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- Satoshi Endo, .et al. Flavonol glycosides of Rosa multiflora regulates intestinal barrier function through inhibiting claudin expression in differentiated Caco-2 cells, Nutr Res, 2019, 4 November
- Oguri G, .et al. Effects of methylglyoxal on human cardiac fibroblast: roles of transient receptor potential ankyrin 1 (TRPA1) channels., Am J Physiol Heart Circ Physiol., 2014, 307(9):H1339-52 PMID: 25172898
Biological Activity
LY2157299 is an orally active transforming growth factor beta receptor (TGF-βR) kinase inhibitor.
Targets
| TβRI (Cell-free assay) | ||||
| 56 nM |
| In vitro (25°C) | DMSO | 66 mg/mL (178.65 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 1%CMC-Na | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.07 mL | 135.35 mL | 270.71 mL |
| 0.5 mM | 5.41 mL | 27.07 mL | 54.14 mL |
| 1 mM | 2.71 mL | 13.54 mL | 27.07 mL |
| 5 mM | 0.54 mL | 2.71 mL | 5.41 mL |
*The above data is based on the productmolecular weight 369.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11017 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 700874-72-2 |
| Formula | C22H19N5O |
| M. Wt | 369.4 |
| Purity | >98% |
| Synonyms | LY-2157299 |
| SMILES | CC1=CC=CC(=N1)C2=NN3CCCC3=C2C4=C5C=C(C=CC5=NC=C4)C(=O)N |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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