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- Val谷rian Pasche,et al. Screening a repurposing library, the Medicines for Malaria Venture Stasis Box, against Schistosoma mansoni, Parasit Vectors, 2018, 11: 298 29764454
- Takeshi Wakida,et al. The CDK-PLK1 axis targets the DNA damage checkpoint sensor protein RAD9 to promote cell proliferation and tolerance to genotoxic stress, eLife, 2017, 6: e29953 29254517
- Majid Momeny,et al. Dacomitinib, a pan-inhibitor of ErbB receptors, suppresses growth and invasive capacity of chemoresistant ovarian carcinoma cells, Sci Rep, 2017, 7: 4204 28646172
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|Storage||at -20°C 3 years Powder|
|SMILES code||CC[[email protected]@H]1C(=O)N(C2=CN=C(N=C2N1C3CCCC3)NC4=C(C=C(C=C4)C(=O)NC5CCN(CC5)C)OC)C|
|BI 2536 is a selective inhibitor of Plk1, which inhibits Plk1 enzyme activity at low nanomolar concentrations.|
|Solubility (25°C) *||In vitro||DMSO||21 mg/mL (40.25 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||100 mg/mL (191.69 mM)|
|In vivo||30% PEG400/0.5% Tween80/5% propylene glycol||15 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||19.17 mL||95.84 mL||191.68mL|
|0.5 mM||3.83 mL||19.17 mL||38.34 mL|
|1 mM||1.92 mL||9.58 mL||19.17 mL|
|5 mM||0.38 mL||1.92 mL||3.83 mL|
*The above data is based on the productmolecular weight 521.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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