Catalog No.
Product Name
Application
Product Information
Citations
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α-Glucosidase Inhibitior
Resveratroloside is an orally active competitive inhibitor of α-glucosidase. It exhibits hypoglycemic and cardioprotective effects, making it a valuable compound for research into diabetes and cardiovascular diseases. This glycoside form of resveratrol facilitates investigations into its potential therapeutic applications in managing glucose metabolism and promoting heart health. -
α-L-fucosidase Inhibitor
Deoxyfuconojirimycin hydrochloride is a selective inhibitor of α-L-fucosidase, demonstrating a Ki value of 10 nM for human liver lysosomal α-L-fucosidase and 140 nM for Charonia lampas α-L-fucosidase. This compound effectively inhibits the activity of all soluble α-L-fucosidases present in human liver, including various post-translationally modified enzyme forms. Deoxyfuconojirimycin hydrochloride is primarily utilized in research focused on fucosidase-related enzyme activity and metabolic pathways, though it does not exhibit anti-HIV properties. -
Tyrosinase Inhibitor
Kushenol A, a non-competitive inhibitor of tyrosinase, effectively blocks the conversion of L-tyrosine to L-DOPA, with IC50 and Ki values of 1.1 μM and 0.4 μM, respectively. Isolated from the root of Sophora flavescens, Kushenol A exhibits antioxidant properties and also inhibits alpha-glucosidase (IC50: 45 μM; Ki: 6.8 μM) and β-amylase. This compound is valuable for research focused on skin whitening and anti-aging applications due to its enzyme inhibitory effects. -
Glucosidase Inhibitor
Gitogenin is a natural steroid derived from the plant Tribulus longipetalus, serving as a selective inhibitor of UDP-glucuronosyltransferase 1A4 (UGT1A4) and α-glucosidase. It exhibits an IC50 of 0.69 μM for UGT1A4 using trifluoperazine as a substrate, and an IC50 of 37.2 μM for α-glucosidase. Gitogenin does not interfere with the activities of major human cytochrome P450 isoforms, making it a valuable reagent for studies in metabolic enzyme pathways and potential therapeutic applications related to glycemic control. -
Glycosidase
Heparinase II is a glycosidase that specifically targets heparin and heparan sulfate. It plays a crucial role in the structural and functional analysis of glycosaminoglycans, making it valuable in anticoagulant research and studies of tumor microenvironment modulation. Its enzymatic activity facilitates investigations into various biological processes, including cell signaling and the interaction of cancer cells with their surrounding matrix. -
Glycosidase Inhibitor
Cedryl acetate is a tricyclic sesquiterpene with notable α-glucosidase inhibitory activity. This compound is isolated from the plant Cunninghamia lanceolata and is valuable in research focused on carbohydrate metabolism and glycosidase inhibition. Its biological activity makes it an important tool for studying metabolic disorders and potential therapeutic interventions. -
GCase 2 Inhibitor
AMP-Deoxynojirimycin is a potent inhibitor of glucocerebrosidase 2 (GCase 2) and ceramide glucosyltransferase. This compound effectively interferes with glucosylceramide (GlcCer) biosynthesis, making it valuable for research related to lysosomal storage disorders and sphingolipid metabolism. Its biological activity positions AMP-Deoxynojirimycin as a significant tool for investigating the roles of GlcCer in various cellular processes and disease mechanisms. -
Fluorescent Substrate
4-Methylumbelliferyl-α-D-Glucopyranoside is a fluorescent substrate targeting α-glucosidase, which releases the fluorescent moiety 4-methylumbelliferyl (4-MU) upon enzymatic cleavage. This compound exhibits pH-dependent fluorescence, with excitation wavelengths of 320 nm in acidic conditions and 360 nm in alkaline conditions, while its emission increases between 445-455 nm as pH decreases. 4-Methylumbelliferyl-α-D-Glucopyranoside serves as a valuable biomarker for assessing α-glucosidase activity in infant blood spot samples, particularly in the context of Fabry and Pompe diseases. -
Glycosidase Substrate
4-Methylumbelliferyl α-L-arabinofuranoside serves as a substrate for glycosidase enzymes, facilitating the cleavage of α-L-arabinofuranosidic bonds. Upon hydrolysis, it generates the fluorescent product 4-methylumbelliferone, allowing for sensitive detection and quantification. This compound is valuable in enzyme activity assays, particularly in studies involving carbohydrate metabolism and glycoside hydrolase activity. -
Glucosidase Inhibitor
Kaempferol 3-O-gentiobioside is a flavonoid that functions as an α-glucosidase inhibitor. Isolated from the leaves of C. alata, this compound demonstrates significant antidiabetic activity by inhibiting carbohydrate enzyme activity, with an IC50 value of 50.0 µM. It serves as a valuable tool for research into glucose metabolism and diabetes treatment applications. -
Chromogenic Glycosidic Ligand
p-Nitrophenyl α-D-mannopyranoside is a chromogenic glycosidic ligand targeting glycosidase enzymes. This compound contains an α-D-mannopyranose moiety with a distinctive axial hydroxyl group at the C2 position, along with a p-nitrophenol portion that absorbs ultraviolet-visible light. p-Nitrophenyl α-D-mannopyranoside is essential for assessing glycosidase activity and exploring the sugar recognition properties of lectins, including Concanavalin A. -
Glycosidase Inhibitor
Glycyrrhisoflavone is a potent α-glucosidase inhibitor that acts primarily by blocking the enzyme's activity, thereby modulating carbohydrate metabolism. This natural prenylflavonoid exhibits significant biological activity, making it useful in research related to diabetes management and metabolic disorders. Its ability to influence glycemic control highlights its potential applications in pharmacological studies and nutraceutical development. -
Weed Inhibitor
Glucobrassicin potassium is a glucosinolate (GSL) that functions as a potent weed inhibitor. Isolated from wild carrot (Raphanus raphanistrum L.), it demonstrates significant potential in biological fumigation and allelopathy research. Its application in weed management studies supports the exploration of sustainable agricultural practices. -
GCase Ligand
GT-02216 is an allosteric ligand for Glucosylceramidase (GCase) that enhances its enzymatic activity. This compound not only promotes the activity of GCase in primary human fibroblasts in a dose-dependent manner but also effectively reduces the accumulation of hexosylsphingosine (HexCer), a substrate linked to various pathologies. Additionally, GT-02216 has demonstrated the ability to decrease Tau accumulation in mutant GBA1 fibroblasts, making it a valuable tool in the study of Parkinson’s disease and related neurodegenerative conditions. -
Glycosidic Hydrolase
α-Rhamnosidase is a glycosidic hydrolase that catalyzes the hydrolysis of α-rhamnosides, facilitating the enzymatic de-glycosylation of a variety of natural flavonoid glycosides. This enzyme plays a critical role in the metabolism of plant glycosides, contributing to the bioavailability of flavonoid compounds. It is widely used in research applications focusing on plant biochemistry, natural product studies, and the analysis of flavonoid bioactivity. -
GCase Inhibitor
Gcase Activator 2 is a pyrrolo[2,3-b]pyrazine that serves as a potent activator of β-glucocerebrosidase (GCase), with an EC50 of 3.8 μM. This compound facilitates GCase dimerization, promoting both K-type and V-type interactions. Gcase Activator 2 displays low metabolic clearance in both human and mouse systems, making it a valuable tool for research into GCase-related biological pathways and potential therapeutic applications in lysosomal storage disorders. -
Sweetener
Erlose is a trisaccharide sucrose derivative and low-calorie sweetener, synthesized through an α-glucosidase-mediated transglycosylation of glucose and sucrose. It possesses approximately half the sweetness of sucrose while maintaining a comparable taste profile. Erlose is primarily employed as a marker for detecting artificial sucrose adulteration in honey and demonstrates efficacy in inhibiting crystal formation and browning reactions during food heat treatment. This compound is valuable in research applications focused on food science and sweetener development. -
CHI3L1 Inhibitor
CHI3L1-IN-3 is a potent inhibitor of CHI3L1, with dissociation constants of 13.76 μM and 13.5 μM as measured by MST and SPR assays, respectively. This compound exhibits favorable pharmacokinetic properties, including extended plasma half-lives and microsomal stability, alongside decreased intrinsic clearance. In biological assays, CHI3L1-IN-3 demonstrates dose-dependent cytotoxicity, effectively reduces spheroid mass, and inhibits cell migration in a three-dimensional multicellular glioblastoma (GBM) spheroid model. It serves as a valuable tool for investigating the roles of CHI3L1 in GBM research. -
Cyclophenyl Alcohol
Cyclophellitol aziridine is a cyclophenol analogue that acts as a potent inhibitor of β-glucosidase. This compound demonstrates significant potential in studying carbohydrate metabolism and related enzymatic pathways. Its inhibitory activity makes it a valuable tool for investigating β-glucosidase-related diseases and for screening potential therapeutic agents. -
Alpha-glucosidase Inhibitor
Valiolamine is an aminocyclitol that functions as an alpha-glucosidase inhibitor. It exhibits significant inhibitory activity against porcine intestinal sucrase and maltase, with Ki values of 30 nM and 350 nM, respectively. This compound is valuable for research applications focused on carbohydrate metabolism, specifically in studying the modulation of glucose absorption and the potential therapeutic approaches to disorders such as diabetes. -
UV Filter
Benzophenone-2 is an organic ultraviolet absorber that serves as a UV filter in various personal care and industrial products, including plastics and coatings. It functions as an endocrine disruptor, impacting estrogen receptor (ERα) and pregnane X receptor (PXR) activity, which may contribute to reproductive toxicity, immune disorders, and metabolic abnormalities. Additionally, Benzophenone-2 exhibits inhibitory activity against α-glucosidase (IC50 = 49.72 μM), making it relevant for research in diabetes mellitus and related metabolic studies. -
Glycosidic Hydrolase
α-L-Arabinofuranosidase is a glycosidic hydrolase that specifically hydrolyzes the non-reducing termini of α-L-arabinofuranosyl residues found in polysaccharides such as arabinoxylan, arabinan, and arabinogalactan. This enzyme plays a crucial role in carbohydrate metabolism and is instrumental in the breakdown of complex carbohydrates. Its applications include enzymatic studies of plant-based polysaccharides and potential use in bioengineering for the modification of dietary fibers. -
Glucocerebrosidase Modulator
β-Glucocerebrosidase modulator 1 is a potent allosteric modulator targeting β-Glucocerebrosidase, with an EC50 of 9.0 μM and a Kd of 0.050 μM. This compound enhances the enzymatic activity of β-Glucocerebrosidase, making it a valuable tool for studying Gaucher disease and related lipid metabolism disorders. Its modulation of enzymatic function assists in elucidating biological pathways and may aid in the development of therapeutic interventions. -
α-Glucosidase Inhibitor
Panasenoside is a flavonoid that acts as an α-glucosidase inhibitor. Derived from Lilium pumilum DC, it has demonstrated significant inhibitory activity against α-glucosidase, making it a valuable tool for research on carbohydrate metabolism and related disorders. This compound is relevant for studies investigating diabetes management and the modulation of postprandial blood glucose levels. -
Alkylresorcinol
5-Nonadecylresorcinol is an alkylresorcinol that functions as an inhibitor of β-hexosaminidase release in vitro. Its biological activity makes it a valuable tool for research investigating the role of β-hexosaminidase in various cellular processes. Applications include studies related to enzyme modulation and potential therapeutic interventions in conditions where β-hexosaminidase activity is implicated. -
Glucocerebrosidase Chaperone
NCGC00092410 is a selective glucocerebrosidase chaperone that enhances the enzyme's activity and lysosomal localization in mutant cell lines. With an IC50 of 31 nM, it demonstrates notable potency without affecting related hydrolases at concentrations up to 77 μM. This reagent is primarily utilized in research focused on Gaucher disease, providing insights into therapeutic strategies for this lysosomal storage disorder. -
CHI3L1:HSIII Inhibitor
CHI3L1-IN-2 is a selective inhibitor of CHI3L1 (Chitinase-3-Like Protein 1) that targets its interaction with heparan sulfate (CHI3L1:HSIII), exhibiting an IC50 of 26 nM. CHI3L1 is a glycoprotein linked to various pathological conditions including inflammation, fibrosis, and cancer. This compound serves as a valuable tool for researchers investigating the role of CHI3L1 in disease processes and therapeutic applications. -
GCase Activator
GCase Activator 3 is a glucocerebrosidase (GCase) activator that enhances enzyme stability and activity. This compound effectively reduces misfolding and degradation of mutant GCase proteins in fibroblasts and dopaminergic neurons, providing a potential therapeutic strategy for conditions such as Parkinson's disease and related synucleinopathies. GCase Activator 3 is instrumental in advancing research aimed at understanding and treating these neurodegenerative disorders. -
Anti-Viral Agent
IHVR-17028 is a broad-spectrum antiviral agent that primarily targets endoplasmic reticulum α-glucosidase I. It demonstrates significant antiviral activity against various viruses, including Bovine viral diarrhea virus (BVDV), Tick-borne choriomeningitis virus (TCRV), and Dengue virus (DENV), with EC50 values of 0.4 μM, 0.26 μM, and 0.3 μM, respectively. With an IC50 of 0.24 μM, it effectively inhibits ER α-glucosidase I, making it a valuable tool for research into infectious diseases. -
Alkaloid
N-Caffeoyl O-methyltyramine is an alkaloid with demonstrated inhibitory activity against α-glucosidase, exhibiting an IC50 value of 103.58 μM. This compound is derived from Cuscuta reflexa and is relevant for research focused on glucose metabolism and diabetes. Its potential applications include studying carbohydrate absorption and metabolic disorders, making it a valuable reagent in biochemical investigations. -
α-Glucosidase Inhibitor
β-Hydroxypropiovanillone is an α-glucosidase inhibitor that demonstrates significant concentration-dependent inhibitory effects on this enzyme. With an IC50 value of 257.8 μg/mL, it is useful for studying carbohydrate metabolism and potential therapeutic applications in managing postprandial hyperglycemia. This compound may serve as a valuable research tool in the exploration of diabetes and related metabolic disorders. -
Isoamylase
Isoamylase, also known as glycogen α-1,6-glucanohydrolase, catalyzes the hydrolysis of α-1,6-glycosidic linkages in glycogen, amylopectin, and α/β-limit dextrins. This enzymatic activity is crucial for the degradation of complex carbohydrates, making Isoamylase valuable for research in carbohydrate metabolism, enzymology, and biotechnology applications. Its ability to selectively cleave α-1,6-glycosidic bonds allows for the detailed study of glycogen structure and function in various biological contexts. -
α-glucosidase Inhibitor
Magnoloside B is an α-glucosidase inhibitor with an IC50 value of 0.69 mM, derived from the stem bark of Magnolia officinalis. It exhibits moderate inhibitory activity against MGC-803 and HepG2 cancer cell lines. This compound is of significant interest for research applications related to cancer and diabetes. -
α-amylase/α-glucosidase/Acetylcholinesterase Inhibitor
Kaempferol-3,7-di-O-β-glucoside is a flavonol that acts as an inhibitor of α-amylase, α-glucosidase, and acetylcholinesterase. This compound has demonstrated protective effects on differentiating neuronal cells, specifically SH-SY5Y, against injury induced by Amyloid β peptide. Its enzyme inhibitory properties and neuroprotective effects indicate potential applications in Alzheimer's disease research and therapeutics. -
Fusion Protein
Berahyaluronidase alfa is a recombinant fusion protein that targets hyaluronidase PH-20 and associated proteins such as HYAL3 and SPAM1. This enzymatic agent facilitates the degradation of hyaluronic acid, thereby promoting increased tissue permeability. It is primarily utilized in the research of advanced and metastatic solid tumors, offering potential insights into tumor progression and therapeutic interventions. -
Glycosidase
Glyoxalase I (Glo-I) is a glycosidase that plays a crucial role in the detoxification of methylglyoxal (MOG). Its primary mechanism involves catalyzing the conversion of MOG to D-lactate, thereby mitigating cellular damage and reducing oxidative stress. This enzyme is significant in studies related to inflammation and cancer, making it an important target for research into therapeutic interventions aimed at these conditions. -
Alpha-glucosidase Inhibitor
(+)-Afzelechin is an alpha-glucosidase inhibitor derived from the rhizomes of Bergenia ligulata. It demonstrates an ID50 value of 0.13 mM, indicating its potency in inhibiting alpha-glucosidase activity. This compound effectively delays carbohydrate absorption, thereby reducing postprandial hyperglycemia and hyperinsulinemia. It serves as a valuable tool for research in metabolic disorders and glycemic control. -
α-glucosidase Inhibitor
Ganoderol B is a potent inhibitor of α-glucosidase, exhibiting significant enzymatic inhibition with an IC50 value of 48.5 μg/mL (119.8 μM). This compound is primarily utilized in research applications related to carbohydrate metabolism and glucose regulation, making it a valuable tool in studies of diabetes and postprandial hyperglycemia. Researchers may leverage Ganoderol B to explore mechanisms of glycemic control and to develop therapeutic strategies targeting α-glucosidase. -
α-Glucosidase Inhibitor
(-)-Pinoresinol 4-O-glucoside serves as a potent α-glucosidase inhibitor, exhibiting an IC50 value of 48.13 µM. This compound promotes cell migration and early differentiation of pre-osteoblasts while enhancing the protein levels of BMP2, phosphorylated Smad1/5/8, and RUNX2. Additionally, it demonstrates protective effects against oxidative stress, hyperglycemia, and hepatic toxicity. (-)-Pinoresinol 4-O-glucoside is a valuable reagent for investigating osteoporosis and periodontal disease. -
GCase Inhibitor
Glucocerebrosidase-IN-1 is a selective inhibitor of glucocerebrosidase (GCase), exhibiting an IC50 of 29.3 μM and a Ki of 18.5 μM. This compound is instrumental in research related to Gaucher disease and Parkinson's disease, allowing for the investigation of GCase's role in these conditions. Its potency and specificity make it a valuable tool for elucidating the biochemical pathways involved in lysosomal storage disorders. -
β-D-mannopyranosidase Substrate
4-Nitrophenyl β-D-mannopyranoside is a specific substrate for the enzyme β-D-mannopyranosidase, facilitating the study of enzymatic activity in carbohydrate metabolism. It also serves as a substrate for GH1-glucosidase and α-L-rhamnosidase, making it a versatile reagent for various glycoside hydrolase assays. This compound is valuable for researchers focused on enzyme kinetics and carbohydrate enzymology. -
α-Glucosidase Inhibitor (AGI)
α-Glucosidase-IN-11 is a potent competitive inhibitor of α-glucosidase, exhibiting an IC50 value of 0.56 μM. This compound selectively binds to tryptophan residues in the enzyme, influencing its protein folding and activity. α-Glucosidase-IN-11 has potential applications in the regulation of carbohydrate metabolism and blood glucose control, making it a valuable tool for diabetes research and therapeutic development. -
Exoglycosidase
α1-6 Mannosidase, Xanthomonas phaseoli is a highly specific exoglycosidase that hydrolyzes unbranched α1-6 linked mannose residues in oligosaccharides. This enzyme plays a crucial role in the structural modification of glycoproteins and polysaccharides, facilitating studies in glycan analysis, carbohydrate metabolism, and enzymatic reaction mechanisms. Its precise activity makes it an essential reagent for research in glycoscience and biochemistry. -
Glycosidase Inhibitor
N-Methylmoranoline is a potent α-glucosidase inhibitor that modulates carbohydrate metabolism by interfering with enzyme activity. This compound demonstrates significant potential in research related to diabetes management and metabolic disorders by reducing glucose absorption. It is utilized in studies exploring glycemic control and the pharmacological effects of glycosidase inhibition. -
Glucosidase Inhibitor
Glucocerebrosidase-IN-1 hydrochloride is a potent and selective inhibitor of glucocerebrosidase (GCase), demonstrating an IC50 of 29.3 μM and a Ki of 18.5 μM. This compound is relevant for research applications concerning Gaucher disease and Parkinson's disease, as it influences cellular metabolism of glucocerebrosides. Its selective inhibition makes it a valuable tool for studying the biochemical pathways associated with these conditions. -
α-glucosidase Inhibitor
Carpachromene is a potent inhibitor of the α-glucosidase enzyme. It has been shown to ameliorate insulin resistance in HepG2 cells by modulating the IR/IRS1/PI3K/Akt/GSK3/FoxO1 signaling pathway. This compound is valuable for researching metabolic disorders and potential therapeutic strategies for diabetes management. -
Tryptophan Derivative
(S)-N-(1H-Indole-3-acetyl)tryptophan is a tryptophan derivative that serves as a weak inhibitor of β-D-glucosidase. Its biological activity may be leveraged in research focused on enzymatic pathways and metabolic processes where β-D-glucosidase plays a significant role. This compound can be utilized in various biochemical studies exploring the interactions and regulation of tryptophan derivatives in cellular contexts. -
Substrate of β-lactosidase
p-Nitrophenyl β-D-lactoside acts as a substrate for β-lactosidase, facilitating the assessment of enzyme activity in various biological applications. This compound is also a substrate for cellobiohydrolase, making it valuable in studies involving carbohydrate metabolism. Its utility in glycobiology research underscores its importance for understanding glycan interactions and enzymatic functions. -
α-Glucosidase Inhibitor
Casuarictin is a potent α-glucosidase inhibitor, exhibiting competitive inhibition with an IC50 of 0.21 μg/mL. It also acts as an inhibitor of presenilin stabilization factor-like protein (PSFL). This compound is valuable for research applications related to Alzheimer's disease and metabolic disorders, providing insights into therapeutic strategies targeting carbohydrate metabolism. -
β-glucosidase Inhibitor
Validamine is a competitive inhibitor of β-glucosidase, demonstrating pH-dependent and dose-dependent inhibition with an IC50 value of 2.92 mM. Its maximum inhibitory effect occurs at the enzyme's optimal pH, making it a valuable tool for studying β-glucosidase function and regulation. This compound can be utilized in research applications focused on carbohydrate metabolism and related pathways.
