(S)-Thalidomide-5-OH is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker, thereby enabling the formation of a PROTAC (proteolysis-targeting chimaera). It serves as a valuable tool in drug discovery and development, particularly in the context of targeted protein degradation strategies.
(S)-Thalidomide-5-OH is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker, thereby enabling the formation of a PROTAC (proteolysis-targeting chimaera). It serves as a valuable tool in drug discovery and development, particularly in the context of targeted protein degradation strategies.
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