PF 477736

Catalog No.: A11520

Chk Inhibitor

PF 477736

PF 477736 Chemical Structure

CAS NO. 952021-60-2

PF 477736 is a selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively).

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Biological Activity

PF 477736 is a selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively).
Chk1 (Cell-free assay) VEGFR2 (Cell-free assay) Fms (Cell-free assay) YES (Cell-free assay) Chk2 (Cell-free assay)
0.49 nM(Ki)8 nM(Ki)10 nM(Ki)14 nM(Ki)47 nM(Ki)
In vitro (25°C) DMSO 5 mg/mL (11.92 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+40% PEG 300 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.84 mL 119.2 mL 238.39 mL
0.5 mM 4.77 mL 23.84 mL 47.68 mL
1 mM 2.38 mL 11.92 mL 23.84 mL
5 mM 0.48 mL 2.38 mL 4.77 mL

*The above data is based on the productmolecular weight 419.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11520
Actions Inhibitor
CAS No. 952021-60-2
Formula C22H25N7O2
M. Wt 419.48
Purity >98%
Synonyms PF-0044736, PF0044736
SMILES CN1C=C(C=N1)C2=NC3=C4C2=CNNC(=O)C4=CC(=C3)NC(=O)[[email protected]@H](C5CCCCC5)N

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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