PF 477736

Catalog No.: A11520

Chk Inhibitor

PF 477736

PF 477736 Chemical Structure

CAS NO. 952021-60-2

PF 477736 is a selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively).

Availability: In stock

Package Price Qty
5 mg

Regular Price: $90.00

Special Price $81.00

10 mg

Regular Price: $140.00

Special Price $126.00

25 mg

Regular Price: $280.00

Special Price $252.00

50 mg

Regular Price: $450.00

Special Price $405.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

PF 477736 is a selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively).
Targets
Chk1 (Cell-free assay) VEGFR2 (Cell-free assay) Fms (Cell-free assay) YES (Cell-free assay) Chk2 (Cell-free assay)
0.49 nM(Ki)8 nM(Ki)10 nM(Ki)14 nM(Ki)47 nM(Ki)
In vitro (25°C) DMSO 6 mg/mL (14.3 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.84 mL 119.2 mL 238.39 mL
0.5 mM 4.77 mL 23.84 mL 47.68 mL
1 mM 2.38 mL 11.92 mL 23.84 mL
5 mM 0.48 mL 2.38 mL 4.77 mL

*The above data is based on the productmolecular weight 419.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11520
Actions Inhibitor
M. Wt 419.48
Formula C22H25N7O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 952021-60-2
Synonyms PF-0044736, PF0044736
SMILES CN1C=C(C=N1)C2=NC3=C4C2=CNNC(=O)C4=CC(=C3)NC(=O)[[email protected]@H](C5CCCCC5)N

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