ZINC09518833 is an α-ketoamide nonpeptidic proteasome inhibitor that demonstrates effective binding to both primed and nonprimed sites of the proteasome, with an IC50 value of 12.4 μM. This compound exhibits significant biological activity relevant to the treatment of multiple myeloma (MM), making it a valuable tool for research in cancer biology and therapeutic development. Its mechanism of action provides insights into proteasomal degradation pathways and their role in oncogenesis.
ZINC09518833 is an α-ketoamide nonpeptidic proteasome inhibitor that demonstrates effective binding to both primed and nonprimed sites of the proteasome, with an IC50 value of 12.4 μM. This compound exhibits significant biological activity relevant to the treatment of multiple myeloma (MM), making it a valuable tool for research in cancer biology and therapeutic development. Its mechanism of action provides insights into proteasomal degradation pathways and their role in oncogenesis.
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