Biological Activity
CHIR-124 is a novel and potent Chk1 inhibitor (IC50: 0.32 nM and 697 nM for Chk1 and Chk2 respectively).
Targets
Target | Value |
---|---|
Chk1 | IC50: 0.3nM |
FLT3 | IC50: 5.8nM |
PDGFR | IC50: 6.6nM |
GSK-3 | IC50: 23.3nM |
Fyn | IC50: 98.8nM |
PKA | IC50: 103.1nM |
PKCγ | IC50: 110nM |
LCK | IC50: 158.3nM |
CDK2/CyclinA | IC50: 191.1nM |
VEGFR1/FLT1 | IC50: 463.6nM |
Cdc2/CyclinB | IC50: 505.7nM |
VEGFR2/Flk1 | IC50: 577.9nM |
PKCβ2 | IC50: 580nM |
PKCα | IC50: 580nM |
Chk2 | IC50: 697.4nM |
FGFR3 | IC50: 1.29μM |
bFGFR | IC50: 2.04μM |
CDK4/CyclinD | IC50: 2.05μM |
PKAβ1 | IC50: 2.25μM |
c-Met | IC50: >3μM |
ERK2 | IC50: 4.31μM |
CABL | IC50: 14.88μM |
In vitro (25°C) | DMSO | 7 mg/mL (16.67 mM) | |
Water | <1 mg/mL (<1 mM) | ||
Ethanol | <1 mg/mL (<1 mM) | ||
In vivo | 1% DMSO/30% polyethylene glycol/1% Tween 80 | 30 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 23.82 mL | 119.08 mL | 238.15 mL |
0.5 mM | 4.76 mL | 23.82 mL | 47.63 mL |
1 mM | 2.38 mL | 11.91 mL | 23.82 mL |
5 mM | 0.48 mL | 2.38 mL | 4.76 mL |
*The above data is based on the productmolecular weight 419.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A11046 |
---|---|
Actions | Inhibitor |
M. Wt | 419.9 |
Formula | C23H22ClN5O |
Solubility | DMSO |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 405168-58-3 |
Synonyms | CHIR124 |
SMILES | C1CN2CCC1[[email protected]@H](C2)NC3=C4C=C(C=CC4=NC(=O)C3=C5NC6=CC=CC=C6N5)Cl |
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