BI 2536

Catalog No.: A10134

PLK inhibitor

BI 2536 Chemical Structure

CAS NO. 755038-02-9

BI 2536 is a selective inhibitor of Plk1, which inhibits Plk1 enzyme activity at low nanomolar concentrations.

Availability: In stock

Package Price Qty
5 mg
$70.00
10 mg
$120.00
50 mg
$320.00
100 mg
$580.00
10mM * 1mL in DMSO
$132.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

BI 2536 is a selective inhibitor of Plk1, which inhibits Plk1 enzyme activity at low nanomolar concentrations.
Targets
Target Value
PLK1IC50: 0.83nM
PLK2IC50: 3.5nM
PLK3IC50: 9.0nM
PI3KαIC50: 2.407μM
MetIC50: 4.754μM
Tie-2IC50: 6.549μM
HGFRIC50: 9.5μM
ErbB4IC50: 9.908μM
AblIC50: >10μM
AxlIC50: >10μM
AMPKIC50: >10μM
AuroraAIC50: >10μM
AuroraBIC50: >10μM
βIRKIC50: >10μM
B-RafIC50: >10μM
BTKIC50: >10μM
CDK1/CyclinB1IC50: >10μM
CDK2/CyclinEIC50: >10μM
Chk1IC50: >10μM
CK1IC50: >10μM
CK2IC50: >10μM
C-RafIC50: >10μM
CSKIC50: >10μM
DYRK1AIC50: >10μM
ECKIC50: >10μM
ERK2IC50: >10μM
FGFR1IC50: >10μM
FGFR3IC50: >10μM
FLT1IC50: >10μM
FLT3IC50: >10μM
GSK-3βIC50: >10μM
HekIC50: >10μM
HER2IC50: >10μM
ITKIC50: >10μM
JAK2IC50: >10μM
JAK3IC50: >10μM
JNK1IC50: >10μM
LCKIC50: >10μM
LynIC50: >10μM
MAPKAPK2IC50: >10μM
MEK1IC50: >10μM
MSK1IC50: >10μM
MKK1IC50: >10μM
NEK6IC50: >10μM
p38αIC50: >10μM
p38βIC50: >10μM
p38γIC50: >10μM
p38δIC50: >10μM
PAK2IC50: >10μM
PDGFRαIC50: >10μM
PDGFRβIC50: >10μM
PDK-1IC50: >10μM
PKAIC50: >10μM
PKBαIC50: >10μM
PKBβIC50: >10μM
PKCαIC50: >10μM
PRAKIC50: >10μM
RETIC50: >10μM
ROCK2IC50: >10μM
RONIC50: >10μM
S6KIC50: >10μM
SGKIC50: >10μM
SrcIC50: >10μM
SykIC50: >10μM
In vitro (25°C) DMSO 21 mg/mL (40.25 mM)
Water <1 mg/mL (<1 mM)
Ethanol 100 mg/mL (191.69 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.17 mL 95.84 mL 191.68 mL
0.5 mM 3.83 mL 19.17 mL 38.34 mL
1 mM 1.92 mL 9.58 mL 19.17 mL
5 mM 0.38 mL 1.92 mL 3.83 mL

*The above data is based on the productmolecular weight 521.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10134
Actions Inhibitor
M. Wt 521.7
Formula C28H39N7O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 755038-02-9
Synonyms BI2536, BI-2536
SMILES CC[[email protected]@H]1C(=O)N(C2=CN=C(N=C2N1C3CCCC3)NC4=C(C=C(C=C4)C(=O)NC5CCN(CC5)C)OC)C

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