E3 Ligase Ligands

Cat. No.

A80487

CAS No.

2468780-76-7

Desamino lenalidomide-5-F

Desamino lenalidomide-5-F is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), essential for directing protein degradation via the ubiquitin-proteasome system. This compound facilitates the recruitment of cereblon and can be utilized to create PROTACs by conjugating it to target protein ligands through a linker. Desamino lenalidomide-5-F is instrumental in studies focusing on targeted protein degradation and the exploration of novel therapeutic strategies in various diseases.

Cat. No.

A80488

CAS No.

2304513-76-4

3-(6-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione

3-(6-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione functions as a Lenalidomide analog with potential utility in targeted protein degradation research. This compound exhibits properties that may facilitate the design of proteolysis-targeting chimeras (PROTACs), thereby enabling the selective degradation of proteins of interest. Further investigation into its biological activity could contribute to advancements in therapeutic strategies aimed at modulating cellular proteostasis and addressing various diseases.

Cat. No.

A80489

CAS No.

1448189-90-9

CRBN ligand-798

CRBN ligand-798 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. It can be conjugated to a target protein ligand via a linker to create a proteolysis-targeting chimera (PROTAC). This compound is valuable for research applications focused on targeted protein degradation and the modulation of cellular pathways involving CRBN.

Cat. No.

A80490

CAS No.

1547162-41-3

Pomalidomide-5-OH

Synonyms: 5-Hydroxy pomalidomide; CC-17368

Pomalidomide-5-OH (5-hydroxy pomalidomide) serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN protein. This compound can be utilized in the synthesis of PROTACs by linking it to other ligands, enabling targeted protein degradation. Its applications in chemical biology and drug discovery make it an essential tool for researchers investigating proteostasis and therapeutic strategies.

Cat. No.

A80491

CAS No.

2641512-77-6

CRBN ligand-394

CRBN ligand-394 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound is instrumental in the development of PROTACs by enabling the conjugation of target protein ligands through a linker. Its utility extends to studies in targeted protein degradation and therapeutic applications.

Cat. No.

A80492

CAS No.

2010986-87-3

VHL Ligand 14

VHL Ligand 14 is a specific ligand for the von Hippel-Lindau (VHL) protein, playing a crucial role in the development of PROTACs that target estrogen receptor α (ERα) for degradation. With a binding affinity of 196 nM, it facilitates the targeted ubiquitination and subsequent proteasomal degradation of ERα. This compound is primarily utilized in research applications focused on cancer biology and targeted protein degradation strategies.

Cat. No.

A80493

CAS No.

2222120-31-0

Lenalidomide 5'-piperazine hydrochloride

Lenalidomide 5'-piperazine hydrochloride is a ligand for the E3 ubiquitin ligase Cereblon (CRBN). It facilitates the recruitment of CRBN to target proteins, enabling the development of proteolysis-targeting chimera (PROTAC) molecules for targeted protein degradation. This compound is particularly useful in research focused on modulating protein levels in cellular pathways, contributing to the study of various diseases and therapeutic interventions.

Cat. No.

A80494

CAS No.

1797406-74-6

(S,S,S)-AHPC-Boc

Synonyms: (S,S,S)-VH032-Boc

(S,S,S)-AHPC-Boc is a stereoisomer of (S,R,S)-AHPC-Boc and serves as a valuable experimental control in research. This compound specifically relates to the recruitment of the von Hippel-Lindau (VHL) protein, which plays a critical role in targeted protein degradation through PROTAC technology. By providing a reliable reference point, (S,S,S)-AHPC-Boc facilitates investigations into the efficacy and selectivity of VHL ligands in cellular systems.

Cat. No.

A80496

CAS No.

2468780-87-0

Lenalidomide-6-F

Lenalidomide-6-F is a modified derivative of Lenalidomide that functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound effectively recruits CRBN, facilitating the targeted degradation of specific proteins via the PROTAC (proteolysis-targeting chimera) mechanism. Lenalidomide-6-F is valuable for research applications focused on the modulation of cellular protein levels and the development of novel therapeutic strategies in cancer and other diseases.

Cat. No.

A80497

CAS No.

2377643-33-7

2-Methoxyphenyl dihydrouracil

2-Methoxyphenyl dihydrouracil serves as a ligand for the cereblon (CRBN) protein, enhancing its interaction in targeted protein degradation assays. This compound is valuable for the development of PROTACs (Proteolysis Targeting Chimeras), facilitating studies in targeted therapy and protein regulation. Its applications extend to research focused on modulating protein levels and understanding ubiquitin-proteasome system mechanisms.

Cat. No.

A80498

CAS No.

2377644-59-0

Hydrouracil-3-Ph-COOH

Hydrouracil-3-Ph-COOH is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in biochemical applications. This compound is designed to be employed in the development of proteolysis-targeting chimeras (PROTACs) by linking to target protein ligands through a suitable linker, making it valuable in targeted protein degradation research. Its utility in creating complex biologics underscores its significance in advancing studies of protein modulation and therapeutic strategies.

Cat. No.

A80499

CAS No.

1547162-46-8

CC-17369

Synonyms: 7-Hydroxy pomalidomide; Pomalidomide metabolite M16

CC-17369 (7-Hydroxy pomalidomide) serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound, a metabolite of Pomalidomide, selectively recruits CRBN, making it a valuable tool in targeted protein degradation studies. CC-17369 can be conjugated to other ligands via a linker to create PROTACs, facilitating research into novel therapeutic strategies for diseases involving protein dysregulation.

Cat. No.

A80500

CAS No.

642072-48-8

MEL24

MEL24 is an inhibitor of the Mdm2 E3 ligase, which plays a critical role in regulating p53 protein levels. This compound significantly reduces cell survival and enhances sensitivity to DNA-damaging agents in a p53-dependent manner. MEL24 is primarily utilized in antitumor research, contributing to studies aimed at understanding and overcoming resistance in cancer therapies.

Cat. No.

A80501

CAS No.

2520105-60-4

Lenalidomide 5'-piperazine-4-methylpiperidine hydrochloride

Lenalidomide 5'-piperazine-4-methylpiperidine hydrochloride is an E3 ligase ligand designed for PROTAC (proteolysis-targeting chimera) development. This compound serves as a protein degrader, featuring a terminal piperidine that facilitates further chemical modifications. Its unique structure allows for enhanced interaction with target proteins, making it a valuable tool for studying targeted protein degradation in various research applications.

Cat. No.

A80502

CAS No.

2154343-28-7

CRBN ligand-660

CRBN ligand-660 is a ligand targeting the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker to construct a proteolysis-targeting chimera (PROTAC), making it useful in studies involving targeted protein degradation and cellular protein modulation. Its application in research enables the exploration of new therapeutic strategies by harnessing the ubiquitin-proteasome system.

Cat. No.

A80503

CAS No.

1547163-38-1

Thalidomide acid

Thalidomide acid is a Thalidomide analog that primarily functions as a target for Proteolysis Targeting Chimeras (PROTACs). It exhibits significant activity in modulating protein degradation and is utilized in chemical biology studies aimed at elucidating proteostasis and targeted therapeutics. This compound serves as a valuable tool in drug discovery and development, particularly for diseases related to dysregulated protein levels.

Cat. No.

A80504

CAS No.

2154356-63-3

2-(2,6-Dioxopiperidin-3-yl)-5-ethynylisoindoline-1,3-dione

2-(2,6-Dioxopiperidin-3-yl)-5-ethynylisoindoline-1,3-dione is a Thalidomide analog primarily engaged in protein degradation pathways through PROTAC technology. Exhibiting modulatory effects on the immune system and anti-angiogenic properties, this compound is instrumental in investigational studies targeting multiple myeloma and other malignancies. Its distinctive structural attributes facilitate the exploration of targeted therapies and the development of innovative drug delivery platforms.

Cat. No.

A80505

CAS No.

2923549-60-2

3-(4-Bromo-2-chlorophenyl)piperidine-2,6-dione

3-(4-Bromo-2-chlorophenyl)piperidine-2,6-dione is a ligand for the CRBN-type E3 ubiquitin ligase, facilitating targeted protein degradation via the PROTAC (proteolysis-targeting chimeras) approach. This compound can be employed in the development of novel therapeutics that harness the ubiquitin-proteasome system for selective removal of specific proteins. Its applications are significant in disease models where modulation of protein levels is desired for research and therapeutic purposes.

Cat. No.

A80506

CAS No.

2599846-40-7

CRBN ligand-224

CRBN ligand-224 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC), allowing for targeted degradation of proteins in cellular systems. Its application is significant in drug discovery and development, particularly for modulating the activity of specific proteins involved in various diseases.

Cat. No.

A80507

CAS No.

2291363-98-7

Desamino lenalidomide-pinacolborane

Desamino lenalidomide-pinacolborane is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand using a linker to create a PROTAC, enabling targeted protein degradation. Its applications extend to the study of ubiquitin-mediated pathways and drug development strategies aimed at modulating protein levels in various biological contexts.

Cat. No.

A80508

CAS No.

1198787-23-3

Desamino lenalidomide-NO2

Desamino lenalidomide-NO2 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in targeted protein degradation pathways. This compound can be conjugated to target protein ligands through a linker to design and develop PROTAC (proteolysis-targeting chimeras) molecules, enabling precise modulation of protein levels in research applications. Its utility in studying protein degradation mechanisms makes it a valuable tool for drug discovery and cancer research.

Cat. No.

A80509

CAS No.

2962967-27-5

CRBN ligand-11

CRBN ligand-11 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating targeted protein degradation. This compound is instrumental in the synthesis of PROTACs (Proteolysis Targeting Chimeras), which are employed in cellular research to modulate protein levels and investigate the role of specific proteins in various biological processes. Its utility in drug discovery and development marks it as a significant tool for researchers exploring innovative therapeutic approaches.

Cat. No.

A80510

CAS No.

2771069-76-0

GNE7599

GNE7599 is a high-affinity von Hippel-Lindau (VHL) ligand, characterized by a dissociation constant (Kd) of 540 pM. This compound serves as a crucial component for the development of Proteolysis Targeting Chimeras (PROTACs), facilitating the targeted degradation of specific proteins. Its ability to bind with high specificity to VHL makes it an invaluable tool for research in targeted protein modulation and therapeutic applications in cancer and other diseases.

Cat. No.

A80511

CAS No.

2230826-33-0

(R,S,S)-VH032

(R,S,S)-VH032 is a ligand for E3 ligase, specifically targeting the von Hippel-Lindau (VHL) protein. This compound inhibits the VHL/HIF-1α interaction and is pivotal in the synthesis of PROTACs. Notably, (R,S,S)-VH032 facilitates the development of tau-targeting small molecule PROTAC C004019, making it a valuable tool in research focused on targeted protein degradation and therapeutic applications.

Cat. No.

A80513

CAS No.

3070323-06-4

MS1262

MS1262 is a selective ligand for the E3 ubiquitin ligase SPOP, targeting the SPOP substrate GLP. This compound facilitates the recruitment of SPOP and is utilized in research to study ubiquitination processes and related signaling pathways. MS1262 serves as a precursor for the synthesis of MS479, further expanding its utility in chemical biology investigations.