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CRBN ligand-368

Ligand for E3 Ligase

CRBN ligand-368 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), essential for targeted protein degradation. It facilitates the recruitment of the cereblon protein, enabling the construction of PROTACs (proteolysis-targeting chimeras) by linking to a target protein ligand. This compound is valuable for research in ubiquitin-proteasome system studies and in the development of therapeutic strategies leveraging targeted protein degradation.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925084-35-9
Applications	Ligand for E3 Ligase
Formula	C₁₂H₉ClN₄O₂
Molecular Weight	276.68
SMILES	O=C1NC(=O)CCN1C=2C=CC=3C=NN=C(Cl)C3C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.