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Biological Activity
GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) is an orally bioavailable CHK1 inhibitor, with an IC50 of 1.2 nM, and has antitumor activity.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.21 mL | 111.06 mL | 222.12 mL |
| 0.5 mM | 4.44 mL | 22.21 mL | 44.42 mL |
| 1 mM | 2.22 mL | 11.11 mL | 22.21 mL |
| 5 mM | 0.44 mL | 2.22 mL | 4.44 mL |
*The above data is based on the productmolecular weight 450.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21567 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1657014-42-0 |
| Formula | C17H23BrCl2N4O |
| M. Wt | 450.2 |
| Purity | >98% |
| Synonyms | ARRY-575 dihydrochloride, ARRY575, ARRY 575; RG7741 dihydrochloride, RG 7741, RG-7741, GDC0575, GDC 0575 |
| SMILES | O=C(C1CC1)NC2=CNC3=C2C(N4C[C@H](N)CCC4)=C(Br)C=C3.[H]Cl.[H]Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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