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CRBN ligand-384

Ligand for E3 Ligase

CRBN ligand-384 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound enables the synthesis of proteolysis-targeting chimeras (PROTACs) by linking with specific target protein ligands through a suitable linker. CRBN ligand-384 is significant in studying targeted protein degradation and biodegradation pathways, making it a valuable tool for researchers investigating cellular regulation and therapeutic interventions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925075-01-8
Applications	Ligand for E3 Ligase
Formula	C₁₁H₁₁N₅O₂
Molecular Weight	245.24
SMILES	O=C1NC(=O)CCN1C=2C=CC=3C(=NNC3C2)N

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.