Catalog No.
Product Name
Application
Product Information
Citations
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FXR-LIFR Modulator
BAR-2227 is a modulator that targets the Farnesoid X Receptor (FXR) as an agonist and inhibits the leukemia inhibitory factor receptor (LIFR). This compound plays a significant role in the investigation of liver fibrosis and associated inflammatory responses. Researchers can utilize BAR-2227 to explore its therapeutic potential in liver diseases and further elucidate underlying mechanisms of fibrosis and inflammation. -
FXR Agonist
Nelumol A is a potent agonist of the farnesoid X receptor (FXR). It is known to regulate bile acid homeostasis, lipid metabolism, and inflammatory responses. Due to its role in metabolic processes, Nelumol A is employed in research studying metabolic disorders, liver diseases, and the pharmacological modulation of FXR pathways. -
FXR Agonist
FXR Agonist 16 is a potent FXR agonist with an EC50 of 2.2 μM, effectively activating FXR transcriptional activity. This compound upregulates small heterodimer partner (SHP) and bile salt export pump (BSEP) while downregulating cytochrome P450 7A1 (Cyp7a1), which contributes to its hepatoprotective properties. FXR Agonist 16 is valuable for research focused on liver injury, demonstrating a reduction in serum AST and ALT levels in models of free fatty acid-induced hepatocellular damage. -
FXR Agonist
FXR Agonist 15 is a potent and selective farnesoid X receptor (FXR) agonist with an EC50 of 0.76 μM. This compound shows high specificity, exhibiting minimal activation of other nuclear receptors such as LXRα/β, PXR, PPARα/β/γ, and THR-β, with EC50 values greater than 10 μM. FXR Agonist 15 demonstrates the ability to mitigate steatosis, lobular inflammation, hepatocyte ballooning, and liver fibrosis, making it a valuable tool for research into nonalcoholic steatohepatitis (NASH). -
FXR Agonist
Fexarene is a potent and selective nonsteroidal agonist of the Farnesoid X Receptor (FXR), exhibiting an EC50 of 36 nM. This compound plays a crucial role in the regulation of cholesterol and bile acid metabolism, making it valuable for research investigating metabolic disorders and liver function. Fexarene's ability to selectively activate FXR positions it as a significant tool for studying its downstream effects in various biological systems. -
Herbicide Safener
Benoxacor is a herbicide safener that primarily acts as a regulator of xenobiotic metabolism. It protects maize from metolachlor toxicity by inducing detoxifying enzymes, such as Glutathione S-transferase, while also activating nuclear receptors like FXR, PXR, and ERRα, and inhibiting aromatase. Research indicates that Benoxacor may exhibit subacute oral toxicity and has been associated with hepatotoxicity in animal models, leading to effects on organ weights and alterations in gut microbiota. This compound is relevant for studies on hepatic steatosis, infertility, breast cancer, and developmental toxicity. -
FXR Agonist
ST-1892 is a potent agonist of the farnesoid X receptor (FXR), exhibiting an EC50 value of 7.2 nM. This compound plays a crucial role in studying metabolic inflammation-related diseases and disorders. Its selective activation of FXR allows for exploration of therapeutic strategies targeting metabolic pathways and liver-related conditions. -
FXR Agonist
GSK2324 is a selective agonist of the farnesoid X receptor (FXR), demonstrating an EC50 of 120 nM. This compound is predominantly utilized in diabetes research, where it plays a pivotal role in the modulation of metabolic processes. Pharmacokinetic studies reveal half-life values of 84 minutes in mice, 170 minutes in rats, 110 minutes in beagle dogs, and 120 minutes in cynomolgus monkeys, indicating its potential for translational studies. -
FXR Activator
5β-Cholane is a potent activator of the farnesoid X receptor (FXR). It plays a critical role in regulating bile acid homeostasis and lipid metabolism, making it a valuable tool for investigating cholesterol and lipid-related disorders. Researchers can utilize 5β-Cholane to better understand the molecular mechanisms underlying metabolic diseases and to explore therapeutic interventions targeting FXR. -
FXR Partial Agonist
FXR agonist 9 is a selective partial agonist of the farnesoid X receptor (FXR) with an EC50 of 0.09 µM, exhibiting 75.13% maximum efficacy. This compound has demonstrated the ability to improve pathological features associated with metabolic dysfunction and steatohepatitis in mouse models induced by a high-fat diet and carbon tetrachloride. FXR agonist 9 is valuable for research into metabolic disorders and liver diseases. -
FXR Antagonist
FXR antagonist 3 is a selective antagonist of the farnesoid X receptor (FXR) with an IC50 of 0.89 μM. This compound exhibits notable activity in modulating intestinal FXR signaling pathways, making it valuable for research related to metabolic disease and bile acid regulation. It serves as a useful tool in studying the physiological roles of FXR in gastrointestinal disorders and potential therapeutic interventions. -
ER α-glucosidases Inhibitor
IHVR-11029 is a potent small molecule inhibitor of ER α-glucosidases, demonstrating an EC50 of 0.09 μM. This compound is primarily utilized in research for exploring glucosidase enzymatic activity and its implications in metabolic disorders. Its specificity and efficacy make it a valuable tool for studies investigating glycosylation processes and related pathways. -
α-glucosidase Inhibitor
CM-10-18 is a potent inhibitor of α-glucosidases I and II, demonstrating significant activity in vitro and in animal models. This compound also exhibits antiviral properties by inhibiting dengue virus (DENV) infection in cultured human cells, while effectively reducing peak viremia in mice. CM-10-18 is valuable for research applications related to glycosidase inhibition and viral pathogenesis. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-5 is a potent α-glucosidase inhibitor, exhibiting an IC50 of 57.9 µM. This compound is valuable for studying the modulation of carbohydrate metabolism and has potential applications in diabetes mellitus research. By inhibiting α-glucosidase, α-Glucosidase-IN-5 may aid in the investigation of glycemic control and the development of therapeutic strategies for diabetes management. -
Herbicide
L-Phosphinothricin is a potent inhibitor of glutamine synthetase and functions as a non-selective herbicide. By competitively inhibiting this enzyme, it leads to the accumulation of toxic ammonium ions in both plants and bacteria, thereby disrupting the photosynthesis process. L-Phosphinothricin demonstrates effective herbicidal activity against a wide range of plant species, including both monocots and dicots. This compound is predominantly absorbed through plant leaves, exhibits minimal translocation, and is rapidly degraded by soil microorganisms, making it valuable for research in weed management across agricultural and non-crop environments. -
Herbicide Safener
Mefenpyr-diethyl is a pyrazoline-type herbicide safener that enhances lipid biosynthesis in cereal crops such as wheat. It effectively mitigates phytotoxic damage from herbicides, including fenoxaprop-p-ethyl and mesosulfuron-methyl, ensuring crop safety and improved lipid content. Notably, the mechanism of action does not involve the induction of glutathione S-transferase (GST) activity in wheat, making Mefenpyr-diethyl a valuable tool for research in plant protection and herbicide safening applications. -
Anticoagulant/Cancer Agent
Fucoidan is a biologically active polysaccharide that functions as an anticoagulant and exhibits antitumor properties. It effectively inhibits α-amylase and α-glucosidase, contributing to its potential applications in metabolic disorder research. Additionally, Fucoidan demonstrates antioxidant and antisteatotic activities, making it a valuable tool for studying various disease processes and therapeutic interventions. -
α-glucosidase Inhibitor
Gallacetophenone is a potent inhibitor of α-glucosidase, displaying an IC50 value of 408.6 μM. This compound demonstrates synergistic effects on mammalian α-glucosidase when combined with 1-Deoxynojirimycin at elevated concentrations. Gallacetophenone is valuable for research into metabolic disorders, particularly type 2 diabetes, by facilitating the understanding of carbohydrate metabolism and its implications in glycemic control. -
UDP-GalNAc Analog
UDP-GalNAz disodium is an analogue of UDP-GalNAc disodium, serving as a donor substrate for N-acetylgalactosaminyltransferases, which facilitate the transfer of GalNAc to various saccharide or peptide acceptors. This compound features an azide group, making it a valuable reagent for click chemistry applications. UDP-GalNAz disodium can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-bearing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions involving DBCO or BCN groups. It is useful in the study of glycosylation pathways and the synthesis of complex glycoproteins. -
Glycosidase
PNGase F is a glycosidase that facilitates the cleavage of internal glycosidic bonds within oligosaccharides. This enzyme effectively removes nearly all N-linked oligosaccharides from glycoproteins, making it a valuable tool in glycoanalytical workflows. Its capability to release N-glycans from glycoproteins enhances the analysis of protein glycosylation patterns in various research applications. -
β-glucosidase fluorogenic substrate
4-Methylumbelliferyl β-D-Glucopyranoside serves as a fluorogenic substrate specifically for β-glucosidase, facilitating the measurement of β-glucosidase activity in various biological assays. Upon enzymatic cleavage, it releases 4-methylumbelliferone, a highly fluorescent compound with an emission maximum between 445-454 nm. The excitation wavelength of 4-methylumbelliferone is influenced by pH, showing peaks at 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively, making it a valuable tool for studying enzyme kinetics and related research applications. -
α/β-Glucosidases Inhibitor
Castanospermine is a natural alkaloid primarily recognized for its role as an α/β-glucosidase inhibitor. This compound exhibits significant biological activities, including anti-inflammatory and antiviral properties, as well as the potential to impede metastatic progression in prostate cancer. Additionally, Castanospermine has applications as an immunosuppressant, proving useful in preventing transplant rejection. Its diverse functionalities make it a valuable tool in various areas of biochemical research. -
β-Hexosaminidase Inhibitor
M-31850 is a selective and competitive inhibitor of β-hexosaminidase, demonstrating IC50 values of 6.0 μM for human HexA and 3.1 μM for human HexB. This compound also inhibits β-N-acetyl-D-hexosaminidase (OfHex2) with a Ki of 2.5 μM. M-31850 is valuable for research applications focused on lysosomal storage disorders and other biological contexts where β-hexosaminidase activity is implicated. -
Hydrolytic Enzymatic Complex
Naringinase is a hydrolytic enzymatic complex that exhibits both α-L-rhamnosidase and β-D-glucosidase activities. This enzyme is widely distributed in nature and plays a crucial role in the biotransformation of glycosides as well as steroids and antibiotics. Naringinase is valuable in research applications involving the hydrolysis of glycosides, facilitating various biochemical studies and industrial processes. -
α-Glucosidase Substrate
4-Nitrophenyl α-D-glucopyranoside is a chromogenic substrate specifically designed for the measurement of α-glucosidase activity. Upon hydrolysis by α-glucosidase, this compound produces a yellow chromophore, allowing for quantitative assessment of enzyme activity. It is widely utilized in biochemical assays to study carbohydrate metabolism and investigate the role of α-glucosidase in various biological processes. -
GCase Substrate
PFB-FDGlu is a highly selective substrate for lysosomal Glucocerebrosidase (GCase), engineered to be metabolized into fluorescein upon GCase activity. This compound is cell permeable, facilitating its use in flow cytometry to measure GCase activity in living cells at the single-cell level. PFB-FDGlu serves as an essential tool for studying GCase function in various biological contexts and is particularly relevant in research related to lysosomal storage disorders. -
Sugar Donor
UDP-GlcNAz disodium is a sugar donor analogue of UDP-GlcNAc disodium, serving as a substrate for various N-acetylgalactosaminyltransferases that facilitate the transfer of GlcNAc to saccharide or peptide acceptors. In addition to its enzymatic applications, UDP-GlcNAz disodium is a valuable click chemistry reagent featuring an azide group, capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It also enables strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-functionalized partners, making it useful for bioconjugation and labeling studies. -
Glycosidic Lyase
Heparitin sulfate lyase, also known as Heparinase III, is a glycosidic lyase that specifically targets heparan sulfate and heparin. This enzyme plays a crucial role in the degradation of glycosaminoglycans and is valuable for studies on low-molecular-weight heparin production. Additionally, Heparitin sulfate lyase is involved in cancer research, providing insights into tumor biology and therapeutic strategies. -
Cysteine Cathepsins Probe
DCG04 is an activity-based probe targeting cysteine cathepsins, serving as a multivalent ligand for the mannose-6-phosphate receptor. This compound enables the selective labeling of various cysteine cathepsins in cell and tissue lysates, facilitating the study of their roles in physiological and pathological processes. DCG04 is useful for researchers investigating enzyme activity and potential therapeutic interventions involving cysteine cathepsins. -
Bifidogenic Factor
Xylotriose is a natural xylooligosaccharide that serves as a bifidogenic factor, promoting the growth of beneficial bifidobacteria in the gastrointestinal tract. Its prebiotic properties enhance gut health by selectively stimulating the proliferation of these microorganisms. Xylotriose is utilized in research applications focused on gut microbiota modulation and may contribute to the development of functional foods aimed at improving digestive health. -
α-L-arabinofuranosidase Substrate
1,4-b-D-Xylopentaose is a linear pentasaccharide comprised of five β-D-xylose units linked by 1,4-glycosidic bonds. This compound functions as a specific substrate for the enzyme barley α-L-arabinofuranosidase, facilitating the study of enzyme activity and carbohydrate metabolism. It is widely utilized in research applications focused on plant cell wall degradation and glycoside hydrolases. -
Glycoside Hydrolase
β-Glucosidase, almond is a glycoside hydrolase that functions as a critical enzyme in cellulose degradation. This enzyme plays a significant role in the hydrolysis of β-glucosidic bonds, facilitating the breakdown of cellulose in various environments, including soils. Its activity is pivotal for assessing soil quality and understanding carbon cycling in ecosystems. Researchers utilize β-Glucosidase for studies related to plant biology, soil microbiology, and environmental monitoring. -
Antioxidant Agent
2-(2-Phenylethyl)chromone is an antioxidant agent that targets free radicals, particularly through the scavenging of ABTS·+. This compound exhibits a range of biological activities, including anti-inflammatory, neuroprotective, anti-tumor, and α-glucosidase inhibitory effects. It is valuable for research applications in inflammation-related diseases, cancer studies, and neurodegenerative disorders. -
α-glucosidase I Inhibitor
Kojibiose is an α-glucosidase I inhibitor that functions as an orally active prebiotic disaccharide. It specifically inhibits the activity of α-glucosidase I, promoting the proliferation of beneficial gut bacteria such as Bifidobacterium and lactic acid bacteria. Additionally, kojibiose serves as a low-calorie sweetener that enhances iron absorption and exhibits antitoxic properties. In vivo studies demonstrate its ability to reduce hepatic expression of inflammatory markers, highlighting its potential applications in metabolic and gastrointestinal research. -
ColA Inhibitor
4',5-Dihydroxyflavone is a potent inhibitor of collagenase A (ColA), with an IC50 value of less than 1 μM. This flavonoid compound also shows inhibitory activity against α-glucosidase and soybean lipoxygenase-1, making it valuable in biochemical research. Its applications include studies focused on anti-toxicity and anti-diabetes, highlighting its potential therapeutic benefits in metabolic and inflammatory disorders. -
α-Glucosidase Inhibitior
Resveratroloside is an orally active competitive inhibitor of α-glucosidase. It exhibits hypoglycemic and cardioprotective effects, making it a valuable compound for research into diabetes and cardiovascular diseases. This glycoside form of resveratrol facilitates investigations into its potential therapeutic applications in managing glucose metabolism and promoting heart health. -
α-L-fucosidase Inhibitor
Deoxyfuconojirimycin hydrochloride is a selective inhibitor of α-L-fucosidase, demonstrating a Ki value of 10 nM for human liver lysosomal α-L-fucosidase and 140 nM for Charonia lampas α-L-fucosidase. This compound effectively inhibits the activity of all soluble α-L-fucosidases present in human liver, including various post-translationally modified enzyme forms. Deoxyfuconojirimycin hydrochloride is primarily utilized in research focused on fucosidase-related enzyme activity and metabolic pathways, though it does not exhibit anti-HIV properties. -
Tyrosinase Inhibitor
Kushenol A, a non-competitive inhibitor of tyrosinase, effectively blocks the conversion of L-tyrosine to L-DOPA, with IC50 and Ki values of 1.1 μM and 0.4 μM, respectively. Isolated from the root of Sophora flavescens, Kushenol A exhibits antioxidant properties and also inhibits alpha-glucosidase (IC50: 45 μM; Ki: 6.8 μM) and β-amylase. This compound is valuable for research focused on skin whitening and anti-aging applications due to its enzyme inhibitory effects. -
Glucosidase Inhibitor
Gitogenin is a natural steroid derived from the plant Tribulus longipetalus, serving as a selective inhibitor of UDP-glucuronosyltransferase 1A4 (UGT1A4) and α-glucosidase. It exhibits an IC50 of 0.69 μM for UGT1A4 using trifluoperazine as a substrate, and an IC50 of 37.2 μM for α-glucosidase. Gitogenin does not interfere with the activities of major human cytochrome P450 isoforms, making it a valuable reagent for studies in metabolic enzyme pathways and potential therapeutic applications related to glycemic control. -
Glycosidase
Heparinase II is a glycosidase that specifically targets heparin and heparan sulfate. It plays a crucial role in the structural and functional analysis of glycosaminoglycans, making it valuable in anticoagulant research and studies of tumor microenvironment modulation. Its enzymatic activity facilitates investigations into various biological processes, including cell signaling and the interaction of cancer cells with their surrounding matrix. -
Glycosidase Inhibitor
Cedryl acetate is a tricyclic sesquiterpene with notable α-glucosidase inhibitory activity. This compound is isolated from the plant Cunninghamia lanceolata and is valuable in research focused on carbohydrate metabolism and glycosidase inhibition. Its biological activity makes it an important tool for studying metabolic disorders and potential therapeutic interventions. -
GCase 2 Inhibitor
AMP-Deoxynojirimycin is a potent inhibitor of glucocerebrosidase 2 (GCase 2) and ceramide glucosyltransferase. This compound effectively interferes with glucosylceramide (GlcCer) biosynthesis, making it valuable for research related to lysosomal storage disorders and sphingolipid metabolism. Its biological activity positions AMP-Deoxynojirimycin as a significant tool for investigating the roles of GlcCer in various cellular processes and disease mechanisms. -
Fluorescent Substrate
4-Methylumbelliferyl-α-D-Glucopyranoside is a fluorescent substrate targeting α-glucosidase, which releases the fluorescent moiety 4-methylumbelliferyl (4-MU) upon enzymatic cleavage. This compound exhibits pH-dependent fluorescence, with excitation wavelengths of 320 nm in acidic conditions and 360 nm in alkaline conditions, while its emission increases between 445-455 nm as pH decreases. 4-Methylumbelliferyl-α-D-Glucopyranoside serves as a valuable biomarker for assessing α-glucosidase activity in infant blood spot samples, particularly in the context of Fabry and Pompe diseases. -
Glycosidase Substrate
4-Methylumbelliferyl α-L-arabinofuranoside serves as a substrate for glycosidase enzymes, facilitating the cleavage of α-L-arabinofuranosidic bonds. Upon hydrolysis, it generates the fluorescent product 4-methylumbelliferone, allowing for sensitive detection and quantification. This compound is valuable in enzyme activity assays, particularly in studies involving carbohydrate metabolism and glycoside hydrolase activity. -
Glucosidase Inhibitor
Kaempferol 3-O-gentiobioside is a flavonoid that functions as an α-glucosidase inhibitor. Isolated from the leaves of C. alata, this compound demonstrates significant antidiabetic activity by inhibiting carbohydrate enzyme activity, with an IC50 value of 50.0 µM. It serves as a valuable tool for research into glucose metabolism and diabetes treatment applications. -
Chromogenic Glycosidic Ligand
p-Nitrophenyl α-D-mannopyranoside is a chromogenic glycosidic ligand targeting glycosidase enzymes. This compound contains an α-D-mannopyranose moiety with a distinctive axial hydroxyl group at the C2 position, along with a p-nitrophenol portion that absorbs ultraviolet-visible light. p-Nitrophenyl α-D-mannopyranoside is essential for assessing glycosidase activity and exploring the sugar recognition properties of lectins, including Concanavalin A. -
Glycosidase Inhibitor
Glycyrrhisoflavone is a potent α-glucosidase inhibitor that acts primarily by blocking the enzyme's activity, thereby modulating carbohydrate metabolism. This natural prenylflavonoid exhibits significant biological activity, making it useful in research related to diabetes management and metabolic disorders. Its ability to influence glycemic control highlights its potential applications in pharmacological studies and nutraceutical development. -
Weed Inhibitor
Glucobrassicin potassium is a glucosinolate (GSL) that functions as a potent weed inhibitor. Isolated from wild carrot (Raphanus raphanistrum L.), it demonstrates significant potential in biological fumigation and allelopathy research. Its application in weed management studies supports the exploration of sustainable agricultural practices. -
GCase Ligand
GT-02216 is an allosteric ligand for Glucosylceramidase (GCase) that enhances its enzymatic activity. This compound not only promotes the activity of GCase in primary human fibroblasts in a dose-dependent manner but also effectively reduces the accumulation of hexosylsphingosine (HexCer), a substrate linked to various pathologies. Additionally, GT-02216 has demonstrated the ability to decrease Tau accumulation in mutant GBA1 fibroblasts, making it a valuable tool in the study of Parkinson’s disease and related neurodegenerative conditions. -
Glycosidic Hydrolase
α-Rhamnosidase is a glycosidic hydrolase that catalyzes the hydrolysis of α-rhamnosides, facilitating the enzymatic de-glycosylation of a variety of natural flavonoid glycosides. This enzyme plays a critical role in the metabolism of plant glycosides, contributing to the bioavailability of flavonoid compounds. It is widely used in research applications focusing on plant biochemistry, natural product studies, and the analysis of flavonoid bioactivity.
