CL-385319 is an N-substituted piperidine compound that targets the H5N1 avian influenza A virus, demonstrating inhibitory activity against infection. It exhibits an IC50 of 27.03±2.54 μM in Madin-Darby canine kidney cells (MDCK) and displays low cytotoxicity with a CC50 of 1.48 mM. CL-385319 effectively inhibits the entry of pseudoviruses carrying various H5N1 strains, although no effect is observed on VSV-G pseudotyped particles. Notably, mutations M24A in HA1 and F110S in HA2 confer resistance to CL-385319, suggesting the significance of these residues for binding efficacy. This compound is suitable for research applications concerning influenza virus entry mechanisms and antiviral drug development.
CL-385319 is an N-substituted piperidine compound that targets the H5N1 avian influenza A virus, demonstrating inhibitory activity against infection. It exhibits an IC50 of 27.03±2.54 μM in Madin-Darby canine kidney cells (MDCK) and displays low cytotoxicity with a CC50 of 1.48 mM. CL-385319 effectively inhibits the entry of pseudoviruses carrying various H5N1 strains, although no effect is observed on VSV-G pseudotyped particles. Notably, mutations M24A in HA1 and F110S in HA2 confer resistance to CL-385319, suggesting the significance of these residues for binding efficacy. This compound is suitable for research applications concerning influenza virus entry mechanisms and antiviral drug development.
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