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(S)-Thalidomide-5-OH

Ligand for E3 Ligase

(S)-Thalidomide-5-OH is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker, thereby enabling the formation of a PROTAC (proteolysis-targeting chimaera). It serves as a valuable tool in drug discovery and development, particularly in the context of targeted protein degradation strategies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	172333-29-8
Applications	Ligand for E3 Ligase
Formula	C₁₃H₁₀N₂O₅
Molecular Weight	274.23
SMILES	O=C1N(C(=O)C=2C1=CC(O)=CC2)[C@@H]3C(=O)NC(=O)CC3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.