Catalog No.
Product Name
Application
Product Information
Citations
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Endogenous Metabolite
Mesoxalate sodium (monohydrate) is an endogenous metabolite that plays a role in various metabolic pathways. Its primary mechanism is influencing the metabolism of oxalate and related compounds. Mesoxalate is utilized in research focused on metabolic disorders and renal function, providing insights into oxalate homeostasis and its implications in health and disease. -
CoA
18:0 Coenzyme A (triammonium) is a substrate for stearoyl-CoA desaturases (SCDs), enzymes that catalyze the desaturation of saturated fatty acids. This compound plays a crucial role in lipid metabolism and is significant in studies focused on fatty acid synthesis and oxidation. It is widely used in research applications investigating metabolic disorders and adipocyte differentiation. -
Endogenous Metabolite
CL-385319 is an N-substituted piperidine compound that targets the H5N1 avian influenza A virus, demonstrating inhibitory activity against infection. It exhibits an IC50 of 27.03±2.54 μM in Madin-Darby canine kidney cells (MDCK) and displays low cytotoxicity with a CC50 of 1.48 mM. CL-385319 effectively inhibits the entry of pseudoviruses carrying various H5N1 strains, although no effect is observed on VSV-G pseudotyped particles. Notably, mutations M24A in HA1 and F110S in HA2 confer resistance to CL-385319, suggesting the significance of these residues for binding efficacy. This compound is suitable for research applications concerning influenza virus entry mechanisms and antiviral drug development. -
Endogenous Metabolite
4,4-Dimethoxy-2-butanone is identified as an endogenous metabolite involved in various biochemical pathways. This compound has potential implications in research focused on metabolic processes and the study of metabolic disorders. Its role as a metabolite makes it valuable for investigations into the physiological effects of metabolites and their impact on cellular functions. -
Endogenous Metabolite
Ethoxyacetic acid is an endogenous metabolite involved in metabolic pathways. It plays a role in various biochemical processes, influencing cellular functions and responses. This compound is utilized in research to study metabolic reactions and the impact of metabolites on cellular dynamics. Its significance in understanding metabolic regulation makes it a valuable tool for investigators in the fields of biochemistry and molecular biology. -
Endogenous Metabolite
H-HomoArg-OH.HCl is an endogenous metabolite primarily involved in the urea cycle and nitric oxide synthesis. This compound plays a significant role in various physiological processes, including the regulation of cardiovascular function and modulation of cellular signaling pathways. It is commonly used in biochemical research to study metabolic pathways and analyze nitrogen metabolism in biological systems. -
Degradative Product of Starch
Maltose monohydrate is a degradative product of starch and serves as a substrate for α-glucosidase, which hydrolyzes maltose into glucose. This compound plays a significant role in various biological processes, including carbohydrate metabolism. Additionally, maltose monohydrate demonstrates protective effects on proteins, membranes, and the photosynthetic electron transport chain under conditions of heat stress and freezing stress, making it valuable for research into stress responses in biological systems. -
Endogenous Metabolite
AalphaC (AαC) is an endogenous metabolite recognized as a potential carcinogen, primarily arising from tobacco smoke exposure. It serves as a crucial biomarker in monitoring tobacco-related health risks, as urinary concentrations of AalphaC are significantly elevated in smokers compared to non-smokers. Additionally, AalphaC levels correlate with serum nicotine concentrations, reinforcing its relevance in tobacco research. Furthermore, dietary factors, such as high-temperature cooked beef, can influence AalphaC urinary levels, while vegetable consumption is associated with reduced levels. AalphaC's distinct biological activity makes it an essential compound for studying tobacco exposure and its health implications. -
Endogenous Metabolite
D-Citrulline is an endogenous metabolite that serves as a precursor in the biosynthesis of nitric oxide. It has been shown to significantly mitigate polymorphonuclear leukocyte (PMN)-induced cardiac contractile dysfunction in isolated perfused rat hearts subjected to ischemia/reperfusion, operating through a non-nitric oxide-mediated mechanism. This compound is valuable for research applications related to cardiovascular physiology and inflammatory responses. -
Endogenous Metabolite
4-Hydroxycyclohexanecarboxylic acid is an endogenous metabolite that plays a role in various biochemical pathways. This compound is recognized for its potential involvement in metabolic processes and can serve as a useful tool for studying metabolic disorders and cyclohexanol derivatives. Its unique structure offers opportunities for exploring the physiological effects and functions of cyclohexyl compounds in biological systems. -
Endogenous Metabolite
16-Doxylstearic acid (16-DSA) is a radical spin label derivative of stearic acid that incorporates a 4,4-dimethyl-3-oxazolidinyloxy group. This compound serves as a valuable tool for studying the biophysical properties of cellular membranes and the dynamics of hydrophobic proteins. Its unique structure allows for electron paramagnetic resonance (EPR) applications, facilitating insights into molecular interactions and membrane organization in biological research. -
Endogenous Metabolite
Cholesteryl Linolenate is an endogenous metabolite that plays a critical role in lipid metabolism. This compound can serve as a key component in studies involving cell membrane dynamics and signaling pathways related to lipid metabolism. Its biological activity makes it valuable for research in metabolic disorders and the effects of lipids on cellular functions. -
Endogenous Metabolite
Butyric acid-13C4 sodium is a stable isotope-labeled compound targeting endogenous metabolites. It plays a crucial role in promoting cell proliferation and regulating gene expression. This reagent is essential for metabolic research and compound development, aiding scientists in elucidating the functions of short-chain fatty acids in biological systems. Additionally, it contributes to studies in nutrition and intestinal health by investigating its impact on probiotic function and the modulation of the intestinal microbiota. -
Endogenous Metabolite
1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride is an endogenous metabolite that functions as an inhibitor of glycogen phosphorylase and α-glucosidases. This naturally occurring pyrrolidine alkaloid, isolated from Arachniodes standishii and Angylocalyx boutiqueanus, plays a critical role in carbohydrate metabolism. Its unique inhibitory properties make it valuable for research applications in studying metabolic disorders and enzyme regulation. -
Endogenous Metabolite
Isopentenyl pyrophosphate trilithium serves as a key intermediate in the biosynthesis of terpenes, functioning as an essential building block in isoprenoid pathways. Its role in cellular metabolism highlights its importance in various biological processes, including growth and development in plants and microorganisms. This compound is valuable for research on metabolic engineering, terpene production, and investigating the biochemical pathways related to isoprenoids. -
Endogenous Metabolite
Nonanoylcarnitine is an endogenous metabolite linked to chronic exposure to polycyclic aromatic hydrocarbons (PAHs). It has been identified as a potential biomarker for assessing metabolic outcomes related to PAH exposure and may provide insights into the prognosis of acute myocardial infarction. This compound serves as a valuable tool in research focused on environmental toxicology and cardiovascular health. -
Endogenous Metabolite
12-Doxylstearic acid is a derivative of stearic acid featuring a hydrophobic spin label provided by the 4,4-dimethyl-3-oxazolinyloxy (DOXYL) group. This compound is primarily employed to investigate the molecular properties of membranes and hydrophobic proteins. Its ability to function as a spin label makes it valuable for applications in electron paramagnetic resonance (EPR) spectroscopy, enabling researchers to analyze lipid dynamics and protein conformational changes within biological systems. -
Endogenous Metabolite
(rac./meso)-Astaxanthin is a carotenoid pigment that functions as a lipid-soluble antioxidant, effectively scavenging free radicals. Found predominantly in marine organisms such as shrimp and salmon, it is an important endogenous metabolite with potential applications in research related to oxidative stress and cellular protection. Studies have demonstrated its bioactive properties, making it relevant for investigations into its role in health and disease prevention. -
Endogenous Metabolite
1,10-Diiododecane, a potent crosslinking reagent, is primarily recognized for its ability to facilitate the synthesis of tetrabutylammonium polygalacturonic acid. This compound also functions as an alkylating agent in the production of both symmetrical and unsymmetrical bis-cryptophanes. Furthermore, 1,10-Diiododecane can be employed in the synthesis of decane under controlled conditions at 20°C, making it a valuable tool in chemical research and organic synthesis applications. -
Endogenous Metabolite
9(S)-HpODE is an endogenous metabolite generated through the action of arachidonate 5-lipoxygenase on linoleic acid. This hydroperoxide can undergo further metabolism by potato hydroperoxide dehydratase, leading to the formation of colneleic acid. As a significant bioactive lipid, 9(S)-HpODE is important in studies related to inflammation and lipid signaling pathways. Its characterization is essential for understanding the role of lipid peroxidation in various biological processes and diseases. -
Endogenous Metabolite
1-Palmitoyl-sn-glycerol 3-phosphate (1-P-GPA) is an endogenous metabolite that serves as a lipid membrane precursor. This compound plays a significant role in cellular membrane biosynthesis and is particularly relevant in the study of non-alcoholic fatty liver disease. Researchers can utilize 1-P-GPA to investigate lipid metabolism and its implications in various metabolic disorders. -
FXR Antagonist
Tauro-α-muricholic acid (T-α-MCA) is a conjugated bile acid that acts as an antagonist of the farnesoid X receptor (FXR), exhibiting an IC50 of 28 µM. This compound is instrumental in modulating FXR signaling pathways, particularly in the context of bile acid activation. Its research applications include investigations into Alzheimer's disease, as well as studies on glucose and lipid metabolism. -
Endogenous Metabolite
2-Naphthalenemethanol is an endogenous metabolite derived from the environmental contaminant 2-methylnaphthalene. This compound has been shown to covalently bind to alveolar proteins, contributing to pulmonary toxicity. It serves as a valuable tool in studies of environmental pollutants and their effects on respiratory health. Researchers may utilize 2-naphthalenemethanol to explore mechanisms of toxicity and assess the biological impact of naphthalene derivatives. -
Endogenous Metabolite
(R)-1-PeCSO, or trans-(+)-S-1-Propenyl-L-cysteine sulfoxide, functions as an endogenous metabolite. This compound is recognized as the primary flavor precursor in onions, contributing significantly to their characteristic taste and aroma. Its significance extends to studies in flavor biochemistry and plant metabolism, making it a valuable tool for research in food science and agricultural biotechnology. -
Endogenous Metabolite
6-Methylnicotinamide is a nicotinamide derivative that functions as an endogenous metabolite. In research settings, it has been observed to exacerbate neurological damage during the acute phases of intracerebral hemorrhage in rat models. Additionally, 6-Methylnicotinamide enhances the coordination interactions between acylamino groups and defective Pb2+ cations, contributing to significant improvements in the efficiency of perovskite solar cells, achieving up to 24.33% efficiency while maintaining excellent stability under environmental stressors such as heat and light. -
Endogenous Metabolite
3α,7α-Dihydroxycoprostanic acid is an endogenous metabolite that serves as a precursor to chenodeoxycholic acid. As a bile acid, it is involved in lipid digestion and absorption. This compound is useful for research applications related to bile acid metabolism, gastrointestinal health, and lipid biochemistry. -
Endogenous Metabolite
2-Amino-5-phenylpyridine is an endogenous metabolite resulting from the pyrolysis of phenylalanine within proteins. This mutagenic heterocyclic aromatic amine has been identified in broiled sardines and is associated with potential carcinogenic properties. It serves as an important compound for research into the mechanisms of mutagenesis and the study of dietary carcinogens. -
Endogenous Metabolite
Enterostatin (human, mouse, rat) is an endogenous pentapeptide that plays a critical role in the regulation of fat intake. By influencing appetite control, it modulates food consumption and energy balance. This peptide is valuable for research applications focusing on obesity, metabolic disorders, and neuroendocrine signaling pathways. -
Endogenous Metabolite
Ginsenoside Ra3 is an endogenous metabolite derived from Panax ginseng, exhibiting potential anti-cancer activity through modulation of cell signaling pathways. This compound has been studied for its ability to inhibit tumor growth and induce apoptosis in various cancer cell lines. Ginsenoside Ra3 may serve as a valuable tool in cancer research and therapeutic development. -
Endogenous Metabolite
N-Acetyl-DL-methionine is an endogenous metabolite that plays a critical role in the metabolism of sulfur-containing amino acids. It is involved in various physiological processes, including protein synthesis and methylation reactions. This compound is valuable for research in metabolic studies, as well as investigating its potential effects on cellular functions and oxidative stress. -
Endogenous Metabolite
Cholesteryl eicosapentaenoate is an endogenous metabolite that serves as a bioactive lipid mediator. It plays a crucial role in lipid metabolism and influences various signaling pathways in cellular processes. This compound is frequently used in research applications focused on inflammation, cardiovascular health, and neurobiology, providing insights into the biological mechanisms influenced by omega-3 fatty acids. -
Lipoxygenase Metabolite
9-HETE is a monohydroxy fatty acid and a key lipoxygenase metabolite derived from arachidonic acid. It plays a significant role in inflammatory processes and is involved in various signaling pathways. This compound is primarily utilized in research applications focused on lipid metabolism, inflammation, and the regulation of immune responses. -
Endogenous Metabolite
Aspartic acid calcium (Calcium L-aspartate) is a chelated compound formed from calcium and L-Aspartic acid. It is notable for its ability to penetrate the blood-brain barrier, making it useful in neurological research. Aspartic acid calcium is often employed in the preparation of prodrugs aimed at colon and cecal tissues, as well as in studies investigating inflammatory conditions. -
Endogenous Metabolite
23,25-Dihydroxy-24-oxovitamin D3 is an endogenous metabolite derived from 24(R),25-Dihydroxyvitamin D3. This compound is significant in the study of vitamin D metabolism and plays a critical role in understanding metabolic diseases. It serves as a valuable research tool for elucidating the biological functions and pathways associated with vitamin D-related disorders. -
Endogenous Metabolite
3-Deoxy-galactosone is a 1,2-dicarbonyl compound that arises from the metabolic degradation of galactose. It is notable for its formation during Maillard and caramelization reactions in food. This endogenous metabolite may serve as a useful marker for studying food chemistry and the effects of glycation on biological systems. Its involvement in various metabolic pathways makes it relevant for research in nutrition and metabolic disorders. -
Endogenous Metabolite
N-methyl-N-dithiocarboxyglucamine sodium is an endogenous metabolite known for its ability to mobilize and facilitate the excretion of metallothionein-bound cadmium (109Cd) in mouse models. This compound effectively reduces cadmium accumulation in the liver and kidneys, which are particularly vulnerable to cadmium-induced toxicity. It serves as a valuable tool for studying heavy metal detoxification processes and evaluating novel therapeutic approaches to mitigate heavy metal toxicity in biological systems. -
Endogenous Metabolite
neo-Inositol is a stereoisomer of inositol that functions as an endogenous metabolite. It is involved in various cellular signaling pathways and can influence insulin sensitivity and neuronal function. Due to its role in metabolic processes, neo-Inositol is a useful reagent for studying metabolic disorders and neurobiological research applications. -
Endogenous Metabolite
Calycanthine is an alkaloid primarily derived from the Calycanthaceae family, with notable presence in the Psychotria genus. This compound exhibits neurotoxic properties, leading to convulsions in biological systems. Its unique mechanism of action makes it a useful tool in research focused on neuropharmacology and the investigation of central nervous system effects. -
Endogenous Metabolite
1-(2-Amino-3-hydroxyphenyl)ethanone is an endogenous metabolite derived from kynurenine, primarily involved in tryptophan metabolism. This compound has been linked to various biological conditions, including bladder cancer, leukemia, and anemia. It serves as a valuable research tool for studying metabolic disturbances and their implications in these diseases. -
Endogenous Metabolite
RBM14C12 is an endogenous metabolite involved in cell signal transduction. This compound plays a critical role in studying lipid metabolism and the structural integrity of cell membranes. RBM14C12 is also utilized in the development of innovative compounds aimed at modulating biological mechanisms associated with lipid-related diseases. -
Endogenous Metabolite
C22 Galactosylceramide is a sphingolipid that functions as an endogenous metabolite with significant roles in the central nervous system. Notably elevated in the spinal cord of mice on a methionine-restricted diet, this compound does not influence levels in the brain or liver. Additionally, it has been detected in the postmortem hippocampus of Alzheimer's disease patients, making it a valuable target for research associated with neurodegenerative conditions. -
Endogenous Metabolite
Iretol (2,4,6-trihydroxyanisole) is an endogenous metabolite and a degradation product derived from a glucoside found in Iris jorentina. It serves as an important intermediate in the biosynthesis of natural isoflavones, including Tectorigenin, Irigenin, and Caviunin. This compound is utilized in various research applications focused on natural product synthesis and the study of isoflavonoid pathways. -
Endogenous Metabolite
C24:1 Dihydro 1-deoxyceramide (m18:0/24:1) is an endogenous metabolite characterized by a long-chain fatty acid (24:1) and a 1-deoxysphingoid backbone. This lipid molecule is known to accumulate in conditions such as obesity and type 2 diabetes (T2D), and its accumulation can be toxic due to its inability to be further metabolized into complex sphingolipids. C24:1 dihydro 1-deoxyceramide has been shown to increase in differentiated adipocytes in vitro, making it relevant for research into metabolic disorders and lipid metabolism. -
Endogenous Metabolite
XR5944 is a potent topoisomerase inhibitor that targets DNA, demonstrating significant anti-tumor activity. It effectively inhibits the activities of both topoisomerase I and II, showcasing impressive potency across various cell lines, with IC50 values ranging from 0.04 to 0.4 nM. XR5944 remains effective in overcoming atypical drug resistance mechanisms, including cells overexpressing P-glycoprotein and multidrug resistance-related proteins. This compound has shown remarkable anti-tumor efficacy in preclinical models of H69 small cell lung cancer and HT29 colon cancer, inducing tumor regression in multiple cases. XR5944 is valuable for research on colon and lung cancer biological processes. -
Endogenous Metabolite
Dihydroxyfumaric acid hydrate is an endogenous metabolite that plays a crucial role in cellular metabolism, particularly in the tricarboxylic acid cycle. It has been studied for its potential antioxidant properties and its involvement in modulating metabolic pathways. This compound is used in research exploring metabolic disorders and neurodegenerative diseases, providing insights into cellular function and potential therapeutic approaches. -
Endogenous Metabolite
2-Ethylpyrazine is an endogenous metabolite known for its role in various metabolic pathways. This compound exhibits biological activity relevant to flavor and aroma profiles in food chemistry and is studied for its potential implications in metabolic disorders. Its applications in research include examining biosynthetic mechanisms and evaluating metabolic processes in various biological systems. -
Fungal Metabolites
5-Hydroxyvanillin is a derivative of ferulic acid, produced by the metabolic processes of various fungi and bacteria. This compound exhibits antioxidant properties and has been shown to have potential anti-inflammatory effects. It is widely used in research related to fungal metabolites, functional foods, and the exploration of natural product chemistry. -
Endogenous Metabolite
TRC210258 is a potent TGR5 agonist that plays a critical role in modulating glucose and lipid metabolism. This compound enhances energy expenditure by promoting the secretion of glucagon-like peptide-1, leading to improved control of hyperglycemia and dyslipidemia in models of diet-induced obesity. Additionally, TRC210258 has demonstrated the ability to reduce plasma triglycerides and low-density lipoprotein cholesterol levels, thereby positively influencing lipid-related cardiovascular risk factors such as remnant cholesterol and triglyceride clearance. Its application in metabolic research highlights its potential for therapeutic intervention in metabolic disorders. -
Endogenous Metabolite
Myricanone is an endogenous metabolite isolated from the bark of Myrica rubra. This compound exhibits potential biological activity, including antioxidant and anti-inflammatory properties. It is primarily utilized in research applications investigating metabolic pathways, natural product studies, and the exploration of its effects on cellular functions. -
Endogenous Metabolite
2-Phenylglycine is an endogenous metabolite known to be present in breast milk during the lactation period from weeks 2 to 4. This compound plays a significant role in metabolic processes and is often used in research applications related to lactation and infant nutrition. Its analysis can provide insights into the nutritional profile of breast milk and its impact on infant development.
