Catalog No.
Product Name
Application
Product Information
Citations
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MAO Inhibitor
Benzylhydrazine is a potent inhibitor of monoamine oxidase (MAO), targeting both brain and liver tissues. It exhibits significant inhibitory activity with pI50 values of 6.3 and 7.0 for brain and liver MAO, respectively. In vivo studies have demonstrated its efficacy in mice, with effective doses (ED50) of 6.5 μmol/kg for brain MAO and 6.2 μmol/kg for liver MAO. This compound is useful for research involving neurochemistry and metabolic studies related to neurotransmitter regulation. -
MAOA Inhibitor
Ethyl homovanillate is a selective inhibitor of monoamine oxidase A (MAOA) with an IC50 value of 8.1 μM. This compound demonstrates significant efficacy in improving depressive-like behavior, as evidenced by enhanced scores in the forced swim test in ICR mice. Ethyl homovanillate is a valuable reagent for investigating the mechanisms underlying neurological diseases, particularly Alzheimer's disease, and offers potential insights into therapeutic strategies for mood regulation. -
Monoamine Oxidase Inhibitor
Pargyline is an irreversible monoamine oxidase (MAO) inhibitor, displaying Ki values of 13 μM and 0.5 μM for MAO-A and MAO-B, respectively. This compound exhibits notable antihypertensive and anticancer activities. Additionally, Pargyline functions as a click chemistry reagent due to its alkyne group, allowing for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. -
MAO-A Inhibitor
Clorgyline is a selective inhibitor of monoamine oxidase A (MAO-A) that is orally active and permeable to the blood-brain barrier. By inhibiting MAO-A, Clorgyline decreases the metabolism of neurotransmitters like serotonin (5-hydroxytryptamine), resulting in increased levels in the brain. This compound is particularly valuable for research applications focused on depression and neurodegenerative diseases. -
Monoamine Oxidase
Monoamine oxidase (MAO) is an enzyme that catalyzes the oxidative deamination of biogenic amines, generating hydrogen peroxide in various tissues, including the brain and peripheral systems. By modulating the levels of neurotransmitters, MAO is crucial for regulating synaptic transmission, emotional behavior, and other vital brain functions. This enzyme is an important target for research into neuropsychiatric disorders and the development of related therapeutic agents. -
MAO-B Inhibitor
Mofegiline hydrochloride is a selective, irreversible inhibitor of monoamine oxidase B (MAO-B), exhibiting a significant preference over monoamine oxidase A (MAO-A) with IC50 values of 3.6 nM and 680 nM, respectively. This compound also inhibits semicarbazide-sensitive amine oxidase (SSAO). Mofegiline hydrochloride is utilized in research focused on neurodegenerative disorders and the modulation of neurotransmitter levels. Its specific action on MAO-B makes it a valuable tool in studies addressing dopamine metabolism and potential therapeutic strategies for Parkinson's disease. -
MAO-B Inhibitor
Tisolagiline is a selective, reversible inhibitor of monoamine oxidase B (MAO-B) with an IC50 of 8 nM. This compound demonstrates neuroprotective effects and possesses anti-neuroinflammatory properties, making it valuable for research in neurological disorders. Tisolagiline may be useful in studying the role of MAO-B in neurodegenerative conditions and evaluating potential therapeutic strategies for such diseases. -
MAO-B Inhibitor
Methyl citrate is a potent inhibitor of Monoamine oxidase B (MAO-B), exhibiting an IC50 value of 0.23 mM. Isolated from the fruits of Opuntia ficus-indica var. saboten, this compound demonstrates significant biological activity relevant for neuropharmacological research. Methyl citrate may be utilized in studies investigating its potential effects on neurodegenerative diseases associated with dopaminergic dysfunction. -
hMAO-A Inhibitor
Obtusin is a selective and competitive inhibitor of human monoamine oxidase-A (hMAO-A) with an IC50 of 11.12 μM and a Ki of 6.15 μM. Isolated from the seeds of Cassia obtusifolia Linn, Obtusin demonstrates potential neuroprotective effects, making it relevant for research into neurodegenerative diseases, particularly those associated with anxiety and depression. Its ability to inhibit hMAO-A may contribute to the modulation of serotonin and norepinephrine levels, offering a valuable tool for elucidating mechanisms underlying mood disorders. -
MAO-A Inhibitor
MAO-A Inhibitor 1 is a selective inhibitor of monoamine oxidase A (MAO-A), exhibiting an IC50 of 100 μM. This compound is instrumental in research applications focused on neuropsychiatric disorders, where modulation of monoamine levels may offer therapeutic potential. It serves as a valuable tool in studies investigating the effects of MAO-A inhibition on neurotransmitter metabolism and related pathophysiological conditions. -
Monoamine Oxidase Inhibitor
Eprobemide is a non-competitive reversible inhibitor of monoamine oxidase A (MAO-A). This compound demonstrates significant activity in modulating neurotransmitter levels by inhibiting the oxidative deamination of monoamines, making it a valuable tool for research in neurochemistry and psychiatric disorders. Eprobemide is utilized in studies exploring depression, anxiety, and other conditions associated with monoamine imbalance. -
MAO-A/MAO-B Inhibitor
(-)-2-Phenylpropylamine is an inhibitor of monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B), exhibiting Ki values of 584 μM and 156 μM, respectively. This compound is utilized in research investigating neurotransmitter regulation and is of particular interest in studies related to mood disorders and neurodegenerative diseases. Its dual inhibition of MAO isoforms makes it a valuable tool for understanding the biochemical pathways involved in monoamine metabolism. -
MAO-B Inhibitor
(Rac)-Rasagiline functions as a selective inhibitor of monoamine oxidase B (MAO-B). This compound exhibits neuroprotective properties, particularly against MPTP-induced neuronal toxicity, making it a valuable tool in Parkinson's disease research. Its capacity to modulate monoaminergic systems may provide insights into therapeutic strategies for neurodegenerative disorders. -
MAO A Inhibitor
Tetrindole mesylate is a selective inhibitor of monoamine oxidase A (MAO A). It competitively inhibits rat brain mitochondrial MAO A with a Ki value of 0.4 μM, while also exhibiting weaker inhibition of MAO B with a Ki of 110 μM. This compound demonstrates antidepressant activity, making it relevant for research in psychiatric disorders and neuropharmacology. -
MAO A Inhibitor
Esuprone is a selective inhibitor of monoamine oxidase A (MAO A) with an IC50 of 7.3 nM, demonstrating significant brain penetration and oral bioavailability. This compound is valuable for neurological research, contributing to the study of mood disorders and neurodegenerative diseases by modulating neurotransmitter levels. -
MAO Inhibitor
Tetrahydroharmine is a selective monoamine oxidase (MAO) inhibitor with an IC50 value of 74 nM for MAO-A. This compound is of significant interest in the study of neurodegenerative diseases, as it may enhance monoamine neurotransmitter levels and provide neuroprotective effects. Its application in research includes exploring therapeutic strategies for conditions like depression and neurodegeneration. -
MAO-B Inhibitor
Tisolagiline monomethylsulfate is a selective, reversible inhibitor of monoamine oxidase B (MAO-B), exhibiting an IC50 of 8 nM. It demonstrates neuroprotective effects and possesses anti-neuroinflammatory properties, making it a valuable compound for researching neurodegenerative diseases and related disorders. This reagent is suitable for studies focused on neuroprotection and inflammation modulation in various cellular and animal models. -
Monoamine Oxidase Inhibitor
Chrysophanol-1-O-β-gentiobioside is an anthraquinone glycoside that selectively inhibits the hMAO-A isozyme, exhibiting an IC50 value of 96.15 μM. This compound is primarily utilized in research focused on the modulation of monoamine oxidase activity, making it relevant for studies on neurological disorders and related pharmacological applications. Its unique structure and biological properties contribute to its potential for advancing therapeutic innovations. -
MAO-A/-B Inhibitor
MAO-IN-M30 dihydrochloride is a selective and irreversible inhibitor of monoamine oxidases A and B, with IC50 values of 37 nM and 57 nM, respectively. This compound demonstrates significant neuroprotective properties, effectively mitigating brain cell apoptosis induced by Dexamethasone. Additionally, it exhibits neurorestorative effects in models of Parkinson's disease, specifically post MPTP and lactacystin. MAO-IN-M30 dihydrochloride functions as a click chemistry reagent due to its alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) for various research applications. -
Monoamine Oxidase Inhibitor
Modaline sulfate is a potent monoamine oxidase (MAO) inhibitor that plays a significant role in the modulation of neurotransmitter levels. It has been primarily investigated for its efficacy in treating depression by preventing the breakdown of serotonin, norepinephrine, and dopamine. This compound serves as a valuable tool in research focused on mood disorders and the neurochemical pathways involved in depression. -
hMAO-B Inhibitor
Ethyl 7-(diethylamino)-2-oxo-2H-chromene-3-carboxylate is a selective inhibitor of human monoamine oxidase B (hMAO-B), demonstrating an IC50 of 45.52 μM. This compound is valuable in research focused on neurodegenerative diseases, as it modulates monoamine metabolism and has implications for the treatment of conditions such as Parkinson's disease. Its potent inhibition of hMAO-B makes it a useful tool for investigating the role of this enzyme in various biological processes. -
MAO-B Inhibitor
Selegiline is a potent, selective, and irreversible inhibitor of monoamine oxidase B (MAO-B), exhibiting an IC50 of 51 nM and demonstrating 450-fold selectivity over MAO-A (IC50 = 23 μM). This compound is primarily researched for its neuroprotective effects and potential therapeutic applications in Parkinson's disease, Alzheimer's disease, and major depressive disorder. Its ability to influence dopaminergic pathways makes it a valuable reagent in studies related to neurodegeneration and mood disorders. -
MAO Inhibitor
Hydroxylamine (50% w/w in water) is a selective inhibitor of monoamine oxidase (MAO), making it valuable in research applications focused on platelet aggregation inhibition. As an important intermediate in the nitrogen cycle, it plays a role in the metabolism of aerobic ammonium-oxidizing microorganisms, including ammonium oxidizing bacteria (AOB) and complete ammonium oxidizing bacteria (comammox). Hydroxylamine also influences nitrous oxide (NO) and nitrogen gas (N2O) emissions by modulating the activity of nitrite-oxidizing bacteria (NOB). -
MAO-A Inhibitor
MAO-A Inhibitor 3 is a selective inhibitor of monoamine oxidase A (MAO-A), displaying an IC50 of greater than 100 μM. This compound is utilized in the investigation of neurological disorders, providing insights into the role of MAO-A in the metabolism of neurotransmitters and its implications in various neuropsychiatric conditions. Its application may contribute to the understanding of the biochemical pathways involved in mood regulation and depression. -
MAO-A Inhibitor
Befloxatone is a selective and reversible inhibitor of Monoamine Oxidase A (MAO-A), exhibiting an IC50 of 4 nM. By inhibiting MAO-A, Befloxatone effectively elevates the tissue levels of monoamines, including striatal dopamine and cortical norepinephrine. This compound is primarily investigated for its potential antidepressant effects, making it a valuable reagent in research related to mood disorders and neuropharmacology. -
MAO-B Inhibitor
MAO-B-IN-8 is a potent reversible inhibitor of monoamine oxidase B (MAO-B), effective in reducing the microglial production of neuroinflammatory mediators. This compound is primarily utilized in neurodegenerative disease research, making it a valuable tool for investigating therapeutic strategies aimed at modulating neuroinflammation and neuronal survival. Its ability to impact neuroinflammatory processes positions MAO-B-IN-8 as a significant reagent in the study of various neurological disorders. -
MAO-B Inhibitor
MAO-B-IN-25 is a selective inhibitor of monoamine oxidase B (MAO-B) with an IC50 of 240 nM. It demonstrates a significantly higher selectivity for MAO-B over MAO-A, with an IC50 of 0.5 nM for the latter. This compound is valuable for research focused on neurodegenerative diseases and the modulation of monoamine neurotransmitter levels, highlighting its potential role in studying Parkinson's disease and related disorders. -
Monoamine Oxidase Inhibitor
7-Hydroxy-3,4-dihydro-2(1H)-quinolinone functions as a selective monoamine oxidase A (MAO-A) inhibitor, exhibiting an IC50 value of 183 μM. This compound primarily role in inhibiting MAO-A suggests potential applications in neuropharmacology and mood disorder research. Due to its lack of effect on MAO-B, it serves as a valuable tool in studies aimed at elucidating the distinct roles of these enzymes in monoamine metabolism. -
Monoamine Oxidase Inhibitor
Glicoricone is a phenolic compound that acts as a monoamine oxidase (MAO) inhibitor, exhibiting an IC50 of 140 μM. In addition to its primary mechanism, Glicoricone interacts with estrogen receptors (ER) and demonstrates estrogen antagonist activity. This compound is valuable for research applications focused on neurodegenerative diseases and hormonal regulation. -
Monoamine Oxidase Inhibitor
MAO-IN-1 is a selective inhibitor of monoamine oxidase B (MAO B), exhibiting an IC50 value of 20 nM. This compound plays a critical role in modulating neurochemical pathways by inhibiting the breakdown of neurotransmitters such as dopamine. Researchers can utilize MAO-IN-1 in studies related to neurodegenerative diseases, psychiatric disorders, and the exploration of metabolic processes involving monoamines. -
Ser/Thr Kinase Inhibitor
Milciclib maleate is a cyclin-dependent kinase inhibitor that primarily targets Ser/Thr kinases, disrupting cell cycle progression in melanoma. It exerts substantial antiproliferative effects by down-regulating genes such as PTTG1, thereby modulating gene expression linked to cell growth regulation. This compound enhances therapeutic sensitivity in p53-mutated melanoma cells, particularly when used in conjunction with PTTG1 silencing, making it valuable for cancer research and potential therapeutic applications. -
Substrate Peptide Of Cathepsin S
Ac-KQKLR-AMC TFA is a substrate peptide for Cathepsin S, conjugated with the fluorescent indicator AMC (Excitation/Emission = 354 nm/442 nm). This reagent facilitates the measurement of Cathepsin S activity, enabling researchers to study proteolytic processes and assess enzyme function in various biological contexts. Its application is crucial for investigations into the role of Cathepsin S in physiological and pathological conditions. -
Ser/Thr Protease Inhibitor
IPR-803 is a potent Ser/Thr protease inhibitor that specifically targets the uPAR·uPA protein-protein interaction. By binding directly to uPAR with sub-micromolar affinity, IPR-803 effectively disrupts this critical interaction. This compound exhibits significant anti-tumor activity, making it a valuable reagent for cancer research and studies focused on protease-related pathways. -
Cysteine Protease
Cathepsin S, human, is a potent cysteine protease that plays a crucial role in the degradation of damaged or harmful proteins within the endolysosomal pathway. This enzyme is implicated in various pathological processes, including arthritis, cancer, and cardiovascular diseases. Its activity makes it a valuable target for research applications aimed at understanding these diseases and developing therapeutic interventions. -
Ser/Thr Protease
CatB-IN-1 is a potent inhibitor of serine/threonine proteases, specifically targeting cathepsin B. This compound exhibits significant anti-invasive activity in various cellular models, effectively reducing the invasiveness of tumor cells such as MCF-10A neoT. Research indicates that CatB-IN-1 can modulate intracellular protein metabolism, thereby influencing tumor cell behavior. Its structure-activity relationship highlights its capability to engage multiple functions of cathepsin B, making it a valuable tool for studies on tumor invasion and metastasis. -
Ser/Thr Protease
Cathepsin Inhibitor 3 is a selective inhibitor of the serine/threonine protease cathepsin S, functioning as a valuable tool in studying protease-mediated biological processes. This compound serves as a non-radioactive precursor in the synthesis of fluorine-18 radiolabeled compounds, facilitating research in molecular imaging. Additionally, Cathepsin Inhibitor 3 features an alkyne group, enabling its use in copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it a versatile reagent for click chemistry applications in chemical biology. -
Lysosomal cysteine protease
Cathepsin H, human liver, is a lysosomal cysteine protease that functions as both an aminopeptidase and an endopeptidase. This enzyme is essential for the catabolism of proteins within the lysosomal system. It plays a significant role in regulating tumor cell behavior and is implicated in the pathological processes of various brain diseases, making it valuable for research in cancer biology and neurodegenerative disorders. -
PCSK9/HMG-CoAR Inhibitor
Dim16 is a dual inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) and HMG-CoA reductase (HMG-CoAR), demonstrating an IC50 value of 19 nM for PCSK9. It effectively inhibits the binding of PCSK9 to the LDL receptor (LDLR) with an IC50 of 0.8 nM. This compound is noted for its role in enhancing LDL uptake in HepG2 cells, making it valuable for research in cholesterol metabolism and cardiovascular diseases. -
Ser/Thr Protease
RWJ-58643 hydrochloride is a selective inhibitor of serine/threonine proteases, specifically targeting β-trypsin. It has demonstrated efficacy in reducing nasal allergy symptoms, eosinophil infiltration, and interleukin-5 (IL-5) levels at low doses, highlighting its potential for modulating allergic inflammation. Notably, administration at higher doses may lead to late eosinophilia and increased IL-5 levels. RWJ-58643 hydrochloride is valuable for research focused on understanding and managing allergic reactions through protease inhibition. -
Ser/Thr Protease Inhibitor
RWJ-58643 is a selective Ser/Thr protease inhibitor that primarily targets β-trypsin, modulating allergic inflammation pathways. This compound has demonstrated significant efficacy in reducing nasal allergy symptoms, eosinophil infiltration, and IL-5 levels at low doses, while high doses have been associated with late eosinophilia and increased IL-5 levels. RWJ-58643 functions by inhibiting the release of β-trypsin from mast cells, making it a valuable tool for research into allergic responses and related inflammatory conditions. -
Ser/Thr Protease
MDK0734 is a selective inhibitor targeting serine/threonine proteases, specifically inhibiting feline hepsin B endopeptidase and exopeptidase activities. It has been shown to effectively reduce tumor cell invasion in vitro, significantly impairing the invasive behavior of MCF-10A neoT cells. MDK0734 opens new avenues for developing clinically relevant compounds aimed at mitigating the damaging effects of feline hepsin B in cancer progression. -
AhR Ligand
β-Naphthoflavone-CH2-Br is a ligand for the arylhydrocarbon receptor (AhR), involved in regulating various biological processes, including xenobiotic metabolism. This compound serves as a key intermediate for synthesizing the PROTAC β-NF-JQ1, facilitating targeted protein degradation research. Its role in modulating AhR activity makes it valuable for studies in toxicology, pharmacology, and cancer research. -
MAO-B Inhibitor
Milacemide is an orally active inhibitor of monoamine oxidase B (MAO-B), classified as a glycinamide derivative. This compound demonstrates anticonvulsant effects by modulating the levels of neurotransmitters; it decreases dihydroxyphenylacetic acid and homovanilic acid while enhancing dopamine and serotonin levels in the caudate nucleus. Milacemide holds potential for research applications related to neurodegenerative disorders, particularly Alzheimer's disease. -
hMAO-B Inhibitor
hMAO-B-IN-7 is a potent inhibitor of human monoamine oxidase-B (hMAO-B) with an IC50 value of 0.79±0.05 μM. This compound effectively penetrates the blood-brain barrier, making it suitable for studies related to neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). Its ability to inhibit hMAO-B positions it as a valuable tool for exploring therapeutic approaches in these conditions. -
MAO-B Inhibitor
MAO-B-IN-39 is a selective monoamine oxidase B (MAO-B) inhibitor that demonstrates an IC50 of 3.61 μM. It exhibits potent induction of NRF2, contributing to its significant anti-inflammatory and neuroprotective effects in oxidative stress-related in vitro models. Additionally, MAO-B-IN-39 has shown high liver microsomal stability and favorable pharmacokinetics in murine studies, indicating its potential utility in Parkinson's disease research. -
MAO-B Inhibitor
MAO-B-IN-21 is a potent inhibitor of monoamine oxidase B (MAO-B) that also demonstrates antioxidant properties. This compound exhibits anti-amyloid-beta (Aβ) aggregation activity, metal-ion chelation, and anti-neuroinflammatory effects, specifically targeting nitric oxide and TNF-α pathways. Additionally, MAO-B-IN-21 is neuroprotective and can cross the blood-brain barrier. Its efficacy in enhancing memory and cognitive function has been established in a mouse model of Alzheimer’s disease induced by Aβ1-42. -
Monoamine Oxidase A Inhibitor
Rubrofusarin triglucoside is a glycoside compound that serves as an inhibitor of human monoamine oxidase A (hMAO-A), demonstrating an IC50 value of 85.5 μM. This compound is isolated from the seeds of Cassia obtusifolia Linn and plays a significant role in neurochemical studies related to mood regulation and depression. Its inhibition of hMAO-A makes it a valuable reagent for research into neuropharmacology and the therapeutic potential of monoamine oxidase inhibitors. -
MAO-B Inhibitor
MAO-B-IN-55 is a reversible competitive inhibitor of monoamine oxidase B (MAO-B), exhibiting an IC50 of 2.9 nM and a remarkable 2750-fold selectivity for MAO-B over MAO-A. This compound is valuable for studying the biochemical pathways involved in Parkinson's disease, making it a significant tool for both in vitro and in vivo research applications focused on neurodegenerative disorders. -
MAO-B Inhibitor
MAO-B-IN-37 is a selective inhibitor of monoamine oxidase B (MAO-B), exhibiting an IC50 value of 270 nM. This compound demonstrates favorable metabolic stability in mouse microsomes, along with strong binding affinity to human serum albumin. It is valuable for research applications focused on neurological disorders and oxidative stress, where modulation of MAO-B activity may provide therapeutic insights. -
MAO Inhibitor
SL-251131 is a reversible non-specific monoamine oxidase (MAO) inhibitor, targeting both MAO-A and MAO-B enzymes. By inhibiting these enzymes, SL-251131 temporarily increases the levels of neurotransmitters such as dopamine, making it a valuable tool for studying neurodegenerative disorders, particularly Parkinson's disease. Its application in research facilitates a deeper understanding of the biochemical pathways involved in dopaminergic signaling and related pathologies.
