SB 431542

Catalog No.: A10826

TGF-beta/Smad inhibitor

SB 431542

SB 431542 Chemical Structure

CAS NO. 301836-41-9

SB 431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I ALK receptors ALK4, ALK5, and ALK7 .

Availability: In stock

Package Price Qty
10 mg
$80.00
25 mg
$160.00
50 mg
$300.00
100 mg
$560.00
10mM * 1mL in DMSO
$80.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Huong Pham, .et al. BMP11 Negatively Regulates Lipid Metabolism in C2C12 Muscle Cells, Biotechnol Bioprocess Eng, 2020, ID: 222137835
  • Tamara Chamberlin, .et al. Obesity Reduces Mammary Epithelial Cell TGFβ1 Activity Through Macrophage-Mediated Extracellular Matrix Remodeling, FASEB J, 2020, Jun;34(6):8611-8624 PMID: 32359100
  • Satoshi Endo, .et al. Flavonol glycosides of Rosa multiflora regulates intestinal barrier function through inhibiting claudin expression in differentiated Caco-2 cells, Nutr Res, 2019, 4 November

Biological Activity

SB 431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I ALK receptors ALK4, ALK5, and ALK7 .
Targets
ALK4 (Cell-free assay) ALK7 (Cell-free assay) ALK5 (Cell-free assay)
N/A94 nM
In vitro (25°C) DMSO 75 mg/mL (195.11 mM)
Water Insoluble
Ethanol 3 mg/mL (7.8 mM)
In vivo 2% DMSO+30% PEG 300+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.01 mL 130.07 mL 260.15 mL
0.5 mM 5.2 mL 26.01 mL 52.03 mL
1 mM 2.6 mL 13.01 mL 26.01 mL
5 mM 0.52 mL 2.6 mL 5.2 mL

*The above data is based on the productmolecular weight 384.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10826
Actions Inhibitor
CAS No. 301836-41-9
Formula C22H16N4O3
M. Wt 384.4
Purity >98%
Synonyms SB-431542, SB431542
SMILES C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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