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- Xiaofei Xin, .et al. ROS responsive polymeric micelles for triggered simultaneous delivery of PLK1 inhibitor/miR-34a and effective synergistic therapy in pancreatic cancer, ACS Appl Mater Interfaces, 2019, 2019
Biological Activity
BI6727 is a highly potent and selective polo-like kinase (PLK) 1 inhibitor (enzyme IC50 = 0.87 nM, EC50 = 11-37 nM on a panel of cancer cell lines).
Targets
| PLK1 (Cell-free assay) | ||||
| 0.87 nM |
| In vitro (25°C) | DMSO | Warmed: 19 mg/mL (30.7 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 4% DMSO+corn oil | 1 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.16 mL | 80.8 mL | 161.6 mL |
| 0.5 mM | 3.23 mL | 16.16 mL | 32.32 mL |
| 1 mM | 1.62 mL | 8.08 mL | 16.16 mL |
| 5 mM | 0.32 mL | 1.62 mL | 3.23 mL |
*The above data is based on the productmolecular weight 618.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10135 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 755038-65-4 |
| Formula | C34H50N8O3 |
| M. Wt | 618.8 |
| Purity | >98% |
| Synonyms | Volasertib, BI-6727 |
| SMILES | CC[[email protected]@H]1C(=O)N(C2=CN=C(N=C2N1C(C)C)NC3=C(C=C(C=C3)C(=O)NC4CCC(CC4)N5CCN(CC5)CC6CC6)OC)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
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