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CRBN ligand-414

Ligand for E3 Ligase

CRBN ligand-414 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this essential protein in targeted protein degradation applications. By linking CRBN ligand-414 to a target protein ligand through a suitable linker, it can be utilized to construct PROTAC molecules for the specific degradation of desired proteins. This compound is instrumental in the study of ubiquitin-proteasome pathways and has significant implications in therapeutic research and drug discovery.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925101-70-6
Applications	Ligand for E3 Ligase
Formula	C₁₄H₁₁N₃O₃
Molecular Weight	269.26
SMILES	O=CC=1N=C2C(C=CC=C2N3C(=O)NC(=O)CC3)=CC1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.