Phepropeptin C

Catalog No.: A77381
Proteasome Inhibitor
Phepropeptin C is a proteasome inhibitor with a reported IC50 of 12.5 μg/mL. This microbial secondary metabolite disrupts protein degradation pathways, leading to the accumulation of regulatory proteins and altered cellular responses. Its ability to modulate proteasome activity makes it a valuable tool for research into cancer biology and other diseases characterized by dysregulated protein homeostasis.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
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Nature volume 551, pages639-643 (2017)
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Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPhepropeptin C is a proteasome inhibitor with a reported IC50 of 12.5 μg/mL. This microbial secondary metabolite disrupts protein degradation pathways, leading to the accumulation of regulatory proteins and altered cellular responses. Its ability to modulate proteasome activity makes it a valuable tool for research into cancer biology and other diseases characterized by dysregulated protein homeostasis.
Product Information
Catalog NumA77381
FormulaC38H60N6O6
Molecular Weight696.92
CAS Number396729-25-2
SMILESO=C1N2[C@](CCC2)([H])C(N[C@H](C(N[C@@H](C(N[C@@](C(N[C@H](C(N[C@@H]1CC3=CC=CC=C3)=O)CC(C)C)=O)([H])[C@@H](C)CC)=O)CC(C)C)=O)CC(C)C)=O
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