CCT245737

Catalog No.: A17239

CHK1 inhibitor

CCT245737

CCT245737 Chemical Structure

CAS NO. 1489389-18-5

CCT245737 is a potent, selective and orally active checkpoint kinase 1 (CHK1) inhibitor. CCT245737 showed CHK1 IC50 = 1.3 nM, CHK2 IC50 = 2440 nM, G2 check point abrogation IC50 = 30 nM. Mouse F (oral)=100%.

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Package Price Qty
5 mg
$90.00
10 mg
$140.00
50 mg
$450.00
100 mg
$700.00
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Biological Activity

CCT245737 is a potent, selective and orally active checkpoint kinase 1 (CHK1) inhibitor. CCT245737 showed CHK1 IC50 = 1.3 nM, CHK2 IC50 = 2440 nM, G2 check point abrogation IC50 = 30 nM. Mouse F (oral)=100%.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.36 mL 131.81 mL 263.61 mL
0.5 mM 5.27 mL 26.36 mL 52.72 mL
1 mM 2.64 mL 13.18 mL 26.36 mL
5 mM 0.53 mL 2.64 mL 5.27 mL

*The above data is based on the productmolecular weight 379.3472. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A17239
Actions Inhibitor
M. Wt 379.3472
Formula C16H16F3N7O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1489389-18-5
Synonyms CCT 245737; CCT-245737
SMILES N#CC1=NC=C(NC2=NC=C(C(F)(F)F)C(NC[[email protected]]3CNCCO3)=C2)N=C1

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