Catalog No.
Product Name
Application
Product Information
Citations
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Ligand for E3 Ligase
CRBN ligand-761 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated with a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). It is useful in research applications focused on targeted protein degradation and the modulation of cellular processes via ubiquitin-mediated pathways. -
E3 Ligase Activator
Thalidomide-1-Me,5-F is a fluorinated E3 ligase activator that functions by promoting the ubiquitination of target proteins. This compound exhibits key biological activity in modulating protein degradation pathways, making it valuable for research in cellular signaling and therapeutic interventions. Additionally, Thalidomide-1-Me,5-F can serve as a substrate for further derivatization via nucleophilic aromatic substitution (SNAr) reactions. -
Ligand for E3 Ligase
Hydrouracil-4-fluorobenzoate is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized to conjugate with target protein ligands through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). Its application is significant in the study of protein degradation pathways and therapeutic development targeting specific proteins for degradation. -
Ligand for E3 Ligase
CRBN ligand-430 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is designed for use in PROTAC (proteolysis targeting chimera) technology, allowing for targeted degradation of specific proteins when linked to a target protein ligand through a suitable linker. Its application is pivotal in the study of protein homeostasis and therapeutic development in diseases where protein dysregulation is a factor. -
Ligand for E3 Ligase
Desamino lenalidomide-5-C-COOH is a ligand for the E3 ubiquitin ligase cereblon (CRBN). It effectively recruits the cereblon protein, enabling the formation of targeted protein degraders. This compound can be connected to a target protein ligand through a linker, facilitating the development of proteolysis-targeting chimeras (PROTACs) for applications in drug discovery and biochemistry research. -
Immunomodulatory/Antineoplastic Agent
Lenalidomide hydrochloride is an oral immunomodulatory agent targeting cereblon (CRBN), acting as a molecular glue. It promotes the selective ubiquitination and degradation of transcription factors IKZF1 and IKZF3 via the CRBN-CRL4 ubiquitin ligase complex. This mechanism effectively inhibits the growth of mature B-cell lymphomas, including multiple myeloma, while also inducing the release of IL-2 from T cells, making it valuable in cancer research and therapeutic applications. -
E3 Ligase Ligand
VHL Ligand 39 is a conjugate of the VHL E3 ligase, acting as a pivotal intermediate in the construction of PROTAC (proteolysis-targeting chimera) molecules. This compound facilitates targeted protein degradation by harnessing the ubiquitin-proteasome system, enabling researchers to modulate protein levels for various biological studies. Its applications extend to investigating cellular signaling pathways and therapeutic mechanisms involving targeted degradation of specific proteins. -
E3 Ligase Ligand
2-(2,6-Dioxopiperidin-3-yl)phthalimidine NMe is an E3 ligase ligand specifically targeting CRBN. This compound features an additional methyl group on the glutarimide moiety of thalidomide, which disrupts its binding affinity to the E3 ligase. It serves as a negative control for the NAMPT degrader SIAIS630121, making it a valuable tool for research involving targeted protein degradation and molecular pathways regulated by E3 ligases. -
Ligands for E3 Ligase
Lenalidomide-5-aminomethyl is a cereblon (CRBN) ligand that facilitates the recruitment of the CRBN protein, enabling targeted cellular degradation. This compound can be utilized as a key component in the development of PROTACs (proteolysis-targeting chimeras), which harness the ubiquitin-proteasome system for the selective degradation of specific proteins. Its significant role in E3 ligase-mediated pathways makes it valuable for research in targeted protein modulation and therapeutic development. -
Target protein ligand
Aster-A Ligand-3 is a target protein ligand that acts as a critical component for the synthesis of PROTAC Aster-A degrader. This compound facilitates targeted protein degradation, making it valuable in the study of protein homeostasis and cellular signaling pathways. Its application is relevant in drug discovery and therapeutic development, particularly for diseases related to protein dysregulation. -
E3 Ligase Ligand
E3 Ligase Ligand 26 is a selective ligand for E3 ubiquitin ligases, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in the synthesis of the PROTAC SOS1 degrader, contributing to targeted protein degradation research. Its application extends to studies of cellular pathways and potential therapeutic interventions for various diseases through the modulation of protein levels. -
E3 Ligase Ligand
E3 Ligase Ligand 46 is a potent ligand that targets E3 ligases, facilitating the development of targeted protein degradation strategies. It is specifically utilized in the synthesis of PROTAC SMARCA2/4 degrader-36, enabling the selective degradation of cellular proteins. This compound offers valuable insights into the role of E3 ligases in cellular signaling and protein homeostasis, making it essential for research in targeted therapeutics and protein regulation. -
Ligands for E3 Ligase
E3 ligase Ligand 42 is an E3 ubiquitin ligase ligand designed for targeted protein degradation applications. It can be conjugated to a target protein ligand via a linker, facilitating the synthesis of PROTAC AR Degrader-6. This compound effectively induces ubiquitination and subsequent degradation of proteins associated with cancer progression, making it a valuable tool for research in cancer biology and therapeutic development. -
E3 Ligase Ligand
E3 Ligase Ligand 68 is an E3 ligase ligand utilized in the development of PROTAC (proteolysis-targeting chimeras) molecules. It facilitates targeted protein degradation by enabling the conjugation of an E3 ligase to a ligand that binds the protein of interest. This reagent is essential for research applications aimed at studying protein homeostasis, disease mechanisms, and therapeutic interventions involving targeted protein degradation. -
MAGE-A11 Inhibitor
SJ1008066 is an inhibitor of the MAGE-A11 protein, demonstrating an IC50 of 0.13 μM. It specifically binds to the MAGE homology domain (MHD), effectively disrupting the interaction between MAGE-A11 and PCF11. This mechanism presents valuable opportunities for research into cancer biology and therapeutic strategies targeting MAGE-A11 associated pathways. -
Cereblon Binder
E3 Ligase Ligand 22 is a cereblon binder that facilitates the targeted degradation of Ikaros and Aiolos proteins through the ubiquitin-proteasome pathway. This compound is valuable for studies investigating protein homeostasis, immune regulation, and the mechanism of action of immunomodulatory drugs. Its selective interaction with cereblon makes it a useful tool for researchers exploring targeted protein degradation strategies in various biological contexts. -
Ligands for E3 Ligase
(R,S,S)-VH032-Me is a ligand for E3 ubiquitin ligase, playing a crucial role in targeted protein degradation through the ubiquitin-proteasome pathway. It can be conjugated to proteins via a linker to create PROTACs such as dTAGV-1-NEG, which facilitate the selective degradation of oncogenic proteins. This compound is essential for studies involving targeted protein degradation, offering valuable insights into cancer biology and therapeutic development.
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Ligand for E3 Ligase
Pomalidomide-5-O-CH3 is a synthetic derivative of Pomalidomide designed as a ligand for cereblon (CRBN), an E3 ubiquitin ligase. This compound facilitates the recruitment of CRBN, enabling targeted protein degradation through PROTAC (proteolysis targeting chimeras) technology. Pomalidomide-5-O-CH3 is valuable for research in targeted therapy and ubiquitin-proteasome system studies, contributing to insights in cancer treatment and cellular regulation. -
Ligands for E3 Ligase
KLHDC2-IN-1 is a ligand that specifically targets the ubiquitin E3 ligase KLHDC2, exhibiting a dissociation constant (Kd) of 160 nM. This compound facilitates the development of PROTACs, which are designed to induce degradation of BRD4 in cellular environments. Its application in cellular research underscores its potential utility in studying protein degradation mechanisms and therapeutic strategies targeting BRD4-related pathways. -
Ligands for E3 Ligase
E3 ligase Ligand 58 is a selective ligand for E3 ligases, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in targeted protein degradation, enabling researchers to explore cellular mechanisms and therapeutic applications. E3 ligase Ligand 58 serves as a valuable tool in drug development and biological research focused on post-translational modifications. -
Atox1/CCS PROTAC Degrader
DA-PROTAC is a selective PROTAC degrader targeting the copper ion-transport proteins Atox1 and CCS. By facilitating the recruitment of E3 ligase, DA-PROTAC promotes the ubiquitination and subsequent proteasomal degradation of both Atox1 and CCS. This compound is particularly valuable for research in triple negative breast cancer, allowing for the investigation of copper transport mechanisms and their implications in tumor biology. -
DCAF1 Ligand
CYCA-117-70 is a ligand for DCAF1, exhibiting a binding affinity (KD) of 70 μM. It serves as an effective chemical handle for the development of proteolysis-targeting chimeras (PROTACs) that recruit DCAF1. This compound is valuable in research aiming to modulate protein degradation pathways, providing insights into cellular regulation and potential therapeutic applications. -
Ligands for E3 Ligase
CRBN ligand-17 is an E3 ubiquitin ligase ligand that targets the cereblon (CRBN) substrate recognition domain. This compound is essential for the design and synthesis of PROTACs (proteolysis-targeting chimeras), which facilitate targeted protein degradation. Its application in research includes studying protein regulation mechanisms and investigating therapeutic strategies for various diseases. -
Ligands for E3 Ligase
Deoxy-thalidomide-OMe is an E3 ligase ligand that plays a crucial role in targeted protein degradation mechanisms. This compound is utilized in the synthesis of PROTAC LRRK2 Degrader-4, facilitating research in the modulation of LRRK2 activity, which has implications in neurodegenerative diseases. Its ability to selectively engage with E3 ligases makes it a valuable tool for advancing studies in protein homeostasis and therapeutic development. -
VHL Ligand
(S,R,R)-VH032 is a selective VHL ligand that facilitates targeted protein degradation through its interaction with the von Hippel-Lindau (VHL) E3 ubiquitin ligase complex. This compound serves as a crucial building block in the synthesis of PROTACs, specifically enabling the development of NCOA4 degrader-1. Its application in research highlights its potential for advancing studies in targeted protein degradation and therapeutic intervention strategies. -
Ligand for E3 Ligase
N-Demethylonalespib is an effective ligand for E3 ligase, playing a crucial role in ubiquitination pathways. This compound is instrumental in the synthesis of DDO3602, facilitating research into protein degradation and cellular regulation. Its application in cellular biology makes it a valuable tool for investigating E3 ligase-targeted therapies. -
Ligands for E3 Ligase
RA183 is a selective ligand for E3 ligases, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enables the targeted degradation of specific proteins by harnessing the ubiquitin-proteasome system, making it a valuable tool in chemical biology and drug discovery. RA183 can be utilized in various research applications aimed at elucidating protein function and developing innovative therapeutic strategies. -
Ligand for E3 Ligase
(S,R,S)-AHPC-Ala is a ligand for E3 ubiquitin ligases, facilitating targeted protein degradation via the ubiquitin-proteasome pathway. This compound is instrumental in the synthesis of PROTAC SMARCA2/4-degrader-23, which is utilized in studies focused on the modulation of the SMARCA2 and SMARCA4 proteins. Its applications encompass research in cancer biology and therapeutic development, contributing to the advancement of targeted therapies. -
E3 Ligase Ligand
Arg12 is a 12-amino acid peptide sequence that functions as a ligand for E3 ubiquitin ligases. This compound is valuable for the synthesis of PROTACs, including the PROTAC PLK1 Degrader-2. Additionally, Arg12 possesses cell-penetrating properties, enabling effective delivery of larger molecules into cells, making it a useful tool in cellular research and therapeutic applications. -
Ligands for E3 Ligase
Lenalidomide-4-aminomethyl is an E3 ligase ligand that specifically targets cereblon (CRBN), facilitating the recruitment of CRBN protein. This compound serves as an essential building block for the development of PROTAC molecules, enabling targeted protein degradation research. Its unique structural features make it a valuable tool for studying CRBN-mediated pathways and exploring therapeutic applications in cancer and other diseases. -
Active Compound
Pomalidomide-piperazine is an active compound that serves as a critical building block for the synthesis of E3 ligands utilized in PROTAC (Proteolysis Targeting Chimeras) development. This compound facilitates targeted protein degradation by linking a protein of interest to an E3 ubiquitin ligase, promoting a novel approach to protein modulation. Its application is significant in drug discovery and therapeutic research focused on precision medicine. -
Ligand for E3 Ligase
E3 Ligase Ligand 31 is a specific ligand for E3 ubiquitin ligases, facilitating targeted protein degradation via the ubiquitin-proteasome system. This compound is instrumental in the synthesis of PTOTAC HSD17B13 degrader 1, making it a valuable tool for research in protein homeostasis and related therapeutic applications. Its utility in studying E3 ligase interactions offers insights into the modulation of protein levels in cellular and biochemical contexts. -
Ligands for E3 Ligase
Cyclopropane-(S,R,S)-AHPC is a selective ligand for E3 ubiquitin ligases, which play a crucial role in ubiquitination processes affecting protein degradation and cellular regulation. This compound is valuable for research into post-translational modifications and protein interactions, enabling studies into cellular signaling pathways and disease mechanisms. Its ability to modulate E3 ligase activity makes it an essential tool for understanding protein homeostasis and developing targeted therapies. -
Ligands for E3 Ligase
E3 Ligase Ligand 44 serves as an effective ligand for E3 ligases, facilitating the development of proteolysis-targeting chimeras (PROTACs) such as the AR Degrader-7. Its primary mechanism involves engaging E3 ligases to promote targeted protein degradation, enabling precise modulation of cellular pathways. This compound is useful in research focused on protein homeostasis, targeted therapy, and the exploration of novel therapeutic strategies in cancer and other diseases. -
E3 ligase Ligand
E3 ligase Ligand 27 is a selective ligand targeting E3 ubiquitin ligases, facilitating the development of targeted protein degradation technologies. This compound is primarily utilized in the synthesis of the PROTAC BcI-2/BcI-xI Degrader-1, promoting the degradation of specific oncogenic proteins. Its application in research supports the investigation of novel therapeutic strategies in cancer treatment through the modulation of protein homeostasis. -
Ligands for E3 Ligase
VH032 analogue-2 is a selective ligand for the E3 ubiquitin ligase von Hippel-Lindau (VHL), facilitating its recruitment in cellular processes. This compound effectively removes its protective group under acidic conditions, enabling its direct utilization in the synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules. VH032 analogue-2 serves as a crucial intermediate for the development of VHL-based PROTACs, making it a valuable tool for research in targeted protein degradation and related fields. -
VHL Ligand
(S,S,S)-VH032 is a ligand for the E3 ubiquitin ligase von Hippel-Lindau (VHL), enabling targeted protein degradation through the formation of PROTACs. It plays a crucial role in the synthesis of PROTAC SGK3 degrader-2, facilitating the selective degradation of SGK3 and other target proteins. This compound is valuable for research in protein regulation and targeted therapeutic strategies. -
E3 Ligase Ligand
E3 Ligase Ligand 25 is a selective ligand for the E3 ubiquitin ligase, facilitating the synthesis of PROTACs, specifically the SOS1 degrader. This compound serves as a critical tool in studies aimed at targeted protein degradation, contributing to the advancement of therapeutic strategies in cancer and other diseases. Researchers can leverage E3 Ligase Ligand 25 to explore ubiquitin-mediated proteolysis and its implications in cellular regulation. -
Ligand for E3 Ligase
Acepromazine-OTs is a ligand for the E3 ligase TRIM21, facilitating the recruitment of this protein in cellular contexts. It can be conjugated to target proteins via a linker to create PROTAC molecules, such as TrimTAC1. Acepromazine-OTs is valuable in research for deciphering protein degradation pathways and exploring targeted protein modulation approaches in therapeutic applications. -
Cereblon Binder
E3 ligase Ligand 21 is a potent cereblon binder that facilitates the targeted degradation of Ikaros and Aiolos via the ubiquitin-proteasome pathway. This compound is valuable for research applications focusing on the modulation of transcription factors involved in hematologic malignancies and immune regulation. Its ability to selectively promote protein degradation makes it an important tool in the study of cellular homeostasis and targeted therapy development. -
E3 Ligase Ligand
E3 ligase Ligand 60 is a selective ligand for E3 ligase, facilitating the synthesis of JV8. This compound plays a pivotal role in targeted protein degradation research and investigation of E3 ligase-mediated pathways. It holds potential for advancing therapeutic strategies in various diseases by modulating protein levels through ubiquitin-proteasome pathways. -
E3 Ligase Ligand
Lenalidomide 5'-piperazine is an E3 ligase ligand that functions as a Cereblon (CRBN) recruitor. This compound can be utilized to create PROTAC (Proteolysis Targeting Chimeras) molecules by linking it to various target protein ligands through a suitable linker. Research applications include the study of targeted protein degradation and the modulation of cellular pathways related to tumorigenesis. -
Ligands for E3 Ligase
VH032-CH2-Boc is a Boc-modified variant of VH032 that functions as a ligand for the E3 ubiquitin ligase von Hippel-Lindau (VHL) protein. This compound is designed to remove the protecting group under acidic conditions, making it suitable for direct incorporation into the synthesis of PROTAC molecules. VH032-CH2-Boc serves as a critical intermediate in the development of PROTACs targeting VHL, facilitating the targeted degradation of various proteins for research applications in drug discovery and cellular biology. -
KLHDC2 Ligand
SJ46411 is a potent ligand for KLHDC2, demonstrating a binding affinity with a Kd of approximately 260 nM as determined by isothermal titration calorimetry. Additional characterization includes SPR Kd of 0.5 μM and a TR-FRET IC50 of 3.9 μM, alongside a notable increase in thermal stability indicated by a ΔTm of 6.0 °C. This compound is valuable for research involving KLHDC2 interactions and can aid in elucidating its biological roles and potential as a therapeutic target. -
E3 Ubiquitin Ligase Ligand
(S)-Deoxy-thalidomide functions as a ligand for E3 ubiquitin ligases, facilitating targeted protein degradation. When conjugated to a target protein via a linker, it forms PROTAC K-Ras Degrader-3, which specifically degrades KRAS mutant proteins. This compound is valuable for research applications in cancer therapeutics, particularly in studies aiming to modulate pathways involving KRAS mutations. -
Ligands for E3 Ligase
E3 Ligase Ligand 13 functions as a ligand for E3 ubiquitin ligases, facilitating the creation of PROTACs (proteolysis-targeting chimeras). These PROTACs are designed to induce ubiquitination-mediated degradation of proteins associated with cancer progression. This compound is essential for research focused on targeted protein degradation and the development of novel therapeutic strategies in oncology. -
Ligands for E3 Ligase Chemical
(R)-Pomalidomide-pyrrolidine is a ligand for the E3 ubiquitin ligase CRBN. It facilitates targeted protein degradation and is instrumental in the development of PROTACs (proteolysis-targeting chimeras). This compound is employed in research to explore novel therapeutic strategies for diverse diseases by harnessing the ubiquitin-proteasome system. -
VHL Ligand
(S,R,S,R)-AHPC-Me is a ligand for the von Hippel-Lindau (VHL) protein, promoting its recruitment in cellular processes. This compound is valuable for research applications involving the regulation of hypoxia-inducible factors (HIFs) and the study of oxygen sensing pathways. Its unique properties enable researchers to explore the mechanisms of VHL-mediated ubiquitination and degradation of target proteins, contributing to a better understanding of various cancers and metabolic disorders. -
E3 Ligase Ligand-Linker Conjugates
Thalidomide-azetidine-CHO is a synthesized ligand designed for E3 ligase applications, incorporating the thalidomide-based cereblon ligand. This compound enables targeted protein degradation through the PROTAC technology, facilitating precise modulation of protein levels within cells. Its key biological activity and role as a linker conjugate make it suitable for diverse research applications in drug discovery and cellular biology. -
Ligands for E3 Ligase
VH032 analogue-1 is an E3 ligase ligand that targets the von Hippel-Lindau (VHL) protein, facilitating its recruitment. This analogue serves as a key intermediate in the synthesis of PROTAC molecules by removing protective groups under acidic conditions. Its role in PROTAC synthesis makes it a valuable tool for researchers developing targeted protein degradation strategies.
