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LY2603618 (IC-83)


Chk inhibitor

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Catalog No. A11036

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
LY2603618 5mg A11036-5

Regular Price: $90.00

Special Price: $81.00

LY2603618 10mg A11036-10

Regular Price: $140.00

Special Price: $126.00

LY2603618 50mg A11036-50

Regular Price: $420.00

Special Price: $378.00

LY2603618 100mg A11036-100

Regular Price: $700.00

Special Price: $630.00

LY2603618 (IC-83) 10mM * 1mL in DMSO A11036-10mM-D

Regular Price: $95.00

Special Price: $85.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

LY2603618 is a chk2 inhibitor that binds to and inhibits the activity of chk2, which may prevent the repair of DNA caused by DNA-damaging agents.

LY2603618 (IC-83)

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Publications citing Adooq Products
LY2603618 (IC-83) Citations (1)
  • Hayakawa K, .et al. Planar compression of extracellular substrates induces S phase arrest via ATM-independent CHK2 activation, Biochem Biophys Res Commun, 2018, Dec 2;506(4):983-989 PMID: 30404732

Chemical Information

Catalog Num A11036
Actions Inhibitor
M. Wt 436.3
Formula C18H22BrN5O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 911222-45-2
Synonyms LY-2603618
SMILES CC1=CC(=C(C=C1Br)NC(=O)NC2=NC=C(N=C2)C)OC[[email protected]@H]3CNCCO3

Biological Activity

LY2603618 is a chk2 inhibitor that binds to and inhibits the activity of chk2, which may prevent the repair of DNA caused by DNA-damaging agents.
Chk1 (Cell-free assay)


Solubility (25°C) * In vitro DMSO 13 mg/mL (29.79 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 2% DMSO, 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.92 mL 114.6 mL 229.2mL
0.5 mM 4.58 mL 22.92 mL 45.84 mL
1 mM 2.29 mL 11.46 mL 22.92 mL
5 mM 0.46 mL 2.29 mL 4.58 mL

*The above data is based on the productmolecular weight 436.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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