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CCT245737 is a potent, selective and orally active checkpoint kinase 1 (CHK1) inhibitor. CCT245737 showed CHK1 IC50 = 1.3 nM, CHK2 IC50 = 2440 nM, G2 check point abrogation IC50 = 30 nM. Mouse F (oral)=100%.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.36 mL | 131.81 mL | 263.61 mL |
| 0.5 mM | 5.27 mL | 26.36 mL | 52.72 mL |
| 1 mM | 2.64 mL | 13.18 mL | 26.36 mL |
| 5 mM | 0.53 mL | 2.64 mL | 5.27 mL |
*The above data is based on the productmolecular weight 379.3472. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A17239 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 379.3472 |
| Formula | C16H16F3N7O |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1489389-18-5 |
| Synonyms | CCT 245737; CCT-245737 |
| SMILES | N#CC1=NC=C(NC2=NC=C(C(F)(F)F)C(NC[[email protected]]3CNCCO3)=C2)N=C1 |
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