PROTAC Hsp90α degrader 1 is a selective degrader targeting the heat shock protein 90 alpha (Hsp90α) through the PROTAC (proteolysis targeting chimeras) mechanism. This compound exhibits significant cytotoxic activity against various breast cancer cell lines, including MDA-MB-231, MDA-MB-468, MCF-7, and MX-1, with IC50 values of 51.48 μM, 16.46 μM, 8.93 μM, and 11.95 μM, respectively. PROTAC Hsp90α degrader 1 is valuable for investigating the role of Hsp90α in oncogenesis and developing targeted therapies for breast cancer.
PROTAC Hsp90α degrader 1 is a selective degrader targeting the heat shock protein 90 alpha (Hsp90α) through the PROTAC (proteolysis targeting chimeras) mechanism. This compound exhibits significant cytotoxic activity against various breast cancer cell lines, including MDA-MB-231, MDA-MB-468, MCF-7, and MX-1, with IC50 values of 51.48 μM, 16.46 μM, 8.93 μM, and 11.95 μM, respectively. PROTAC Hsp90α degrader 1 is valuable for investigating the role of Hsp90α in oncogenesis and developing targeted therapies for breast cancer.
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