NMS-1286937

Catalog No.: A13045

PLK inhibitor

NMS-1286937

NMS-1286937 Chemical Structure

CAS NO. 1034616-18-6

NMS-1286937 is an orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity.

Availability: In stock

Package Price Qty
10 mg
$100.00
25 mg
$180.00
50 mg
$260.00
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Biological Activity

NMS-1286937 is an orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity.
Targets
PLK1 PLK2 PLK3
2 nM>10 μM>10 μM
In vitro DMSO Warmed: 38 mg/mL (71.36 mM)
Water Insoluble
Ethanol Warmed: 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.78 mL 93.89 mL 187.79 mL
0.5 mM 3.76 mL 18.78 mL 37.56 mL
1 mM 1.88 mL 9.39 mL 18.78 mL
5 mM 0.38 mL 1.88 mL 3.76 mL

*The above data is based on the productmolecular weight 532.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13045
Actions Inhibitor
CAS No. 1034616-18-6
Formula C24H27F3N8O3
M. Wt 532.52
Purity >98%
Synonyms NMS1286937, NMS-P937
SMILES CN1CCN(CC1)C2=CC(=C(C=C2)OC(F)(F)F)NC3=NC=C4CCC5=C(C4=N3)N(N=C5C(=O)N)CCO
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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