TIR-199 is a selective dual proteasome inhibitor targeting the PSMB5 subunit of the constitutive proteasome and the PSMB8 subunit of the immunoproteasome. This compound exhibits significant cytotoxicity against various tumor cell lines, making it a valuable tool for cancer research. TIR-199 is particularly relevant for studies focused on multiple myeloma and the underlying mechanisms of proteasome inhibition in neoplastic cell death.
TIR-199 is a selective dual proteasome inhibitor targeting the PSMB5 subunit of the constitutive proteasome and the PSMB8 subunit of the immunoproteasome. This compound exhibits significant cytotoxicity against various tumor cell lines, making it a valuable tool for cancer research. TIR-199 is particularly relevant for studies focused on multiple myeloma and the underlying mechanisms of proteasome inhibition in neoplastic cell death.
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