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DMH-1

Catalog No.: A12820

ALK2 inhibitor

DMH-1

DMH-1 Chemical Structure

CAS NO. 1206711-16-1

DMH-1 is a selective inhibitor of the bone morphogenic protein (BMP) ALK2 receptor (IC50 = 108 nM).

Availability: In stock

Package Price Qty
10 mg
$80.00
25 mg
$150.00
50 mg
$230.00
100 mg
$500.00
10mM * 1mL in DMSO
$89.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Teresa Rayon, .et al. Species-specific pace of development is associated with differences in protein stability, Science, 2020, Sep 18;369(6510):eaba7667 PMID: 32943498

Biological Activity

DMH-1 is a selective inhibitor of the bone morphogenic protein (BMP) ALK2 receptor (IC50 = 108 nM).
Targets
ALK2
107.9 nM
In vitro (25°C) DMSO Warmed: 21 mg/mL (55.19 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+35% PEG 300+2% Tween 80+ddH2O 1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.29 mL 131.43 mL 262.85 mL
0.5 mM 5.26 mL 26.29 mL 52.57 mL
1 mM 2.63 mL 13.14 mL 26.29 mL
5 mM 0.53 mL 2.63 mL 5.26 mL

*The above data is based on the productmolecular weight 380.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12820
Actions Inhibitor
CAS No. 1206711-16-1
Formula C24H20N4O
M. Wt 380.44
Purity >98%
Synonyms DMH1
SMILES CC(C)OC1=CC=C(C=C1)C2=CN3C(=C(C=N3)C4=CC=NC5=CC=CC=C45)N=C2
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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