Total item
Cart Subtotal
$0.00 - Hayakawa K, .et al. Planar compression of extracellular substrates induces S phase arrest via ATM-independent CHK2 activation, Biochem Biophys Res Commun, 2018, Dec 2;506(4):983-989 PMID: 30404732
Biological Activity
LY2603618 is a chk2 inhibitor that binds to and inhibits the activity of chk2, which may prevent the repair of DNA caused by DNA-damaging agents.
Targets
| Chk1 (Cell-free assay) | ||||
| In vitro (25°C) | DMSO | 13 mg/mL (29.79 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 2% DMSO, 30% PEG400/0.5% Tween80/5% propylene glycol | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.92 mL | 114.6 mL | 229.2 mL |
| 0.5 mM | 4.58 mL | 22.92 mL | 45.84 mL |
| 1 mM | 2.29 mL | 11.46 mL | 22.92 mL |
| 5 mM | 0.46 mL | 2.29 mL | 4.58 mL |
*The above data is based on the productmolecular weight 436.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11036 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 436.3 |
| Formula | C18H22BrN5O3 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 911222-45-2 |
| Synonyms | LY-2603618 |
| SMILES | CC1=CC(=C(C=C1Br)NC(=O)NC2=NC=C(N=C2)C)OC[[email protected]@H]3CNCCO3 |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
AZD7762
AZD7762 is a potent ATP-competitive checkpoint kinase inhibitor that drives checkpoint abrogation and potentiates DNA-targeted therapies.
CCT241533 hydrochloride
CCT241533 Hcl is a potent serine/threonine checkpoint kinase (Chk2) inhibitor with IC50 of 3 nM; shows minimal cross-reactivity against a pa…
PF 477736
PF 477736 is a selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively).
CCT241533
CCT241533 is a potent and selective Inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors.
MK-1775
MK-1775 is a potent and selective Wee1 kinase inhibitor in vitro and in vivo.
CCT244747
CCT244747 is a novel potent, highly selective, orally active ATP-competitive CHK1 inhibitor with potential anticancer activity,
BML-277
BML-277 (Chk2 Inhibitor II) is a Chk2 (checkpoint kinase 2) inhibitor.
SCH 900776 (MK-8776)
SCH900776 is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. I…
Keywords:buy LY2603618 (IC-83) | LY2603618 (IC-83) Supplier | purchase | cost | manufacturer | order | distributor | buy 911222-45-2| 911222-45-2 Supplier | purchase 911222-45-2 | 911222-45-2 cost | 911222-45-2 manufacturer | order 911222-45-2 | 911222-45-2 distributor
Adooq Quality Guarantee
We promise all products perform as described.