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CRBN ligand-491

Ligand for E3 Ligase

CRBN ligand-491 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. This compound serves as a crucial component in the design of PROTACs (proteolysis-targeting chimeras), enabling targeted degradation of proteins in cellular systems. Its application is significant in drug discovery and the study of ubiquitin-mediated proteolysis.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925095-16-3
Applications	Ligand for E3 Ligase
Formula	C₁₄H₁₁N₃O₃
Molecular Weight	269.26
SMILES	O=CC1=NC=CC2=C1C=CC=C2N3C(=O)NC(=O)CC3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.