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BI6727 (Volasertib)

Catalog No.: A10135

PLK Inhibitor

BI6727 (Volasertib)

BI6727 (Volasertib) Chemical Structure

CAS NO. 755038-65-4

BI6727 is a highly potent and selective polo-like kinase (PLK) 1 inhibitor (enzyme IC50 = 0.87 nM, EC50 = 11-37 nM on a panel of cancer cell lines).

Availability: In stock

Package Price Qty
5 mg

Regular Price: $75.00

Special Price $60.00

10 mg

Regular Price: $139.00

Special Price $111.20

50 mg

Regular Price: $450.00

Special Price $360.00

100 mg

Regular Price: $750.00

Special Price $600.00

10mM * 1mL in DMSO

Regular Price: $152.00

Special Price $121.60

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Xiaofei Xin, .et al. ROS responsive polymeric micelles for triggered simultaneous delivery of PLK1 inhibitor/miR-34a and effective synergistic therapy in pancreatic cancer, ACS Appl Mater Interfaces, 2019, 2019

Biological Activity

BI6727 is a highly potent and selective polo-like kinase (PLK) 1 inhibitor (enzyme IC50 = 0.87 nM, EC50 = 11-37 nM on a panel of cancer cell lines).
PLK1 (Cell-free assay)
0.87 nM
In vitro (25°C) DMSO Warmed: 19 mg/mL (30.7 mM)
Water Insoluble
Ethanol Insoluble
In vivo 4% DMSO+corn oil 1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.16 mL 80.8 mL 161.6 mL
0.5 mM 3.23 mL 16.16 mL 32.32 mL
1 mM 1.62 mL 8.08 mL 16.16 mL
5 mM 0.32 mL 1.62 mL 3.23 mL

*The above data is based on the productmolecular weight 618.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10135
Actions Inhibitor
CAS No. 755038-65-4
Formula C34H50N8O3
M. Wt 618.8
Purity >98%
Synonyms Volasertib, BI-6727
SMILES CC[[email protected]@H]1C(=O)N(C2=CN=C(N=C2N1C(C)C)NC3=C(C=C(C=C3)C(=O)NC4CCC(CC4)N5CCN(CC5)CC6CC6)OC)C

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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