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CRBN ligand-581

Ligand for E3 Ligase

CRBN ligand-581 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound effectively recruits the cereblon protein, facilitating targeted protein degradation through the formation of PROTACs (Proteolysis Targeting Chimeras). Its utility in research extends to the development of novel therapeutic strategies and the study of ubiquitin-mediated degradation pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925085-87-4
Applications	Ligand for E3 Ligase
Formula	C₁₂H₁₃N₅O₂
Molecular Weight	259.27
SMILES	O=C1NC(=O)CCN1C=2C=C(N)C3=C(C=NN3C)C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.