Catalog No.: A10442

PLK Inhibitor


GSK461364 Chemical Structure

CAS NO. 929095-18-1

GSK461364 is an ATP-competitive inhibitor of polo-like kinase 1 (Plk1).

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Biological Activity

GSK461364 is an ATP-competitive inhibitor of polo-like kinase 1 (Plk1).
PLK1 (Cell-free assay)
2.2 nM(Ki)
In vitro (25°C) DMSO 9 mg/mL (16.55 mM)
Water Insoluble
Ethanol 27 mg/mL (49.66 mM)
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.4 mL 91.98 mL 183.96 mL
0.5 mM 3.68 mL 18.4 mL 36.79 mL
1 mM 1.84 mL 9.2 mL 18.4 mL
5 mM 0.37 mL 1.84 mL 3.68 mL

*The above data is based on the productmolecular weight 543.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10442
Actions Inhibitor
CAS No. 929095-18-1
Formula C27H28F3N5O2S
M. Wt 543.6
Purity >98%
Synonyms GSK 461364, GSK-461364
SMILES C[[email protected]](C1=CC=CC=C1C(F)(F)F)OC2=C(SC(=C2)N3C=NC4=C3C=C(C=C4)CN5CCN(CC5)C)C(=O)N

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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