Chk



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Catalog No. Product Name Application Product Information
A10113 SALE

AZD7762

Chk1 & Chk2 inhibitor
AZD7762 is a potent ATP-competitive checkpoint kinase inhibitor that drives checkpoint abrogation and potentiates DNA-targeted therapies.
A13575 SALE

BML-277

Chk2 Inhibitor
BML-277 (Chk2 Inhibitor II) is a Chk2 (checkpoint kinase 2) inhibitor.
A11108

CCT241533

Chk2 inhibitor
CCT241533 is a potent and selective Inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors.
A15038

CCT241533 hydrochloride

Chk2 inhibitor
CCT241533 Hcl is a potent serine/threonine checkpoint kinase (Chk2) inhibitor with IC50 of 3 nM; shows minimal cross-reactivity against a panel of kinases at 1 uM.
A15550

CCT244747

CHK1 inhibitor
CCT244747 is a novel potent, highly selective, orally active ATP-competitive CHK1 inhibitor with potential anticancer activity,
A11046 SALE

CHIR-124

CHK Inhibitor
CHIR-124 is a novel and potent Chk1 inhibitor (IC50: 0.32 nM and 697 nM for Chk1 and Chk2 respectively).
A11036 SALE

LY2603618 (IC-83)

Chk inhibitor
LY2603618 is a chk2 inhibitor that binds to and inhibits the activity of chk2, which may prevent the repair of DNA caused by DNA-damaging agents.
A10599 SALE

MK-1775

WEE1 Inhibitor
MK-1775 is a potent and selective Wee1 kinase inhibitor in vitro and in vivo.
A11520 SALE

PF 477736

Chk Inhibitor
PF 477736 is a selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively).
A15480 SALE

SB 218078

Chk1 Inhibitor
SB 218078 is an inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively)
A11167 SALE

SCH 900776 (MK-8776)

Chk1 inhibitor

SCH900776 is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. It specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents.

A12703 SALE

SCH900776 (S-isomer)

CHK1 Inhibitor
SCH900776 is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities.
A13403 SALE

ZCL-278

Cdc42 GTPase inhibitor
ZCL-278 is a selective inhibitor of Cdc42. Targets the binding site of the Cdc42 guanine nucleotide exchange factor, intersectin (ITSN). Inhibits Cdc42-mediated cellular effects, including microspike formation in 3T3 fibroblasts and neuronal branching in primary neonatal cortical neurons. Also suppresses cell motility and migration in PC3 cells, without cytotoxic effects.

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