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Catalog No.: A11017

TGF-βR Inhibitor


LY2157299 Chemical Structure

CAS NO. 700874-72-2

LY2157299 is an orally active transforming growth factor beta receptor (TGF-βR) kinase inhibitor.

Availability: In stock

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5 mg
10 mg
25 mg
100 mg
10mM * 1mL in DMSO
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  • Satoshi Endo, .et al. Flavonol glycosides of Rosa multiflora regulates intestinal barrier function through inhibiting claudin expression in differentiated Caco-2 cells, Nutr Res, 2019, 4 November
  • Oguri G, .et al. Effects of methylglyoxal on human cardiac fibroblast: roles of transient receptor potential ankyrin 1 (TRPA1) channels., Am J Physiol Heart Circ Physiol., 2014, 307(9):H1339-52 PMID: 25172898

Biological Activity

LY2157299 is an orally active transforming growth factor beta receptor (TGF-βR) kinase inhibitor.
TβRI (Cell-free assay)
56 nM
In vitro (25°C) DMSO 66 mg/mL (178.65 mM)
Water Insoluble
Ethanol Insoluble
In vivo 1%CMC-Na 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.07 mL 135.35 mL 270.71 mL
0.5 mM 5.41 mL 27.07 mL 54.14 mL
1 mM 2.71 mL 13.54 mL 27.07 mL
5 mM 0.54 mL 2.71 mL 5.41 mL

*The above data is based on the productmolecular weight 369.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11017
Actions Inhibitor
CAS No. 700874-72-2
Formula C22H19N5O
M. Wt 369.4
Purity >98%
Synonyms LY-2157299

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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