GSK461364

Catalog No.: A10442

PLK Inhibitor

GSK461364

GSK461364 Chemical Structure

CAS NO. 929095-18-1

GSK461364 is an ATP-competitive inhibitor of polo-like kinase 1 (Plk1).

Availability: In stock

Package Price Qty
5 mg

Regular Price: $80.00

Special Price $72.00

10 mg

Regular Price: $150.00

Special Price $135.00

25 mg

Regular Price: $300.00

Special Price $270.00

50 mg

Regular Price: $480.00

Special Price $432.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

GSK461364 is an ATP-competitive inhibitor of polo-like kinase 1 (Plk1).
Targets
PLK1 (Cell-free assay)
2.2 nM(Ki)
In vitro (25°C) DMSO 10 mg/mL (18.39 mM)
Water <1 mg/mL (<1 mM)
Ethanol 30 mg/mL (55.18 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.4 mL 91.98 mL 183.96 mL
0.5 mM 3.68 mL 18.4 mL 36.79 mL
1 mM 1.84 mL 9.2 mL 18.4 mL
5 mM 0.37 mL 1.84 mL 3.68 mL

*The above data is based on the productmolecular weight 543.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A10442
Actions Inhibitor
M. Wt 543.6
Formula C27H28F3N5O2S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 929095-18-1
Synonyms GSK 461364, GSK-461364
SMILES C[[email protected]](C1=CC=CC=C1C(F)(F)F)OC2=C(SC(=C2)N3C=NC4=C3C=C(C=C4)CN5CCN(CC5)C)C(=O)N

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