CCT245737

Catalog No.: A17239

CHK1 inhibitor

CCT245737

CCT245737 Chemical Structure

CAS NO. 1489389-18-5

CCT245737 is a potent, selective and orally active checkpoint kinase 1 (CHK1) inhibitor. CCT245737 showed CHK1 IC50 = 1.3 nM, CHK2 IC50 = 2440 nM, G2 check point abrogation IC50 = 30 nM. Mouse F (oral)=100%.

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Package Price Qty
5 mg
$90.00
10 mg
$140.00
50 mg
$450.00
100 mg
$700.00
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Biological Activity

CCT245737 is a potent, selective and orally active checkpoint kinase 1 (CHK1) inhibitor. CCT245737 showed CHK1 IC50 = 1.3 nM, CHK2 IC50 = 2440 nM, G2 check point abrogation IC50 = 30 nM. Mouse F (oral)=100%.
In vitro DMSO Warmed: 72 mg/mL (189.8 mM)
Water Insoluble
Ethanol Warmed: 9 mg/mL (23.72 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.36 mL 131.81 mL 263.61 mL
0.5 mM 5.27 mL 26.36 mL 52.72 mL
1 mM 2.64 mL 13.18 mL 26.36 mL
5 mM 0.53 mL 2.64 mL 5.27 mL

*The above data is based on the productmolecular weight 379.3472. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A17239
Actions Inhibitor
CAS No. 1489389-18-5
Formula C16H16F3N7O
M. Wt 379.3472
Solubility DMSO
Purity >98%
Synonyms CCT 245737; CCT-245737
SMILES N#CC1=NC=C(NC2=NC=C(C(F)(F)F)C(NC[[email protected]]3CNCCO3)=C2)N=C1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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