20S Proteasome-IN-2

Catalog No.: A77332
Proteasome Inhibitor
20S Proteasome-IN-2 is a selective inhibitor of the human 20S proteasome, specifically targeting the β5 subunit with an IC50 of 0.18 μM. This compound exhibits significant anti-proliferative effects in both in vitro and in vivo models, effectively inducing cell cycle arrest at the G2/M phase. It serves as a valuable tool for research focused on cancer biology and the mechanisms of proteasome function.
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5mg
10mg
50mg
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Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description20S Proteasome-IN-2 is a selective inhibitor of the human 20S proteasome, specifically targeting the β5 subunit with an IC50 of 0.18 μM. This compound exhibits significant anti-proliferative effects in both in vitro and in vivo models, effectively inducing cell cycle arrest at the G2/M phase. It serves as a valuable tool for research focused on cancer biology and the mechanisms of proteasome function.
Product Information
Catalog NumA77332
FormulaC30H44N4O8S
Molecular Weight620.76
CAS Number2028300-31-2
SMILESO=C(N[C@@H](COC)C(N[C@@H](CC(C)C)C(C1=CC=CO1)=O)=O)[C@@H](NS(=O)(C2=CC=C(C)C=C2)=O)CC(NCC(C)(C)C)=O
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