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Biological Activity
LDN-214117 is a selective and potent ALK2 inhibitor. LDN-214117 inhibited ALK2 most, with a biochemical IC50 of 24 nM.
Targets
| ALK2 | ||||
| 24 nM |
| In vitro (25°C) | DMSO | 74 mg/mL (176.39 mM) | |
| Water | Insoluble | ||
| Ethanol | 74 mg/mL (176.39 mM) | ||
| In vivo | 2% DMSO+30% PEG 300+2% Tween 80+ddH2O | 2 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.84 mL | 119.18 mL | 238.37 mL |
| 0.5 mM | 4.77 mL | 23.84 mL | 47.67 mL |
| 1 mM | 2.38 mL | 11.92 mL | 23.84 mL |
| 5 mM | 0.48 mL | 2.38 mL | 4.77 mL |
*The above data is based on the productmolecular weight 419.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16096 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1627503-67-6 |
| Formula | C25H29N3O3 |
| M. Wt | 419.52 |
| Purity | >98% |
| Synonyms | LDN214117, LDN 214117 |
| SMILES | COC1=C(OC)C(OC)=CC(C2=C(C)N=CC(C3=CC=C(N4CCNCC4)C=C3)=C2)=C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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