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SB 431542


TGF-beta/Smad inhibitor

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Catalog No. A10826

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
SB 431542 10mg A10826-10

Regular Price: €76.00

Special Price: €68.40

SB 431542 25mg A10826-25

Regular Price: €152.00

Special Price: €136.80

SB 431542 50mg A10826-50

Regular Price: €285.00

Special Price: €256.50

SB 431542 100mg A10826-100

Regular Price: €532.00

Special Price: €478.80

SB 431542 10mM * 1mL in DMSO A10826-10mM-D

Regular Price: €76.00

Special Price: €68.40

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

SB 431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7 .

SB 431542

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Chemical Information

Catalog Num A10826
Actions Inhibitor
M. Wt 384.4
Formula C22H16N4O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 301836-41-9
Synonyms SB-431542, SB431542
SMILES C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5

Biological Activity

SB 431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7 .
ALK4 (Cell-free assay) ALK7 (Cell-free assay) ALK5 (Cell-free assay)
N/A94 nM


Solubility (25°C) * In vitro DMSO 77 mg/mL (200.31 mM)
Water <1 mg/mL (<1 mM)
Ethanol 3 mg/mL (7.8 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.01 mL 130.07 mL 260.15mL
0.5 mM 5.2 mL 26.01 mL 52.03 mL
1 mM 2.6 mL 13.01 mL 26.01 mL
5 mM 0.52 mL 2.6 mL 5.2 mL

*The above data is based on the productmolecular weight 384.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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