PF 477736

Name: PF 477736
Brand: Adooq Bioscience
SKU: A11520
Rating: 100 (268 reviews)

Catalog No.: A11520

Chk Inhibitor

PF 477736 Chemical Structure

CAS NO. 952021-60-2

PF 477736 is a selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively).

Availability: In stock

Package	Price	Qty
5 mg	$90.00
10 mg	$140.00
25 mg	$280.00
50 mg	$450.00
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Biological Activity

PF 477736 is a selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively).

Targets

Chk1 (Cell-free assay)	VEGFR2 (Cell-free assay)	Fms (Cell-free assay)	YES (Cell-free assay)	Chk2 (Cell-free assay)
0.49 nM(Ki)	8 nM(Ki)	10 nM(Ki)	14 nM(Ki)	47 nM(Ki)

Solubility *

In vitro (25°C)	DMSO	5 mg/mL (11.92 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+40% PEG 300	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.84 mL	119.2 mL	238.39 mL
0.5 mM	4.77 mL	23.84 mL	47.68 mL
1 mM	2.38 mL	11.92 mL	23.84 mL
5 mM	0.48 mL	2.38 mL	4.77 mL

*The above data is based on the productmolecular weight 419.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A11520
Actions	Inhibitor
CAS No.	952021-60-2
Formula	C22H25N7O2
M. Wt	419.48
Solubility	DMSO
Purity	>98%
Synonyms	PF-0044736, PF0044736
SMILES	CN1C=C(C=N1)C2=NC3=C4C2=CNNC(=O)C4=CC(=C3)NC(=O)[[email protected]@H](C5CCCCC5)N
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.