RO3280

Catalog No.: A13245

PLK1 inhibitor

RO3280

RO3280 Chemical Structure

CAS NO. 1062243-51-9

RO3280 is a potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 3 nM.

Availability: In stock

Package Price Qty
5 mg
$120.00
10 mg
$200.00
25 mg
$400.00
50 mg
$700.00
10mM * 1mL in DMSO
$189.00
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Biological Activity

RO3280 is a potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 3 nM.
In vitro DMSO 87 mg/mL (160.04 mM)
Water Insoluble
Ethanol 87 mg/mL (160.04 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.4 mL 91.98 mL 183.96 mL
0.5 mM 3.68 mL 18.4 mL 36.79 mL
1 mM 1.84 mL 9.2 mL 18.4 mL
5 mM 0.37 mL 1.84 mL 3.68 mL

*The above data is based on the productmolecular weight 543.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13245
Actions Inhibitor
CAS No. 1062243-51-9
Formula C27H35F2N7O3
M. Wt 543.61
Solubility DMSO
Purity >98%
Synonyms RO 3280, RO-3280
SMILES CN1CCC(CC1)NC(=O)C2=CC(=C(C=C2)NC3=NC=C4C(=N3)N(CC(C(=O)N4C)(F)F)C5CCCC5)OC
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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