Cadmium pyrithione is a metal compound that serves as a potent proteasome inhibitor, specifically targeting protein deubiquitinase activity. Its application leads to significant accumulation of ubiquitinated proteins in cancer and primary leukemia cells, contributing to its anticancer effects. By prominently inhibiting deubiquitinase activities, such as USP14 and UCHL5, Cadmium pyrithione induces apoptosis via caspase activation, while showing a lesser impact on 20S proteasome activity. Additionally, its suppression of proteasome function has been demonstrated to impede tumor growth in animal xenograft models, highlighting its potential for cancer research.
Cadmium pyrithione is a metal compound that serves as a potent proteasome inhibitor, specifically targeting protein deubiquitinase activity. Its application leads to significant accumulation of ubiquitinated proteins in cancer and primary leukemia cells, contributing to its anticancer effects. By prominently inhibiting deubiquitinase activities, such as USP14 and UCHL5, Cadmium pyrithione induces apoptosis via caspase activation, while showing a lesser impact on 20S proteasome activity. Additionally, its suppression of proteasome function has been demonstrated to impede tumor growth in animal xenograft models, highlighting its potential for cancer research.
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