SB 431542

Catalog No.: A10826

TGF-beta/Smad inhibitor

SB 431542 Chemical Structure

CAS NO. 301836-41-9

SB 431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7 .

Availability: In stock

Package Price Qty
10 mg

Regular Price: $80.00

Special Price $64.00

25 mg

Regular Price: $160.00

Special Price $128.00

50 mg

Regular Price: $300.00

Special Price $240.00

100 mg

Regular Price: $560.00

Special Price $448.00

10mM * 1mL in DMSO
$80.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

SB 431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7 .
Targets
ALK4 (Cell-free assay) ALK7 (Cell-free assay) ALK5 (Cell-free assay)
N/A94 nM
In vitro (25°C) DMSO 77 mg/mL (200.31 mM)
Water <1 mg/mL (<1 mM)
Ethanol 3 mg/mL (7.8 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.01 mL 130.07 mL 260.15 mL
0.5 mM 5.2 mL 26.01 mL 52.03 mL
1 mM 2.6 mL 13.01 mL 26.01 mL
5 mM 0.52 mL 2.6 mL 5.2 mL

*The above data is based on the productmolecular weight 384.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10826
Actions Inhibitor
M. Wt 384.4
Formula C22H16N4O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 301836-41-9
Synonyms SB-431542, SB431542
SMILES C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5

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