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LY2603618 (IC-83)

LY2603618 (IC-83)

Name: LY2603618 (IC-83)
Brand: Adooq Bioscience
SKU: A11036
Rating: 100 (1 reviews)

Catalog No.: A11036

Chk inhibitor

Product Citations (1)

LY2603618 (IC-83) Chemical Structure

CAS NO. 911222-45-2

LY2603618 is a chk2 inhibitor that binds to and inhibits the activity of chk2, which may prevent the repair of DNA caused by DNA-damaging agents.

Availability: In stock

Package	Price	Qty
5 mg	$90.00
10 mg	$140.00
50 mg	$420.00
100 mg	$700.00
10mM * 1mL in DMSO	$95.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq LY2603618 (IC-83)

Hayakawa K, .et al. Planar compression of extracellular substrates induces S phase arrest via ATM-independent CHK2 activation, Biochem Biophys Res Commun, 2018, Dec 2;506(4):983-989 PMID: 30404732

Biological Activity

LY2603618 is a chk2 inhibitor that binds to and inhibits the activity of chk2, which may prevent the repair of DNA caused by DNA-damaging agents.

Targets

Chk1 (Cell-free assay)

Solubility *

In vitro (25°C)	DMSO	12 mg/mL (27.5 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG400+0.5% Tween80+5% Propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.92 mL	114.6 mL	229.2 mL
0.5 mM	4.58 mL	22.92 mL	45.84 mL
1 mM	2.29 mL	11.46 mL	22.92 mL
5 mM	0.46 mL	2.29 mL	4.58 mL

*The above data is based on the productmolecular weight 436.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A11036
Actions	Inhibitor
CAS No.	911222-45-2
Formula	C18H22BrN5O3
M. Wt	436.3
Purity	>98%
Synonyms	LY-2603618
SMILES	CC1=CC(=C(C=C1Br)NC(=O)NC2=NC=C(N=C2)C)OC[[email protected]@H]3CNCCO3
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.