BI6727 (Volasertib)

Catalog No.: A10135

PLK Inhibitor

BI6727 (Volasertib)

BI6727 (Volasertib) Chemical Structure

CAS NO. 755038-65-4

BI6727 is a highly potent and selective polo-like kinase (PLK) 1 inhibitor (enzyme IC50 = 0.87 nM, EC50 = 11-37 nM on a panel of cancer cell lines).

Availability: In stock

Package Price Qty
5 mg

Regular Price: $75.00

Special Price $60.00

10 mg

Regular Price: $139.00

Special Price $111.20

50 mg

Regular Price: $450.00

Special Price $360.00

100 mg

Regular Price: $750.00

Special Price $600.00

10mM * 1mL in DMSO
$152.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

BI6727 is a highly potent and selective polo-like kinase (PLK) 1 inhibitor (enzyme IC50 = 0.87 nM, EC50 = 11-37 nM on a panel of cancer cell lines).
Targets
PLK1 (Cell-free assay)
0.87 nM
In vitro (25°C) DMSO 50 mg/mL (80.8 mM)
Water <1 mg/mL (<1 mM)
Ethanol 124 mg/mL (200.38 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.16 mL 80.8 mL 161.6 mL
0.5 mM 3.23 mL 16.16 mL 32.32 mL
1 mM 1.62 mL 8.08 mL 16.16 mL
5 mM 0.32 mL 1.62 mL 3.23 mL

*The above data is based on the productmolecular weight 618.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A10135
Actions Inhibitor
M. Wt 618.8
Formula C34H50N8O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 755038-65-4
Synonyms Volasertib, BI-6727
SMILES CC[[email protected]@H]1C(=O)N(C2=CN=C(N=C2N1C(C)C)NC3=C(C=C(C=C3)C(=O)NC4CCC(CC4)N5CCN(CC5)CC6CC6)OC)C

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