Catalog No.
Product Name
Application
Product Information
Citations
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GCase Inhibitor
Gcase Activator 2 is a pyrrolo[2,3-b]pyrazine that serves as a potent activator of β-glucocerebrosidase (GCase), with an EC50 of 3.8 μM. This compound facilitates GCase dimerization, promoting both K-type and V-type interactions. Gcase Activator 2 displays low metabolic clearance in both human and mouse systems, making it a valuable tool for research into GCase-related biological pathways and potential therapeutic applications in lysosomal storage disorders. -
Sweetener
Erlose is a trisaccharide sucrose derivative and low-calorie sweetener, synthesized through an α-glucosidase-mediated transglycosylation of glucose and sucrose. It possesses approximately half the sweetness of sucrose while maintaining a comparable taste profile. Erlose is primarily employed as a marker for detecting artificial sucrose adulteration in honey and demonstrates efficacy in inhibiting crystal formation and browning reactions during food heat treatment. This compound is valuable in research applications focused on food science and sweetener development. -
CHI3L1 Inhibitor
CHI3L1-IN-3 is a potent inhibitor of CHI3L1, with dissociation constants of 13.76 μM and 13.5 μM as measured by MST and SPR assays, respectively. This compound exhibits favorable pharmacokinetic properties, including extended plasma half-lives and microsomal stability, alongside decreased intrinsic clearance. In biological assays, CHI3L1-IN-3 demonstrates dose-dependent cytotoxicity, effectively reduces spheroid mass, and inhibits cell migration in a three-dimensional multicellular glioblastoma (GBM) spheroid model. It serves as a valuable tool for investigating the roles of CHI3L1 in GBM research. -
Cyclophenyl Alcohol
Cyclophellitol aziridine is a cyclophenol analogue that acts as a potent inhibitor of β-glucosidase. This compound demonstrates significant potential in studying carbohydrate metabolism and related enzymatic pathways. Its inhibitory activity makes it a valuable tool for investigating β-glucosidase-related diseases and for screening potential therapeutic agents. -
Alpha-glucosidase Inhibitor
Valiolamine is an aminocyclitol that functions as an alpha-glucosidase inhibitor. It exhibits significant inhibitory activity against porcine intestinal sucrase and maltase, with Ki values of 30 nM and 350 nM, respectively. This compound is valuable for research applications focused on carbohydrate metabolism, specifically in studying the modulation of glucose absorption and the potential therapeutic approaches to disorders such as diabetes. -
UV Filter
Benzophenone-2 is an organic ultraviolet absorber that serves as a UV filter in various personal care and industrial products, including plastics and coatings. It functions as an endocrine disruptor, impacting estrogen receptor (ERα) and pregnane X receptor (PXR) activity, which may contribute to reproductive toxicity, immune disorders, and metabolic abnormalities. Additionally, Benzophenone-2 exhibits inhibitory activity against α-glucosidase (IC50 = 49.72 μM), making it relevant for research in diabetes mellitus and related metabolic studies. -
Glycosidic Hydrolase
α-L-Arabinofuranosidase is a glycosidic hydrolase that specifically hydrolyzes the non-reducing termini of α-L-arabinofuranosyl residues found in polysaccharides such as arabinoxylan, arabinan, and arabinogalactan. This enzyme plays a crucial role in carbohydrate metabolism and is instrumental in the breakdown of complex carbohydrates. Its applications include enzymatic studies of plant-based polysaccharides and potential use in bioengineering for the modification of dietary fibers. -
Glucocerebrosidase Modulator
β-Glucocerebrosidase modulator 1 is a potent allosteric modulator targeting β-Glucocerebrosidase, with an EC50 of 9.0 μM and a Kd of 0.050 μM. This compound enhances the enzymatic activity of β-Glucocerebrosidase, making it a valuable tool for studying Gaucher disease and related lipid metabolism disorders. Its modulation of enzymatic function assists in elucidating biological pathways and may aid in the development of therapeutic interventions. -
α-Glucosidase Inhibitor
Panasenoside is a flavonoid that acts as an α-glucosidase inhibitor. Derived from Lilium pumilum DC, it has demonstrated significant inhibitory activity against α-glucosidase, making it a valuable tool for research on carbohydrate metabolism and related disorders. This compound is relevant for studies investigating diabetes management and the modulation of postprandial blood glucose levels. -
Alkylresorcinol
5-Nonadecylresorcinol is an alkylresorcinol that functions as an inhibitor of β-hexosaminidase release in vitro. Its biological activity makes it a valuable tool for research investigating the role of β-hexosaminidase in various cellular processes. Applications include studies related to enzyme modulation and potential therapeutic interventions in conditions where β-hexosaminidase activity is implicated. -
Glucocerebrosidase Chaperone
NCGC00092410 is a selective glucocerebrosidase chaperone that enhances the enzyme's activity and lysosomal localization in mutant cell lines. With an IC50 of 31 nM, it demonstrates notable potency without affecting related hydrolases at concentrations up to 77 μM. This reagent is primarily utilized in research focused on Gaucher disease, providing insights into therapeutic strategies for this lysosomal storage disorder. -
CHI3L1:HSIII Inhibitor
CHI3L1-IN-2 is a selective inhibitor of CHI3L1 (Chitinase-3-Like Protein 1) that targets its interaction with heparan sulfate (CHI3L1:HSIII), exhibiting an IC50 of 26 nM. CHI3L1 is a glycoprotein linked to various pathological conditions including inflammation, fibrosis, and cancer. This compound serves as a valuable tool for researchers investigating the role of CHI3L1 in disease processes and therapeutic applications. -
GCase Activator
GCase Activator 3 is a glucocerebrosidase (GCase) activator that enhances enzyme stability and activity. This compound effectively reduces misfolding and degradation of mutant GCase proteins in fibroblasts and dopaminergic neurons, providing a potential therapeutic strategy for conditions such as Parkinson's disease and related synucleinopathies. GCase Activator 3 is instrumental in advancing research aimed at understanding and treating these neurodegenerative disorders. -
Anti-Viral Agent
IHVR-17028 is a broad-spectrum antiviral agent that primarily targets endoplasmic reticulum α-glucosidase I. It demonstrates significant antiviral activity against various viruses, including Bovine viral diarrhea virus (BVDV), Tick-borne choriomeningitis virus (TCRV), and Dengue virus (DENV), with EC50 values of 0.4 μM, 0.26 μM, and 0.3 μM, respectively. With an IC50 of 0.24 μM, it effectively inhibits ER α-glucosidase I, making it a valuable tool for research into infectious diseases. -
Alkaloid
N-Caffeoyl O-methyltyramine is an alkaloid with demonstrated inhibitory activity against α-glucosidase, exhibiting an IC50 value of 103.58 μM. This compound is derived from Cuscuta reflexa and is relevant for research focused on glucose metabolism and diabetes. Its potential applications include studying carbohydrate absorption and metabolic disorders, making it a valuable reagent in biochemical investigations. -
α-Glucosidase Inhibitor
β-Hydroxypropiovanillone is an α-glucosidase inhibitor that demonstrates significant concentration-dependent inhibitory effects on this enzyme. With an IC50 value of 257.8 μg/mL, it is useful for studying carbohydrate metabolism and potential therapeutic applications in managing postprandial hyperglycemia. This compound may serve as a valuable research tool in the exploration of diabetes and related metabolic disorders. -
Isoamylase
Isoamylase, also known as glycogen α-1,6-glucanohydrolase, catalyzes the hydrolysis of α-1,6-glycosidic linkages in glycogen, amylopectin, and α/β-limit dextrins. This enzymatic activity is crucial for the degradation of complex carbohydrates, making Isoamylase valuable for research in carbohydrate metabolism, enzymology, and biotechnology applications. Its ability to selectively cleave α-1,6-glycosidic bonds allows for the detailed study of glycogen structure and function in various biological contexts. -
α-glucosidase Inhibitor
Magnoloside B is an α-glucosidase inhibitor with an IC50 value of 0.69 mM, derived from the stem bark of Magnolia officinalis. It exhibits moderate inhibitory activity against MGC-803 and HepG2 cancer cell lines. This compound is of significant interest for research applications related to cancer and diabetes. -
α-amylase/α-glucosidase/Acetylcholinesterase Inhibitor
Kaempferol-3,7-di-O-β-glucoside is a flavonol that acts as an inhibitor of α-amylase, α-glucosidase, and acetylcholinesterase. This compound has demonstrated protective effects on differentiating neuronal cells, specifically SH-SY5Y, against injury induced by Amyloid β peptide. Its enzyme inhibitory properties and neuroprotective effects indicate potential applications in Alzheimer's disease research and therapeutics. -
Fusion Protein
Berahyaluronidase alfa is a recombinant fusion protein that targets hyaluronidase PH-20 and associated proteins such as HYAL3 and SPAM1. This enzymatic agent facilitates the degradation of hyaluronic acid, thereby promoting increased tissue permeability. It is primarily utilized in the research of advanced and metastatic solid tumors, offering potential insights into tumor progression and therapeutic interventions. -
Glycosidase
Glyoxalase I (Glo-I) is a glycosidase that plays a crucial role in the detoxification of methylglyoxal (MOG). Its primary mechanism involves catalyzing the conversion of MOG to D-lactate, thereby mitigating cellular damage and reducing oxidative stress. This enzyme is significant in studies related to inflammation and cancer, making it an important target for research into therapeutic interventions aimed at these conditions. -
Alpha-glucosidase Inhibitor
(+)-Afzelechin is an alpha-glucosidase inhibitor derived from the rhizomes of Bergenia ligulata. It demonstrates an ID50 value of 0.13 mM, indicating its potency in inhibiting alpha-glucosidase activity. This compound effectively delays carbohydrate absorption, thereby reducing postprandial hyperglycemia and hyperinsulinemia. It serves as a valuable tool for research in metabolic disorders and glycemic control. -
α-glucosidase Inhibitor
Ganoderol B is a potent inhibitor of α-glucosidase, exhibiting significant enzymatic inhibition with an IC50 value of 48.5 μg/mL (119.8 μM). This compound is primarily utilized in research applications related to carbohydrate metabolism and glucose regulation, making it a valuable tool in studies of diabetes and postprandial hyperglycemia. Researchers may leverage Ganoderol B to explore mechanisms of glycemic control and to develop therapeutic strategies targeting α-glucosidase. -
α-Glucosidase Inhibitor
(-)-Pinoresinol 4-O-glucoside serves as a potent α-glucosidase inhibitor, exhibiting an IC50 value of 48.13 µM. This compound promotes cell migration and early differentiation of pre-osteoblasts while enhancing the protein levels of BMP2, phosphorylated Smad1/5/8, and RUNX2. Additionally, it demonstrates protective effects against oxidative stress, hyperglycemia, and hepatic toxicity. (-)-Pinoresinol 4-O-glucoside is a valuable reagent for investigating osteoporosis and periodontal disease. -
GCase Inhibitor
Glucocerebrosidase-IN-1 is a selective inhibitor of glucocerebrosidase (GCase), exhibiting an IC50 of 29.3 μM and a Ki of 18.5 μM. This compound is instrumental in research related to Gaucher disease and Parkinson's disease, allowing for the investigation of GCase's role in these conditions. Its potency and specificity make it a valuable tool for elucidating the biochemical pathways involved in lysosomal storage disorders. -
β-D-mannopyranosidase Substrate
4-Nitrophenyl β-D-mannopyranoside is a specific substrate for the enzyme β-D-mannopyranosidase, facilitating the study of enzymatic activity in carbohydrate metabolism. It also serves as a substrate for GH1-glucosidase and α-L-rhamnosidase, making it a versatile reagent for various glycoside hydrolase assays. This compound is valuable for researchers focused on enzyme kinetics and carbohydrate enzymology. -
α-Glucosidase Inhibitor (AGI)
α-Glucosidase-IN-11 is a potent competitive inhibitor of α-glucosidase, exhibiting an IC50 value of 0.56 μM. This compound selectively binds to tryptophan residues in the enzyme, influencing its protein folding and activity. α-Glucosidase-IN-11 has potential applications in the regulation of carbohydrate metabolism and blood glucose control, making it a valuable tool for diabetes research and therapeutic development. -
Exoglycosidase
α1-6 Mannosidase, Xanthomonas phaseoli is a highly specific exoglycosidase that hydrolyzes unbranched α1-6 linked mannose residues in oligosaccharides. This enzyme plays a crucial role in the structural modification of glycoproteins and polysaccharides, facilitating studies in glycan analysis, carbohydrate metabolism, and enzymatic reaction mechanisms. Its precise activity makes it an essential reagent for research in glycoscience and biochemistry. -
Glycosidase Inhibitor
N-Methylmoranoline is a potent α-glucosidase inhibitor that modulates carbohydrate metabolism by interfering with enzyme activity. This compound demonstrates significant potential in research related to diabetes management and metabolic disorders by reducing glucose absorption. It is utilized in studies exploring glycemic control and the pharmacological effects of glycosidase inhibition. -
Glucosidase Inhibitor
Glucocerebrosidase-IN-1 hydrochloride is a potent and selective inhibitor of glucocerebrosidase (GCase), demonstrating an IC50 of 29.3 μM and a Ki of 18.5 μM. This compound is relevant for research applications concerning Gaucher disease and Parkinson's disease, as it influences cellular metabolism of glucocerebrosides. Its selective inhibition makes it a valuable tool for studying the biochemical pathways associated with these conditions. -
α-glucosidase Inhibitor
Carpachromene is a potent inhibitor of the α-glucosidase enzyme. It has been shown to ameliorate insulin resistance in HepG2 cells by modulating the IR/IRS1/PI3K/Akt/GSK3/FoxO1 signaling pathway. This compound is valuable for researching metabolic disorders and potential therapeutic strategies for diabetes management. -
Tryptophan Derivative
(S)-N-(1H-Indole-3-acetyl)tryptophan is a tryptophan derivative that serves as a weak inhibitor of β-D-glucosidase. Its biological activity may be leveraged in research focused on enzymatic pathways and metabolic processes where β-D-glucosidase plays a significant role. This compound can be utilized in various biochemical studies exploring the interactions and regulation of tryptophan derivatives in cellular contexts. -
Substrate of β-lactosidase
p-Nitrophenyl β-D-lactoside acts as a substrate for β-lactosidase, facilitating the assessment of enzyme activity in various biological applications. This compound is also a substrate for cellobiohydrolase, making it valuable in studies involving carbohydrate metabolism. Its utility in glycobiology research underscores its importance for understanding glycan interactions and enzymatic functions. -
α-Glucosidase Inhibitor
Casuarictin is a potent α-glucosidase inhibitor, exhibiting competitive inhibition with an IC50 of 0.21 μg/mL. It also acts as an inhibitor of presenilin stabilization factor-like protein (PSFL). This compound is valuable for research applications related to Alzheimer's disease and metabolic disorders, providing insights into therapeutic strategies targeting carbohydrate metabolism. -
β-glucosidase Inhibitor
Validamine is a competitive inhibitor of β-glucosidase, demonstrating pH-dependent and dose-dependent inhibition with an IC50 value of 2.92 mM. Its maximum inhibitory effect occurs at the enzyme's optimal pH, making it a valuable tool for studying β-glucosidase function and regulation. This compound can be utilized in research applications focused on carbohydrate metabolism and related pathways. -
α-Glucosidase/α-Aamylase Inhibitor
Diphlorethohydroxycarmalol is a phlorotannin that serves as an inhibitor of α-glucosidase and α-amylase, exhibiting IC50 values of 0.16 mM and 0.53 mM, respectively. This compound demonstrates significant anti-diabetic activity, making it relevant for research focused on glucose metabolism and diabetes management. Its mechanism of action highlights its potential application in developing therapeutic strategies for metabolic disorders. -
β-glucocerebrosidase Activator
N-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine is a β-glucocerebrosidase activator that enhances enzyme activity by approximately 20%. This reagent is valuable for research into lysosomal storage disorders and related protein misfolding diseases, facilitating studies aimed at understanding and potentially treating these conditions. -
α-glucosidase Inhibitor
p-Hydroxyphenethyl trans-ferulate is an α-glucosidase inhibitor known for its anti-hyperglycemic properties, exhibiting an IC50 value of 19.24 ± 1.73 µM against yeast α-glucosidase. This compound also demonstrates antioxidant and anti-inflammatory activities, making it a valuable tool in the study of metabolic disorders. Additionally, p-Hydroxyphenethyl trans-ferulate has shown potential in inhibiting cancer cell proliferation and modulating serotonergic activity, supporting its application in cancer and neurological research. -
Sugar Donor
UDP-GlcNAz serves as an analog of UDP-GlcNAc, functioning primarily as a sugar donor substrate for N-acetylgalactosaminyltransferases. These enzymes utilize UDP-GlcNAz to transfer N-acetylglucosamine to saccharide or peptide acceptors. Featuring an azide group, UDP-GlcNAz is also a valuable click chemistry reagent, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules. Its versatility makes it suitable for various applications in chemical biology and glycobiology research. -
Glycoside
2-Methylbutyl β-D-glucopyranoside is a glycoside that functions as an aroma precursor in apple fruit. Upon enzymatic hydrolysis, it releases the volatile compound 2-methylbutanol, which contributes to the characteristic aroma profile of various food products. This reagent is useful in research focused on food flavor chemistry and the biochemical processes underlying flavor development in fruits. -
GCase Modulator
GCase modulator-1 is a Quinazoline derivative targeting GCase (Glucosidase) with an AC50 of 2.23 μM. This compound serves as a potent modulator, influencing GCase activity and its associated metabolic pathways. It is primarily utilized in research focused on lysosomal storage disorders and potential therapeutic strategies for related conditions. -
α-galactosidase A Inhibitor
Migalastat is an orally active inhibitor of α-galactosidase A, functioning primarily as a molecular chaperone with an IC50 value of 0.04 μM for human α-Gal A. This compound selectively binds to the active site of specific unstable mutant forms of α-galactosidase A, promoting their proper transport to the lysosome. Upon dissociating in the acidic lysosomal environment, Migalastat enhances the biological activity of the mutant enzyme, making it a valuable tool in research related to lysosomal storage disorders. -
Endoplasmic Reticulum α-Glucosidases I and II Inhibitor
EB-0156 is a potent inhibitor of endoplasmic reticulum α-glucosidases I and II, exhibiting IC50 values of 0.0479 μM and less than 0.001 μM, respectively. Derived from valiolamine, this compound demonstrates broad-spectrum antiviral activity. EB-0156 is valuable for research focused on developing therapeutic agents against both existing and emerging viral pathogens. -
Glycosidase Inhibitor
1,3-Dipalmitoleoyl glycerol is an α-glucosidase inhibitor with significant biological activity derived from sea cucumber viscera. This compound demonstrates varying degrees of inhibitory effects on α-glucosidase from diverse sources, making it valuable for research into carbohydrate metabolism and related disorders. Its application in studying glycosidase functions can provide insights into metabolic pathways and potential therapeutic targets. -
GAA Agonist
N-4′-(p-Trifluoromethylphenyl)butyl-DAB is a potent agonist of lysosomal acid α-glucosidase (GAA). This compound enhances intracellular GAA activity in a dose-dependent manner, specifically in fibroblasts from Pompe disease patients harboring the M519V mutation. It serves as a valuable tool for research into enzyme replacement therapies and the cellular mechanisms underlying lysosomal storage disorders. -
Molecular Chaperone
N-Octyl-α-4-epivalienamine is a potent molecular chaperone that enhances the expression of deficient β-galactosidase activity. This compound has demonstrated the ability to alleviate symptoms and improve survival rates in mouse models of GM1-gangliosidosis. N-Octyl-α-4-epivalienamine is valuable for research involving neurogenetic diseases and the development of therapeutic strategies targeting lysosomal storage disorders. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-6 is a competitive inhibitor of α-glucosidase, exhibiting an IC50 of 5.69 µM. This compound demonstrates potential anti-diabetic activity by modulating carbohydrate metabolism. It is applicable in research focused on diabetes treatment and metabolic disorders. -
α-Glucosidase Inhibitor
Flaccidoside III is a triterpenoid compound that functions as an α-glucosidase inhibitor, exhibiting an IC50 value of 256.7 μM. It demonstrates significant potential for antioxidant and antidiabetic activities, making it a valuable reagent in metabolic research and studies aimed at understanding glucose regulation. Its effects on α-glucosidase modulation contribute to its implications in diabetes management research. -
α-Glucosidase Inhibitor
3-Oxo-hop-22(29)-ene is a potent inhibitor of α-glucosidase, predominantly affecting yeast enzymes. This compound exhibits moderate inhibitory effects on the viability of Trichomonas cruzi and Leishmania mexicana, suggesting its potential as a therapeutic agent against these pathogens. Additionally, 3-Oxo-hop-22(29)-ene displays marginal anti-inflammatory activity, highlighting its multifaceted biological applications in research. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-4 is a reversible, mixed-type inhibitor of α-glucosidase, exhibiting an IC50 value of 12.98 μM. This compound serves as a valuable tool for studying carbohydrate metabolism and its associated disorders, including diabetes and obesity. Its ability to modulate α-glucosidase activity makes it suitable for research into therapeutic strategies targeting glycemic control.
