TCL1 is a selective non-covalent inhibitor that targets the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, exhibiting an IC50 of approximately 26 μM. By disrupting the recognition and transport of ubiquitinated proteins, TCL1 inhibits proteasomal degradation, thereby influencing intracellular protein metabolism. This compound shows significant potential for studying hematological malignancies and related therapeutic strategies.
TCL1 is a selective non-covalent inhibitor that targets the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, exhibiting an IC50 of approximately 26 μM. By disrupting the recognition and transport of ubiquitinated proteins, TCL1 inhibits proteasomal degradation, thereby influencing intracellular protein metabolism. This compound shows significant potential for studying hematological malignancies and related therapeutic strategies.
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