Catalog No.
Product Name
Application
Product Information
Citations
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Endogenous Metabolite
13-cis-Retinyl acetate is a metabolite of vitamin A, specifically an active isomer derived from Retinyl acetate. This compound is known to play a significant role in various biological processes, including vision and cellular growth regulation. Its unique structure and activity make it a valuable tool for research applications studying vitamin A metabolism and its physiological effects. -
Endogenous Metabolite
Cyclanilide, an endogenous metabolite, acts as a plant growth regulator primarily used in cotton cultivation. It influences various growth stages by modulating physiological processes, which can enhance crop yield and quality. Its applicability in agricultural research makes it a valuable tool for exploring plant growth dynamics and metabolism. -
Endogenous Metabolite
4,4'-Disulfanediylbis(2-aminobutanoic acid) is an endogenous metabolite that plays a crucial role in various biochemical pathways. It serves as a potential biomarker in metabolic studies, enabling researchers to investigate redox states and sulfur metabolism. This compound is valuable for research applications focused on metabolic regulation and cellular signaling. -
Endogenous Metabolite
18-Hydroxycorticosterone is a corticosteroid and an endogenous metabolite derived from corticosterone. It plays a crucial role in the regulation of electrolyte balance and blood pressure. This compound is essential for research into adrenal gland function, mineralocorticoid activity, and conditions associated with electrolyte disturbances, such as hyperaldosteronism. -
Endogenous Metabolite
1-O-Hexadecyl-2-O-docosahexaenoyl-sn-glycero-3-phosphorylcholine is an endogenous metabolite that plays a crucial role in lipid metabolism. It is primarily involved in signaling pathways related to obesity and metabolic disorders. This compound can be utilized in research to investigate the biological mechanisms underlying obesity and its potential impact on health. -
Endogenous Metabolite
Cortisol sulfate, also known as Cortisol 21-sulfate, is an endogenous metabolite of cortisol. As a specific ligand for intracellular transcortin, it plays a crucial role in regulating corticosteroid activity within the body. This compound is instrumental in research applications focused on stress response, glucocorticoid signaling, and metabolic pathways related to endocrine function. -
Endogenous Metabolite
Triarachidin is an endogenous metabolite that plays a significant role in the biosynthesis of lipids and other cellular functions. As a bioactive compound, it contributes to various metabolic pathways and cellular signaling mechanisms. Triarachidin is essential for research related to lipid metabolism, cellular physiology, and the exploration of metabolic disorders. -
Endogenous Metabolite
Lucidenic acid LM1 is a natural triterpenoid derived from the fungus Ganoderma lucidum. It is an endogenous metabolite that exhibits various biological activities, including anti-inflammatory and antioxidant properties. This compound has potential applications in research focused on oxidative stress, inflammation, and the exploration of fungal bioactive substances. -
Endogenous Metabolite
Phenylacetyl CoA is an endogenous metabolite that serves as an acyl-CoA derivative in metabolic pathways. It functions as a substrate for acceptor oxidoreductases, playing a critical role in the anaerobic metabolism of phenylalanine in denitrifying bacteria, such as Thauera aromatica. This compound is essential for studies on microbial metabolism and can be applied in research investigating the enzymatic processes of anaerobic organisms. -
Endogenous Metabolite
Urolithin M7 is an endogenous metabolite derived from gut microbiota metabolism. It exhibits significant inhibitory effects on oxidative stress and modulates inflammatory signaling pathways. Urolithin M7 is a valuable reagent for research applications focused on gut microbiota metabolism and cardiovascular disease mechanisms. -
Endogenous Metabolite
2,3-Diaminopropanoic acid hydrochloride is an endogenous metabolite known for its role as a biochemical building block and regulator in various metabolic pathways. It has been implicated in amino acid metabolism and can serve as a substrate in the synthesis of bioactive peptides. This compound is useful in research applications focusing on cellular metabolism, neurobiology, and the study of metabolic disorders. -
Endogenous Metabolite
11-Oxo etiocholanolone, also known as 11-Ketoetiocholanolone, is an endogenous metabolite that serves as a crucial marker for the detection of cortisol metabolites in feces and urine. This steroid plays a significant role in studies related to stress response and hormone metabolism. Its potential function as a pheromone further enhances its relevance in neuroendocrine research and behavioral studies. -
Endogenous Metabolite
Pteridine-2,4(1H,3H)-dione is an endogenous metabolite with a significant role in various biochemical pathways. This compound is involved in the regulation of cellular processes and may influence cellular responses to oxidative stress. Research applications include studies on metabolic pathways, enzyme activity, and the biological implications of pteridine derivatives in health and disease. -
Endogenous Metabolite
PNU-100440 is an endogenous metabolite of Linezolid, which primarily functions as an antibiotic targeting bacterial ribosomal protein synthesis. This compound is used in research to study the pharmacological profile of Linezolid and its metabolic pathway, providing insights into its therapeutic and side effects. The analysis of PNU-100440 can contribute to a better understanding of antibiotic metabolism and resistance in microbial organisms. -
Endogenous Metabolite
Hydroxy bosentan is an endogenous metabolite derived from Bosentan, primarily processed by the cytochrome P450 system in the liver. This compound retains 10%-20% of Bosentan's pharmacological activity, serving as a significant contributor to the overall therapeutic effects of the parent compound. Hydroxy bosentan is useful in research focused on metabolic pathways and the pharmacokinetics of endothelin receptor antagonists. -
Endogenous Metabolite
Cholesterol glucuronide is an endogenous metabolite that acts primarily through its role as a conjugate of cholesterol. It is produced in the liver by the enzyme UDP-glucuronosyltransferase and plays a significant role in cholesterol metabolism and transport. This compound is valuable for research applications focusing on lipid metabolism, cholesterol homeostasis, and related metabolic disorders. -
Endogenous Metabolite
Vitamin D3 octanoate, an octanoate ester of cholecalciferol, serves as an endogenous metabolite. It is known to induce cellular differentiation and inhibit the proliferation of cancer cells, making it a valuable compound for cancer research. This reagent is also applicable in studies focusing on vitamin D metabolism and its broader implications in cellular health. -
Endogenous Metabolite
3-(3-Hydroxyphenyl)propionic acid (3HPPA) functions as an endothelium-dependent promoter of nitric oxide (NO) release and an activator of endothelial nitric oxide synthase (eNOS). This compound facilitates vascular smooth muscle relaxation by enhancing NO synthesis in endothelial cells, leading to vasodilation and decreased peripheral vascular resistance. In studies, 3HPPA has shown a dose-dependent ability to lower systolic and diastolic blood pressure in spontaneously hypertensive rats without affecting cardiac contractility or heart rate. Its antihypertensive and vascular protective properties make it a valuable reagent for investigating cardiovascular disease prevention and treatment. -
Endogenous Metabolite
Hexokinase, Yeast is an enzyme that catalyzes the phosphorylation of glucose, playing a crucial role in the glycolytic pathway. This enzyme is vital for cellular energy production, contributing to the maintenance of mitochondrial integrity and promoting cell survival. It serves as an important reagent for studies focused on metabolic regulation and energy dynamics within yeast models. -
Endogenous Metabolite
Sorbitol-6-phosphate 2-dehydrogenase from Escherichia coli is a key enzyme that facilitates the conversion of D-sorbitol 6-phosphate to D-fructose 6-phosphate. This dehydrogenase exhibits a significantly faster rate of oxidation of D-sorbitol 6-phosphate, being ten times more efficient than the reduction of D-fructose 6-phosphate. It is vital for various metabolic pathways and cellular processes, making it a valuable reagent for research in metabolic engineering and enzymology studies. -
Endogenous Metabolite
1-1(Z)-Octadecenyl-2-docosahexaenoyl-sn-glycero-3-PE (18:0p/22:6-PE) is an endogenous metabolite that serves as a key structural component in cellular membranes. This lipid, identified in rat brain tissue through mass spectrometry imaging, exhibits unique structural and distribution properties. It has implications in research focused on lipid metabolism and neurobiology, facilitating the exploration of fatty acid chain isomers and their roles in physiological processes. -
Endogenous Metabolite
3-(3-Hydroxyphenyl)-3-hydroxypropanoic acid is an endogenous metabolite identified in urine that plays a significant role in biological processes. It is utilized in research related to autism, aiding in the investigation of metabolic pathways and potential biomarkers. This compound may provide insights into the biochemical alterations associated with neurodevelopmental disorders. -
Endogenous Metabolite
PG 9 maleate is an endogenous metabolite that primarily enhances central cholinergic transmission, resulting in analgesic effects. This compound demonstrates protective activity against memory loss induced by agents such as scopolamine and dicyclomine within a defined dosage range. Notably, PG 9 maleate exhibits significant selectivity for the M4/M1 receptor subtypes, suggesting a potential mechanism underlying its analgesic and neuroprotective properties. Additionally, it promotes acetylcholine release, thereby enhancing its overall biological efficacy. -
PNMT Inhibitor
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline is a selective inhibitor of phenylethanolamine N-methyltransferase (PNMT), exhibiting a Ki value of 0.3 μM. This compound is primarily utilized in research exploring psychiatric disorders associated with Alzheimer's disease and Parkinson's disease. Its mechanism of action makes it a valuable tool for studying the role of PNMT in neurodegenerative conditions. -
Endogenous Metabolite
Prosulfocarb is an effective herbicide that targets selective weed species in winter cereals. Its primary mechanism involves the inhibition of the biosynthesis of essential fatty acids in plants. This compound is instrumental in managing biotic resistance among weed populations, contributing to more effective agricultural practices. Research applications include studies on environmental impact, residue transfer, and the volatility effects that influence contamination patterns in target and non-target areas. -
Endogenous Metabolite
Thioetheramide-PC (1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine) is a modified phospholipid that serves as a competitive, reversible inhibitor of secretory phospholipase A2 (sPLA2). With an IC50 value of 2 μM at a substrate concentration of 0.5 mM, Thioetheramide-PC interacts with both the catalytic and activation sites of the enzyme, exhibiting tighter binding to the activation site. This unique dual interaction may facilitate phospholipase activation at low concentrations, making Thioetheramide-PC a valuable tool for studying sPLA2-related biological processes and mechanisms. -
Endogenous Metabolite
AZD-3199 is an ultra-long-acting beta2 adrenergic agonist primarily targeting the beta2 adrenergic receptor. It exhibits significant bronchodilator activity, making it a candidate for therapeutic use in asthma and chronic obstructive pulmonary disease (COPD) research. Its prolonged action facilitates investigations into novel treatment strategies for managing these respiratory conditions. -
Endogenous Metabolite
Dabrafenib carboxylic acid is the carboxylate metabolite of dabrafenib, primarily functioning as an endogenous metabolite. This compound retains the capacity to modulate signaling pathways associated with MAPK/ERK pathway alterations. It serves as a valuable tool for studying the pharmacokinetics and biological effects of dabrafenib in cancer research, particularly in the context of melanoma and other tumors with BRAF mutations. -
Endogenous Metabolite
Ranelic acid is an endogenous metabolite with metal cation chelating activity. It plays a vital role in the inhibition of osteoporosis and the enhancement of bone mineral density. Additionally, derivatives of ranelic acid display complex and highly substituted thiophene ring structures, providing potential avenues for further research in bone health and related metabolic pathways. -
Endogenous Metabolite
KBP-5493 is an endogenous metabolite that can be detected in biological fluids such as urine and plasma. This compound plays a significant role in metabolic pathways and may provide insights into various physiological processes. Its detection is essential for research applications in metabolomics and biomarker discovery. -
Fungal Metabolite
Stephacidin B is a fungal metabolite that exhibits significant cytotoxic activity against various human tumor cell lines. Notably, it demonstrates the strongest cytotoxic effects against testosterone-dependent LNCaP prostate cancer cells. This compound can be utilized in cancer research applications to explore therapeutic strategies and mechanisms of action related to prostate cancer. -
Endogenous Metabolite
SU9518 is a selective tyrosine kinase inhibitor targeting PDGFRα, demonstrating significant anti-fibrotic properties. This compound effectively inhibits the progression of proliferative vitreoretinopathy (PVR) in rabbit models involving fibroblasts and Müller cells, showing promising results without discernible toxicity. SU9518 holds potential for therapeutic applications in PVR and other proliferative ocular disorders characterized by fibrosis and gliosis. -
Endogenous Metabolite
PF-05387252 is a potent and selective inhibitor of IRAK4, effectively targeting endogenous Toll-like receptor (TLR) signaling pathways. This compound exhibits significant anti-inflammatory activity in experimental models, suggesting potential therapeutic applications in conditions such as psoriasis. While PF-05387252 has demonstrated efficacy in reducing inflammation in animal studies, its effectiveness in clinical settings for psoriasis has yet to be established. -
Herbicide
Pinoxaden is a selective post-emergence herbicide that targets a wide range of annual grass weeds. As a member of the phenylpyrazolines class, it effectively inhibits specific enzymes involved in the biosynthesis of plant growth regulators, disrupting normal growth processes in target species. Its primary applications include agricultural settings where control of grass weeds is essential for crop management and yield improvement. -
Endogenous Metabolite
Darexaban maleate is a direct factor Xa inhibitor, primarily utilized in the research of venous thromboembolism prevention. Its major metabolite, Darexaban glucitol, exhibits pharmacological activity and is formed in the human liver and intestine via UGT1A9 and UGT1A10-mediated glucitolation. The glucitolation exhibits a K(m) value greater than 250 μM in the liver, while in the intestine, it displays substrate inhibition kinetics with a K(m) of 27.3 μM. The presence of fatty acid-free bovine serum albumin significantly lowers the unbound K(m) values in human liver microsomes and UGT1A9. -
Endogenous Metabolite
13-cis-Vitamin A palmitate is an endogenous metabolite and a geometrical isomer of vitamin A palmitate. Exhibiting approximately 75% of the biological activity of all-trans-vitamins A palmitate, this compound is crucial in various physiological processes, including vision and cellular differentiation. It serves as an important research tool in studies focused on retinoid metabolism and its implications in health and disease. -
Endogenous Metabolite
α-Triglycidyl isocyanurate is an antitumor agent that primarily targets DNA by alkylating and cross-linking its structure, thereby inhibiting DNA replication. This compound demonstrates significant cytotoxic effects and maintains stability in fresh human plasma and whole blood, indicating favorable biocompatibility. Metabolism predominantly occurs in rat liver via an NADPH-independent pathway, and the complexity of its metabolic processes allows for a partial restoration of cytotoxicity under specific conditions. Its properties make α-Triglycidyl isocyanurate a valuable reagent for cancer research and therapeutic studies. -
Endogenous Metabolite
1,3-Dipalmitoyl-2-linoleoylglycerol is a triacylglycerol characterized by the presence of palmitic acid at the sn-1 and sn-3 positions and linoleic acid at the sn-2 position. This compound serves as an endogenous metabolite involved in various biological processes, including cellular signaling and lipid metabolism. It is relevant for research applications focused on lipid biochemistry, metabolism studies, and the exploration of membrane dynamics. -
Endogenous Metabolite
Palmitoleic acid sodium is an endogenous metabolite that plays a crucial role in lipid metabolism and cell signaling. This fatty acid has been shown to possess potential neuroprotective effects, particularly in the context of cerebrovascular disorders. It is utilized in research for its ability to modulate inflammatory pathways and support cardiovascular health, making it a valuable tool for studies related to metabolic disease and stroke prevention. -
Endogenous Metabolite
Atrazine mercapturate is an endogenous metabolite of the herbicide Atrazine, detectable in urinary samples. This compound serves as a reliable biomarker for confirming human exposure to Atrazine, facilitating research into its environmental and health impacts. Its detection is critical for studies on herbicide metabolism and toxicity in various populations. -
Endogenous Metabolite
Circumdatin A is an endogenous metabolite isolated from a fungal culture, characterized through detailed NMR spectral analysis. It exhibits potential biological activities that are currently being investigated in various research applications, particularly in the fields of biochemistry and natural product chemistry. Its unique structural attributes may contribute to understanding metabolic pathways and fungal biosynthesis. -
Endogenous Metabolite
(S)-3,4-Dihydroxybutyric acid sodium is an endogenous metabolite primarily associated with the metabolism of gamma-aminobutyric acid (GABA). It is notably excreted at elevated levels in individuals with succinic semialdehyde dehydrogenase (SSADH) deficiency. This compound serves as a valuable biomarker for diagnostic research and metabolic studies related to GABAergic dysfunction and neurological disorders. -
Endogenous Metabolite
PMPMEase-IN-2 is an inhibitor of polyprenylated protein methylesterase, targeting the regulation of polyprenylated protein metabolism. This regulation is crucial for maintaining normal cellular function and survival, with dysregulation linked to degenerative diseases and cancer. PMPMEase-IN-2 holds potential applications in cancer research, providing a specific approach for investigating the modulation of polyprenylated protein pathways. -
Endogenous Metabolite
Uridine 5'-triphosphate tris salt acts primarily as an endogenous metabolite involved in cellular energy transfer and nucleotide synthesis. It plays critical roles in RNA synthesis and is essential for various biochemical pathways, including signal transduction and cellular metabolism. This reagent is widely utilized in research applications such as studying nucleoside triphosphate dynamics and investigating metabolic processes in cell biology. -
Endogenous Metabolite
Triflusulfuron-methyl is a selective herbicide that acts by inhibiting the enzyme acetolactate synthase (ALS), which is crucial for the biosynthesis of branched-chain amino acids. It demonstrates significant biological activity in controlling specific weed species by disrupting their growth and development. This compound is commonly used in agricultural research to study herbicide resistance mechanisms and assess crop safety against ALS inhibitors. -
Endogenous Metabolite
Moperone hydrochloride is a selective antagonist of the dopamine D2 receptor. It demonstrates significant biological activity in modulating dopaminergic neurotransmission, making it valuable in the research of psychiatric disorders such as schizophrenia and other dopamine-related conditions. This compound is essential for studies aimed at understanding the role of dopamine in mental health and the development of antipsychotic therapies. -
Endogenous Metabolite
sEH-IN-12 is a potent inhibitor of soluble epoxide hydrolase (sEH) that effectively blocks its activity. This compound demonstrates strong biological activity and has been utilized in the construction and selection of small molecule libraries. The development of sEH-IN-12 offers a valuable tool for drug discovery efforts aimed at targeting sEH for therapeutic interventions. -
Fungal Metabolite
Aculene A is a norsesquiterpene derived from the fungus Aspergillus aculeatus, primarily targeting fungal metabolic pathways. It exhibits significant biological activity, making it valuable for research applications in mycology and natural product studies. Aculene A may serve as a lead compound for investigating fungal interactions and the development of antifungal agents. -
Endogenous Metabolite
Neogen, also known as Jadinol PU, is an endogenous metabolite that plays a crucial role in immune system restoration and hematopoiesis. It demonstrates significant activity in supporting the recovery of immune functions following cytotoxic treatments. This compound is particularly useful in research focused on improving outcomes for patients undergoing chemotherapy. -
Endogenous Metabolite
Antiarrhythmic agent-3 is an endogenous metabolite that enhances the efficacy of antiarrhythmic treatments while improving the inhibition index. Its antiarrhythmic properties are associated with its hydrophobicity, reflected in its log P value. Additionally, its potential central nervous system toxicity is linked to the interplay between its hydrophobic characteristics and acid constant (pKa). This compound is primarily utilized in research related to cardiac rhythm management and toxicity studies.
