Catalog No.: A11046

CHK Inhibitor


CHIR-124 Chemical Structure

CAS NO. 405168-58-3

CHIR-124 is a novel and potent Chk1 inhibitor (IC50: 0.32 nM and 697 nM for Chk1 and Chk2 respectively).

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Biological Activity

CHIR-124 is a novel and potent Chk1 inhibitor (IC50: 0.32 nM and 697 nM for Chk1 and Chk2 respectively).
Target Value
Chk1IC50: 0.3nM
FLT3IC50: 5.8nM
PDGFRIC50: 6.6nM
GSK-3IC50: 23.3nM
FynIC50: 98.8nM
PKAIC50: 103.1nM
PKCγIC50: 110nM
LCKIC50: 158.3nM
CDK2/CyclinAIC50: 191.1nM
VEGFR1/FLT1IC50: 463.6nM
Cdc2/CyclinBIC50: 505.7nM
VEGFR2/Flk1IC50: 577.9nM
PKCβ2IC50: 580nM
PKCαIC50: 580nM
Chk2IC50: 697.4nM
FGFR3IC50: 1.29μM
bFGFRIC50: 2.04μM
CDK4/CyclinDIC50: 2.05μM
PKAβ1IC50: 2.25μM
c-MetIC50: >3μM
ERK2IC50: 4.31μM
CABLIC50: 14.88μM
In vitro (25°C) DMSO 7 mg/mL (16.67 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.82 mL 119.08 mL 238.15 mL
0.5 mM 4.76 mL 23.82 mL 47.63 mL
1 mM 2.38 mL 11.91 mL 23.82 mL
5 mM 0.48 mL 2.38 mL 4.76 mL

*The above data is based on the productmolecular weight 419.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11046
Actions Inhibitor
M. Wt 419.9
Formula C23H22ClN5O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 405168-58-3
Synonyms CHIR124
SMILES C1CN2CCC1[[email protected]@H](C2)NC3=C4C=C(C=CC4=NC(=O)C3=C5NC6=CC=CC=C6N5)Cl

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