CHIR-124

Catalog No.: A11046

CHK Inhibitor

CHIR-124

CHIR-124 Chemical Structure

CAS NO. 405168-58-3

CHIR-124 is a novel and potent Chk1 inhibitor (IC50: 0.32 nM and 697 nM for Chk1 and Chk2 respectively).

Availability: In stock

Package Price Qty
5 mg

Regular Price: $70.00

Special Price $56.00

10 mg

Regular Price: $120.00

Special Price $96.00

25 mg

Regular Price: $220.00

Special Price $176.00

100 mg

Regular Price: $620.00

Special Price $496.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

CHIR-124 is a novel and potent Chk1 inhibitor (IC50: 0.32 nM and 697 nM for Chk1 and Chk2 respectively).
Targets
Target Value
Chk1IC50: 0.3nM
FLT3IC50: 5.8nM
PDGFRIC50: 6.6nM
GSK-3IC50: 23.3nM
FynIC50: 98.8nM
PKAIC50: 103.1nM
PKCγIC50: 110nM
LCKIC50: 158.3nM
CDK2/CyclinAIC50: 191.1nM
VEGFR1/FLT1IC50: 463.6nM
Cdc2/CyclinBIC50: 505.7nM
VEGFR2/Flk1IC50: 577.9nM
PKCβ2IC50: 580nM
PKCαIC50: 580nM
Chk2IC50: 697.4nM
FGFR3IC50: 1.29μM
bFGFRIC50: 2.04μM
CDK4/CyclinDIC50: 2.05μM
PKAβ1IC50: 2.25μM
c-MetIC50: >3μM
ERK2IC50: 4.31μM
CABLIC50: 14.88μM
In vitro (25°C) DMSO 7 mg/mL (16.67 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.82 mL 119.08 mL 238.15 mL
0.5 mM 4.76 mL 23.82 mL 47.63 mL
1 mM 2.38 mL 11.91 mL 23.82 mL
5 mM 0.48 mL 2.38 mL 4.76 mL

*The above data is based on the productmolecular weight 419.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A11046
Actions Inhibitor
M. Wt 419.9
Formula C23H22ClN5O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 405168-58-3
Synonyms CHIR124
SMILES C1CN2CCC1[[email protected]@H](C2)NC3=C4C=C(C=CC4=NC(=O)C3=C5NC6=CC=CC=C6N5)Cl

Product Tags

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
You may also be interested in the following product(s)
Keywords:buy CHIR-124 | CHIR-124 Supplier | purchase CHIR-124 | CHIR-124 cost | CHIR-124 manufacturer | order CHIR-124 | CHIR-124 distributor | buy 405168-58-3| 405168-58-3 Supplier | purchase 405168-58-3 | 405168-58-3 cost | 405168-58-3 manufacturer | order 405168-58-3 | 405168-58-3 distributor
Rewards