BI 2536

Name: BI 2536
SKU: A10134
Price: 70 USD
Rating: 5 (10 reviews)

Catalog No.: A10134

PLK inhibitor

Adooq's BI 2536 has been cited by 10 publications

BI 2536 is a selective inhibitor of Plk1, which inhibits Plk1 enzyme activity at low nanomolar concentrations.

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Data Sheet

SDS

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Adooq Products cited in reputable paper

Adooq's BI 2536 has been cited by 10 publications

Nuria Gallisa-Sune, .et al. , Nat Commun, 2023, Apr 27;14(1):2434 PMID: 37105961

Kei K Ito, .et al. , J Cell Biol, 2021, Mar 1;220(3):e202005153 PMID: 33492359

Ryuzaburo Yuki, .et al. , J Cell Mol Med, 2021, Feb;25(3):1677-1687 PMID: 33465289

Yamagishi A, .et al. , Int J Mol Sci, 2020, Feb 5;21(3) PMID: 32033461

Bucko PJ, .et al. , Elife, 2019, Dec 24;8. pii: e52220 PMID: 31872801

Watanabe K, .et al. , Nat Commun, 2019, Feb 25;10(1):931 PMID: 30804344

Valérian Pasche, .et al. , Parasit Vectors, 2018, 11: 298 PMID: 29764454

Takeshi Wakida, .et al. , eLife, 2017, 6: e29953 PMID: 29254517

Majid Momeny, .et al. , Sci Rep, 2017, 7: 4204 PMID: 28646172

Ifuji A, .et al. , Exp Cell Res, 2017, Nov 15;360(2):347-357 PMID: 28942021

Biological Activity

Discription

BI 2536 is a selective inhibitor of Plk1, which inhibits Plk1 enzyme activity at low nanomolar concentrations.

Targets

Target	Value

Chemical Information

Catalog Num	A10134
Formula	C28H39N7O3
Molecular Weight	521.7
CAS Number	755038-02-9
SMILES	CC[C@@H]1C(=O)N(C2=CN=C(N=C2N1C3CCCC3)NC4=C(C=C(C=C4)C(=O)NC5CCN(CC5)C)OC)C
Synonyms	BI2536, BI-2536
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility

In vitro (25°C)	DMSO	21 mg/mL (40.25 mM)
	Water	Insoluble
	Ethanol	98 mg/mL (187.86 mM)
In vivo	30% PEG 400+0.5% Tween 80+5% Propylene glycol	14 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.17 mL	95.84 mL	191.68 mL
0.5 mM	3.83 mL	19.17 mL	38.34 mL
1 mM	1.92 mL	9.58 mL	19.17 mL
5 mM	0.38 mL	1.92 mL	3.83 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Product Name	Price	Stock
BI 2536 5mg	$70.00	In stock
BI 2536 10mg	$120.00	In stock
BI 2536 50mg	$320.00	In stock
BI 2536 100mg	$580.00	In stock
*BI 2536 10mM 1mL in DMSO**	$132.00	In stock