LMP7/LMP2-IN-1 is a potent inhibitor of the immunoproteasome subunits LMP7 and LMP2, exhibiting IC50 values of 257 nM and 10 nM, respectively. This compound effectively reduces antibody production and downregulates B cells in the germinal centers of the spleen as well as plasma cells in NP-OVA-immunized mice. LMP7/LMP2-IN-1 is valuable for research into autoimmune diseases and the modulation of immune responses.
LMP7/LMP2-IN-1 is a potent inhibitor of the immunoproteasome subunits LMP7 and LMP2, exhibiting IC50 values of 257 nM and 10 nM, respectively. This compound effectively reduces antibody production and downregulates B cells in the germinal centers of the spleen as well as plasma cells in NP-OVA-immunized mice. LMP7/LMP2-IN-1 is valuable for research into autoimmune diseases and the modulation of immune responses.
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