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LDN-214117

Name: LDN-214117
Brand: Adooq Bioscience
SKU: A16096
Availability: InStock

Cat. No. A16096 CAS 1627503-67-6

ALK2 inhibitor

LDN-214117 is a selective and potent ALK2 inhibitor. LDN-214117 inhibited ALK2 most, with a biochemical IC50 of 24 nM.

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Biological Activity

Target & Activity

Target	Activity	Value
ALK2		24 nM

Cellular Effect

Cell Line	Activity	Value	Description	Reference
C2C12	IC50	100 nM	Inhibition of BMP6-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assay	[PMID: 25101911]
C2C12	IC50	1022 nM	Inhibition of BMP4-induced BMP receptor in mouse C2C12 cells after 30 mins by luciferase reporter gene assay	[PMID: 25101911]
C2C12	IC50	960 nM	Inhibition of BMP2-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assay	[PMID: 25101911]
HEK-293T	IC50	1171 nM	Inhibition of ALK3 (unknown origin) expressed in HEK293T cells after 30 mins by luciferase reporter gene assay	[PMID: 25101911]
HEK-293T	IC50	16000 nM	Inhibition of TGFbeta1-induced TGFbeta type 1 ALK5 in HEK293T cells after 30 mins by luciferase reporter gene assay	[PMID: 25101911]
HEK-293T	IC50	27 nM	Inhibition of ALK1 (unknown origin) expressed in HEK293T cells after 30 mins by luciferase reporter gene assay	[PMID: 25101911]
HEK-293T	IC50	27 nM	Inhibition of ALK2 (unknown origin) expressed in HEK293T cells after 30 mins by luciferase reporter gene assay	[PMID: 25101911]

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1627503-67-6
Applications	ALK2 inhibitor
Formula	C₂₅H₂₉N₃O₃
Molecular Weight	419.52
SMILES	COC1=C(OC)C(OC)=CC(C2=C(C)N=CC(C3=CC=C(N4CCNCC4)C=C3)=C2)=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

Solvent	Reported Solubility
DMSO	74 mg/mL (176.39 mM)
Water	Insoluble
Ethanol	74 mg/mL (176.39 mM)

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

In Vivo Preparation

Concentration: 2 mg/mL
Vehicle: 2% DMSO+30% PEG 300+2% Tween 80+ddH2O

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.