogenous Metabolite
8-(3-Chlorostyryl)caffeine is a selective antagonist of the A2a adenosine receptor, demonstrating a significant 520-fold selectivity in radioligand binding assays conducted in rat brain. It effectively inhibits adenylylase with a 22-fold selectivity in rat chromaffin cells. Co-administration with the A1-selective antagonist CPX has been shown to enhance exercise activity. Additionally, 8-(3-Chlorostyryl)caffeine exhibits potent inhibitory activity against MAO-B in primate mitochondrial systems. This compound serves as a valuable tool for studying adenosine receptor signaling and its effects on physiological processes. -
Endogenous Metabolite
Tetracosanoyl-sulfatide is an endogenous metabolite that serves as a significant molecular marker in various biological processes. Its primary role in the research of Mild Metachromatic Leukodystrophy allows for the investigation of lipid metabolism and myelin degradation. This metabolite is valuable for studying the pathophysiology of lysosomal storage disorders and for developing potential diagnostic tools and therapeutic strategies. -
Endogenous Metabolite
11-trans-Leukotriene C4 is a derivative of trans-Leukotriene C4 (LTC4) and functions as an important endogenous metabolite involved in inflammatory responses. It plays a crucial role in mediating allergic reactions and is implicated in various pathological conditions associated with inflammation. This compound is valuable for research related to inflammation, allergy, asthma, and other diseases where leukotrienes contribute to disease pathology. -
Endogenous Metabolite
Calcitriol lactone (1α,25-Dihydroxyvitamin D3-26,23-lactone) is an endogenous metabolite of vitamin D3 with significant biological activity in bone health, cell differentiation, and immune function. As the active form of vitamin D, it is involved in regulating calcium and phosphate metabolism, thereby influencing various physiological processes. Calcitriol lactone is utilized in research to study vitamin D signaling pathways and their implications in bone disorders and immune responses. -
Endogenous Metabolite
N4-Acetylsulfamethazine is a metabolite of sulfamethazine, a widely utilized sulfonamide in veterinary medicine, specifically within the poultry farming sector. This compound serves as an endogenous metabolite, playing a role in the metabolic pathway of sulfonamides. It is relevant for research applications focusing on drug metabolism, residues in livestock, and the environmental impact of veterinary pharmaceuticals. -
Endogenous Metabolite
Metoprolol acid is an endogenous metabolite of the beta-blocker metoprolol. Although it does not exhibit pharmacological activity, it serves as a useful biomarker for studying the metabolism and pharmacokinetics of metoprolol in various biological samples. Researchers can detect metoprolol acid using solid phase extraction coupled with reversed phase high-performance liquid chromatography, employing fluorescence detection and specific eluents to ensure accurate analysis. -
Fungal Metabolite
Epicoccamide is a tetramic acid derivative that serves as a secondary metabolite derived from the fungus Epicoccum purpurascens. This compound exhibits antifungal properties, making it a valuable tool for researching fungal biology and exploring potential therapeutic applications in mycology. Its unique structure and biological activity offer insights into fungal metabolite functions and their interactions within ecological systems. -
Endogenous Metabolite
(S)-Higenamine, an endogenous metabolite and S-enantiomer of Higenamine, is a key precursor in the biosynthesis of benzylisoquinoline alkaloids. It is synthesized through the condensation of dopamine with 4-hydroxyphenylacetaldehyde via the enzyme norcoclaurine synthase. This compound plays a significant role in various biological activities, making it valuable for research in neurobiology and pharmacology. -
Endogenous Metabolite
STF-038533 is an inhibitor of the cAMP response element-binding protein (CREB), primarily targeting its transcriptional activity. This compound effectively suppresses the expression of CREB target genes, thereby modulating cellular signaling pathways. STF-038533 is invaluable for research into diseases associated with aberrant CREB activity, offering insights into therapeutic strategies for CREB-related disorders. -
Endogenous Metabolite
Pinoxepin hydrochloride is an antipsychotic compound primarily targeting neuropsychiatric conditions. It exhibits sedative and antidepressant properties, making it valuable in the study of mental disorders such as schizophrenia and depression. Additionally, Pinoxepin hydrochloride has been noted for its potential to enhance sleep quality, contributing to its utility in related research applications. -
Endogenous Metabolite
RI-61 is an endogenous metabolite that modulates neurotransmitter activity. This compound exhibits significant efficacy in alleviating symptoms associated with migraine, cluster headache, new daily persistent headache, and cyclical vomiting syndrome. Research applications include the study of pain mechanisms and therapeutic approaches for headache disorders. -
Endogenous Metabolite
Deleobuvir sodium is a non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase, targeting viral replication. This compound exhibits significant anti-hepatitis C virus activity, making it a valuable tool for research into hepatitis C treatment. Its use facilitates the study of viral mechanisms and the development of therapeutic strategies aimed at combating hepatitis C infection. -
Endogenous Metabolite
11-trans Leukotriene E4 is an isomer of the endogenous metabolite Leukotriene E4 (LTE4) and functions primarily as a potent bronchoconstrictor. It exhibits equipotent activity to LTE4 in inducing contractions in guinea pig ileum. This compound is valuable for research into leukotriene pathways, inflammatory responses, and respiratory disorders. -
Fungal Metabolite
Neoechinulin C is a fungal metabolite belonging to the indolediketopiperazine alkaloid class. It exhibits protective effects on neuronal cells against paraquat-induced damage, making it a valuable compound for research related to neurodegenerative diseases such as Parkinson's disease. This compound is useful in studying mechanisms of cell protection and potential therapeutic strategies in neurobiology. -
Endogenous Metabolite
Bendiocarb is a carbamate compound that primarily acts as an inhibitor of the enzyme acetylcholinesterase. This inhibition results in increased levels of acetylcholine, which plays a crucial role in neurotransmission and muscle contraction. Bendiocarb is utilized in research applications focusing on neurobiology and the study of cholinergic systems, as well as in the examination of potential neurotoxic effects. -
Endogenous Metabolite
SKF 103784 is a vasopressin antagonist that targets the action of vasopressin, inhibiting its physiological effects linked to antidiuresis. This compound is valuable for investigating biological processes related to water and sodium homeostasis. Furthermore, SKF 103784 can be utilized in research to elucidate pathological mechanisms associated with cardiovascular diseases and endocrine disorders. -
Endogenous Metabolite
H-0106 dihydrochloride is a selective inhibitor of Rho-associated kinase (ROCK), primarily targeting the modulation of intraocular pressure (IOP). This compound exhibits significant IOP-lowering activity, as demonstrated in primate models. Research indicates that while H-0106 dihydrochloride effectively inhibits the ROCK enzyme, the relationship between ROCK inhibition and IOP reduction may not be straightforward, warranting further investigation into its mechanisms of action in ocular health. -
Endogenous Metabolite
3-(2-Aminopropyl)phenol is an endogenous metabolite known for its ability to elevate blood pressure. This compound has been shown to effectively alleviate symptoms of orthostatic hypotension in patients, significantly increasing blood pressure both at rest and upon standing after oral administration. Additionally, 3-(2-Aminopropyl)phenol may aid in mitigating pathological orthostatic adjustment disorders with minimal impact on heart rate and a favorable side effect profile. These properties make it a valuable tool for researching blood pressure regulation and related disorders. -
Fungal Metabolite
Berninamycin D is a cyclic peptide fungal metabolite that exhibits potent antifungal activity. Isolated from the fermentation of Streptomyces bernensis, this compound serves as an important tool in studying antifungal mechanisms and microbial interactions. It is applicable in various research settings focused on fungal pathogenesis and the development of new antifungal therapeutics. -
Endogenous Metabolite
(Rac)-Eflucimibe is an ACAT inhibitor that modulates endogenous hypercholesterolemia. It demonstrates significant potency and efficacy as an anti-hypercholesterol agent in various animal models of hypercholesterolemia. This compound is useful for investigating cholesterol metabolism and understanding the mechanisms of cholesterol regulation in biological systems. -
Endogenous Metabolite
Phenolic acid is an endogenous metabolite that plays a crucial role in various biochemical processes. Known for its antioxidant properties, it participates in the modulation of cellular signaling pathways and has implications in metabolic regulations. This compound is widely utilized in research exploring oxidative stress, inflammation, and metabolic disorders. -
Endogenous Metabolite
1,2-Dioleoyl-3-lauroyl-rac-glycerol is a triglyceride that serves as an endogenous metabolite, widely studied for its structural and distribution characteristics in various biological matrices. It has been identified in human milk, infant formula, and both mammalian and vegetable oils. This compound is useful in research focusing on lipid metabolism, nutrition, and the biochemical composition of milk fats. -
Endogenous Metabolite
DBPR110 is a potent inhibitor of nonstructural protein 5A (NS5A), specifically targeting hepatitis C virus (HCV) replication. It demonstrates significant antiviral activity with an EC50 of 3.9 ± 0.9 pM against HCV1b replicon reporter expression, and a selectivity index exceeding 12,800,000. Additionally, DBPR110 reduces HCV2a replicon activity with an EC50 of 228.8 pM and a selectivity index of over 173,130. This compound exhibits synergistic effects when used in combination with interferon alpha (IFN-α) and other antiviral agents, suggesting its potential as a viable small molecule therapeutic for HCV treatment. -
Endogenous Metabolite
FPL-55712 is a cysteine leukotriene type 1 receptor antagonist that exhibits anti-inflammatory effects. This compound effectively inhibits the biological responses induced by leukotrienes, thereby reducing allergic reactions and alleviating airway inflammation. FPL-55712 holds promise for research applications related to asthma and allergic rhinitis management. -
Endogenous Metabolite
AHR Activator 1 is an aryl hydrocarbon receptor (AHR) activator that modulates fibroblast growth factor-2 (FGF2)-induced branching morphogenesis. It functions by inhibiting AHR signaling, thereby preventing cellular branch formation. Additionally, AHR Activator 1 interacts with dissociated linkers, highlighting their significance in the inhibitory effects of AHR agonists on branching. This compound is valuable for studying mammary gland morphogenesis and understanding the mechanisms underlying FGF-induced invasion. -
Endogenous Metabolite
Muscarinic agonist 1 (AF267) targets muscarinic acetylcholine receptors, which are vital for cognitive function. This compound exhibits potential in alleviating cognitive impairments, making it a valuable tool for research into neurodegenerative diseases and cognitive disorders. Its mechanism of action provides insight into cholinergic signaling and its role in cognitive processes, thus serving as a significant reagent in neuroscience studies. -
Fungal Metabolite
Aspericin C is a pyran derivative derived from the marine fungus Rhizopus sp. 2-PDA-61. This compound exhibits cytotoxic effects against various cancer cell lines, including P388, A549, HL-60, and BEL-7420, with IC50 values of 14.6, 7.1, 61.4, and 24.2 μM, respectively. Aspericin C serves as a valuable tool for researching antitumor activity and the mechanisms underlying cytotoxicity in cancer biology. -
Endogenous Metabolite
YM471 free base is a selective non-peptide antagonist targeting vasopressin V1A and V2 receptors. It demonstrates high affinity for these receptors in rat models, with binding affinities (K values) of 0.16 nM for V1A and 0.77 nM for V2. This compound is valuable for investigating the role of vasopressin receptors in various physiological and pathological conditions. -
Endogenous Metabolite
(S)-CPP sodium is an inhibitor of the branched-chain α-ketoacid dehydrogenase complex (BCKDC) kinase, also known as BDK. By negatively regulating BCKDC activity, (S)-CPP effectively activates the complex and significantly reduces plasma concentrations of branched-chain amino acids such as leucine, isoleucine, and valine in wild-type mice. This agent is useful for research applications investigating metabolic pathways and the regulation of amino acid levels in physiological and pathological contexts. -
Endogenous Metabolite
VB-201 is an oxidized phospholipid small molecule that functions as an anti-inflammatory agent. It inhibits innate cell activation mediated by CD14 and Toll-like receptor 2, thereby providing insight into inflammatory pathways. This compound is instrumental in studying the progression of atherosclerosis and serves as a valuable tool for research in cardiovascular diseases. -
Endogenous Metabolite
Neostigmine iodide is a reversible inhibitor of acetylcholinesterase, enhancing muscle tone and function. This compound is primarily utilized in the management of myasthenia gravis, aiming to improve muscle strength in affected patients. Additionally, Neostigmine iodide is employed in anesthetic procedures to counteract the effects of nondepolarizing muscle relaxants, such as rocuronium, thereby facilitating recovery from anesthesia. -
Endogenous Metabolite
Lifirafenib hydrochloride is a reversible inhibitor of the B-RAFV600E mutation, exhibiting significant antitumor activity in solid tumors, including melanoma, thyroid cancer, and low-grade serous ovarian cancer. This compound demonstrates selective cytotoxicity by preferentially targeting cancer cells harboring B-RAFV600E and EGFR mutations or amplifications. In preclinical studies, Lifirafenib has been shown to inhibit tumor growth in a dose-dependent manner, resulting in partial and complete tumor regression in animal models, making it a valuable tool for cancer research applications. -
Endogenous Metabolite
Complement factor I is a serine protease that serves to downregulate complement activity both in the fluid phase and on cell surfaces, primarily in association with cofactors such as factor H, complement receptor 1 (CR1/CD35), C4 binding protein (C4BP), or membrane cofactor protein (MCP/CD46). Its regulatory role is crucial in maintaining immune homeostasis and preventing tissue damage due to excessive complement activation. This enzyme is valuable in research applications focusing on immunology, autoimmune disorders, and the modulation of complement-mediated processes. -
Endogenous Metabolite
Chlorambucyl-proline is an amino acid derivative exhibiting inhibitory activity against bovine pulmonary vasoconstrictor enzyme. This compound functions as an irreversible inhibitor by forming ester bonds with the enzyme's aspartic or glutamic acid residues, leading to permanent enzyme inactivation. The rate of inactivation by chlorambucyl-proline is influenced by pH, with increased activity observed in the 5-8 range, making it a valuable tool for studying enzymatic regulation and function in physiological pH environments. -
Endogenous Metabolite
LY-79771 hydrochloride is a phenethanolamine compound that serves as an endogenous metabolite with antiobesity properties. It is primarily involved in inhibiting fat regain following energy deprivation, thereby aiding in weight management. This reagent is suitable for research applications focused on metabolic health and obesity-related studies. -
Endogenous Metabolite
Flurbiprofen sodium is a nonsteroidal anti-inflammatory drug (NSAID) targeting inflammatory pathways through the inhibition of carbonic anhydrase. It exhibits significant anti-inflammatory and analgesic properties, making it useful in the treatment of periodontal disease by reducing bone resorption. Additionally, Flurbiprofen sodium can be formulated into biodegradable microspheres for effective compound delivery, particularly within periodontal pockets, with the release kinetics influenced by the concentration of the polymer and polyvinyl alcohol used in its preparation. This compound is valuable for research into periodontal therapies and inflammation-related studies. -
Endogenous Metabolite
M-0002 hydrochloride is an antagonist of the vasopressin V2 receptor, acting as a key regulator of water balance and blood pressure. This compound is primarily investigated for its potential to inhibit ascites formation, making it relevant in research related to fluid retention disorders. Its favorable biological properties support further exploration in clinical applications. -
Endogenous Metabolite
Sermetacin (SH-G 318AB) is an endogenous metabolite with notable anti-inflammatory properties. This compound demonstrates strong biocompatibility, particularly in the RAW 264.7 mouse macrophage cell line, making it suitable for various biological applications. Sermetacin exhibits an anti-inflammatory response comparable to indomethacin, indicating its potential utility in research focused on inflammation pathways and therapeutic delivery mechanisms. -
Endogenous Metabolite
δ-CEHC is a metabolite of δ-tocopherol that acts primarily as an endogenous antioxidant. It demonstrates significant antioxidant activity, which may play a role in protecting cells from oxidative stress. δ-CEHC is utilized in research focused on investigating cellular responses to oxidative damage and exploring its potential therapeutic effects in various oxidative stress-related diseases. -
Endogenous Metabolite
Cyclo(Pro-Hyp) is a collagen-derived cyclic dipeptide that serves as an endogenous metabolite. Known for its role in promoting the proliferation of skin fibroblasts, Cyclo(Pro-Hyp) is crucial in tissue reconstruction processes. Its biological activity makes it a valuable reagent for research applications focusing on collagen metabolism and cellular regeneration in dermatological studies. -
Endogenous Metabolite
Cis-Vitamin K1 is an endogenous metabolite of Vitamin K that plays a critical role in the regulation of blood coagulation through its action as a cofactor for gamma-carboxylase. It promotes the post-translational modification of various proteins involved in hemostasis. This compound is utilized in research related to vitamin K biochemistry, coagulation studies, and the exploration of related metabolic pathways. Additionally, cis-Vitamin K1 may be investigated for its potential interactions in various physiological processes and disease states. -
Fungal Metabolite
Aspercolorin is a cyclic peptide fungal metabolite that exhibits significant antimicrobial properties. It has been studied for its potential use in inhibiting fungal growth, making it a valuable compound in antifungal research. Its unique structure and biological activity lend it to applications in investigating fungal metabolism and pathogenicity. -
Endogenous Metabolite
Pfn1-IN-2 is a selective inhibitor of Profilin1 (Pfn1), designed to disrupt the interaction between Pfn1 and actin filaments. This compound effectively decreases the levels of filamentous (F) actin within cells, leading to diminished migration and proliferation of endothelial cells. Pfn1-IN-2 demonstrates significant inhibition of endothelial cell angiogenic capabilities in both in vitro and in vivo research settings, making it a valuable tool for studies in angiogenesis and cellular dynamics. -
Fungal Metabolite
Carbolactone is a biologically active fungal metabolite known for its diverse biological activities. This compound exhibits antimicrobial properties, making it a valuable tool for research in mycology and natural product studies. Carbolactone's interaction with fungal systems can aid in the exploration of potential new antifungal agents and contribute to the understanding of fungal metabolism. -
Endogenous Metabolite
N-Succinyl-L-glutamate 5-semialdehyde is an endogenous metabolite involved in the glutamate metabolic pathway. It plays a significant role in the biosynthesis and metabolism of amino acids, particularly in the regulation of neurotransmitter levels. This compound is useful for research applications focused on metabolic processes, neurotransmission, and amino acid regulation. -
Endogenous Metabolite
VEC6 (NSC 11435) is an inhibitor of the VEZF1-DNA interaction, demonstrating significant activity in modulating vascular responses during ischemic retinopathy. It effectively reduces pathological angiogenesis while promoting lymphangiogenesis by influencing the expression of distinct gene sets in endothelial cells. VEC6 inhibits VEZF1-mediated transcriptional activity, thereby impacting endothelial cell proliferation and sprouting. This compound serves as a valuable tool for studying the molecular mechanisms of angiogenesis and lymphangiogenesis in various research applications. -
Endogenous Metabolite
MyomiRs-IN-1 is a specific inhibitor targeting endogenous metabolites involved in muscle cell differentiation. It effectively downregulates myoD protein translation in C2C12 cells without altering myoD mRNA levels, thereby affecting the expression of muscle differentiation markers. By modulating the regulatory pathway between miR-221/222 and myoD, MyomiRs-IN-1 is a valuable tool for researchers investigating muscle development and associated disorders. -
Endogenous Metabolite
A 62176 hydrochloride is a potent inhibitor of DNA topoisomerase II, demonstrating significant activity in disrupting purine synthesis in cancer cells. By interacting with G-quadruplex structures, A 62176 hydrochloride reduces c-MYC mRNA expression and displaces nucleosomes from the non-template strand of rDNA. This mechanism leads to DNA damage that necessitates repair via BRCA1/2-mediated homologous recombination and DNA-PK-mediated non-homologous end-joining pathways, highlighting its potential applications in cancer research and therapeutic development. -
Endogenous Metabolite
L-Lysine orotate is a salt composed of L-lysine and orotic acid, functioning as an endogenous metabolite. This compound has been shown to potentiate the toxicity of extracts from the mushroom Amanita phalloides, making it relevant for studies investigating mycotoxin effects and metabolic pathways related to amino acids. Its unique interaction profile can be advantageous in research focused on toxicology and pharmacology.
