Catalog No.
Product Name
Application
Product Information
Citations
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E3 Ligase Ligand
Arg12 is a 12-amino acid peptide sequence that functions as a ligand for E3 ubiquitin ligases. This compound is valuable for the synthesis of PROTACs, including the PROTAC PLK1 Degrader-2. Additionally, Arg12 possesses cell-penetrating properties, enabling effective delivery of larger molecules into cells, making it a useful tool in cellular research and therapeutic applications. -
Ligands for E3 Ligase
Lenalidomide-4-aminomethyl is an E3 ligase ligand that specifically targets cereblon (CRBN), facilitating the recruitment of CRBN protein. This compound serves as an essential building block for the development of PROTAC molecules, enabling targeted protein degradation research. Its unique structural features make it a valuable tool for studying CRBN-mediated pathways and exploring therapeutic applications in cancer and other diseases. -
Active Compound
Pomalidomide-piperazine is an active compound that serves as a critical building block for the synthesis of E3 ligands utilized in PROTAC (Proteolysis Targeting Chimeras) development. This compound facilitates targeted protein degradation by linking a protein of interest to an E3 ubiquitin ligase, promoting a novel approach to protein modulation. Its application is significant in drug discovery and therapeutic research focused on precision medicine. -
Ligand for E3 Ligase
E3 Ligase Ligand 31 is a specific ligand for E3 ubiquitin ligases, facilitating targeted protein degradation via the ubiquitin-proteasome system. This compound is instrumental in the synthesis of PTOTAC HSD17B13 degrader 1, making it a valuable tool for research in protein homeostasis and related therapeutic applications. Its utility in studying E3 ligase interactions offers insights into the modulation of protein levels in cellular and biochemical contexts. -
Ligands for E3 Ligase
Cyclopropane-(S,R,S)-AHPC is a selective ligand for E3 ubiquitin ligases, which play a crucial role in ubiquitination processes affecting protein degradation and cellular regulation. This compound is valuable for research into post-translational modifications and protein interactions, enabling studies into cellular signaling pathways and disease mechanisms. Its ability to modulate E3 ligase activity makes it an essential tool for understanding protein homeostasis and developing targeted therapies. -
Ligands for E3 Ligase
E3 Ligase Ligand 44 serves as an effective ligand for E3 ligases, facilitating the development of proteolysis-targeting chimeras (PROTACs) such as the AR Degrader-7. Its primary mechanism involves engaging E3 ligases to promote targeted protein degradation, enabling precise modulation of cellular pathways. This compound is useful in research focused on protein homeostasis, targeted therapy, and the exploration of novel therapeutic strategies in cancer and other diseases. -
E3 ligase Ligand
E3 ligase Ligand 27 is a selective ligand targeting E3 ubiquitin ligases, facilitating the development of targeted protein degradation technologies. This compound is primarily utilized in the synthesis of the PROTAC BcI-2/BcI-xI Degrader-1, promoting the degradation of specific oncogenic proteins. Its application in research supports the investigation of novel therapeutic strategies in cancer treatment through the modulation of protein homeostasis. -
Ligands for E3 Ligase
VH032 analogue-2 is a selective ligand for the E3 ubiquitin ligase von Hippel-Lindau (VHL), facilitating its recruitment in cellular processes. This compound effectively removes its protective group under acidic conditions, enabling its direct utilization in the synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules. VH032 analogue-2 serves as a crucial intermediate for the development of VHL-based PROTACs, making it a valuable tool for research in targeted protein degradation and related fields. -
VHL Ligand
(S,S,S)-VH032 is a ligand for the E3 ubiquitin ligase von Hippel-Lindau (VHL), enabling targeted protein degradation through the formation of PROTACs. It plays a crucial role in the synthesis of PROTAC SGK3 degrader-2, facilitating the selective degradation of SGK3 and other target proteins. This compound is valuable for research in protein regulation and targeted therapeutic strategies. -
E3 Ligase Ligand
E3 Ligase Ligand 25 is a selective ligand for the E3 ubiquitin ligase, facilitating the synthesis of PROTACs, specifically the SOS1 degrader. This compound serves as a critical tool in studies aimed at targeted protein degradation, contributing to the advancement of therapeutic strategies in cancer and other diseases. Researchers can leverage E3 Ligase Ligand 25 to explore ubiquitin-mediated proteolysis and its implications in cellular regulation. -
Ligand for E3 Ligase
Acepromazine-OTs is a ligand for the E3 ligase TRIM21, facilitating the recruitment of this protein in cellular contexts. It can be conjugated to target proteins via a linker to create PROTAC molecules, such as TrimTAC1. Acepromazine-OTs is valuable in research for deciphering protein degradation pathways and exploring targeted protein modulation approaches in therapeutic applications. -
Cereblon Binder
E3 ligase Ligand 21 is a potent cereblon binder that facilitates the targeted degradation of Ikaros and Aiolos via the ubiquitin-proteasome pathway. This compound is valuable for research applications focusing on the modulation of transcription factors involved in hematologic malignancies and immune regulation. Its ability to selectively promote protein degradation makes it an important tool in the study of cellular homeostasis and targeted therapy development. -
E3 Ligase Ligand
E3 ligase Ligand 60 is a selective ligand for E3 ligase, facilitating the synthesis of JV8. This compound plays a pivotal role in targeted protein degradation research and investigation of E3 ligase-mediated pathways. It holds potential for advancing therapeutic strategies in various diseases by modulating protein levels through ubiquitin-proteasome pathways. -
E3 Ligase Ligand
Lenalidomide 5'-piperazine is an E3 ligase ligand that functions as a Cereblon (CRBN) recruitor. This compound can be utilized to create PROTAC (Proteolysis Targeting Chimeras) molecules by linking it to various target protein ligands through a suitable linker. Research applications include the study of targeted protein degradation and the modulation of cellular pathways related to tumorigenesis. -
Ligands for E3 Ligase
VH032-CH2-Boc is a Boc-modified variant of VH032 that functions as a ligand for the E3 ubiquitin ligase von Hippel-Lindau (VHL) protein. This compound is designed to remove the protecting group under acidic conditions, making it suitable for direct incorporation into the synthesis of PROTAC molecules. VH032-CH2-Boc serves as a critical intermediate in the development of PROTACs targeting VHL, facilitating the targeted degradation of various proteins for research applications in drug discovery and cellular biology. -
KLHDC2 Ligand
SJ46411 is a potent ligand for KLHDC2, demonstrating a binding affinity with a Kd of approximately 260 nM as determined by isothermal titration calorimetry. Additional characterization includes SPR Kd of 0.5 μM and a TR-FRET IC50 of 3.9 μM, alongside a notable increase in thermal stability indicated by a ΔTm of 6.0 °C. This compound is valuable for research involving KLHDC2 interactions and can aid in elucidating its biological roles and potential as a therapeutic target. -
E3 Ubiquitin Ligase Ligand
(S)-Deoxy-thalidomide functions as a ligand for E3 ubiquitin ligases, facilitating targeted protein degradation. When conjugated to a target protein via a linker, it forms PROTAC K-Ras Degrader-3, which specifically degrades KRAS mutant proteins. This compound is valuable for research applications in cancer therapeutics, particularly in studies aiming to modulate pathways involving KRAS mutations. -
Ligands for E3 Ligase
E3 Ligase Ligand 13 functions as a ligand for E3 ubiquitin ligases, facilitating the creation of PROTACs (proteolysis-targeting chimeras). These PROTACs are designed to induce ubiquitination-mediated degradation of proteins associated with cancer progression. This compound is essential for research focused on targeted protein degradation and the development of novel therapeutic strategies in oncology. -
Ligands for E3 Ligase Chemical
(R)-Pomalidomide-pyrrolidine is a ligand for the E3 ubiquitin ligase CRBN. It facilitates targeted protein degradation and is instrumental in the development of PROTACs (proteolysis-targeting chimeras). This compound is employed in research to explore novel therapeutic strategies for diverse diseases by harnessing the ubiquitin-proteasome system. -
VHL Ligand
(S,R,S,R)-AHPC-Me is a ligand for the von Hippel-Lindau (VHL) protein, promoting its recruitment in cellular processes. This compound is valuable for research applications involving the regulation of hypoxia-inducible factors (HIFs) and the study of oxygen sensing pathways. Its unique properties enable researchers to explore the mechanisms of VHL-mediated ubiquitination and degradation of target proteins, contributing to a better understanding of various cancers and metabolic disorders. -
E3 Ligase Ligand-Linker Conjugates
Thalidomide-azetidine-CHO is a synthesized ligand designed for E3 ligase applications, incorporating the thalidomide-based cereblon ligand. This compound enables targeted protein degradation through the PROTAC technology, facilitating precise modulation of protein levels within cells. Its key biological activity and role as a linker conjugate make it suitable for diverse research applications in drug discovery and cellular biology. -
Ligands for E3 Ligase
VH032 analogue-1 is an E3 ligase ligand that targets the von Hippel-Lindau (VHL) protein, facilitating its recruitment. This analogue serves as a key intermediate in the synthesis of PROTAC molecules by removing protective groups under acidic conditions. Its role in PROTAC synthesis makes it a valuable tool for researchers developing targeted protein degradation strategies. -
E3 Ligase Ligand
(R,S,S)-VH032-Me TFA is a selective E3 ligase ligand that serves as a crucial tool for the development of targeted protein degradation strategies. This compound is utilized in the synthesis of dTAGV-1 hydrochloride, facilitating research into ubiquitin-proteasome system modulation and its implications in cancer and cellular biology. Its ability to modulate E3 ligase activity makes it valuable for investigating innovative therapeutic approaches in biomedical research. -
BCL-xL/BCL-2 Ligand
BCL-xL/BCL-2 Ligand 1 is a selective ligand targeting BCL-xL and BCL-2 proteins. This compound serves as a crucial component in the development of PROTACs (proteolysis-targeting chimeras), which promote targeted degradation of specific proteins through E3 ligase recruitment. It is valuable for research focused on apoptosis, cancer biology, and therapeutic development aimed at modulating cell survival pathways. -
Ligand for E3 Ligase
(3S)Lenalidomide-5-Br is a potent ligand for E3 ubiquitin ligases, facilitating targeted protein degradation through the ubiquitin-proteasome system. This compound is instrumental in research applications involving the development of PROTACs, notably in the synthesis of Cbl-b-IN-1. Its unique structure allows for specific interaction with target proteins, making it a valuable tool in cellular and molecular biology studies. -
Ligands for E3 Ligase
VH032-NH-CO-CH2-NHBoc is a Boc-modified ligand that targets the von Hippel-Lindau (VHL) protein, functioning as a crucial component for developing Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the recruitment of VHL to specific target proteins, enabling targeted degradation of these proteins through the ubiquitin-proteasome pathway. Under acidic conditions, VH032-NH-CO-CH2-NHBoc removes the Boc protection, allowing for the formation of PROTAC molecules that capitalize on VHL's E3 ligase activity. Its application is significant in studies focusing on targeted protein degradation and therapeutic development. -
CRBN Ligand
CRBN Ligand-191 is an E3 ligase ligand that targets the cereblon (CRBN) protein, facilitating ubiquitination and subsequent degradation of tagged substrates. This compound is essential in the synthesis of PROTACs, such as the PROTAC ALK degrader-4, which enables selective degradation of specific oncoproteins. Researchers can utilize CRBN Ligand-191 to explore targeted protein degradation mechanisms and study protein homeostasis in various biological contexts. -
Ligands for E3 Ligase
VHL Ligand 36 is a selective ligand for the von Hippel-Lindau (VHL) E3 ligase, facilitating targeted ubiquitination of substrate proteins. This compound is instrumental in research applications focused on studying the VHL pathway and its implications in various cellular processes, including tumorigenesis and hypoxia response. Additionally, VHL Ligand 36 serves as a precursor for synthesizing SD-2301, expanding its utility in chemical biology investigations. -
Ligands for E3 Ligase
4-[(1E)-2-Nitroethenyl]benzoic acid is a specific ligand for E3 ligase, which plays a crucial role in ubiquitination and protein degradation. This compound facilitates the synthesis of PROTAC BRD4 Degrader-38, enabling targeted degradation of specific proteins within cellular pathways. Its application in protein targeting and degradation makes it a valuable tool for researchers investigating proteostasis and related therapeutic interventions. -
Cereblon Ligand
E3 Ligase Ligand 54 is a selective ligand for the E3 ubiquitin ligase Cereblon, playing a crucial role in targeted protein degradation. This compound facilitates the synthesis of PROTAC Degrader SJ44236, enabling the investigation of protein homeostasis and therapeutic strategies in cancer research. Its utility in studying ubiquitin-proteasome pathways makes it a valuable tool for drug discovery and development. -
Ligands for E3 Ligase
Pomalidomide 5'-fluoro-6'-piperazine-4-methylpiperidine hydrochloride is a ligand that targets the E3 ubiquitin ligase cereblon (CRBN). This compound is designed to facilitate the recruitment of cereblon protein for targeted protein degradation. Pomalidomide 5'-fluoro-6'-piperazine-4-methylpiperidine hydrochloride can be utilized in the development of PROTACs by linking to other protein ligands, enabling innovative research in protein homeostasis and disease modulation. -
E3 ligase ligand
DCAF11 ligand 2 is an E3 ligase ligand that facilitates the recruitment of DCAF11. This compound is essential for the development of PROTACs, specifically for synthesizing the BRD4 degrader LGF308, which targets BRD4 for ubiquitination and proteasomal degradation. The ability to harness DCAF11 ligand 2 in research applications contributes significantly to the advancement of targeted protein degradation strategies. -
E3 Ligase Ligand
CRBN ligand-895 is an E3 ubiquitin ligase ligand that specifically targets cereblon (CRBN), facilitating the recruitment of this crucial protein. This compound serves as a valuable building block for the synthesis of PROTACs, including PROTAC HDAC8 Degrader-4. Its application extends to the study of protein degradation pathways and the development of innovative therapeutic strategies in various disease models. -
E3 Ligase Ligand
E3 Ligase Ligand 34 is an E3 ligase ligand that facilitates targeted protein degradation through the development of PROTACs. This compound is integral to the synthesis of PROTAC SMARCA2/4-degrader-35, enabling the selective degradation of SMARCA2 and SMARCA4 proteins. Its application in research supports the exploration of protein homeostasis and regulation pathways within cellular processes. -
MDM2 E3 Ligase Inhibitor
MEL23 is an MDM2 E3 ligase inhibitor that specifically targets the E3 ligase activity of the MDM2-MDMX complex. This compound effectively inhibits the ubiquitination of MDM2 and p53, leading to decreased viability in cells expressing wild-type p53. Additionally, MEL23 stabilizes MDM2 through a mechanism that does not involve p53 transcription, making it a valuable tool for research into cancer biology and therapeutic strategies targeting the p53 pathway. -
Ligand for E3 Ligase
E3 Ligase Ligand 75 is a ligand designed to selectively engage E3 ubiquitin ligases. This compound plays a pivotal role in the development of proteolysis-targeting chimeras (PROTACs), including the synthesis of K-Ras Degrader-7. It facilitates targeted protein degradation, making it a valuable tool in studies of protein regulation and therapeutic applications in cancer research. -
E3 Ligase Ligand
RR-11055 is a ligand for the E3 ligase cereblon, demonstrating a binding affinity with a Ki value of 0.38 μM. This compound is instrumental in the synthesis of PROTAC degrader ERD-1233, making it valuable for research in targeted protein degradation and modular drug design. Its ability to interact with E3 ligases positions RR-11055 as a significant tool for studying ubiquitin-mediated proteolysis. -
E3 ligase ligand
(S)-(S,R,S,R)-AHPC-Me-N3 is an E3 ligase ligand that facilitates targeted protein degradation through the synthesis of PROTAC molecules. It plays a crucial role in the development of PROTAC SMARCA2 degrader-32, enabling precise modulation of protein levels in cellular systems. This compound is valuable for researchers focused on protein degradation therapies and E3 ligase research. -
Ligands for E3 Ligase
N-Boc-SBP-0636457-OH is a ligand specifically targeting E3 ubiquitin ligases, facilitating the recruitment of IAP E3 ligases. This compound can be conjugated with Bcl-xL ligands via a linker to create the PROTAC Bcl-xL degrader-1, advancing research in targeted protein degradation and therapeutic applications in cancer biology. Its utility in the development of bifunctional molecules positions it as a valuable tool for studying protein homeostasis and signaling pathways. -
Ligands for E3 Ligase
E3 Ligase Ligand 77 is a ligand targeting the CRBN type E3 ubiquitin ligase. This compound facilitates the synthesis of PROTACs, including PROTAC RET Degrader 1. Its primary application is in the development of targeted protein degradation strategies, enabling researchers to investigate and manipulate protein levels in various biological contexts. E3 Ligase Ligand 77 serves as a valuable tool in cellular and molecular biology studies. -
E3 Ubiquitin Ligase Binder
E3 Ubiquitin Ligase Binder-1 is a targeted ligand for E3 ubiquitin ligases, exhibiting potent binding affinity. This compound has significant implications in studies of protein degradation pathways and ubiquitination processes. It is especially useful in research focused on cellular signaling, protein homeostasis, and disease mechanisms related to ubiquitin-mediated proteolysis. -
Ligand for E3 Ligase
Thalidomide-methylpyrrolidine is a ligand for E3 ubiquitin ligases, serving as an important tool in the study of protein degradation pathways. This compound has potential applications in research focused on cellular signaling, proteostasis, and the modulation of the ubiquitin-proteasome system. Additionally, it can be utilized as a precursor in the synthesis of CW-3308, facilitating further investigation into its biological effects. -
Ligand for E3 Ligase
ALAPYIP is a specific ligand for E3 ubiquitin ligase, effectively recruiting the VHL-E3 ligase. This compound plays a critical role in ubiquitination processes and can be utilized in the synthesis of FPP29. ALAPYIP is valuable for research aimed at understanding protein degradation pathways and the regulation of cellular processes through controlled ubiquitin signaling. -
E3 Ligase Ligand
E3 Ligase Ligand 50 is a specific ligand for the E3 ubiquitin ligase Cereblon. This compound facilitates the synthesis of proteolysis-targeting chimeras (PROTACs), specifically the BTK Degrader-10. It serves as a valuable tool in research applications focused on targeted protein degradation and therapeutic interventions in various diseases. -
DCAF11 Ligand
DCAF11 ligand 1 is a specific ligand for the E3 ubiquitin ligase DCAF11. This compound is instrumental in the synthesis of PROTACs, specifically in the development of FF2039. Its utility in drug discovery and research applications makes it valuable for studies involving targeted protein degradation mechanisms. -
Ligand for E3 Ligase
(S,R,S)-AHPC-Ac is a ligand for E3 ubiquitin ligases, facilitating the ubiquitination process crucial for protein degradation. This compound is instrumental in the development of PROTACs, such as SMARCA2/4-degrader-22, and is utilized in research focusing on targeted protein degradation mechanisms. Its role in modulating E3 ligase activity makes it valuable for studies in cellular signaling and protein homeostasis. -
Ligands for E3 Ligase
(S,S,S)-VH032-cyclopropane-F is a ligand that targets E3 ubiquitin ligases, facilitating the selective degradation of specific proteins through the ubiquitin-proteasome system. This compound can be conjugated to target protein ligands using a linker to generate PROTAC derivatives, such as cis-VZ185, which are valuable tools for studying protein dynamics and cellular functions. Its unique mechanism provides opportunities for innovative research in targeted protein degradation and therapeutic development. -
Ligands for E3 Ligase
E3 Ligase Ligand 33 (56-9B) acts as a ligand for E3 ubiquitin ligases, facilitating the ubiquitination process crucial for protein degradation and regulation. This compound is particularly valuable in anti-cancer research, where modulation of protein turnover can influence tumor progression and cell survival. Its application in target identification and pathway analysis makes it an essential tool for advancing understanding of ubiquitin-mediated signaling. -
Ligand for E3 Ligase
(S,R,S)-AHPC-O-CF3 serves as a ligand for E3 ubiquitin ligases, facilitating targeted protein degradation through the ubiquitin-proteasome system. This compound can be utilized in the synthesis of PROTAC SMARCA2/4-degrader-20, which is instrumental for studying the modulation of SMARCA2 and SMARCA4 proteins. Its applications extend to research involving targeted therapy and novel drug development strategies in cancer and other diseases. -
VHL Ligand
(S,R,S)-AHPC dihydrochloride is a VH032-based ligand that facilitates the recruitment of the von Hippel-Lindau (VHL) protein. This compound can be conjugated to various target proteins, such as BCR-ABL1, using a linker to create PROTACs like GMB-475. GMB-475 demonstrates significant biological activity by inducing degradation of BCR-ABL1, exhibiting an IC50 of 1.11 μM in Ba/F3 cells. This compound is valuable for research in targeted protein degradation and therapeutic development.
